Tag: 200-300

The author of 《Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition》 were Wyllie, Susan; Brand, Stephen; Thomas, Michael; De Rycker, Manu; Chung, Chun-wa; Pena, Imanol; Bingham, Ryan P.; Bueren-Calabuig, Juan A.; Cantizani, Juan; Cebrian, David; Craggs, Peter D.; Ferguson, Liam; Goswami, Panchali; Hobrath, Judith; Howe, Jonathan; Jeacock, Laura; Ko, Eun-Jung; Korczynska, Justyna; MacLean, Lorna; Manthri, Sujatha; Martinez, Maria S.; Mata-Cantero, Lydia; Moniz, Sonia; NA1/4hs, Andrea; Osuna-Cabello, Maria; Pinto, Erika; Riley, Jennifer; Robinson, Sharon; Rowland, Paul; Simeons, Frederick R. C.; Shishikura, Yoko; Spinks, Daniel; Stojanovski, Laste; Thomas, John; Thompson, Stephen; Gaza, Elisabet Viayna; Wall, Richard J.; Zuccotto, Fabio; Horn, David; Ferguson, Michael A. J.; Fairlamb, Alan H.; Fiandor, Jose M.; Martin, Julio; Gray, David W.; Miles, Timothy J.; Gilbert, Ian H.; Read, Kevin D.; Marco, Maria; Wyatt, Paul G.. And the article was published in Proceedings of the National Academy of Sciences of the United States of America in 2019. Synthetic Route of C12H17BO2 The author mentioned the following in the article:

Visceral leishmaniasis (VL), caused by the protozoan parasites Leishmania donovani and Leishmania infantum, is one of the major parasitic diseases worldwide. There is an urgent need for new drugs to treat VL, because current therapies are unfit for purpose in a resource-poor setting. Here, we describe the development of a preclin. drug candidate, GSK3494245/DDD01305143/compound 8, with potential to treat this neglected tropical disease. The compound series was discovered by repurposing hits from a screen against the related parasite Trypanosoma cruzi. Subsequent optimization of the chem. series resulted in the development of a potent cidal compound with activity against a range of clin. relevant L. donovani and L. infantum isolates. Compound 8 demonstrates promising pharmacokinetic properties and impressive in vivo efficacy in our mouse model of infection comparable with those of the current oral antileishmanial miltefosine. Detailed mode of action studies confirm that this compound acts principally by inhibition of the chymotrypsin-like activity catalyzed by the β5 subunit of the L. donovani proteasome. High-resolution cryo-EM structures of apo and compound 8-bound Leishmania tarentolae 20S proteasome reveal a previously undiscovered inhibitor site that lies between the β4 and β5 proteasome subunits. This induced pocket exploits β4 residues that are divergent between humans and kinetoplastid parasites and is consistent with all of our exptl. and mutagenesis data. As a result of these comprehensive studies and due to a favorable developability and safety profile, compound 8 is being advanced toward human clin. trials. In the experiment, the researchers used 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6Synthetic Route of C12H17BO2)

4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) can be used to prepare sulfinamide derivatives by reacting with diethylaminosulfur trifluoride (DAST) and potassium phenyltrifluoroborate.Synthetic Route of C12H17BO2

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《Mechanism of the Electrical Conductivity of a Film Consisting of Dielectric Nanoparticles with Surface Donor Centers》 was published in Journal of Surface Investigation: X-Ray, Synchrotron and Neutron Techniques in 2020. These research results belong to Kharlamov, V. F.. Electric Literature of C4H12KNaO10 The article mentions the following:

Abstract-: Restrictions imposed on the characteristics of a semiconductor by the condition that ohmic losses in it are zero are established using equations of the thermodn. of irreversible processes. A consequence of the neg. value of the static permittivity of a semiconductor consisting of nanogranules or microgranules is that the intensity E of the external elec. field in its volume is zero. Because of the action of thermodn. forces, the ohmic losses in the semiconductor are zero (jE = 0, where E = 0) or nonzero depending on the direction of the constant elec. current in a closed circuit. Theor. explanation of the exptl. data for the elec. conductivity of films consisting of Al2O3 and/ or NiO nanoparticles with chemisorbed hydrogen atoms is obtained.Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Electric Literature of C4H12KNaO10) was used in this study.

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Electric Literature of C4H12KNaO10 Potassium sodium tartrate tetrahydrate has been used in the preparation of Lowry reagent for the determination of microsomal protein concentration in rat hepatic microsomes by Lowry method.

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Safety of Octadecan-9-olOn March 31, 2002, Ohrui, Hiroshi; Terashima, Hanae; Imaizumi, Keiichiro; Akasaka, Kazuaki published an article in Proceedings of the Japan Academy, Series B: Physical and Biological Sciences. The article was 《A solution of the “”intrinsic problem”” of diastereomer method in chiral discrimination: Development of a method for highly efficient and sensitive discrimination of chiral alcohols》. The article mentions the following:

Very potent fluorescent chiral labeling reagents for alcs., (R,R)- and (S,S)-2-(anthracene-2,3-dicarboximido)cyclohexanecarboxylic acids, were developed. By labeling with them, the enantiomeric discriminations of primary alcs. having a Me branching at the carbon from 2 to 9 by 1H-NMR and from 2 to 16 by HPLC were achieved. Further, HPLC separations of all four optical isomers of Me branched secondary alcs. and enantiomers of 9-nonadecanol were also achieved. The experimental process involved the reaction of Octadecan-9-ol(cas: 591-70-8Safety of Octadecan-9-ol)

Octadecan-9-ol(cas: 591-70-8) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group. Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.Safety of Octadecan-9-ol

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Wang, Qiao;Xu, Zetao;Cao, Yiting;Chen, Yuanqing;Du, Xing;Yang, Yang;Wang, Zhihong published 《Two-dimensional ultrathin perforated Co₃O₄ nanosheets enhanced PMS-Activated selective oxidation of organic micropollutants in environmental remediation》. The research results were published in《Chemical Engineering Journal (Amsterdam, Netherlands)》 in 2022.Computed Properties of C15H16O The article conveys some information:

Here a two-dimensional (2D) ultrathin perforated Co₃O₄ nanosheet is rationally designed by a wet-chem. synthesis to activate peroxymonosulfate (PMS) for efficient selective oxidation And the physicochem. properties of catalyst were investigated by series of techniques. The Co₃O₄ nanosheets achieved a 98.0% degradation efficiency of bisphenol A (BPA) within 30 min, showing a 4 times higher kinetic constant (0.112 min^-1) and 5 times lower Co²⁺ leakage (6.5 μg/L), than com. Co₃O₄ microspheres. The great enhancement in catalytic performance was ascribed to the large surface area and pore diameter in porous 2D structure, as well as the strong electrostatic attraction with PMS. Moreover, the influence of several parameters such as initial pH, temperatures, humic acids and inorganic anions in the system on the remaval of BPA were systematically studied. Since sulfate radicals (SO·^–₄) were proved to be the primary reactive oxygen species by EPR measurements and quenching experiments, the PMS/Co₃O₄ nanosheets exhibits a highly selective oxidation on aromatics with electron donating groups (i.e., -OH and -CH₃), while a relatively low value for organics with electron-withdrawing groups (e.g., -NO₂ and -COOH). A high ionization potential threshold was determined to be greater than 9.39 eV, corresponding to a high oxidation ability to react with the organics Finally, possible degradation pathways were proposed based on twenty intermediate products determined from mass spectrometry. The experimental procedure involved many compounds, such as 4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) .

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.Computed Properties of C15H16O 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

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Zhang, Xinxin;Wei, Dong;Li, Chunying;Wei, Li;Zhao, Min published 《Effectiveness of sodium sulfite as an electron acceptor for bioenhanced treatment of salt-containing water produced from ASP flooding》 in 2021. The article was appeared in 《Chemosphere》. They have made some progress in their research.Safety of 2-Hexyl-1-decanol The article mentions the following:

The wastewater produced from alk.-surfactant-polymer (ASP) flooding is a complex multiphase mixture that contains oil, polymers, surfactants and other pollutants and is thus a salt-containing industrial waste recalcitrant to treatments. Through laboratory tests, this study assessed the effectiveness of using sodium sulfite as an electron acceptor for a modified anaerobic baffled reactor (ABR) for removing oil, suspended solids, polymers and surfactants from salt-containing wastewater produced from ASP flooding. During the 90-day operation, the method established in this study successively removed 52.8%, 98.6%, 77.0%, 21.2% and 21.5% of the COD (COD), oil, suspended solids, polymers and surfactants, resp., from the wastewater. The changes in organic compounds in the reactor during the treatment were monitored through gas chromatog.-mass spectrometry (GC-MS), and the results showed that the established method was very effective in removing alkanes, alkenes, cycloalkanes, aromatic hydrocarbons and esters, and the organic macromols. in the wastewater were degraded to small mols. The main bacterial species and microbial communities in the reactor were characterized using mol. biol. techniques, and the results indicated that under the stress of high pH and salts, Halomonas sp. gradually dominated and played a major role in degrading hydrocarbons. The findings of this study can aid the development of a cost-effective biol. system to treat the water produced from ASP flooding. The experimental procedure involved many compounds, such as 2-Hexyl-1-decanol (cas: 2425-77-6) .

2-Hexyl-1-decanol(cas: 2425-77-6) is a fatty acid that is found in the essential oils of plants and has been shown to have fungicidal properties.Safety of 2-Hexyl-1-decanol It has also been shown to inhibit the growth of Candida glabrata when used as a cationic surfactant.

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Wang, Yunwei;Ren, Pengju;Gu, Xianmo;Wen, Xiaodong;Wang, Yingyong;Guo, Xiangyun;Waclawik, Eric R.;Zhu, Huaiyong;Zheng, Zhanfeng published 《Probing the mechanism of benzaldehyde reduction to chiral hydrobenzoin on the CNT surface under near-UV light irradiation》 in 2016. The article was appeared in 《Green Chemistry》. They have made some progress in their research.Quality Control of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol The article mentions the following:

Metal-free CNTs exhibit high activity (conversion rate 99.6%, 6 h) towards the synthesis of chiral hydrobenzoin from benzaldehyde under near-UV light irradiation (320-400 nm). The CNT structure before and after the reaction, the interaction between the mol. and the CNT surface, the intermediate products, the substitution effect and the influence of light on the reaction were examined using various techniques. A photoexcited conduction electron transfer (PECET) mechanism for the photocatalytic reduction using CNTs was proposed. This finding provides a green photocatalytic route for the production of hydrobenzoin and highlights a potential photocatalytic application of CNTs. The experimental procedure involved many compounds, such as rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) .

Desymmetrization of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas:579-43-1 Quality Control of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol) using chiral phosphine catalyst has been reported. Conversion of meso-hydrobenzoin to trans-stillbene oxide by treatment with an aryl sulfonyl chloride and aqueous sodium hydroxide has been reported.

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Lopez-Velazquez, Khirbet;Guzman-Mar, Jorge L.;Montalvo-Herrera, Teresa J.;Mendiola-Alvarez, Sandra Y.;Villanueva-Rodriguez, Minerva published 《Efficient photocatalytic removal of four endocrine-disrupting compounds using N-doped BiOBr catalyst under UV-Vis radiation》. The research results were published in《Journal of Environmental Chemical Engineering》 in 2021.Recommanded Product: 140-66-9 The article conveys some information:

A mixture of four endocrine-disrupting compounds (EDCs [17β-estradiol, 17α-ethinylestradiol, bisphenol A, and 4-tert-octylphenol]) was removed from aqueous solution using the N-doped BiOBr semiconductor (N = 10 and 20 wt%) easily prepared via microwave-assisted solvothermal synthesis. The N₂₀BiOBr semiconductor showed the highest photocatalytic activity achieving the complete degradation of the EDCs, and 53.5% of mineralization in 240 min. Moreover, the toxicity of the mixture was reduced to moderate levels (from 90 to 47.5% of inhibition of the bioluminescence of V. fischeri). The high efficiency of N₂₀BiOBr for EDCs removal was attributed to the increase of the sp. surface area and the effective separation of photogenerated charges by effect of N incorporation. The main photogenerated species involved in the degradation of the pollutants were the superoxide radicals (O^·-2) and photo-holes (h+), and a possible photocatalytic activation mechanism was proposed where suggests the active participation of oxygen vacancies. Addnl., N₂₀BiOBr demonstrated excellent chem. and photocatalytic stability after four reuse cycles. Therefore, doping BiOBr with N constitutes a suitable and efficient strategy for the photocatalytic removal of a mixture of hazardous pollutants such as EDCs in water, with potential application in tertiary decontamination processes. The experimental procedure involved many compounds, such as 4-tert-Octylphenol (cas: 140-66-9) .

4-tert-Octylphenol(cas: 140-66-9) has been used as a reference standard for the determination of the analyte in water samples using ultra-high-performance liquid chromatography/tandem mass spectrometry (UHPLC/MS/MS).Recommanded Product: 140-66-9

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Li, Chao;Zhou, Jiadong;Song, Jiali;Xu, Jinqiu;Zhang, Huotian;Zhang, Xuning;Guo, Jing;Zhu, Lei;Wei, Donghui;Han, Guangchao;Min, Jie;Zhang, Yuan;Xie, Zengqi;Yi, Yuanping;Yan, He;Gao, Feng;Liu, Feng;Sun, Yanming published 《Non-fullerene acceptors with branched side chains and improved molecular packing to exceed 18% efficiency in organic solar cells》. The research results were published in《Nature Energy》 in 2021.Category: alcohols-buliding-blocks The article conveys some information:

Mol. design of non-fullerene acceptors is of vital importance for high-efficiency organic solar cells. The branched alkyl chain modification is often regarded as a counter-intuitive approach, as it may introduce an undesirable steric hindrance that reduces charge transport in non-fullerene acceptors. Here we show the design and synthesis of a highly efficient non-fullerene acceptor family by substituting the beta position of the thiophene unit on a Y6-based dithienothiophen[3,2-b]-pyrrolobenzothiadiazole core with branched alkyl chains. It was found that such a modification to a different alkyl chain length could completely change the mol. packing behavior of non-fullerene acceptors, leading to improved structural order and charge transport in thin films. An unprecedented efficiency of 18.32% (certified value of 17.9%) with a fill factor of 81.5% is achieved for single-junction organic solar cells. This work reveals the importance of the branched alkyl chain topol. in tuning the mol. packing and blend morphol., which leads to improved organic photovoltaic performance.2-Hexyl-1-decanol (cas: 2425-77-6) were involved in the experimental procedure.

2-Hexyl-1-decanol(cas: 2425-77-6) has been shown to inhibit the growth of b16 mouse melanoma cells, suggesting it may be useful for treating skin cancer.Category: alcohols-buliding-blocks This fatty acid also has transport properties and can form hydrogen bonds with other molecules.

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Application In Synthesis of 2-Hexyl-1-decanolIn 2021, Ozen, Tevfik;Demirtas, Ibrahim published 《Comparison of the chemical composition and bioactive properties of extracts prepared from the mature Turkish and Brazilian banana peels》. 《International Journal of Chemistry and Technology (Kilis, Turkey)》published the findings. The article contains the following contents:

The banana (Musa sp.) plant grows in tropical and subtropical regions. The fruit of the banana is eaten and the peel of the banana is discarded. In this study, chem. analyzes (HPLCTOF/MS ve GC-MS) and biochem. activities (antioxidant and antimicrobial) of Et acetate (Ea) and methanol/chloroform (Me/Ch) extracts prepared from banana peel (Bbp) grown in Brazil and banana peel (Tbp) grown in Turkey were investigated. Cetene, 4-hydroxybenzoic, palmitic, linoleic, stearic, gentisic and syringic acid are the most abundant compounds in the extracts The total antioxidant activity of Tbp-Ea (A_0.5: 36.84 μg/mL), inhibition of lipid peroxidation of Bbp-Ea (IC₅₀: 3.22 μg/mL), reducing power of Tbp-Me/Ch (A_0.5: 4.96 μg/mL), DPPH• scavenging activity of Bbp-Ea (IC₅₀: 8.54 μg/mL), metal chelating activity of Tbp-Ea (IC₅₀: 16.54 μg/mL) and H₂O₂ scavenging activity of Tbp-Me/Ch (IC₅₀: 0.36 μg/mL) were found the most effective. It was exhibited that extracts were effective against gramneg. and gram-pos. bacteria. In conclusion, the phytochem. and biochem. results of the TbP and Bbp extracts will contribute further pharmacol., biochem. and pharmacol. investigations.2-Hexyl-1-decanol (cas: 2425-77-6) were involved in the experimental procedure.

2-Hexyl-1-decanol(cas: 2425-77-6) is a fatty acid that is found in the essential oils of plants and has been shown to have fungicidal properties.Application In Synthesis of 2-Hexyl-1-decanol It has also been shown to inhibit the growth of Candida glabrata when used as a cationic surfactant.

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Kuwano, Satoru;Masuda, Toshinobu published 《N-Heterocyclic Carbene Catalyzed Monoacylation of Vicinal Diols》 in 2016. The article was appeared in 《Synthesis》. They have made some progress in their research.Computed Properties of C14H14O2 The article mentions the following:

The N-heterocyclic carbene (NHC)-catalyzed monoacylation of vicinal diols is described. Monoacylated compounds of 1,2-, 1,3-, and 1,4-diols are obtained in good yields and selectivity under mild reaction conditions at ambient temperature The experimental procedure involved many compounds, such as rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) .

rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas: 579-43-1 Computed Properties of C14H14O2) has been used in the preparation of trans-methyl meso-hydrobenzoin phosphite.

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