Tag: 200-300

Dethiation of α-methyl and α-phenylmercaptopropionic acid derivatives was written by Hannoun, Mohammad. And the article was included in Megallat Gamiat Al-Nagah Al-Abhat, A: Al-Ulum Al-Tabiiyyat in 2002.Category: alcohols-buliding-blocks This article mentions the following:

Dethiation of α-(3-benzoylphenyl)-α-Me and α-phenylmercaptopropionic acid with Raney nickel gave 2-(3-benzoylphenyl)propionic acid (20%), 2-[(3-α-hydroxybenzyl)phenyl]propionic acid (46%) and 2-(3-benzylphenyl)propionic acid (18%), resp. In the experiment, the researchers used many compounds, for example, 2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid (cas: 59960-32-6Category: alcohols-buliding-blocks).

2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid (cas: 59960-32-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis and photocrosslinking of disulfonated poly(arylene ether sulfone) copolymers for potential reverse osmosis membrane materials was written by Nebipasagil, Ali;Sundell, Benjamin J.;Lane, Ozma R.;Mecham, Sue J.;Riffle, Judy S.;McGrath, James E.. And the article was included in Polymer in 2016.SDS of cas: 4074-88-8 This article mentions the following:

Disulfonated poly(arylene ether sulfone) random copolymers with controlled oligomeric mol. weights were synthesized via nucleophilic aromatic substitution step polymerization A monofunctional endcapping reagent, meta-aminophenol, was utilized to control the mol. weight of the oligomers and to install telechelic amine endgroups. The meta-aminophenol end-capped oligomers were reacted with acryloyl chloride to obtain novel crosslinkable poly(arylene ether sulfone) oligomers with acrylamide groups on both ends. The chem. compositions of the functional oligomers were characterized by ¹H NMR spectroscopy to determine the degree of sulfonation and concentrations of acrylamide endgroups. The acrylamide-terminated oligomers were crosslinked with UV radiation in the presence of a multifunctional acrylate and a UV photoinitiator. Transparent, free-standing, dense films were obtained with high gel fractions. FTIR spectroscopy was utilized to observe the progress of the photo-crosslinking reaction. Thin films were cast from either aqueous or water-methanol solutions The crosslinked disulfonated poly(arylene ether sulfone) networks exhibited reduced water uptake and swelling relative to their linear counterparts. SEM and AFM showed that the photo-crosslinked thin films had smooth surfaces. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8SDS of cas: 4074-88-8).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.SDS of cas: 4074-88-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Long-Term Oral Administration of Piceatannol (3,5,3′,4′-Tetrahydroxystilbene) Attenuates Colon Tumor Growth Induced by Azoxymethane Plus Dextran Sulfate Sodium in C57BL/6J Mice was written by Kimura, Yoshiyuki. And the article was included in Nutrition and Cancer in 2022.COA of Formula: C14H12O4 This article mentions the following:

The effects of 3,5,3′,4′-tetrahydroxystilbene (piceatannol) on azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced colon cancer growth and changes in IL-1β, IL-6, tumor necrosis factor-α (cytokines), MCP-1, vascular endothelial growth factor, and PD-1 colon levels were investigated herein. AOM (10 mg/kg, i.p.) on day 0 induced colorectal carcinogenesis. On day 3, mice were provided with water containing 1.5% (w/v) DSS ad libitum for 3 day, and this 3-day drinking protocol was repeated twice. Piceatannol (5 and 12.5 mg/kg, twice daily) was orally administered to mice for 7-, 7-, 7-, and 6-day and then discontinued for 14-, 15-, and 16-day. Cytokines, chemokine, and PD-1 colon levels were measured by the resp. ELISA kits. In mice administered piceatannol (12.5 mg/kg), the tumor number, tumor area, and Ki-67-pos. cell numbers decreased by 30.1%, 57.2%, and 89.1%, resp., colon MCP-1 and PD-1 levels showed reductions of 43.8% and 70.9%, resp., and COX-2-pos. cell numbers declined by 60.2%. The inhibitory effects of piceatannol on AOM/DSS-induced colon tumor growth appear to be associated with reductions in colon MCP-1 and PD-1 levels through the downregulated expression of COX-2 in the tumor microenvironment. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6COA of Formula: C14H12O4).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.COA of Formula: C14H12O4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

One-pot synthesis of pH-sensitive poly(RGD-co-β-amino ester)s for targeted intracellular drug delivery was written by Qiao, Zeng-Ying;Qiao, Sheng-Lin;Fan, Gang;Fan, Yun-Shan;Chen, Yu;Wang, Hao. And the article was included in Polymer Chemistry in 2014.SDS of cas: 4074-88-8 This article mentions the following:

We report a convenient synthetic approach for one-pot preparation of poly(β-amino ester)s copolymerized with peptides. A family of copolymers with tertiary amine groups was synthesized by copolymerizing di(ethylene glycol) diacrylate (DEDA), poly(ethylene glycol) diacrylate (PEGDA), 3-(diethylamino)propylamine (DEPA) and GGRGD peptides using the Michael addition reaction. The hydrophobic/hydrophilic properties of the resulting copolymers are adjusted by altering the feed ratios of DEDA and PEGDA. The copolymers self-assembled into nanoparticles with sizes around 60-140 nm in aqueous media, which were confirmed by dynamic light scattering (DLS) and transmission electron microscopy (TEM) techniques. The copolymers exhibit pH sensitive properties upon introduction of DEPA moieties, which were proved by pyrene fluorescence and pH titration measurements. The acid-triggered dissociation behaviors of the nanoparticles were studied by DLS and Nile red (NR) release experiments, revealing that the sizes of dissociated copolymer nanoparticles were closely relevant to their compositions The nanoparticles can load the hydrophobic anticancer drug, i.e., doxorubicin (DOX). The DOX-loaded nanoparticles were stable in a neutral phosphate buffer solution with a payload leakage less than 20% at 37 °C. However, a significant acid-triggered DOX release was accomplished at pH 5.0 with release efficiency up to 60-80%. Because of the decoration of Arg-Gly-Asp (RGD) peptides onto the poly(β-amino ester)s, the DOX-encapsulated nanoparticles formed by poly(RGD-co-β-amino ester)s can be internalized by cancer cells via an α_vβ₃ integrin-mediated endocytosis pathway and accumulated in the lysosomes that provide an acidic environment to promote the release of DOX. Finally, the DOX-encapsulated copolymer nanoparticles with the targeted RGD peptide exhibited higher efficiency to kill U87 human glioblastoma cancer cells than that without RGD, which was further proved by cellular uptake of DOX-loaded nanoparticles. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8SDS of cas: 4074-88-8).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.SDS of cas: 4074-88-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis, phase-transition behavior and oil adsorption performance of porous poly(oligo(ethylene glycol) alkyl ether acrylate) gels was written by Safi, Syed Ragib;Nakata, Taku;Hara, Shyotaro;Gotoh, Takehiko;Iizawa, Takashi;Nakai, Satoshi. And the article was included in Polymers (Basel, Switzerland) in 2020.COA of Formula: C10H14O5 This article mentions the following:

To probe the effects of pendant side-chain structures on the properties of porous thermoresponsive polymer gels, oligo(ethylene glycol) alkyl ether acrylates were polymerised in an aqueous medium under radical-mediated phase-separation conditions. The monomer structures varied according to the lengths and termini of their ethylene glycol side chains. The porous poly(oligo(ethylene glycol) alkyl ether acrylate) (POEGA) gels exhibited variable lower critical solution temperatures (LCSTs) but similar and rapid swelling-deswelling behaviors. Although the LCST of the poly(tri(ethylene glycol) monomethyl ether acrylate) (PTEGA) gel decreased with increasing aqueous NaCl or CaCl2 concentration, PTEGA showed excellent thermosensitivity in highly concentrated salt solutions, recommending its application in saline environments. Examination of PTEGA adsorption performance in an oil-water emulsion showed that n-tridecane adsorption increased with temperature Although n-tridecane was effectively adsorbed at 70°C, its release from the fully adsorbed PTEGA gel was difficult despite a temperature reduction from 70 to 20°C. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8COA of Formula: C10H14O5).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.COA of Formula: C10H14O5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Structural and functional analysis of lignostilbene dioxygenases from Sphingobium sp. SYK-6 was written by Kuatsjah, Eugene;Chan, Anson C. K.;Katahira, Rui;Haugen, Stefan J.;Beckham, Gregg T.;Murphy, Michael E. P.;Eltis, Lindsay D.. And the article was included in Journal of Biological Chemistry in 2021.Recommanded Product: (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol This article mentions the following:

Lignostilbene-α,β-dioxygenases (LSDs) are iron-dependent oxygenases involved in the catabolism of lignin-derived stilbenes. Sphingobium sp.SYK-6 contains eight LSD homologs with undetermined physiol. roles. To investigate which homologs are involved in the catabolism of dehydrodiconiferyl alc. (DCA), derived from β-5 linked lignin subunits, we heterologously produced the enzymes and screened their activities in lysates. The seven soluble enzymes all cleaved lignostilbene, but only LSD2, LSD3, and LSD4 exhibited high specific activity for 3-(4-hydroxy-3-(4-hydroxy-3-methoxystyryl)-5-methoxyphenyl) acrylate (DCA-S) relative to lignostilbene. LSD4 catalyzed the cleavage of DCA-S to 5-formylferulate and vanillin and cleaved lignostilbene and DCA-S (∼10⁶ M^-1 s^-1) with tenfold greater specificity than pterostilbene and resveratrol. X-ray crystal structures of native LSD4 and the catalytically inactive cobalt-substituted Co-LSD4 at 1.45 Å resolution revealed the same fold, metal ion coordination, and edge-to-edge dimeric structure as observed in related enzymes. Key catalytic residues, Phe-59, Tyr-101, and Lys-134, were also conserved. Structures of Co-LSD4·vanillin, Co-LSD4·lignostilbene, and Co-LSD4·DCA-S complexes revealed that Ser-283 forms a hydrogen bond with the hydroxyl group of the ferulyl portion of DCA-S. This residue is conserved in LSD2 and LSD4 but is alanine in LSD3. Substitution of Ser-283 with Ala minimally affected the specificity of LSD4 for either lignostilbene or DCA-S. By contrast, substitution with phenylalanine, as occurs in LSD5 and LSD6, reduced the specificity of the enzyme for both substrates by an order of magnitude. This study expands our understanding of an LSD critical to DCA catabolism as well as the physiol. roles of other LSDs and their determinants of substrate specificity. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Recommanded Product: (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Recommanded Product: (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Behaviour of pharmaceuticals and personal care products in constructed wetland compartments: Influent, effluent, pore water, substrate and plant roots was written by Hijosa-Valsero, Maria;Reyes-Contreras, Carolina;Dominguez, Carmen;Becares, Eloy;Bayona, Josep M.. And the article was included in Chemosphere in 2016.Quality Control of 2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid This article mentions the following:

Seven mesocosm-scale constructed wetlands (CWs) with different design configurations, dealing with primary-treated urban wastewater, were assessed for the concentration, distribution and fate of ten pharmaceutical and personal care products (PPCPs) [ibuprofen, ketoprofen, naproxen, diclofenac, salicylic acid, caffeine, carbamazepine, Me dihydrojasmonate, galaxolide and tonalide] and eight of their transformation products (TPs). Apart from influent and effluent, various CW compartments were analyzed, namely, substrate, plant roots and pore water. PPCP content in pore water depended on the specific CW configuration. Macrophytes can take up PPCPs through their roots. Ibuprofen, salicylic acid, caffeine, Me dihydrojasmonate, galaxolide and tonalide were present on the root surface with a predominance of galaxolide and caffeine in all the planted systems. Naproxen, ibuprofen, salicylic acid, Me dihydrojasmonate, galaxolide and tonalide were uptaken by the roots. In order to better understand the removal processes, biomass measurement and biodegradability studies through the characterization of internal-external isomeric linear alkylbenzenes present on the gravel bed were performed. Three TPs namely, ibuprofen-amide, 3-ethylbenzophenone and 4-hydroxy-diclofenac were identified for the first time in wetland pore water and effluent water, which suggests de novo formation (they were not present in the influent). Conversely, O-desmethyl-naproxen was degraded through the wetland passage since it was detected in the influent but not in the subsequent treatment stages. Biodegradation pathways are therefore suggested for most of the studied PPCPs in the assessed CWs. In the experiment, the researchers used many compounds, for example, 2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid (cas: 59960-32-6Quality Control of 2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid).

2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid (cas: 59960-32-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Quality Control of 2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dealkenylative Ni-Catalyzed Cross-Coupling Enabled by Tetrazine and Photoexcitation was written by Chen, Si-Cong;Zhu, Qi;Cao, Yuhui;Li, Chen;Guo, Yinliang;Kong, Lingran;Che, Jinteng;Guo, Zhixian;Chen, Han;Zhang, Nan;Fang, Xianhe;Lu, Jia-Tian;Luo, Tuoping. And the article was included in Journal of the American Chemical Society in 2021.Product Details of 68716-49-4 This article mentions the following:

A new and general method to functionalize the C(sp³)-C(sp²) bond of alkyl and alkene linkages has been developed, leading to the dealkenylative generation of carbon-centered radicals that can be intercepted to underwent Ni-catalyzed C(sp³)-C(sp²) cross-coupling. This one-pot protocol leverages the easily procured alkene feedstocks for organic synthesis with excellent functional group compatibility without the need for a photoredox catalyst. In the experiment, the researchers used many compounds, for example, 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4Product Details of 68716-49-4).

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Product Details of 68716-49-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Vinylation of Aldehydes Using Mn/Cr Alloy and a N₄-Ligand/Ni^II-Catalyst was written by Harnying, Wacharee;Berkessel, Albrecht. And the article was included in Chemistry – A European Journal in 2015.Recommanded Product: 2-Bromo-6-(2-methyl-1,3-dioxolan-2-yl)pyridine This article mentions the following:

An efficient and practical protocol for the Cr/Ni-catalyzed vinylation of aldehydes, based on the use of Mn/Cr alloy (ca. 10 % Cr) and TMSCl is reported. In the presence of NiCl₂ (0.3 mol %) and 6,6′-diacetyl-2,2′-bipyridine bis(2,6-diisopropylphenyl)imine as an N₄-chelating ligand (1 mol%), the vinylations proceed smoothly at room temperature The presence of catalytic amounts of MeOH and LiOAc as additives was found to further promote the efficiency of the catalytic system, even in the absence of the ligand. Detailed reaction monitoring revealed that LiOAc accelerates the product alc. silylation, thus increasing the turnover rate. In the experiment, the researchers used many compounds, for example, 2-Bromo-6-(2-methyl-1,3-dioxolan-2-yl)pyridine (cas: 49669-14-9Recommanded Product: 2-Bromo-6-(2-methyl-1,3-dioxolan-2-yl)pyridine).

2-Bromo-6-(2-methyl-1,3-dioxolan-2-yl)pyridine (cas: 49669-14-9) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Recommanded Product: 2-Bromo-6-(2-methyl-1,3-dioxolan-2-yl)pyridine

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cascade Cross-Coupling of Dienes: Photoredox and Nickel Dual Catalysis was written by Huang, Long;Zhu, Chen;Yi, Liang;Yue, Huifeng;Kancherla, Rajesh;Rueping, Magnus. And the article was included in Angewandte Chemie, International Edition in 2020.Safety of 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane This article mentions the following:

Chem. transformations based on cascade reactions have the potential to simplify the preparation of diverse and architecturally complex mols. dramatically. Herein, the authors disclose an unprecedented and efficient method for the cross-coupling of radical precursors, dienes, and electrophilic coupling partners via a photoredox- and nickel-enabled cascade cross-coupling process. The cascade reaction furnishes a diverse array of saturated carbo- and heterocyclic scaffolds, thus providing access to a quick gain in C-C bond saturation In the experiment, the researchers used many compounds, for example, 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4Safety of 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane).

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Safety of 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts