Tag: 200-300

Photo-Organocatalytic Enantioselective Radical Cascade Reactions of Unactivated Olefins was written by Bonilla, Pablo;Rey, Yannick P.;Holden, Catherine M.;Melchiorre, Paolo. And the article was included in Angewandte Chemie, International Edition in 2018.Electric Literature of C12H16BBrO2 This article mentions the following:

Radical cascade processes are invaluable for their ability to rapidly construct complex chiral mols. from simple substrates. However, implementing catalytic asym. variants is difficult. Reported herein is a visible-light-mediated organocatalytic strategy that exploits the excited-state reactivity of chiral iminium ions to trigger radical cascade reactions with high enantioselectivity. By combining two sequential radical-based bond-forming events, the method converts unactivated olefins and α,β-unsaturated aldehydes into chiral adducts in a single step. The implementation of an asym. three-component radical cascade further demonstrates the complexity-generating power of this photochem. strategy. In the experiment, the researchers used many compounds, for example, 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4Electric Literature of C12H16BBrO2).

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Electric Literature of C12H16BBrO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Amide Synthesis by Nickel/Photoredox-Catalyzed Direct Carbamoylation of (Hetero)Aryl Bromides was written by Alandini, Nurtalya;Buzzetti, Luca;Favi, Gianfranco;Schulte, Tim;Candish, Lisa;Collins, Karl D.;Melchiorre, Paolo. And the article was included in Angewandte Chemie, International Edition in 2020.Computed Properties of C12H16BBrO2 This article mentions the following:

Herein, the authors report a one-electron strategy for catalytic amide synthesis that enables the direct carbamoylation of (hetero)aryl bromides. This radical cross-coupling approach, which is based on the combination of nickel and photoredox catalysis, proceeds at ambient temperature and uses readily available dihydropyridines as precursors of carbamoyl radicals. The method’s mild reaction conditions make it tolerant of sensitive-functional-group-containing substrates and allow the installation of an amide scaffold within biol. relevant heterocycles. In addition, the authors installed amide functionalities bearing electron-poor and sterically hindered amine moieties, which would be difficult to prepare with classical dehydrative condensation methods. In the experiment, the researchers used many compounds, for example, 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4Computed Properties of C12H16BBrO2).

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Computed Properties of C12H16BBrO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A Clear-Cut Example of Selective Bpin-Bdan Activation and Precise Bdan Transfer on Boron Conjugate Addition was written by Cid, Jessica;Carbo, Jorge J.;Fernandez, Elena. And the article was included in Chemistry – A European Journal in 2014.Product Details of 1214264-88-6 This article mentions the following:

Activating the non-sym. Bpin-Bdan diboron reagent with alkoxide leads to the formation of two possible adducts: MeO^–→Bpin-Bdan or MeO^–→Bdan-Bpin. Exptl. and theor. investigation confirms that the MeO^–→Bpin interaction is preferred and thus selective formation of a C-Bdan bond upon reaction with an activated C:C bond. In the experiment, the researchers used many compounds, for example, 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-naphtho[1,8-de][1,3,2]diazaborinine (cas: 1214264-88-6Product Details of 1214264-88-6).

2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-naphtho[1,8-de][1,3,2]diazaborinine (cas: 1214264-88-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Product Details of 1214264-88-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Properties of thiol-vinyl PDLC films without additional photoinitiator was written by Lee, Jin Woo;Kim, Joon Ki;Ahmad, Farzana;Jamil, Muhammad;Jeon, Young Jae. And the article was included in Liquid Crystals in 2014.Related Products of 4074-88-8 This article mentions the following:

Polymer-dispersed liquid crystal (PDLC) films block UV light and have been used as smart windows, light shutters and rear screens on buildings. Generally, PDLCs are fabricated by photopolymerization using photoinitiators (PIs), which may induce film degradation by UV light. In this study, we report the fabrication of thiol-vinyl PDLC films by the polymerization-induced phase separation method without the addition of PI. The stoichiometric ratio of the thiol and vinyl monomers was optimized based on variations in the FT-IR absorbance intensity. The fabricated films displayed good electro-optical properties. The durability of the PDLC films (with and without PI) was investigated by observation under UV irradiation for 10 days, following which the films were characterised using a spectrophotometer, scanning electron microscope and polarised optical microscope. The thiol-vinyl PDLC film without PI exhibited good physicochem. durability and low haze variation under UV irradiation In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Related Products of 4074-88-8).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Related Products of 4074-88-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Systemic metastasis-targeted nanotherapeutic reinforces tumor surgical resection and chemotherapy was written by Xu, Minjun;Hu, Kaili;Liu, Yipu;Huang, Yukun;Liu, Shanshan;Chen, Yu;Wang, Dayuan;Zhou, Songlei;Zhang, Qian;Mei, Ni;Lu, Huiping;Li, Fengan;Gao, Xiaoling;Chen, Jun. And the article was included in Nature Communications in 2021.Category: alcohols-buliding-blocks This article mentions the following:

Failure of conventional clin. therapies such as tumor resection and chemotherapy are mainly due to the ineffective control of tumor metastasis. Metastasis consists of three steps: (i) tumor cells extravasate from the primary sites into the circulation system via epithelial-mesenchymal transition (EMT), (ii) the circulating tumor cells (CTCs) form “micro-thrombi” with platelets to evade the immune surveillance in circulation, and (iii) the CTCs colonize in the pre-metastatic niche. Here, we design a systemic metastasis-targeted nanotherapeutic (H@CaPP) composed of an anti-inflammatory agent, piceatannol, and an anti-thrombotic agent, low mol. weight heparin, to hinder the multiple steps of tumor metastasis. H@CaPP is found efficiently impeded EMT, inhibited the formation of “micro-thrombi”, and prevented the development of pre-metastatic niche. When combined with surgical resection or chemotherapy, H@CaPP efficiently inhibits tumor metastasis and prolonged overall survival of tumor-bearing mice. Collectively, we provide a simple and effective systemic metastasis-targeted nanotherapeutic for combating tumor metastasis. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Category: alcohols-buliding-blocks).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nickel-Catalyzed Intermolecular Carbobromination of Alkynes was written by Takahashi, Toshifumi;Kurahashi, Takuya;Matsubara, Seijiro. And the article was included in ACS Catalysis in 2020.Name: 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane This article mentions the following:

The nickel-catalyzed intermol. carbobrominations of alkynes with aryl bromides to form highly substituted and functionalized alkenyl bromides such as I [R¹ = n-Pr, n-pentyl, Bu; R² = n-Pr, n-pentyl, Br; R¹R² = (CH₂)₁₀, (CH₂)₁₃; Ar = 2-MeC₆H₄, 4-MeCOC₆H₄, 1-anthracenyl, etc.]. The reductive elimination of carbon-bromine bond from a Ni(II) species, which was usually a disfavored process, was achieved from a high-valent Ni(III) species in this reaction. This transformation not only expands the scope of transition-metal-complex-promoted bond-forming reactions but also, more particularly, accomplished the formation of labile bonds, which was as challenging to achieve as the cleavage of inert bonds, such as C-O or C-H bonds. In the experiment, the researchers used many compounds, for example, 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4Name: 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane).

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Name: 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Optimization of ultrasonic cellulase-assisted extraction and antioxidant activity of natural polyphenols from passion fruit was written by Wang, Wei;Gao, Yu-Ting;Wei, Ji-Wen;Chen, Yin-Feng;Liu, Qing-Lei;Liu, Hui-Min. And the article was included in Molecules in 2021.Product Details of 10083-24-6 This article mentions the following:

In this paper, ultrasonic cellulase extraction (UCE) was applied to extract polyphenols from passion fruit. The extraction conditions for total phenol content (TPC) and antioxidant activity were optimized using response surface methodol. (RSM) coupled with a Box-Behnken design (BBD). The results showed that the liquid-to-solid ratio (X₂) was the most significant single factor and had a pos. effect on all responses. The ANOVA anal. indicated quadratic models fitted well as TPC with R² = 0.903, DPPH scavenging activity with R² = 0.979, and ABTS scavenging activity with R² = 0.981. The optimal extraction parameters of passion fruit were as follows: pH value of 5 at 30°C for extraction temperature, 50:1 (w/v) liquid-to-solid ratio with extraction time for 47 min, the exptl. values were found matched with those predicted. IR spectroscopy suggested that the extract contained the structure of polyphenols. Furthermore, three main polyphenols were identified and quantified by HPLC. The results showed the content of phenolic compounds and antioxidant activity of the optimized UCE were 1.5∼2 times higher than that determined by the single extraction method and the Soxhlet extraction method, which indicates UCE is a competitive and effective extraction technique for natural passion fruit polyphenols. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Product Details of 10083-24-6).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Product Details of 10083-24-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mild, Selective Ru-Catalyzed Deuteration Using D₂O as a Deuterium Source was written by Eisele, Pascal;Ullwer, Franziska;Scholz, Sven;Plietker, Bernd. And the article was included in Chemistry – A European Journal in 2019.Related Products of 68716-49-4 This article mentions the following:

A method for the selective deuteration of polyfunctional organic mols. using catalytic amounts of [RuCl₂(PPh₃)₃] and D₂O as a deuterium source is presented. Through variation of additives like CuI, KOH, and various amounts of zinc powder, orthogonal chemoselectivities in the deuteration process were observed Mechanistic investigation indicated the presence of different, defined Ru-complexes under the given specific conditions. In the experiment, the researchers used many compounds, for example, 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4Related Products of 68716-49-4).

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Related Products of 68716-49-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Glucose-responsive oral insulin delivery platform for one treatment a day in diabetes was written by Xiao, Yufen;Tang, Zhongmin;Huang, Xiangang;Joseph, John;Chen, Wei;Liu, Chuang;Zhou, Jun;Kong, Na;Joshi, Nitin;Du, Jianzhong;Tao, Wei. And the article was included in Matter in 2021.SDS of cas: 68716-49-4 This article mentions the following:

Oral delivery of insulin is of great convenience in treating diabetes but is still subject to the harsh gastrointestinal tract. Herein, we developed an intelligent oral insulin platform based on glucose-responsive polymeric nanoparticles (NPs), which possess the following advantages: (1) protect the integrity and bioavailability of loaded insulin against gastrointestinal tract, (2) overcome the intestinal epithelial barriers via neonatal Fc receptor-mediated transport, and (3) on-demand release of insulin dependent solely on blood glucose levels to avoid hyperglycemia and hypoglycemia caused by unsafe doses of insulin. Notably, our oral NPs extended the therapeutic effect to up to 16 h in type 1 diabetic mice. To our knowledge, this is the longest effective time among such types of oral insulin platforms reported to date and may reduce the frequency of insulin administration to once daily. This platform might be useful for the oral delivery of biologics in treating diabetes and related complications. In the experiment, the researchers used many compounds, for example, 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4SDS of cas: 68716-49-4).

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.SDS of cas: 68716-49-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Characterization and quantification of metabolites of racemic ketoprofen excreted in urine following oral administration to man by ¹H-NMR spectroscopy, directly coupled HPLC-MS and HPLC-NMR, and circular dichroism was written by Skordi, E.;Wilson, I. D.;Lindon, J. C.;Nicholson, J. K.. And the article was included in Xenobiotica in 2004.COA of Formula: C16H16O3 This article mentions the following:

The identity of the human metabolites of ketoprofen (2-(3-benzoylphenyl)-propanoic acid) excreted via urine was investigated after a single oral dose of the racemic drug. Drug metabolites were concentrated and partially purified from urine using solid-phase extraction chromatog. before separation and identification by directly coupled HPLC-MS and HPLC-NMR. The metabolites identified were the ester glucuronides of the parent drug and its phase I metabolites, 2-[3-(3-hydroxybenzoyl)phenyl]-propanoic acid, 2-[3-(4-hydroxybenzoyl)phenyl]-propanoic acid and 2-[3-(hydroxy(phenyl)methyl)phenyl]-propanoic acid, the latter formed by reduction of the ketone group of ketoprofen. In addition, two novel minor metabolites were identified as the ether glucuronides of 2-[3-(3-hydroxybenzoyl)phenyl]-propanoic acid and 2-[3-(4-hydroxybenzoyl)phenyl]-propanoic acid. These conjugates were all observed as diastereoisomeric pairs of unequal proportions. Purification of these metabolites by preparative chromatog. allowed stereochem. assignments. Metabolites were quantified by ¹H-NMR spectroscopy after spectral simplification achieved by hydrolysis of the conjugates. In the experiment, the researchers used many compounds, for example, 2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid (cas: 59960-32-6COA of Formula: C16H16O3).

2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid (cas: 59960-32-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.COA of Formula: C16H16O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts