Tag: 200-300

Qiao, Lizhen;Sun, Ruiting;Tao, Yuan;Yan, Yang published 《New low viscous hydrophobic deep eutectic solvents for the ultrasound-assisted dispersive liquid-liquid microextraction of endocrine-disrupting phenols in water, milk and beverage》. The research results were published in《Journal of Chromatography A》 in 2022.Safety of 4-(2-Phenylpropan-2-yl)phenol The article conveys some information:

In the present work, several new hydrophobic deep eutectic solvents (HDESs) were prepared with quaternary ammonium salts as hydrogen bond acceptors (HBAs) and salicylate esters as hydrogen bond donors (HBDs). Then, the obtained HDESs were used as extraction solvents to establish an ultrasound-assisted dispersive liquid-liquid microextraction method combined with high-performance liquid chromatog.-UV detection technique for the determination of four endocrine-disrupting phenols (EDPs) compounds One of the obtained HDESs composed of tetrabutylammonium chloride (N4444Cl) and Me salicylate possessed a viscosity of 89.28 mPa·s lower than most reported ionic HDESs (>200 mPa·s), and the low viscous HDES was selected as the optimal extraction solvent. Several key parameters affecting the extraction efficiency were investigated, including the type and volume of HDES, ultrasound time, sample solution pH and salt addition Under the optimized exptl. conditions, the proposed method had good coefficients of determination (R2 > 0.9976) in the linear range of 0.5-400μg·L-1, the limits of quantification and limits of detection resp. were 0.5-2.5μg·L-1 and 0.25-1μg·L-1, and the recoveries were in the range of 81.79-109.82%. Finally, the method was used for the preconcentration and determination of EDPs in different samples, including bottled water, tea beverage and milk.4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) were involved in the experimental procedure.

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.Safety of 4-(2-Phenylpropan-2-yl)phenol 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

Reference:
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Electric Literature of C16H34OIn 2020, Choinska, Renata;Piasecka-Jozwiak, Katarzyna;Chablowska, Beata;Dumka, Justyna;Lukaszewicz, Aneta published 《Biocontrol ability and volatile organic compounds production as a putative mode of action of yeast strains isolated from organic grapes and rye grains》. 《Antonie van Leeuwenhoek》published the findings. The article contains the following contents:

Abstract: The inhibiting activity of three yeast strains belonging to Pichia kudriavzevii, Pichia occidentalis, and Meyerozyma quilliermondii/Meyerozyma caribbica genera against common plant pathogens representing Mucor spp., Penicillium chrysogenum, Penicillium expansum, Aspergillus flavus, Fusarium cereals, Fusarium poae, as well as Botrytis cinerea genera was investigated. The yeast strains tested had a pos. impact on growth inhibition of all target plant pathogens. The degree of inhibition was more than 50% and varied depending on both the yeast antagonist and the mold. Et esters of medium-chain fatty acids, phenylethyl alc., and its acetate ester prevailed among the analyzed volatile organic compounds (VOCs) emitted by yeasts in the presence of the target plant pathogens. Due to the method used, assuming no contact between the antagonist and the pathogen, the antagonistic activity of the yeast strains studied resulted mainly from the production of biol. active VOCs. Moreover, the antagonistic activity was not only restricted to a single plant pathogen but effective towards molds of different genera, making the yeast strains studied very useful for potential application in biol. control. And 2-Hexyl-1-decanol (cas: 2425-77-6) was used in the research process.

2-Hexyl-1-decanol(cas: 2425-77-6) has been shown to inhibit the growth of b16 mouse melanoma cells, suggesting it may be useful for treating skin cancer.Electric Literature of C16H34O This fatty acid also has transport properties and can form hydrogen bonds with other molecules.

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Pan, Hui-Jie;Lin, Yamei;Gao, Taotao;Lau, Kai Kiat;Feng, Wei;Yang, Binmiao;Zhao, Yu published 《Catalytic Diastereo- and Enantioconvergent Synthesis of Vicinal Diamines from Diols through Borrowing Hydrogen》. The research results were published in《Angewandte Chemie, International Edition》 in 2021.Category: alcohols-buliding-blocks The article conveys some information:

Authors present herein an unprecedented diastereoconvergent synthesis of vicinal diamines from diols through an economical, redox-neutral process. Under cooperative ruthenium and Lewis acid catalysis, readily available anilines and 1,2-diols (as a mixture of diastereomers)couple to forge two C-N bonds in an efficient and diastereoselective fashion. By identifying an effective chiral iridium/phosphoric acid co-catalyzed procedure, the first enantioconvergent double amination of racemic 1,2-diols has also been achieved, resulting in a practical access to highly valuable enantioenriched vicinal diamines. And rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) was used in the research process.

rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas: 579-43-1 Category: alcohols-buliding-blocks) has been used in the preparation of trans-methyl meso-hydrobenzoin phosphite.

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Rech, Jeromy James;Neu, Justin;Qin, Yunpeng;Samson, Stephanie;Shanahan, Jordan;Josey, Richard F. III;Ade, Harald;You, Wei published 《Designing Simple Conjugated Polymers for Scalable and Efficient Organic Solar Cells》 in 2021. The article was appeared in 《ChemSusChem》. They have made some progress in their research.Quality Control of 2-Hexyl-1-decanol The article mentions the following:

Conjugated polymers have a long history of exploration and use in organic solar cells, and over the last twenty-five years, marked increases in the solar cell efficiency were achieved. However, the synthetic complexity of these materials has also drastically increased, which makes the scalability of the highest-efficiency materials difficult. If conjugated polymers could be designed to exhibit both high efficiency and straightforward synthesis, the road to com. reality would be more achievable. For that reason, a new synthetic approach was designed towards PTQ10 (=poly[(thiophene)-alt-(6,7-difluoro-2-(2-hexyldecyloxy)quinoxaline)]). The new synthetic approach to make PTQ10 brought a significant reduction in cost (1/7th the original) and could also easily accommodate different side chains to move towards green processing solvents. Furthermore, high-efficiency organic solar cells were demonstrated with a PTQ10:Y6 blend exhibiting approx. 15% efficiency. To complete the study, the researchers used 2-Hexyl-1-decanol (cas: 2425-77-6) .

2-Hexyl-1-decanol(cas: 2425-77-6) has been shown to inhibit the growth of b16 mouse melanoma cells, suggesting it may be useful for treating skin cancer.Quality Control of 2-Hexyl-1-decanol This fatty acid also has transport properties and can form hydrogen bonds with other molecules.

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Formula: C15H16OIn 2022, Ling, Meiqi;Yu, Kaifeng;Wang, Jian;Wang, Honghua;Nie, Heran;Wang, Zhipeng;Zhou, Guangyuan published 《Synthesis and pyrolysis mechanism of phenolphthalein poly(aryl ether sulfone) containing isopropyl groups》. 《Thermochimica Acta》published the findings. The article contains the following contents:

A novel phenolphthalein poly(aryl ether sulfone) polymer containing iso-Pr groups (iPrPESC) has been successfully synthesized by S_N2 aromatic nucleophilic polycondensation reaction. The pyrolysis mechanism and behavior of iPrPESC were investigated by thermogravimetry coupled with Fourier transform IR spectroscopy and pyrolysis combined with gas chromatog./mass spectrometry. TG-FTIR and Py-GC/MS were used to identify the thermal decomposition products and to determine the possible thermal degradation mechanism. The main mechanism for iPrPESC was one-stage pyrolysis involving main-chain random scission, and the major products of SO₂ and phenol were released from the sulfone and ether groups in iPrPESC. The thermal degradation activation energy of iPrPESC was calculated to be 151 ± 4 and 139 ± 4 kJ mol^-1 by the Flynn-Wall-Ozawa and Kissinger methods, resp., which were much lower than that of phenolphthalein poly(aryl ether sulfone). Furthermore, introduction of iso-Pr groups on the main chain can significantly reduce the char yield. The experimental procedure involved many compounds, such as 4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) .

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.Formula: C15H16O 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

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Formula: C14H14O2In 2020, Murayama, Hiroaki;Heike, Yoshito;Higashida, Kosuke;Shimizu, Yohei;Yodsin, Nuttapon;Wongnongwa, Yutthana;Jungsuttiwong, Siriporn;Mori, Seiji;Sawamura, Masaya published 《Iridium-Catalyzed Enantioselective Transfer Hydrogenation of Ketones Controlled by Alcohol Hydrogen-Bonding and sp³-C-H Noncovalent Interactions》. 《Advanced Synthesis & Catalysis》published the findings. The article contains the following contents:

Iridium-catalyzed enantioselective transfer hydrogenation of ketones with formic acid was developed using a prolinol-phosphine chiral ligand. Cooperative action of the iridium atom and the ligand through alc.-alkoxide interconversion was crucial to facilitate the transfer hydrogenation. Various ketones including alkyl aryl ketones, ketoesters, and an aryl heteroaryl ketone were competent substrates. An attractive feature of this catalysis was efficient discrimination between the alkyl and aryl substituents of the ketones, promoting hydrogenation with the identical sense of enantioselection regardless of steric demand of the alkyl substituent and thus resulting in a rare case of highly enantioselective transfer hydrogenation of tert-alkyl aryl ketones. Quantum chem. calculations revealed that the sp³-C-H/π interaction between an sp³-C-H bond of the prolinol-phosphine ligand and the aryl substituent of the ketone was crucial for the enantioselection in combination with O-H···O/sp³-C-H···O two-point hydrogen-bonding between the chiral ligand and carbonyl group.rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) were involved in the experimental procedure.

Desymmetrization of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas:579-43-1 Formula: C14H14O2) using chiral phosphine catalyst has been reported. Conversion of meso-hydrobenzoin to trans-stillbene oxide by treatment with an aryl sulfonyl chloride and aqueous sodium hydroxide has been reported.

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Kawashima, Yukio;Onishi, Yuta;Tatarazako, Norihisa;Yamamoto, Hirotaka;Koshio, Masaaki;Oka, Tomohiro;Horie, Yoshifumi;Watanabe, Haruna;Nakamoto, Takashi;Yamamoto, Jun;Ishikawa, Hidenori;Sato, Tomomi;Yamazaki, Kunihiko;Iguchi, Taisen published 《Summary of 17 chemicals evaluated by OECD TG229 using Japanese Medaka, Oryzias latipes in EXTEND 2016》 in 2022. The article was appeared in 《Journal of Applied Toxicology》. They have made some progress in their research.Computed Properties of C14H22O The article mentions the following:

In June 2016, the Ministry of the Environment of Japan announced a program ”EXTEND2016” on the implementation of testing and assessment for endocrine active chems., consisting of a two-tiered strategy. The aim of the Tier 1 screening and the Tier 2 testing is to identify the impacts on the endocrine system and to characterize the adverse effects to aquatic animals by endocrine disrupting chems. detected in the aquatic environment in Japan. For the consistent assessment of the effects on reproduction associated with estrogenic, anti-estrogenic, androgenic, and/or anti-androgenic activities of chems. throughout Tier 1 screening to Tier 2 testing, a unified test species, Japanese medaka (Oryzias latipes), has been used. For Tier 1 screening, the in vivo Fish Short-Term Reproduction Assay (OECD test guideline Number 229) was conducted for 17 chems. that were nominated based on the results of environmental monitoring, existing knowledge obtained from a literature survey, and pos. results in reporter gene assays using the estrogen receptor of Japanese medaka. In the 17 assays using Japanese medaka, adverse effects on reproduction (i.e., reduction in fecundity and/or fertility) were suggested for 10 chems., and a significant increase of hepatic vitellogenin in males, indicating estrogenic (estrogen receptor agonistic) potency, was found for eight chems. at the concentrations in which no overt toxicity was observed Based on these results, and the frequency and the concentrations detected in the Japanese environment, estrone, 4-nonylphenol (branched isomers), 4-tert-octylphenol, tri-Ph phosphate, and bisphenol A were considered as high priority candidate substances for the Tier 2 testing. And 4-tert-Octylphenol (cas: 140-66-9) was used in the research process.

4-tert-Octylphenol(cas: 140-66-9) is a common environmental pollutant showing weak estrogenic effects.Computed Properties of C14H22O It has been shown to cause harm to vertebrate male reproductive systems.

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Liu, Fang;Jin, Panpan;Gong, Hansheng;Sun, Zhilan;Du, Lihui;Wang, Daoying published 《Antibacterial and antibiofilm activities of thyme oil against foodborne multiple antibiotics-resistant Enterococcus faecalis》. The research results were published in《Poultry Science》 in 2020.Application of 2425-77-6 The article conveys some information:

The inhibitory and bactericidal activities of thyme oil against the foodborne multiple antibiotics-resistant Enterococcus faecalis biofilm were evaluated in this study. Gas chromatog.-mass spectrometry revealed that more than 70% of the composition of thyme oil is thymol. Crystal violet staining assay showed that 128 and 256μg/mL thyme oil significantly inhibited the biofilm formation of E. faecalis. The cell adherence of E. faecalis, as shown by its swimming and swarming motilities, was reduced by thyme oil. The exopolysaccharide (EPS) quantification assay showed that thyme oil inhibited the EPS synthesis in E. faecalis biofilms. The 3D-view observations through confocal laser scanning and SEM suggested that cell adherence and biofilm thickness were decreased in thyme oil-treated biofilms. Quant. real-time analyses showed that the transcription of ebp and epa gene clusters, which were related to cell mobility and EPS production, was inhibited by thyme oil. Thus, thyme oil effectively inhibited the biofilm formation of E. faecalis by affecting cell adherence and EPS synthesis. Furthermore, 2,048 and 4,096μg/mL thyme oil can effectively inactivate E. faecalis population in the mature E. faecalis biofilms by 5.75 and 7.20 log CFU/mL, resp., after 30 min of treatment. Thus, thyme oil at different concentrations can be used as an effective antibiofilm or germicidal agent to control E. faecalis biofilms.2-Hexyl-1-decanol (cas: 2425-77-6) were involved in the experimental procedure.

2-Hexyl-1-decanol(cas: 2425-77-6) may be employed as an organic solvent to study the extraction of non-polar acidic drugs from human plasma by parallel artificial liquid membrane extraction (PALME). Application of 2425-77-6

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Cano, Rafael;Perez, Juana M.;Ramon, Diego J. published 《Osmium impregnated on magnetite as a heterogeneous catalyst for the syn-dihydroxylation of alkenes》. The research results were published in《Applied Catalysis, A: General》 in 2014.Recommanded Product: rel-(1R,2S)-1,2-Diphenylethane-1,2-diol The article conveys some information:

A new catalyst derived from osmium has been prepared, fully characterized and tested in the dihydroxylation of alkenes. The catalyst was prepared by wet impregnation methodol. of OsCl₃·3H₂O on a com. micro-magnetite surface. The catalyst allowed the reaction with one of the lowest osmium loadings for a heterogeneous catalyst and was selective for the monodihydroxylation of 1,5-dienes. Moreover, the catalyst was easily removed from the reaction medium by the simple use of a magnet. The selectivity of catalyst is very high with conversions up to 99%. Preliminary kinetics studies showed a first-order reaction rate with respect to the catalyst. To complete the study, the researchers used rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) .

Desymmetrization of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas:579-43-1 Recommanded Product: rel-(1R,2S)-1,2-Diphenylethane-1,2-diol) using chiral phosphine catalyst has been reported. Conversion of meso-hydrobenzoin to trans-stillbene oxide by treatment with an aryl sulfonyl chloride and aqueous sodium hydroxide has been reported.

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Gao, Xiaofang;Lin, Jiani;Zhang, Li;Lou, Xinyao;Guo, Guanghui;Peng, Na;Xu, Huan;Liu, Yi published 《Iodine-Initiated Dioxygenation of Aryl Alkenes Using tert-Butylhydroperoxides and Water: A Route to Vicinal Diols and Bisperoxides》 in 2021. The article was appeared in 《Journal of Organic Chemistry》. They have made some progress in their research.Reference of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol The article mentions the following:

An environment-friendly and efficient dioxygenation of aryl alkenes for the construction of vicinal diols ArCH(OH)CH(OH)R [Ar = Ph, 2-MeC₆H₄, 4-MeC₆H₄, etc.; R = H, Br, Me, etc.] was developed in water with iodine as the catalyst and tert-butylhydroperoxides (TBHPs) as the oxidant. The protocol was efficient, sustainable, and operationally simple. Detailed mechanistic studies indicated that one of the hydroxyl groups was derived from water and the other one was derived from TBHP. Addnl., the bisperoxides ArCH(OOtBu)CH(OOtBu)R [Ar = Ph, 4-MeC₆H₄, 3-FC₆H₄, etc.] could be obtained in good yields with iodine as the catalyst, Na₂CO₃ as the additive, and propylene carbonate as the solvent, instead. And rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) was used in the research process.

Desymmetrization of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas:579-43-1 Reference of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol) using chiral phosphine catalyst has been reported. Conversion of meso-hydrobenzoin to trans-stillbene oxide by treatment with an aryl sulfonyl chloride and aqueous sodium hydroxide has been reported.

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