Tag: 200-300

HPLC of Formula: 599-64-4《Removal of selected emerging micropollutants from wastewater treatment plant effluent by advanced non-oxidative treatment – A lab-scale case study from Serbia》 was published in 2021. The authors were Bogunovic, Minja;Ivancev-Tumbas, Ivana;Cesen, Marjeta;Sekulic, Tatjana Djakovic;Prodanovic, Jelena;Tubic, Aleksandra;Heath, David;Heath, Ester, and the article was included in《Science of the Total Environment》. The author mentioned the following in the article:

The presence of 48 emerging micropollutants was tested in influent and effluent from primary and secondary treatment at a municipal wastewater treatment plant (WWTP) in Serbia. Sixteen emerging micropollutants (active pharmaceutical ingredients, bisphenols, parabens and UV filters) had concentrations >LOQ (maximum concentrate 33.4μg/L). The removal efficiency of primary treatment ranged from 2.0% – 96.0%. In the case of secondary treatment, except for ketoprofen (61.0%), diclofenac (62.6%) and carbamazepine (-20.0%), all other measured micropollutants had removal efficiency above 77.0%. Advanced non-oxidative lab-scale treatments were investigated. Powd. activated carbon (PAC) adsorption achieved removal efficiencies in the range 52.4-99.9%, novel coagulation with natural coagulant isolated from beans achieved removal efficiencies in range 3.2-99.9%, conventional coagulation with ferric chloride 3.12-96.4%, combined adsorption/coagulation 2.69-99.9% and combined PAC/ultrafiltration (PAC/UF) 60-99.9%. For most of the micropollutants, their removal efficiencies were similar to that reported in the literature. Novel natural coagulant showed significant potential compared to the conventional coagulant during a short episode of sub-optimal WWTP operation. When natural coagulant was applied as a part of an adsorption/coagulation hybrid process, there was no neg. effect on PAC adsorption, while for conventional coagulant that was not always the case. Also, a structure property relationship (SPR) study revealed correlations between the removal efficiency of the majority of treatments applied and total polar surface area (TPSA) of the micropollutants. And 4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) was used in the research process.

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.HPLC of Formula: 599-64-4 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

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Martin, Teo;Salamone, Michela;Bietti, Massimo published 《Hydrogen atom transfer from 1,2- and 1,3-diols to the cumyloxyl radical. The role of structural effects on metal-ion induced C-H bond deactivation》. The research results were published in《Chemical Communications (Cambridge, United Kingdom)》 in 2019.Reference of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol The article conveys some information:

Strong C-H bond deactivation toward HAT has been observed in the reactions of the cumyloxyl radical with 1,2- and 1,3-diols, following addition of Li⁺ and Ca²⁺. Weaker effects have been observed with Mg²⁺. The role of the substrate structure and of the metal ion in the formation of Lewis acid-base complexes is discussed. To complete the study, the researchers used rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) .

Desymmetrization of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas:579-43-1 Reference of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol) using chiral phosphine catalyst has been reported. Conversion of meso-hydrobenzoin to trans-stillbene oxide by treatment with an aryl sulfonyl chloride and aqueous sodium hydroxide has been reported.

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Recommanded Product: 140-66-9《Gonadal Soma-Derived Factor Expression is a Potential Biomarker for Predicting the Effects of Endocrine-Disrupting Chemicals on Gonadal Differentiation in Japanese Medaka (Oryzias Latipes)》 was published in 2022. The authors were Horie, Yoshifumi;Kanazawa, Nobuhiro;Takahashi, Chiho;Tatarazako, Norihisa;Iguchi, Taisen, and the article was included in《Environmental Toxicology and Chemistry》. The author mentioned the following in the article:

Chems. with androgenic or estrogenic activity induce the sex reversal and/or intersex condition in various teleost fish species. Previously, we reported that exposure to 17α-methyltestosterone, bisphenol A, or 4-nonylphenol induces changes in expression of the gonadal soma-derived factor (gsdf) gene accompanied by disruption of gonadal differentiation in Japanese medaka (Oryzias latipes). These findings suggest that gsdf expression might be a useful biomarker for predicting the potential effect of chems. on gonadal differentiation. We examined the gsdf expression in Japanese medaka exposed to chems. with estrogenic or androgenic activity. Exposure to the androgenic steroid 17β-trenbolone at 0.5-22.1μg/L induced the development of ovotestis (presence of ovarian tissue with testicular tissue) and female-to-male sex reversal in XX embryos, and exposure at 6.32 and 22.1μg/L significantly increased gsdf expression in XX embryos compared with controls at developmental stage 38 (1 day before hatching). In the present study, no statistically significant difference in gsdf mRNA expression was observed after exposure to 17β-estradiol, 17α-ethinylestradiol, and 4-t-octylphenol, which have estrogenic activity. In addition, antiandrogenic chems. or chems. without endocrine-disrupting activity did not induce changes in gsdf expression in XX or XY embryos. Thus, an increase in gsdf expression after androgen exposure was observed in XX embryos. Together, these findings indicate that gsdf expression might be useful for predicting the adverse effect of chems. on gonadal differentiation.4-tert-Octylphenol (cas: 140-66-9) were involved in the experimental procedure.

4-tert-Octylphenol(cas: 140-66-9) is a common environmental pollutant showing weak estrogenic effects.Recommanded Product: 140-66-9 It has been shown to cause harm to vertebrate male reproductive systems.

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Reference of 2-Hexyl-1-decanolIn 2020, Temerdashev, Z. A.;Milevskaya, V. V.;Ryabokon’, L. P.;Latin, N. N.;Kiseleva, N. V.;Nagalevskii, M. V. published 《Identification and Determination of the Components of Garden Sage (Salvia officinalis L.) Essential Oil, Isolated by Different Extraction Methods》. 《Journal of Analytical Chemistry》published the findings. The article contains the following contents:

We studied the component composition of the essential oil of garden sage (Salvia officinalis L.), obtained by various extraction methods. Essential oils were obtained by hydrodistillation and subcritical CO2 extraction, supercritical fluid extraction, and subcritical extraction with solid-phase and liquid-liquid preconcentration The components were identified by comparing the recorded mass spectra with the spectra of individual compounds and the data of the NIST07 and WILEY8 data bases. For all extraction methods, the major essential oil components were 1,8-cineole, camphor, α-thujone, β-thujone, borneol, 4-terpineol, β-caryophyllene, β-caryophyllene oxide, and viridiflorol. The concentration of analytes in the extracts varied depending on the extraction method. In total, 104 components were identified in the extracts, of which 30 were extracted by hydrodistillation, 32 by subcritical CO2 extraction, 14 by supercritical fluid extraction, 46 and 62 by subcritical extraction with solid-phase and liquid-liquid extraction into the organic phase. An increase in the number of components in more stringent extraction methods as compared to hydrodistillation showed that, in the extracts, a deeper decomposition of macrocomponents might take place, except for camphor. And 2-Hexyl-1-decanol (cas: 2425-77-6) was used in the research process.

2-Hexyl-1-decanol(cas: 2425-77-6) is a branched alcohol. It is one of the constituent of the essential oil, extracted from the roots of Adiantum flabellulatum. Reference of 2-Hexyl-1-decanol

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Grover, Aman;Kaur, Ramandeep;Mohiuddin, Irshad;Malik, Ashok K.;Aulakh, Jatinder Singh;Tsang, Yiu Fai;Kim, Ki-Hyun published 《Surfactant-modified Zn/Al-layered double hydroxides for efficient extraction of alkyl phenols from aqueous samples》 in 2019. The article was appeared in 《Environmental Research》. They have made some progress in their research.Related Products of 599-64-4 The article mentions the following:

Zn/Al-layered double hydroxides (LDHs) modified by sodium dodecylsulfate (SDS) were synthesized as a hydrophobic organic sorbent via urea hydrolysis. LDHs were applied as adsorbent for solid phase extraction (SPE) anal. to determine three alkylphenols (namely, p-tert-amylphenol (PTAP), p-cumylphenol (PCP), and p-n-octylphenol (POP)) in water samples using gas chromatog.-mass spectrometry. The extraction efficiency was optimized by adjusting key variables of eluent volume, eluent type, sample flow rate, adsorbent amount, pH, and the effect of salt addition Under the optimal conditions, APs showed excellent linearity (1-250 ng/mL: R2 > 0.99) and reproducibility (relative standard deviation: <5%). The detection limits for PTAP, PCP, and POP were 19, 16, and 33 pg/mL, resp. LDHs based SPE method offered high recovery for aqueous samples (e.g., 83.2-99.46%) with enhanced reusability (e.g., up to 10 cycles). The feasibility of the developed method has thus been validated for quantitation of three alkyl phenols (i.e., PTAP, PCP, and POP) in aqueous environmental samples with high sensitivity and good stability. To complete the study, the researchers used 4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) .

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.Related Products of 599-64-4 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

Reference:
Alcohol – Wikipedia,
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Lee, Seok-Hee;Seo, Huiwon;Seo, Hyeyeong;Lazari, Maria;D’Agostino, Martin;Byrd, Nick;Yoon, Kyong Sup;Lee, Hee-Seok;Park, Yooheon published 《An In vitro dimerization assay for the adverse outcome pathway approach in risk assessment of human estrogen receptor α-mediated endocrine-disrupting chemicals》. The research results were published in《Chemosphere》 in 2022.Application In Synthesis of 4-(2-Phenylpropan-2-yl)phenol The article conveys some information:

The adverse outcome pathway (AOP) has been recently proposed as an effective framework for chem. risk assessment. The AOP framework offers the advantage of effectively integrating individual in vitro studies and in silico prediction models. Thus, the development of an effective testing method to measure key events caused by chems. is essential for chem. risk assessment through a fully developed AOP framework. We developed a human cell-based estrogen receptor α (ERα) dimerization assay using the bioluminescence resonance energy transfer (BRET) technique and evaluated the ERα dimerization activities of 72 chems. Fifty-one chems. were identified to mediate dimerization of ERα, and the BRET-based ERα dimerization assay could effectively measure the events that mediated dimerization of ERα by the estrogenic chems. These results were compared with the results of pre-existing assay to determine whether the BRET-based ERα dimerization assay could be employed as an in vitro test method to provide scientific information for explaining key events as a part of the AOP framework. Consequently, we propose that the BRET-based ERα dimerization assay is suitable for measuring the chem.-mediated dimerization of ERα, a key event in the AOP framework for cellular-level risk assessment of estrogenic chems. To complete the study, the researchers used 4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) .

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.Application In Synthesis of 4-(2-Phenylpropan-2-yl)phenol 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

Reference:
Alcohol – Wikipedia,
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Li, Jing;Wu, Yalin;Bai, Huahua;Wen, Xiangli;Zhou, Qingxiang;Yuan, Yongyong;Liu, Yongli;Chen, Chunmao;Guo, Libing published 《Highly efficient adsorption and mechanism of alkylphenols on magnetic reduced graphene oxide》 in 2021. The article was appeared in 《Chemosphere》. They have made some progress in their research.Application of 140-66-9 The article mentions the following:

The influence of alkylphenols to environment cannot be ignored, as they are common product from chem. industries and potential threat to human health. Some alkylphenols are listed as persistent toxic substances (PTS) by the United Nations Environment Program (UNEP). In this study, the optimized magnetic reduced graphene oxide (MrGO) was synthesized by a facile solvothermal method, and investigated for adsorption of three typical alkylphenols. In neutral condition, MrGO showed extremely high adsorption capacity of three typical alkylphenols, 4-heptylphenol (4-HP), 4-tert-octylphenol (4-OP), and 4-nonylphenol (4-NP), which could reach 938.9 mg g^-1 (40 °C), 987.8 mg g^-1 (40 °C), and 989.7 mg g^-1 (20 °C), resp. This study revealed that the adsorption process was a heterogeneous multi-layer phys. adsorption, and the adsorption rates were related to the number of unoccupied vacancies on the adsorbent surface. From batch experiments and d. functional theory (DFT) calculations, the main adsorption interactions between MrGO and alkylphenols were deduced to be π-π, hydrogen-bond, and hydrophobic interactions. What′s more, the different affinities of MrGO towards different targets were further distinguished and explained in detail. The wonderful stability and recyclability of MrGO made it a promising cost-effective remediation candidate.4-tert-Octylphenol (cas: 140-66-9) were involved in the experimental procedure.

4-tert-Octylphenol(cas: 140-66-9) is a common environmental pollutant showing weak estrogenic effects.Application of 140-66-9 It has been shown to cause harm to vertebrate male reproductive systems.

Reference:
Alcohol – Wikipedia,
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Application In Synthesis of 4-(2-Phenylpropan-2-yl)phenol《An interim internal Threshold of Toxicologic Concern (iTTC) for chemicals in consumer products, with support from an automated assessment of ToxCast dose response data》 was published in 2020. The authors were Blackburn, Karen L.;Carr, Gregory;Rose, Jane L.;Selman, Bastian G., and the article was included in《Regulatory Toxicology and Pharmacology》. The author mentioned the following in the article:

Addnl. non-animal methods are urgently needed to meet regulatory and animal welfare goals. TTC is a broadly used risk assessment tool. TTC based on external dose has limited utility for multi-route exposure and some types of structure activity relationship assessments. An internal TTC (iTTC), where thresholds are based on blood concentration, would extend the applicability of TTC. While work is on-going to develop robust iTTC thresholds, we propose an interim conservative iTTC. Specifically, an interim iTTC of 1μM, supported by the published experience of the pharmaceutical industry, a literature review of non-drug chem./receptor interactions, and anal. of ToxCast data. ToxCast data were used to explore activity vs. the 1μM interim iTTC and recommendations for the anal. and interpretation of HTS data. Test concentration-based points of departure were classified to identify quality of fit to the Hill Model. We identified, for exclusion from the approach, estrogen receptor and androgen receptor targets as potent chem./receptor interactions potentially associated with low dose exposure to non-pharmaceutical active ingredients in addition to the original TTC exclusions. With these exclusions, we conclude that a 1μM plasma concentration is unlikely to be associated with significant biol. effects from chems. not intentionally designed for biol. activity. To complete the study, the researchers used 4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) .

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.Application In Synthesis of 4-(2-Phenylpropan-2-yl)phenol 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

Reference:
Alcohol – Wikipedia,
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Product Details of 599-64-4In 2022, Ma, Chuan;Kumagai, Shogo;Saito, Yuko;Kameda, Tomohito;Yoshioka, Toshiaki published 《An integrated utilization strategy of printed circuit boards and waste tire by fast co-pyrolysis: Value-added products recovery and heteroatoms transformation》. 《Journal of Hazardous Materials》published the findings. The article contains the following contents:

Fast co-pyrolysis has been suggested as a promising technique to solve the environmental issues and simultaneously recover value-added products from polymer wastes. However, to date, no studies have focused on fast co-pyrolysis of printed circuit boards (PCB) and waste tire (WT). Therefore, we comprehensively investigated the fast co-pyrolysis of PCB and WT using pyrolysis-gas chromatog./mass spectrometry. The results show that an increase in temperature during fast pyrolysis improved the interactions between the PCB and WT pyrolyzates, increasing the formation of aliphatic and aromatic compounds The formation of p-cymene was greatly induced by the isomerization and dehydrogenation reactions of -limonene. Co-pyrolysis reduced the formation of brominated phenols and benzothiazole from PCB and WT pyrolysis, resp., whereas promoted the interactions between Br- and S/N-containing radicals, concentrating them into heavy compounds Increasing the temperature enhanced the release of heteroatom compounds The findings suggest that debromination of PCB achieved via dehydrogenation of WT pyrolysis provoked secondary reactions of olefins and interactions of heteroatom radicals. The major products were accurately predicted by different fitting models using response surface methodol., indicating the synergistic interactions during co-pyrolysis. The results were beneficial for optimizing the exptl. parameters to obtain the maximum yield of desired products. To complete the study, the researchers used 4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) .

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.Product Details of 599-64-4 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

Reference:
Alcohol – Wikipedia,
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HPLC of Formula: 140-66-9《4-Octylphenol induces developmental abnormalities and interferes the differentiation of neural crest cells in Xenopus laevis embryos》 was published in 2021. The authors were Xu, Yang;Jang, Ji Hyun;Gye, Myung Chan, and the article was included in《Environmental Pollution (Oxford, United Kingdom)》. The author mentioned the following in the article:

Developmental toxicity of 4-octylphenol (OP), an estrogenic endocrine disruptor was verified using frog embryo teratogenesis assay Xenopus. LC50, EC50Malformtion and EC50Melanocyte-dysgenesis of OP were 9.9, 10.5, and 2.4μM, resp. In tadpoles, despite the low teratogenic index, 2μM OP significantly inhibited head cartilage development and tail malformation. The total length of tadpole was significantly increased at 5μM and decreased at 10μM OP. In OP-treated tadpoles, head cartilages were frequently missed and col2a1 mRNA was decreased at 2μM, indicating a chondrogenic defect in developing head. In the head skin of 1μM OP-treated tadpoles, number of melanocytes and melanogenic pathway genes expression were significantly decreased. In the head-neck junction of stage 22 embryos, OP increased foxd3 and sox10 mRNA and SOX10(+) neural crest cells (NCCs) in somite mesoderm and endoderm, indicating the inhibition of chondrogenic differentiation, ectopic migration to endoderm, and undifferentiation of NCCs by OP. Together, OP-induced head dysplasia and inhibition of melanogenesis may be attributable to deregulation of neural crest cells in embryos. In tadpoles, OP at 1μM significantly increased lipid hydroperoxide and induced spliced xbp1 mRNA, an IRE1 pathway endoplasmic reticulum stress (ERS) marker and p-eIF2α protein, a PERK pathway ERS marker. OP at 10μM induced CHOP mRNA, pro-apoptotic genes expression, DNA fragmentation, and cleaved caspase-3, suggesting that OP differentially induced ERS and apoptosis according to the concentration in embryos. In 5-10μM OP-treated stage 22 embryos and stage 45 tadpole heads, Ki67 was significantly increased, suggesting the apoptosis-induced proliferation of embryonic cells in the OP-treated embryos. Together, OP should be managed as a developmental toxicant altering the behavior of NCCs in vertebrates. The experimental procedure involved many compounds, such as 4-tert-Octylphenol (cas: 140-66-9) .

4-tert-Octylphenol(cas: 140-66-9) is a common environmental pollutant showing weak estrogenic effects.HPLC of Formula: 140-66-9 It has been shown to cause harm to vertebrate male reproductive systems.

Reference:
Alcohol – Wikipedia,
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