Tag: 200-300

Synthesis of annulated 1,4-dioxanes and perhydro-1,4-oxazines by domino-Wacker-carbonylation and domino-Wacker-Mizoroki-Heck reactions was written by Tietze, Lutz F.;Heins, Arne;Soleiman-Beigi, Mohammad;Raith, Christian. And the article was included in Heterocycles in 2009.Recommanded Product: tert-Butyl (trans-2-hydroxycyclohexyl)carbamate This article mentions the following:

Pd(II)-catalyzed domino reactions for the formation of 1,4-dioxanes and perhydro-1,4-oxazines starting from hydroxy alkenes are described. The domino-Wacker-carbonylation comprises a Wacker oxidation, subsequent CO-insertion, and a nucleophilic substitution of the intermediately formed Pd-species. The domino-Wacker-Mizoroki-Heck reaction proceeds via a Wacker oxidation, subsequent insertion into the olefinic π-bond of α,β-unsaturated carbonyl compounds, and β-hydride elimination. In the experiment, the researchers used many compounds, for example, tert-Butyl (trans-2-hydroxycyclohexyl)carbamate (cas: 121282-70-0Recommanded Product: tert-Butyl (trans-2-hydroxycyclohexyl)carbamate).

tert-Butyl (trans-2-hydroxycyclohexyl)carbamate (cas: 121282-70-0) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Recommanded Product: tert-Butyl (trans-2-hydroxycyclohexyl)carbamate

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LC-ESI-QTOF-MS/MS profiling and antioxidant activity of phenolics from custard apple fruit and by-products was written by Du, Junxi;Zhong, Biming;Subbiah, Vigasini;Barrow, Colin J.;Dunshea, Frank R.;Suleria, Hafiz A. R.. And the article was included in Separations in 2021.HPLC of Formula: 10083-24-6 This article mentions the following:

Custard apple is an edible fruit grown in tropical and subtropical regions. Due to its abundant nutrient content and perceived health benefits, it is a popular food for consumption and is utilized as a medicinal aid. Although some published research had provided the phenolic compound of custard apple, the comprehensive phenolic profiling of Australian grown custard apple is limited. Hence, this research aimed to evaluate the phenolic content and antioxidant potential by various phenolic content and antioxidant assays, followed by characterization and quantification of the phenolic profile using LC-ESI-QTOF-MS/MS and HPLC-PDA. African Pride peel had the highest value in TPC (61.69 ± 1.48 mg GAE/g), TFC (0.42 ± 0.01 mg QE/g) and TTC (43.25 ± 6.70 mg CE/g), followed by Pink′s Mammoth peel (19.37 ± 1.48 mg GAE/g for TPC, 0.27 ± 0.03 mg QE/g for TFC and 10.25 ± 1.13 mg CE/g for TTC). African Pride peel also exhibited the highest antioxidant potential for TAC (43.41 ± 1.66 mg AAE/g), FRAP (3.60 ± 0.14 mg AAE/g) and ABTS (127.67 ± 4.60 mg AAE/g), whereas Pink′s Mammoth peel had the highest DPPH (16.09 ± 0.34 mg AAE/g), RPA (5.32 ± 0.14 mg AAE/g), •OH-RSA (1.23 ± 0.25 mg AAE/g) and FICA (3.17 ± 0.18 mg EDTA/g). LC-ESI-QTOF-MS/MS experiment successfully characterized 85 phenolic compounds in total, encompassing phenolic acids (20), flavonoids (42), stilbenes (4), lignans (6) and other polyphenols (13) in all three parts (pulp, peel and seeds) of custard apple. The phenolic compounds in different portions of custard apples were quantified by HPLC-PDA, and it was shown that African Pride peel had higher concentrations of the most abundant phenolics. This is the first study to provide the comprehensive phenolic profile of Australian grown custard apples, and the results highlight that each part of custard apple can be a rich source of phenolics for the utilization of custard apple fruit and waste in the food, animal feeding and nutraceutical industries. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6HPLC of Formula: 10083-24-6).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.HPLC of Formula: 10083-24-6

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The bioactivity of prenylated stilbenoids and their structure-activity relationship was written by Bo, Shengtao;Sui, Kiat Chang;Shan, Youxia;Chen, Yipeng;Liu, Hui;Li, Bailin;Jiang, Yueming;Zhu, Hong;Yang, Bao. And the article was included in Food Research International in 2022.Formula: C14H12O4 This article mentions the following:

Dietary prenylated stilbenoids present in many food resources, and have good bioactivities. However, their structure-activity relationships are rarely reported. In this work, eighteen C- and O-prenylated stilbenoids were chem. semisynthesized using one-step approach. They all could inhibit sugar digestive enzymes, including α-glucosidase and α-amylase. 4-Geranyl piceatannol from jackfruit showed the strongest activity by suppressing dipeptidyl peptidase-IV (DPP-IV) activity. The enzyme inhibition kinetics were measured and the inhibition mechanism was revealed. Evaluation of antioxidant activity highlighted that the introduction of prenyl with increasing prenyl chain length can significantly increase the antioxidant activity of stilbenoids. Our results suggested that prenylated stilbenoids could be used as functional food additives to decrease postprandial blood sugar levels by inhibiting sugar digestive enzymes and DPP-IV. Prenylated stilbenoids present remarkable DPP-IV inhibitory activity, providing more useful information for the prevention of type 2 diabetes. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Formula: C14H12O4).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Formula: C14H12O4

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Organosuperbase-Catalyzed 1,1-Diboration of Alkynes was written by Doan, Son H.;Ton, Nhan N. H.;Mai, Binh Khanh;Nguyen, Thanh Vinh. And the article was included in ACS Catalysis in 2022.Related Products of 1214264-88-6 This article mentions the following:

1,1-Diboryl alkenes are versatile building blocks in organic synthesis and medicinal chem. However, there have been only a small number of established methods to prepare this class of compounds, and most of them used transition-metal catalysts, which are undesirable in the preparation of biol. relevant compounds Herein, authors report an unprecedented application of P₁–^tBu phosphazene as a superbasic organocatalyst to promote 1,1-diboration reactions of unactivated aromatic and electron-deficient terminal alkynes. The dual Bronsted and Lewis basicity of this phosphazene enables the activation of reaction substrates and allows for high regio- and stereoselectivity to be obtained. A combination of thorough exptl. and computational studies suggests interesting mechanistic insights for these phosphazene-catalyzed diboration reactions, which are also discussed in detail. In the experiment, the researchers used many compounds, for example, 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-naphtho[1,8-de][1,3,2]diazaborinine (cas: 1214264-88-6Related Products of 1214264-88-6).

2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-naphtho[1,8-de][1,3,2]diazaborinine (cas: 1214264-88-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Related Products of 1214264-88-6

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Alcohol – Wikipedia,
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Lithium bromide, an inexpensive and efficient catalyst for opening of epoxide rings by amines at room temperature under solvent-free condition was written by Chakraborti, Asit K.;Rudrawar, Santosh;Kondaskar, Atul. And the article was included in European Journal of Organic Chemistry in 2004.Electric Literature of C13H19NO This article mentions the following:

Lithium bromide has been found to be an inexpensive and efficient catalyst for the opening of epoxide rings by amines, and this provides an environmentally friendly method for the synthesis of β-amino alcs. Aromatic and aliphatic amines react with cycloalkene oxides to exclusively form trans-2-(aryl/alkylamino)cycloalkanols in high yields. A 98-100% selectivity in favor of nucleophilic attack at the benzylic carbon atom of styrene oxide is observed with aromatic amines. However, aliphatic amines exhibit a marginal preference for the reaction at the terminal carbon atom of the epoxide ring in styrene oxide. Non-styrenoidal, unsym. alkene oxides undergo selective nucleophilic attack at the sterically less hindered carbon atom by aniline. The chelation effect of the Li⁺ ion enables selective opening of the epoxide ring in 3-phenoxypropylene oxide in the presence of styrene oxide. In the experiment, the researchers used many compounds, for example, Trans-2-(benzylamino)cyclohexanol (cas: 40571-86-6Electric Literature of C13H19NO).

Trans-2-(benzylamino)cyclohexanol (cas: 40571-86-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Electric Literature of C13H19NO

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Alcohol – Wikipedia,
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Facile synthesis of axially chiral styrene-type carboxylic acids via palladium-catalyzed asymmetric C-H activation was written by Yang, Chi;Wu, Tian-Rui;Li, Yan;Wu, Bing-Bing;Jin, Ruo-Xing;Hu, Duo-Duo;Li, Yuan-Bo;Bian, Kang-Jie;Wang, Xi-Sheng. And the article was included in Chemical Science in 2021.Reference of 68716-49-4 This article mentions the following:

A novel method by a one-step introduction of axial chirality and sterically hindered group were developed for facile synthesis of axially chiral styrene-type carboxylic acids. With the palladium-catalyzed C-H arylation and olefination of readily available cinnamic acid established, this transformation demonstrated excellent yield, excellent stereocontrol (up to 99% yield and 99% ee), and broad substrate scope under mild conditions. The axially chiral styrene-type carboxylic acids produced were successfully applied to Cp*Co(III)-catalyzed asym. C-H activation reactions, indicating their potential as chiral ligands or catalysts in asym. synthesis. In the experiment, the researchers used many compounds, for example, 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4Reference of 68716-49-4).

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Reference of 68716-49-4

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Alcohol – Wikipedia,
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A high-throughput analytical strategy based on QuEChERS-dSPE/HPLC-DAD-ESI-MSⁿ to establish the phenolic profile of tropical fruits was written by Silva, Catarina;Camara, Jose S.;Perestrelo, Rosa. And the article was included in Journal of Food Composition and Analysis in 2021.SDS of cas: 10083-24-6 This article mentions the following:

Tropical fruits are a rich source of phenolic compounds which are favorable in defending the human body against damage induced by free radicals (e.g., ROS, RNS). In the current work, a high throughput anal. approach based on a simple extraction procedure (QuEChERS-dSPE) combined with high-performance liquid chromatog.-diode array detector-electrospray ionization-mass spectrometry (HPLC-DAD-ESI-MSⁿ) was used to establish the phenolic profile of tropical fruits. The proposed method showed good linearity (r2 ≥0.991), precision (RSD < 8%), as well as low limits of detection (LOD ≤ 19.7 μg/L) and quantification (LOQ ≤ 65.8 μg/L). Thirty-four phenolic compounds were identified as belonging to different chem. groups, from which only 6 were common to all tropical fruits. Pitanga showed the highest relative phenolic concentration (99.5 mg/100 g of fruit), with the passion fruit (17.5 mg/100 g of fruit) the lowest. Flavonols were the most predominant chem. group in tropical fruits, representing 77.9, 60.1, and 55.8% of the phenolic composition of pitanga, passion fruit and mango, resp. The data obtained allow deep and comprehensive insights into the phenolic composition of tropical fruits in order to explore its potential bioactive activity. Nevertheless, in vivo assays using fruit extracts will be essential to recognize their potential health-promoting properties. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6SDS of cas: 10083-24-6).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.SDS of cas: 10083-24-6

Referemce:
Alcohol – Wikipedia,
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ACe inhibitory and antihypertensive activities of wine lees and relationship among bioactivity and phenolic profile was written by Lopez-Fernandez-Sobrino, Raul;Soliz-Rueda, Jorge R.;Margalef, Maria;Arola-Arnal, Anna;Suarez, Manuel;Bravo, Francisca I.;Muguerza, Begona. And the article was included in Nutrients in 2021.Recommanded Product: 10083-24-6 This article mentions the following:

Wine lees (WL) are byproducts generated in the winemaking process. The aim of this study was to investigate the angiotensin-converting enzyme inhibitory (ACEi) activity, and the blood pressure (BP) lowering effect of WL from individual grape varieties. The relationship among their activities and phenolic profiles was also studied. Three WL, from Cabernet, Mazuela, and Garnacha grape varieties, were firstly selected based on their ACEi properties. Their phenolic profiles were fully characterized by UHPLC-ESI-Q-TOF-MS. Then, their potential antihypertensive effects were evaluated in spontaneously hypertensive rats (SHR). BP was recorded before and after their oral administrations (2, 4, 6, 8, 24, and 48 h) at a dose of 5 mL/kg bw. Cabernet WL (CWL) exhibited a potent antihypertensive activity, similar to that obtained with the drug Captopril. This BP-lowering effect was related to the high amount of anthocyanins and flavanols present in these lees. In addition, a potential hypotensive effect of CWL was discarded in normotensive Wistar-Kyoto rats. Finally, the ACEi and antihypertensive activities of CWL coming from a different harvest were confirmed. Our results suggest the potential of CWL for controlling arterial BP, opening the door to com. use within the wine industry. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Recommanded Product: 10083-24-6).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Recommanded Product: 10083-24-6

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Alcohol – Wikipedia,
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Effect of intramolecular crosslinker properties on the mechanochemical fragmentation of covalently folded polymers was written by Levy, Avishai;Goldstein, Hadar;Brenman, Dolev;Diesendruck, Charles E.. And the article was included in Journal of Polymer Science (Hoboken, NJ, United States) in 2020.Reference of 4074-88-8 This article mentions the following:

The mechanochem. stability of polymers in solution is enhanced if the chains are covalently folded. Under shear forces, the addnl. bonds absorb mech. energy and inhibit unfolding, and as a result, slow down fragmentation. However, not all crosslinkers are equal in terms of their properties (length, strength, etc.). In order to understand the role of these added bonds in the polymers’ stability under mech. stress, a thorough study compares the rate of mechanochem. on single-chain polymer nanoparticles which have been folded with crosslinkers with different lengths, strengths, positioning, and valencies. The usage of bonds with different mech. strengths in the crosslinkers was found to be the most powerful way to change the mechanochem. fragmentation rate. In addition, positioning and valency also play significant role in the mech. stabilization mechanism. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Reference of 4074-88-8).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Reference of 4074-88-8

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Alcohol – Wikipedia,
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Resveratrol: Mechanistic and therapeutic perspectives in pulmonary arterial hypertension was written by Mirhadi, Elaheh;Roufogalis, Basil D.;Banach, Maciej;Barati, Mehdi;Sahebkar, Amirhossein. And the article was included in Pharmacological Research in 2021.Application In Synthesis of (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol This article mentions the following:

Resveratrol, trans 3,5,4-trihydroxystilbene, is a stilbenoid polyphenol with a wide range of properties including antioxidant, neuroprotective, cardioprotective, anti-inflammatory and anticancer activities. It is found in the skins of grape (50-100μg/mL), red wine, peanuts, bilberries, blueberries and cranberries. The most important effects of resveratrol have been found in cardiovascular disease, with pulmonary arterial hypertension (PAH) being a major severe and progressive component. Many factors are involved in the pathogenesis of PAH, including enzymes, transcription factors, proteins, chemokines, cytokines, hypoxia, oxidative stress and others. Resveratrol treats PAH through its actions on various signaling pathways. These signaling pathways are mainly suppressed SphK1-mediated NF-κB activation, BMP/SMAD signaling pathway, miR-638 and NR4A3/cyclin D1 pathway, SIRT1 pathway, Nrf-2, HIF-1 α expression, MAPK/ERK1 and PI3K/AKT pathways, and RhoA-ROCK signaling pathway. Resveratrol efficiently inhibits the proliferation of pulmonary arterial smooth muscle cells and right ventricular remodeling, which are underlying processes leading to enhanced PAH. While supportive evidence from randomized controlled trials is yet to be available, current in vitro and in vivo studies seem to be convincing and suggest a therapeutic promise for the use of resveratrol in PAH. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Application In Synthesis of (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Application In Synthesis of (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts