Tag: 200-300

Microfluidic Janus fibers with dual thermoresponsive behavior for thermoactuation was written by Razzaq, Wasif;Serra, Christophe A.;Chan-Seng, Delphine. And the article was included in European Polymer Journal in 2022.Recommanded Product: Diethyleneglycoldiacrylate This article mentions the following:

Thermoresponsive bilayer hydrogels have gained attention due to their fast response time and excellent recovery. A side-by-side capillary-based microfluidic device has been used to produce thermoresponsive Janus fibers by photopolymerization of monomer streams. These fibers had one of their parts consisting in a thermoresponsive polymer obtained from oligo(ethylene glycol) acrylate, 2-ethoxyethyl acrylate, and poly(ethylene glycol) diacrylate, while the other one consisted in a non-thermoresponsive polymer. The fibers showed reversible coiling and uncoiling phenomena with two temperature transitions upon heating (and cooling). The unexpected dual thermoresponsiveness was investigated by screening a wide range of parameters including the nature of the photoinitiator and comonomers. The transition temperatures were tuned from 0 to 80° by varying the comonomer composition, but also the nature and concentration of the crosslinker used. The ability of these Janus fibers to act as thermally-triggered actuators was demonstrated by performing up to four heating-cooling cycles and attaching a small weight at one of the extremities of the fiber. These results pave the way to the development of easily tunable polymer-based fibrous thermoactuators. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Recommanded Product: Diethyleneglycoldiacrylate).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Recommanded Product: Diethyleneglycoldiacrylate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Applicability of quinolizino-coumarins for monitoring free radical photopolymerization by fluorescence spectroscopy was written by Kaminska, Iwona;Ortyl, Joanna;Popielarz, Roman. And the article was included in Polymer Testing in 2015.SDS of cas: 4074-88-8 This article mentions the following:

Applicability of com. available 2,3,5,6-1H,4H-tetrahydro-quinolizino[9,9a,1-gh]coumarin (Coumarin 6H) and its 9-Me (Coumarin 102), 9-trifluoromethyl (Coumarin 153) and 10-carboxy (Coumarin 343) derivatives as fluorescent mol. probes for monitoring progress of free radical photopolymerization of several acrylic and methacrylic monomers by fluorescence probe technique (FPT) had been tested. The progress of the photopolymerization was monitored using a specially designed cure monitoring system. It was found that all the quinolizino-coumarins shifted their fluorescence spectra towards shorter wavelengths with progress of polymerization, which enabled monitoring the progress in terms of fluorescence intensity ratios as the progress indicator. Coumarin 6H turned out to be the most sensitive to changes occurring during polymerization Coumarin 102 and Coumarin 153 exhibited only about 20% lower sensitivity than that of Coumarin 6H, so those were also good enough for the cure monitoring of acrylic monomers, except for tetraethylene glycol diacrylate, where the quinolizino-coumarins response was disturbed by some fluorescent side product. Moreover, it had been found that the FPT technique has some limitations in the case of monofunctional monomers. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8SDS of cas: 4074-88-8).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.SDS of cas: 4074-88-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Using Chlorotrifluoroethane for Trifluoroethylation of (Hetero)aryl Bromides and Chlorides via Nickel Catalysis was written by Li, Xuefei;Gao, Xing;He, Chun-Yang;Zhang, Xingang. And the article was included in Organic Letters in 2021.Category: alcohols-buliding-blocks This article mentions the following:

A nickel-catalyzed reductive cross-coupling between industrial chem. CF₃CH₂Cl and (hetero)aryl bromides and chlorides was reported. The reaction was synthetically simple without the preparation of arylmetals and exhibits high functional group tolerance. The utility of this protocol was demonstrated by the late-stage modification of pharmaceuticals, providing a facile route for medicinal chem. In the experiment, the researchers used many compounds, for example, 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4Category: alcohols-buliding-blocks).

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Immunoprotective potential of Ayurvedic herb Kalmegh (Andrographis paniculata) against respiratory viral infections – LC-MS/MS and network pharmacology analysis was written by Banerjee, Subhadip;Kar, Amit;Mukherjee, Pulok K.;Haldar, Pallab K.;Sharma, Nanaocha;Katiyar, Chandra Kant. And the article was included in Phytochemical Analysis in 2021.Application In Synthesis of (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol This article mentions the following:

Immunity boosting has emerged as a global strategy to fight the SARS-CoV-2 pandemic situation. In India, AYUSH systems of medicine have been promoted as an immune-protection strategy. Andrographis paniculata (Burm. F) Nees (AP) mentioned in Ayurveda has been widely used for treating sore throat, flu, and upper respiratory tract infections which may provide possible novel therapeutic approaches, exclusively targeting SARS-CoV-2 and its pathways. The present work uses liquid chromatog.-tandem mass spectrometry (LC-MS/MS) metabolomics and combination synergy anal. based on network pharmacol. to mine multimode evidence to understand the possible mechanism of action, diseases association, protein-protein interaction and major pathways involved therein. Metabolite profiling was performed by Agilent QTOF LC-MS/MS system. Network pharmacol. anal. was performed by using functional annotation anal. based on databases like Binding DB, STRING, DAVID and KEGG for further data mining. Further combination synergy was evaluated using “neighborhood approach” and networks were constructed through Cytoscape 3.2.1. The mols. from kalmegh provides immune-protection and anti-viral response via involving different pathways, like toll-like receptor pathway, PI3/AKT pathway and MAP kinase pathways against COVID-19 infection. The KEGG anal. showed that in a vast majority of the most enriched pathways, AP were associated with viral infections and upper respiratory tract infections. The results suggest a synergy between andrographolide and other mols. identified as safe and efficacious anti-inflammatory agent having effects on upper respiratory tract infections and can significantly decrease the production of cytokines and pro-inflammatory factors in viral infections. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Application In Synthesis of (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Application In Synthesis of (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Luminescent tungsten(VI) complexes as photocatalysts for light-driven C-C and C-B bond formation reactions was written by Yu, Daohong;To, Wai-Pong;Tong, Glenna So Ming;Wu, Liang-Liang;Chan, Kaai-Tung;Du, Lili;Phillips, David Lee;Liu, Yungen;Che, Chi-Ming. And the article was included in Chemical Science in 2020.Safety of 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane This article mentions the following:

The realization of photocatalysis for practical synthetic application hinges on the development of inexpensive photocatalysts which can be prepared on a large scale. Herein an air-stable, visible-light-absorbing photoluminescent tungsten(VI) complex which can be conveniently prepared at the gram-scale is described. This complex could catalyze photochem. organic transformation reactions including borylation of aryl halides R¹X (X = Cl, Br, I; R¹ = 4-[ethoxy(oxo)methane]phenyl, naphthalen-2-yl, 3,5-dimethylphenyl, etc.), reductive coupling of benzyl bromides R²CH₂Br (R² = Ph, 3,4-dimethoxyphenyl, 2-bromophenyl, etc.) for C-C bond formation, reductive coupling of phenacyl bromides R³C(O)CH₂Br (R³ = Ph, 4-fluorophenyl, 2-methoxyphenyl, 3,5-bis(trifluoromethyl)phenyl) and decarboxylative coupling of redox-active esters of alkyl carboxylic acid with high product yields and broad functional group tolerance. In the experiment, the researchers used many compounds, for example, 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4Safety of 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane).

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Safety of 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Superwetting comonomers reduce adhesion of E. coli BL21 was written by Khan, Madiha F.;Luong, Nicholas;Kurian, Jerry;Brook, Michael A.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2017.Recommanded Product: 4074-88-8 This article mentions the following:

The adhesion of Escherichia coli to copolymers of methacrylates and a trisiloxane-polyether acrylate surfactant was found to be at a min. with copolymers containing a low (20%) fraction of the surfactant monomer. Rather than wettability, hardness, or water uptake, adhesion was found to be limited by the presence of low concentrations of bound surfactant that can interact with hydrophobic domains on the bacterium inhibiting anchoring to the polymer surface. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Recommanded Product: 4074-88-8).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Recommanded Product: 4074-88-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Water compatible stir-bar devices imprinted with underivatised glyphosate for selective sample clean-up was written by Gomez-Caballero, Alberto;Diaz-Diaz, Goretti;Bengoetxea, Olatz;Quintela, Amaia;Unceta, Nora;Goicolea, M. Aranzazu;Barrio, Ramon J.. And the article was included in Journal of Chromatography A in 2016.Reference of 4074-88-8 This article mentions the following:

This paper reports the development of stir bars with a new MIP based coating, for the selective sorptive extraction of the herbicide glyphosate (GLYP). Mol. imprinting of the polymer has directly been carried out employing underivatised GLYP as the template mol. Due to the poor solubility of the target compound in organic solvents, the MIP methodol. has been optimized for rebinding in aqueous media, being the synthesis and the rebinding steps carried out in water:methanol mixtures and pure aqueous media. The coating has been developed by radical polymerization initiated by UV energy, using N-allylthiourea and 2-dimethyl aminoethyl methacrylate as functional monomers and ethylene glycol dimethacrylate as the crosslinker. Mech. stability of the coating has been improved using 1,3-divinyltetramethyldisiloxane in the polymerization mixture Under the optimized conditions, the MIP has demonstrated excellent selectivity for the target compound in the presence of structural analogs, including its major metabolites. The applicability of the proposed method to real matrixes has also been assessed using river water and soil samples. Registered mean recoveries ranged from 90.6 to 97.3% and RSD values were below 5% in all cases, what confirmed the suitability of the described methodol. for the selective extraction and quantification of GLYP. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Reference of 4074-88-8).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Reference of 4074-88-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Role of N, N’-Diboryl-4,4′-bipyridinylidene in the Transition-Metal-Free Borylation of Aryl Halides and Direct C-H Arylation of Unactivated Benzene was written by Waghamare, Akash B.;Raut, Ravindra K.;Patel, Niranjan;Majumdar, Moumita. And the article was included in European Journal of Inorganic Chemistry in 2022.COA of Formula: C12H16BBrO2 This article mentions the following:

N,N’-Diboryl-4,4′-bipyridinylidene (^BBiPy) was utilized in sub-stoichiometric amounts along with anionic base as one electron donor species for both transition metal-free borylation of aryl halides and arene C-H functionalization with aryl iodides for biaryl syntheses. Reaction between ^BBiPy and potassium tert-butoxide or methoxide led to the formation of 4,4′-bipyridine radical anion (BiPy·^–) with the release of an electron. The BiPy·- was structurally characterized. The single electron released was transferred to aryl halides generating aryl radicals, which then react with diboron in the presence of methoxide to form aryl boronate and with unactivated benzene in the presence of tert-butoxide to form biaryls. Substrate scopes studies showed that aryl iodides and bromides undergo borylation (1B-12B), while only aryl iodides undergo C-C bond formation with arene C-H (1C-8C) through radical chain reaction. Mechanisms for C-B and C-C bond formation have been proposed based on the exptl. findings. In the experiment, the researchers used many compounds, for example, 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4COA of Formula: C12H16BBrO2).

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.COA of Formula: C12H16BBrO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Highly enantioselective rhodium-catalyzed cross-coupling of boronic acids and racemic allyl halides was written by Gonzalez, Jesus;van Dijk, Lucy;Goetzke, F. Wieland;Fletcher, Stephen P.. And the article was included in Nature Protocols in 2019.Reference of 68716-49-4 This article mentions the following:

Although Csp²-Csp² Suzuki-Miyaura couplings (SMCs) are widely used in small-mol. synthesis, related methods that allow the incorporation of Csp³-hybridized coupling partners, particularly in an asym. manner, are less developed. This protocol describes catalytic asym. SMC reactions that provide access to enantiomerically enriched cyclic allylic products. The method couples racemic allyl halide starting materials with sp²-hybridized boronic acid derivatives and is compatible with heterocyclic coupling partners. These reactions are catalyzed by a rhodium-ligand complex and typically display very high levels of enantioselectivity (>95% enantiomeric excess (ee)). In this protocol, a detailed procedure using a dihydropyridine-derived allyl chloride for the synthesis of (-)-(S)-tert-butyl-3-(4-bromophenyl)-3,6-dihydropyridine-1(2H)-carboxylate, an intermediate in the synthesis of the anticancer drug niraparib is reported. This procedure affords 1.17 g (86% yield) of the coupling product with 96% ee. The initial exptl. setup of the reaction takes 45-50 min, and the reaction is complete within 4-5 h. In the experiment, the researchers used many compounds, for example, 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4Reference of 68716-49-4).

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Reference of 68716-49-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Albumin Nanoparticle Endocytosing Subset of Neutrophils for Precision Therapeutic Targeting of Inflammatory Tissue Injury was written by Bachmaier, Kurt;Stuart, Andrew;Singh, Abhalaxmi;Mukhopadhyay, Amitabha;Chakraborty, Sreeparna;Hong, Zhigang;Wang, Li;Tsukasaki, Yoshikazu;Maienschein-Cline, Mark;Ganesh, Balaji B.;Kanteti, Prasad;Rehman, Jalees;Malik, Asrar B.. And the article was included in ACS Nano in 2022.Name: (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol This article mentions the following:

The complex involvement of neutrophils in inflammatory diseases makes them intriguing but challenging targets for therapeutic intervention. Here, we tested the hypothesis that varying endocytosis capacities would delineate functionally distinct neutrophil subpopulations that could be specifically targeted for therapeutic purposes. By using uniformly sized (∼120 nm in diameter) albumin nanoparticles (ANP) to characterize mouse neutrophils in vivo, we found two subsets of neutrophils, one that readily endocytosed ANP (ANPhigh neutrophils) and another that failed to endocytose ANP (ANPlow population). These ANPhigh and ANPlow subsets existed side by side simultaneously in bone marrow, peripheral blood, spleen, and lungs, both under basal conditions and after inflammatory challenge. Human peripheral blood neutrophils showed a similar duality. ANPhigh and ANPlow neutrophils had distinct cell surface marker expression and transcriptomic profiles, both in naive mice and in mice after endotoxemic challenge. ANPhigh and ANPlow neutrophils were functionally distinct in their capacities to kill bacteria and to produce inflammatory mediators. ANPhigh neutrophils produced inordinate amounts of reactive oxygen species and inflammatory chemokines and cytokines. Targeting this subset with ANP loaded with the drug piceatannol, a spleen tyrosine kinase (Syk) inhibitor, mitigated the effects of polymicrobial sepsis by reducing tissue inflammation while fully preserving neutrophilic host-defense function. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Name: (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Name: (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts