Tag: 200-300

Quality Control of 4-(2-Phenylpropan-2-yl)phenolIn 2022, Nakazawa, Tomomi;Yamaguchi, Yuko;Fukunaga, Yachiyo;Tamura, Kazutoshi published 《A possible critical dosing period of p-cumylphenol for development of cystic kidneys in rat neonates》. 《Journal of Toxicologic Pathology》published the findings. The article contains the following contents:

In accordance with a previous report on cystic kidneys induced in rat neonates when dosed with p-cumylphenol (PCP) for 18 days from postnatal day (PND) 4, 3 rat neonates were dosed with PCP once a day for 14 days, either from PND 14, 21, 28, 35, or 42 as W2, W3, W4, W5, and W6 groups, resp., to investigate whether dosing periods in different PNDs influenced the development of cystic renal tubules. The lesion was striking in the W2 group and at a lesser magnitude in the W3 group, whereas either kidney was unaffected when dosing was initiated beyond PND 28. These findings, together with the results from the previous study, suggested that PND 14-28 is a critical dosing period for PCP to develop cystic kidneys in rat neonates. The lining epithelium of the cystic tubules was immunohistochem. pos. for AQP2. This finding and the anatomical location indicated that the cystic tubules were of collecting duct origin. Either obstruction, fluid accumulation, or reparative hyperplasia of the lining epithelium was unlikely to be involved in the formation of cystic tubules lined with a monolayer of cuboidal or columnar epithelium with a high nuclear d. Thus, the follow-up investigation on PCP suggested a critical dosing period of PND 14-28 in rat neonates for the development of cystic dilation of renal collecting ducts. This study further supports that additive hyperplasia of the lining epithelium is a fundamental basis of this unique lesion. To complete the study, the researchers used 4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) .

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.Quality Control of 4-(2-Phenylpropan-2-yl)phenol 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

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Xu, Qiuxiang;Fu, Qizi;Liu, Xuran;Wang, Dongbo;Wu, Yanxin;Li, Yifu;Yang, Jingnan;Yang, Qi;Wang, Yali;Li, Hailong;Ni, Bing-Jie published 《Mechanisms of potassium permanganate pretreatment improving anaerobic fermentation performance of waste activated sludge》. The research results were published in《Chemical Engineering Journal (Amsterdam, Netherlands)》 in 2021.Reference of 2-Hexyl-1-decanol The article conveys some information:

Potassium permanganate (KMnO₄), one typical strong oxidant, is used extensively in various applications. However, its impact on anaerobic fermentation of waste activated sludge is unknown. This paper therefore aims to investigate its effect on generation of short-chain fatty acids (SCFAs) and qualities of fermentation liquor and fermented solid sludge. Exptl. results showed that when KMnO₄ increased from 0 to 0.1 g/TSS, the highest SCFAs production enhanced from 33.9 to 251.8 mg COD/g VSS. The mechanism anal. revealed that KMnO₄ addition increased the disintegration of sludge cells and the degradation of substantial recalcitrant organics in sludge such as humus and lignocellulose, thereby provided more substances for SCFAs generation. UV absorption spectroscopy anal. showed that KMnO₄ addition destroyed unsaturated conjugated bonds and decreased organics aromaticity, thereby promoting humus and lignocellulose degradation In addition, the sludge mixture was separated into liquid and solid fraction after anaerobic fermentation, and the components in fermentation liquid and solid sludge were tested. It was found that the addition of KMnO₄ effectively reduced the categories and total detected frequency of refractory organic pollutants in fermentation liquid, which improved the quality of the produced SCFAs. KMnO₄ addition also increased the inactivation of fecal coliforms and degradation of emerging contaminants in fermented sludge, which were helpful to its final disposal. And 2-Hexyl-1-decanol (cas: 2425-77-6) was used in the research process.

2-Hexyl-1-decanol(cas: 2425-77-6) has been shown to inhibit the growth of b16 mouse melanoma cells, suggesting it may be useful for treating skin cancer.Reference of 2-Hexyl-1-decanol This fatty acid also has transport properties and can form hydrogen bonds with other molecules.

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HPLC of Formula: 599-64-4《A tiered high-throughput screening approach for evaluation of estrogen and androgen receptor modulation by environmentally relevant bisphenol A substitutes》 was published in 2020. The authors were Keminer, Oliver;Teigeler, Matthias;Kohler, Manfred;Wenzel, Andrea;Arning, Juergen;Kassner, Franziska;Windshuegel, Bjoern;Eilebrecht, Elke, and the article was included in《Science of the Total Environment》. The author mentioned the following in the article:

Bisphenol A (BPA) is a high production volume chem. with a broad application spectrum. As an endocrine disrupting chem., mainly by modulation of nuclear receptors (NRs), BPA has an adverse impact on organisms and is identified as a substance of very high concern under the European REACH regulation. Various BPA substitution candidates have been developed in recent years, however, information concerning the endocrine disrupting potential of these substances is still incomplete or missing. In this study, we intended to investigate the endocrine potential of BPA substitution candidates used in environmentally relevant applications such as thermal paper or epoxy resins. Based on an extensive literature and patent search, 33 environmentally relevant BPA substitution candidates were identified. In order to evaluate the endocrine potential of the BPA replacements, a screening cascade consisting of biochem. and cell-based assays was employed to investigate substance binding to the NRs estrogen receptor α and β, as well as androgen receptor, co-activator recruitment and NR-mediated reporter gene activation. In addition, a computational docking approach for retrospective prediction of receptor binding was carried out. Our results show that some BPA substitution candidates, for which so far no or only very few data were available, possess a substantial endocrine disrupting potential (TDP, BPZ), while several substances (BPS, D-8, DD70, DMP-OH, TBSA, D4, CBDO, ISO, VITC, DPA, and DOPO) did not reveal any NR binding. To complete the study, the researchers used 4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) .

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.HPLC of Formula: 599-64-4 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

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Thouennon, Erwan;Delfosse, Vanessa;Bailly, Remy;Blanc, Pauline;Boulahtouf, Abdelhay;Grimaldi, Marina;Barducci, Alessandro;Bourguet, William;Balaguer, Patrick published 《Insights into the activation mechanism of human estrogen-related receptor γ by environmental endocrine disruptors》 in 2019. The article was appeared in 《Cellular and Molecular Life Sciences》. They have made some progress in their research.Computed Properties of C15H16O The article mentions the following:

The estrogen-related receptor γ (ERRγ, NR3B3) is a constitutively active nuclear receptor which has been proposed to act as a mediator of the low-dose effects of a number of environmental endocrine-disrupting chems. (EDCs) such as the xenoestrogen bisphenol-A (BPA). To better characterize the ability of exogenous compounds to bind and activate ERRγ, we used a combination of cell-based, biochem., structural and computational approaches. A purposely created stable cell line allowed for the determination of the EC50s for over 30 environmental ERRγ ligands, including previously unknown ones. Interestingly, affinity constants (Kds) of the most potent compounds measured by isothermal titrationcalorimetry were in the 50-500 nM range, in agreement with their receptor activation potencies. Crystallog. anal. of the interaction between the ERRγ ligand-binding domain (LBD) and compounds of the bisphenol, alkylphenol and naphthol families revealed a partially shared binding mode and minimal alterations of the receptor conformation upon ligand binding. Further biophys. characterizations coupled to mol. dynamics simulations suggested a mechanism through which ERRγ ligands would exhibit their agonistic properties by preserving the transcriptionally active form of the receptor while rigidifying some loop regions with associated functions. This unique mechanism contrasts with the classical one involving a ligand-induced repositioning and stabilization of the C-terminal activation helix H12. The experimental procedure involved many compounds, such as 4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) .

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.Computed Properties of C15H16O 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

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Name: 4-(2-Phenylpropan-2-yl)phenolIn 2021, Yue, Wenlong;Yin, Chao-Fan;Sun, Limin;Zhang, Jie;Xu, Ying;Zhou, Ning-Yi published 《Biodegradation of bisphenol-A polycarbonate plastic by Pseudoxanthomonas sp. strain NyZ600》. 《Journal of Hazardous Materials》published the findings. The article contains the following contents:

Bisphenol-A polycarbonate (PC) is a widely used engineering thermoplastic and its release has caused damage to the ecosystem. Microbial degradation of plastic represents a sustainable approach for PC reduction In this study, a bacterial strain designated Pseudoxanthomonas sp. strain NyZ600 capable of degrading PC was isolated from activated sludge by using di-Ph carbonate as a surrogate substrate. Within a 30-day period of incubating with strain NyZ600, PC films were analyzed with at. force microscopy, scanning electron microscope, water contact angle, XPS, fourier transform IR spectroscopy, differential scan calorimeter and thermogravimetric anal. technique. The analyses results indicated that the treated PC films were bio-deteriorated and formed some “corrosion pits” on the PC film surface. In addition, strain NyZ600 performed broad depolymerization of PC indicated by the reduction of Mn from 23.55 to 16.75 kDa and Mw from 45.67 to 31.97 kDa and two degradation products bisphenol A and 4-cumylphenol (the two monomers of PC) were also found, which established that PC were biodegraded by strain NyZ600. Combing all above results, it is clear that the strain NyZ600 can degrade PC which provides a unique example for bacterial degradation of PC and a feasibility for the removal of PC waste.4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) were involved in the experimental procedure.

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.Name: 4-(2-Phenylpropan-2-yl)phenol 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

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Reference of 2-Hexyl-1-decanol《Characterization of the physicochemical changes and volatile compound fingerprinting during the chicken sugar-smoking process》 was published in 2021. The authors were Chang, Hong;Wang, Ying;Xia, Qiang;Pan, Daodong;He, Jun;Zhang, Haimeng;Cao, Jinxuan, and the article was included in《Poultry Science》. The author mentioned the following in the article:

Sugar-smoking contributes to improving flavor attributes of meat products. However, there is rather limited information concerning the relationship between sugar-smoking process parameters and volatile compound (VC) fingerprinting as well as related quality attributes of sugar-smoked chicken. In this work, the changes in VC across the whole sugar-smoking process were determined and analyzed and physicochem. properties, free fatty acid, thiobarbituric acid reactive substances values, and E-nose were also performed to characterize the quality properties of sugar-smoked chicken breast (CB) and chicken skin (CS). Results suggested that a higher amount (P < 0.05) of total VC was observed in CS compared with CB during the whole processing, which may be correlated with higher thiobarbituric acid reactive substances values, and higher polyunsaturated fatty acid/saturated fatty acid ratio. According to E-nose anal., the volatile flavor is clearly separated in the sugar-smoking stage. Volatile fingerprinting results revealed that heterocycles were the characteristic flavor formed during sugar-smoking process and hexanal, nonanal, furfural, 5-methyl-2-furancarboxaldehyde, and 2-acetyl-5-methylfuran were the major volatiles of the CS, which was closely related to lipid oxidation and caramelization reaction. Above all, the flavor of sugar-smoked chicken was mainly derived from CS and sugar-smoked process improved the flavor of CS. This study could provide theor. guidance for regulation of the color and flavor of sugar-smoked chicken and further promote the development of the industry. And 2-Hexyl-1-decanol (cas: 2425-77-6) was used in the research process.

2-Hexyl-1-decanol(cas: 2425-77-6) is a branched alcohol. It is one of the constituent of the essential oil, extracted from the roots of Adiantum flabellulatum. Reference of 2-Hexyl-1-decanol

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Today I want to share an article with you. The article is 《Performance evaluation of ceramic membrane bioreactor: effect of operational parameters on micropollutant removal and membrane fouling》,you can find this article in 《Environmental Science and Pollution Research》. The following contents are mentioned:

This paper presents the removal of nine potential endocrine disruptors including pesticides, pharmaceuticals and industrial chems. using a submerged membrane bioreactor (MBR) system. Two lab-scale submerged MBRs having ceramic membranes were operated at three different sludge retention times (SRT: 15, 45, 90 days) and two hydraulic retention times (HRT: 12, 6 h) and the effects of SRT and HRT on both micropollutant removal and membrane fouling were investigated. While the effect of SRT and HRT change was observed on the removal of atrazine, fluoxetine, penconazole, no significant change was detected for the other micropollutants studied. It was determined that physicochem. properties such as distribution coefficient (LogD) and hydrophobicity of micropollutants are also effective on the removal efficiency of micropollutants. High removal efficiencies (≥ 97.5%) were observed for hydrophobic pollutants (logD > 3.2) except for penconazole (72.1%) and for hydrophilic pollutants (logD < 3.2) except for atrazine (42.5%). Membrane fouling was significantly affected by different operational parameters applied, with the slowest fouling occurring at 45 days of SRT and 12 h of HRT. However, micropollutant addition did not have a significant effect on membrane fouling. It has been shown that the simultaneous and effective treatment performance for micropollutants makes the membrane bioreactor system a promising wastewater treatment process. To complete the study, the researchers used 4-tert-Octylphenol (cas: 140-66-9) .

4-tert-Octylphenol(cas: 140-66-9) is a common environmental pollutant showing weak estrogenic effects.Application In Synthesis of 4-tert-Octylphenol It has been shown to cause harm to vertebrate male reproductive systems.

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Yasui, Masamichi;Hanaya, Kengo;Sugai, Takeshi;Higashibayashi, Shuhei published 《Metal-free thermal organocatalytic pinacol coupling of arylaldehydes using an isonicotinate catalyst with bis(pinacolato)diboron》 in 2021. The article was appeared in 《RSC Advances》. They have made some progress in their research.Related Products of 579-43-1 The article mentions the following:

The metal-free thermal organocatalytic pinacol coupling of arylaldehydes has been developed. The intermol. coupling of arylaldehydes catalyzed by t-Bu isonicotinate with bis(pinacolato)diboron as the co-reducing agent afforded 1,2-diphenylethane-1,2-diols. This reaction was also applicable to the intramol. coupling of 1,1′-biphenyl-2,2′-dicarbaldehydes to afford 9,10-dihydrophenanthrene-9,10-diols. Various functional groups were tolerated under this coupling condition.rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) were involved in the experimental procedure.

Desymmetrization of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas:579-43-1 Related Products of 579-43-1) using chiral phosphine catalyst has been reported. Conversion of meso-hydrobenzoin to trans-stillbene oxide by treatment with an aryl sulfonyl chloride and aqueous sodium hydroxide has been reported.

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Duijndam, Britt;Tedeschi, Massimo;van der Stel, Wanda;van den Hoorn, Tineke;van der Burg, Bart;Bouwman, Peter;van der Laan, Jan Willem;van de Water, Bob published 《Evaluation of an imaging-based in vitro screening platform for estrogenic activity with OECD reference chemicals》 in 2022. The article was appeared in 《Toxicology In Vitro》. They have made some progress in their research.Category: alcohols-buliding-blocks The article mentions the following:

Estrogen receptor alpha (ERα) is often a primary target of endocrine disrupting chems. (EDCs) and therefore several biochem. and cell-based assays for the detection of chems. with estrogenic properties have been developed in the past. However, the current approaches are not suitable for the monitoring of pathway activation dynamics, and they are mostly based on expression constructs that lack physiol. promoter regulation. We recently developed MCF7 fluorescent reporter cell lines of 3 different green fluorescent protein (GFP)-tagged ERα target genes: GREB1, PGR and TFF1. These reporters are under control of the full physiol. promoter region and allow the monitoring of dynamic pro-proliferative pathway activation on a single cell level using a live-cell imaging set-up. In this study, we systematically characterized the response of these reporters to a full reference compound set of known estrogenic and non-estrogenic chems. as defined by the Organization for Economic Co-Operation and Development (OECD). We linked activation of the pro-proliferative ERα pathway to a potential adverse outcome by addnl. monitoring cell cycle progression and proliferation. The correct classification of the OECD reference compounds showed that our reporter platform has the same sensitivity and specificity as other validated artificial ERα pathway reporters, such as the ERα CALUX and VM7 Luc ER TA assay. By monitoring several key events (i.e. ER target activation, cell cycle progression and proliferation), and subsequently determining Point-of-Departure (POD) values, our reporter panel can be used in high-throughput testing for a physiol. more relevant, quant. temporal endocrine modulation anal. to improve human carcinogen risk assessment. To complete the study, the researchers used 4-tert-Octylphenol (cas: 140-66-9) .

4-tert-Octylphenol(cas: 140-66-9) has been used as a reference standard for the determination of the analyte in water samples using ultra-high-performance liquid chromatography/tandem mass spectrometry (UHPLC/MS/MS).Category: alcohols-buliding-blocks

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Wang, Liguo;Zhao, Lu;Liu, Xian;Fu, Jianjie;Zhang, Aiqian published 《SepPCNET: Deeping Learning on a 3D Surface Electrostatic Potential Point Cloud for Enhanced Toxicity Classification and Its Application to Suspected Environmental Estrogens》. The research results were published in《Environmental Science & Technology》 in 2021.Quality Control of 4-(2-Phenylpropan-2-yl)phenol The article conveys some information:

Deep learning (DL) offers an unprecedented opportunity to revolutionize the landscape of toxicity prediction based on quant. structure-activity relationship (QSAR) studies in the big data era. However, the structural description in the reported DL-QSAR models is still restricted to the two-dimensional level. Inspired by point clouds, a type of geometric data structure, a novel three-dimensional (3D) mol. surface point cloud with electrostatic potential (SepPC) was proposed to describe chem. structures. Each surface point of a chem. is assigned its 3D coordinate and mol. electrostatic potential. A novel DL architecture SepPCNET was then introduced to directly consume unordered SepPC data for toxicity classification. The SepPCNET model was trained on 1317 chems. tested in a battery of 18 estrogen receptor-related assays of the ToxCast program. The obtained model recognized the active and inactive chems. at accuracies of 82.8 and 88.9%, resp., with a total accuracy of 88.3% on the internal test set and 92.5% on the external test set, which outperformed other up-to-date machine learning models and succeeded in recognizing the difference in the activity of isomers. Addnl. insights into the toxicity mechanism were also gained by visualizing critical points and extracting data-driven point features of active chems.4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) were involved in the experimental procedure.

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.Quality Control of 4-(2-Phenylpropan-2-yl)phenol 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

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