Tag: 200-300

Liu, Xufang;Rong, Xianle;Liu, Shihan;Lan, Yu;Liu, Qiang published 《Cobalt-Catalyzed Desymmetric Isomerization of Exocyclic Olefins》. The research results were published in《Journal of the American Chemical Society》 in 2021.COA of Formula: C15H16O The article conveys some information:

Chiral cyclic olefins, 1-methylcyclohexenes, are versatile building blocks for the synthesis of pharmaceuticals and natural products. Despite the prevalence of these structural motifs, the development of efficient synthetic methods remains an unmet challenge. Herein the authors report a novel desym. isomerization of exocyclic olefins using a series of newly designed chiral cobalt catalysts, which enables a straightforward construction of chiral 1-methylcyclohexenes with diversified functionalities. The synthetic utility of this methodol. is highlighted by a concise and enantioselective synthesis of a natural product, β-bisabolene. The versatility of the reaction products is further demonstrated by multifarious derivatization. To complete the study, the researchers used 4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) .

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.COA of Formula: C15H16O 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

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Tang, Xiaowen;Luo, Xiang;Su, Qiong;Wei, Gaofei;Meng, Shan-Shui;Chan, Albert S. C. published 《Chemoselective dual functionalization of phenols via relay catalysis of borane with different forms》 in 2021. The article was appeared in 《CCS Chemistry》. They have made some progress in their research.Application In Synthesis of 4-(2-Phenylpropan-2-yl)phenol The article mentions the following:

A highly efficient and chemoselective dual functionalization of unprotected phenols with α- or β- hydroxyl acids was presented. A variety of valuable benzofuranones and dihydrocoumarins were delivered in moderate to high yields. D. functional theory (DFT) calculations and control experiments indicated that an untypical Friedel-Crafts alkylation and the subsequent lactonization were catalyzed by the Lewis acid form and the Bronsted acid form of borane, resp. Gram-scale experiments and late-stage functionalization of complex mols. were performed to highlight the utility of this reaction. And 4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) was used in the research process.

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.Application In Synthesis of 4-(2-Phenylpropan-2-yl)phenol 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

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Li, Shuying;Hu, Tiantian;Bertotto, Luisa Becker;Jiang, Yao;Gui, Wenjun;Schlenk, Daniel published 《Pesticide and Surfactant Mixtures Alter Sexual Differentiation in Japanese Medaka (Oryzias latipes)》 in 2021. The article was appeared in 《ACS ES&T Water》. They have made some progress in their research.Product Details of 140-66-9 The article mentions the following:

Effects-directed analyses of water extracts from the San Francisco Bay Delta of California using estrogenic activity indicated that the pesticides, bifenthrin, and diuron, as well as alkylphenol surfactants, were observed in active fractions. To determine whether the estrogenic activity of the mixture had any impacts on sexual development, Japanese medaka (Oryzias latipes) embryos were exposed to an ambient concentration of the compounds, individually and as mixtures, using components of the US Environmental Protection Agency (USEPA), Endocrine Disruptor Screening Program, and Organization for Economic Co-operation and Development (OECD) assay. In medaka exposed to diuron, or surfactants alone, the percentages of phenotypic females were 88.9 ± 19.2% and 66.4 ± 3.8%, resp. When diuron was combined with surfactants, 93.3 ± 5.8% of the animals were female. To evaluate whether phenotypic females were changed from genetically male animals, the expression of the male-specific gene (DMY) was measured in animals following treatment. Treatments with ambient concentrations of surfactants and diuron had animals with higher percentages (78 ± 19%) of phenotypic females that were derived from genotypic males. Our results demonstrated that mixtures of pesticides and surfactants may alter sexual development after embryonic exposure in fish.4-tert-Octylphenol (cas: 140-66-9) were involved in the experimental procedure.

4-tert-Octylphenol(cas: 140-66-9) is a common environmental pollutant showing weak estrogenic effects.Product Details of 140-66-9 It has been shown to cause harm to vertebrate male reproductive systems.

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Lee, Seok-Hee;Seo, Huiwon;Seo, Hyeyeong;Lazari, Maria;D’Agostino, Martin;Byrd, Nick;Yoon, Kyong Sup;Lee, Hee-Seok;Park, Yooheon published 《An In vitro dimerization assay for the adverse outcome pathway approach in risk assessment of human estrogen receptor α-mediated endocrine-disrupting chemicals》. The research results were published in《Chemosphere》 in 2022.Product Details of 140-66-9 The article conveys some information:

The adverse outcome pathway (AOP) has been recently proposed as an effective framework for chem. risk assessment. The AOP framework offers the advantage of effectively integrating individual in vitro studies and in silico prediction models. Thus, the development of an effective testing method to measure key events caused by chems. is essential for chem. risk assessment through a fully developed AOP framework. We developed a human cell-based estrogen receptor α (ERα) dimerization assay using the bioluminescence resonance energy transfer (BRET) technique and evaluated the ERα dimerization activities of 72 chems. Fifty-one chems. were identified to mediate dimerization of ERα, and the BRET-based ERα dimerization assay could effectively measure the events that mediated dimerization of ERα by the estrogenic chems. These results were compared with the results of pre-existing assay to determine whether the BRET-based ERα dimerization assay could be employed as an in vitro test method to provide scientific information for explaining key events as a part of the AOP framework. Consequently, we propose that the BRET-based ERα dimerization assay is suitable for measuring the chem.-mediated dimerization of ERα, a key event in the AOP framework for cellular-level risk assessment of estrogenic chems.4-tert-Octylphenol (cas: 140-66-9) were involved in the experimental procedure.

4-tert-Octylphenol(cas: 140-66-9) is a common environmental pollutant showing weak estrogenic effects.Product Details of 140-66-9 It has been shown to cause harm to vertebrate male reproductive systems.

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Safety of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol《Convenient synthesis of ethylene carbonates from carbon dioxide and 1,2-diols at atmospheric pressure of carbon dioxide》 was published in 2016. The authors were Kitamura, Tsugio;Inoue, Yusuke;Maeda, Taisei;Oyamada, Juzo, and the article was included in《Synthetic Communications》. The author mentioned the following in the article:

An efficient and convenient synthesis of ethylene carbonates was achieved by the reaction of carbon dioxide with 1,2-diols in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), followed by treatment with 1-bromobutane. This DBU-promoted transformation proceeded at atm. pressure of carbon dioxide at 25°C and gave ethylene carbonates in good yields. The experimental procedure involved many compounds, such as rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) .

Desymmetrization of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas:579-43-1 Safety of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol) using chiral phosphine catalyst has been reported. Conversion of meso-hydrobenzoin to trans-stillbene oxide by treatment with an aryl sulfonyl chloride and aqueous sodium hydroxide has been reported.

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Category: alcohols-buliding-blocksIn 2021, Ma, Chuan;Sanchez-Rodriguez, Daniel;Kamo, Tohru published 《A comprehensive study on the oxidative pyrolysis of epoxy resin from fiber/epoxy composites: Product characteristics and kinetics》. 《Journal of Hazardous Materials》published the findings. The article contains the following contents:

Thermal treatment has been the most feasible process to recycle valuable carbon fibers and obtain fuel and chems. from waste fiber/epoxy composites. The present work studied the oxidative pyrolysis behaviors of epoxy resin from fiber/epoxy composites using a thermogravimetric apparatus and a fixed-bed reactor, resp. The effects of various O₂ concentrations on the thermal behaviors of epoxy resin were investigated and the product characteristics were analyzed. Furthermore, a multi distributed activation energy model (multi-DAEM) was first developed to determine the oxidative pyrolysis kinetics of epoxy resin under various atmospheres. Results showed that the degradation behaviors of epoxy resin were largely altered by the O₂ concentrations High O₂ concentrations accelerated the primary decomposition of epoxy resin and shifted the oxidation of resin residue into lower temperatures High contents of methylcyclohexene and phenolic derivatives were detected in liquid products. In air atm., high yields of CO and CO₂ were generated and distributed in several stages. The kinetic anal. indicated that the multi-DAEM method can well explain the oxidative pyrolysis behaviors of epoxy resin. A min. six-reaction fitting process can perfectly simulate the oxidative pyrolysis of epoxy resin. The predictions for various O₂ concentrations were in good agreement with the exptl. tests. To complete the study, the researchers used 4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) .

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.Category: alcohols-buliding-blocks 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

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Obara, Naoyuki;Hirasawa, Shota;Tamura, Masazumi;Nakagawa, Yoshinao;Tomishige, Keiichi published 《Oxidative Cleavage of Vicinal Diols with the Combination of Platinum and Vanadium Catalysts and Molecular Oxygen》 in 2016. The article was appeared in 《ChemCatChem》. They have made some progress in their research.Related Products of 579-43-1 The article mentions the following:

The combination of Pt/C and V₂O₅ catalysts gave good performance for the oxidative cleavage of trans-1,2-cyclohexanediol into adipic acid via 2-hydroxycyclohexanone. The yield of adipic acid reached 90% in the one-pot oxidative cleavage of trans-1,2-cyclohexanediol. The yield was higher than that obtained in the oxidation of 2-hydroxycyclohexanone with V catalyst, and the higher yield was due to the low 2-hydroxycyclohexanone concentration during the one-pot oxidation of trans-1,2-cyclohexanediol. Cyclic vicinal diols having a six-membered ring and linear vicinal diols having two secondary OH groups were converted into dicarboxylic acids and two carboxylic acids, resp. The activity of the Pt catalyst decreased during the reaction, and the activity was partially restored by treating the used catalyst with H₂ at 573 K. Even without regeneration, the turnover number based on total Pt could reach ≈1000 in a long reaction with an increased amount of trans-1,2-cyclohexanediol. And rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) was used in the research process.

rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas: 579-43-1 Related Products of 579-43-1) has been used in the preparation of trans-methyl meso-hydrobenzoin phosphite.

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Mistry, Nisha;Fletcher, Stephen P. published 《Phosphoramidite ligands based on simple 1,2-diols: synthesis, use in copper-catalyzed asymmetric additions, and achirotopic stereogenic phosphorus centres》 in 2016. The article was appeared in 《Advanced Synthesis & Catalysis》. They have made some progress in their research.Name: rel-(1R,2S)-1,2-Diphenylethane-1,2-diol The article mentions the following:

Phosphoramidite ligands are widely used in catalysis and normally constructed from large C₂-sym. diols such as BINOL or TADDOL. We report here on new ligands I (R¹ = R² = Ph , R¹-R² = (CH₂)₄; R³, R⁴ = CHMePh, CHPh₂, ⁱPr) based on a set of simple diols, 1,2-diphenyl-1,2-ethanediol, cis- and trans-1,2-cyclohexanol, that had been previously overlooked. Ligands based on (S,S)-trans-cyclohexanediol and (R,R)-(+)-1,2-diphenyl-1,2-ethanediol, in combination with both chiral and achiral amines, were tested in 3 different copper-catalyzed asym. reactions and up to 89% ee was observed A different ligand gave the best results in each reaction examined Using meso-cis-cyclohexanediol and meso-cis-diphenyl-1,2-ethanediol with a chiral non-racemic amine gave diastereomeric ligands bearing achirotopic stereogenic phosphorus atoms which were characterized with the assistance of x-ray crystallog. and variable temperature NMR studies. This work provides a new set of ligands that may be useful in some asym. reactions when phosphoramidites based on BINOL and TADDOL are ineffective. We also identify a novel stereochem. feature of phosphoramidites that may be useful in asym. catalysis and ligand design. To complete the study, the researchers used rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) .

Desymmetrization of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas:579-43-1 Name: rel-(1R,2S)-1,2-Diphenylethane-1,2-diol) using chiral phosphine catalyst has been reported. Conversion of meso-hydrobenzoin to trans-stillbene oxide by treatment with an aryl sulfonyl chloride and aqueous sodium hydroxide has been reported.

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Gu, Yilu;Tobino, Tomohiro;Nakajima, Fumiyuki published 《Determining the Relative Importance of Dietborne and Waterborne Toxicity of 4-tert-Butylphenol and 4-tert-Octylphenol to the Benthic Crustacean, Heterocypris incongruens》 in 2021. The article was appeared in 《Environmental Science & Technology》. They have made some progress in their research.Product Details of 140-66-9 The article mentions the following:

Organic pollutants with high solid-water equilibrium partition coefficients are adsorbed into solid particles and are easily ingested by benthic organisms, potentially causing dietborne toxicity. Whether dietborne toxicity is more important than waterborne toxicity for such chems. remains to be determined In this study, we identify the most relevant uptake route for the toxicity of two alkylphenols, 4-tert-butylphenol (4tBP), and 4-tert-octylphenol (4tOP). To achieve this, 6-day toxicity tests under two exposure conditions, namely dietary exposure (clean water + contaminated food) and combined exposure (contaminated water + contaminated food) were conducted on a benthic ostracod, Heterocypris incongruens. The toxicol. important exposure routes were confirmed by the consistency of dietary and aqueous dose-response relationships under different exposure conditions. During the test, frequent renewal of water and food was performed to reduce variability in the exposure conditions. The results showed that, under the equilibrium condition, the dietary exposure route was toxicol. more important than the aqueous route for 4tBP, whereas the waterborne exposure route was more important than the dietary exposure route for 4tOP. This study provides a novel approach to identify the most relevant uptake pathways for chem. toxicity, which better explains the importance of exposure routes in toxicity effects.4-tert-Octylphenol (cas: 140-66-9) were involved in the experimental procedure.

4-tert-Octylphenol(cas: 140-66-9) has been used as a reference standard for the determination of the analyte in water samples using ultra-high-performance liquid chromatography/tandem mass spectrometry (UHPLC/MS/MS).Product Details of 140-66-9

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Arunachalam, Rajendran;Chinnaraja, Eswaran;Valkonen, Arto;Rissanen, Kari;Sen, Shovan K.;Natarajan, Ramalingam;Subramanian, Palani S. published 《Enantiomeric Resolution of Asymmetric-Carbon-Free Binuclear Double-Stranded Cobalt(III) Helicates and Their Application as Catalysts in Asymmetric Reactions》. The research results were published in《Inorganic Chemistry》 in 2018.Name: rel-(1R,2S)-1,2-Diphenylethane-1,2-diol The article conveys some information:

A series of double-stranded binuclear helicates [Co₂(H1)₂]⁴⁺, [Co₂(H2)₂]⁴⁺, and [Co₂(H3)₂]⁴⁺, derived from monodeprotonated bis-pyridyl hydrazine-based ligands of H₂1, H₂2, and H₂3 with one, two, and three -CH₂ spacers, were obtained. These asym.-carbon-free racemic helicates were separated into their ΔΔ and ΛΛ enantiomers. The resolved helicates were examined for the first time as enantioselective catalysts in asym. benzoylation and nitroaldol reactions. To complete the study, the researchers used rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) .

Desymmetrization of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas:579-43-1 Name: rel-(1R,2S)-1,2-Diphenylethane-1,2-diol) using chiral phosphine catalyst has been reported. Conversion of meso-hydrobenzoin to trans-stillbene oxide by treatment with an aryl sulfonyl chloride and aqueous sodium hydroxide has been reported.

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