Tag: 200-300

In 2019,Analytical Chemistry (Washington, DC, United States) included an article by Hu, Kun; Lv, Yuanxia; Ye, Fanggui; Chen, Tao; Zhao, Shulin. Formula: C9H6O6. The article was titled 《Boric-Acid-Functionalized Covalent Organic Framework for Specific Enrichment and Direct Detection of cis-Diol-Containing Compounds by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry》. The information in the text is summarized as follows:

Design and synthesis of a novel matrix that serves as highly selective adsorption material are significant for the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) anal. of small mols. in complicated biosamples. The authors presented a facile 1-pot strategy for the synthesis of boric-acid-functionalized covalent organic frameworks (B-COFs) by using 2,4,6-trihydroxy-1,3,5-benzenetrialdehyde, benzidine, and 4-aminophenyl-boronic acid as ligands. Compared with bare COFs, the B-COFs have similar crystallinity, sp. surface, and well-developed pore structure. The surface area and average pore size of B-COFs were 238.0 m2/g and 1.2 nm, resp. The resulting material was used as an adsorbent for selective enrichment of cis-diol-containing compounds based on an affinity reaction between phenylboronic acid and cis-diol. Using luteolin, riboflavin, and pyrocatechol as model analytes, the enrichment ability of B-COFs as a matrix was examined by MALDI-TOF MS assay, and its high selectivity against target analytes was obtained in the presence of 100 times more anti-nonspecific compounds than that even in the complicated biosample. The limits of detection for luteolin, riboflavin, and pyrocatechol were as low as fg/mL with B-COF enrichment. The B-COFs were further employed and validated for specific enrichment and direct detection of target analytes with complex samples such as human serum, milk, and Capsicum samples. Large surface area, numerous boric-acid active sites, and super stability make B-COFs with high enrichment capacity, high selectivity and sensitivity, satisfying reproducibility, and excellent applicability in MALDI-TOF MS assays. In the part of experimental materials, we found many familiar compounds, such as 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Formula: C9H6O6)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives.Formula: C9H6O6Phloroglucinols are known for their broad-spectrum antiviral, antibacterial, antifungal, antihelminthic, and phytotoxic activities.

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Mertins, Kristin; Zapf, Alexander; Beller, Matthias published an article in Journal of Molecular Catalysis A: Chemical. The title of the article was 《Catalytic borylation of o-xylene and heteroarenes via C-H activation》.Name: 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane The author mentioned the following in the article:

Ir and Rh complexes catalyze the borylation of xylene and different heteroarenes using pinacolborane via C-H activation. Various five-membered heterocycles such as thiophene, pyrrole, thionaphthene, and indole derivatives yield the borylated products in moderate to good yields. In general, the reactions proceed with high selectivity to give borylation ortho to the heteroatom. The experimental process involved the reaction of 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0Name: 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane)

2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.Name: 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

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Ganda, Sylvia; Wong, Chin Ken; Stenzel, Martina H. published an article in Macromolecules (Washington, DC, United States). The title of the article was 《Corona-Loading Strategies for Crystalline Particles Made by Living Crystallization-Driven Self-Assembly》.COA of Formula: C12H20O6 The author mentioned the following in the article:

Self-assembled block copolymer (BCP) nanoparticles offer exciting opportunities for drug delivery applications. A key feature of using BCP nanoparticles for drug delivery is their ability to accommodate therapeutic cargoes within their particle core. This has become widely established for BCP nanoparticles with an amorphous core. The same, however, cannot be achieved with BCP nanoparticles with a crystalline core. This is because the encapsulation of therapeutic cargoes in a crystalline particle core disrupts crystallinity and ultimately leads to particle disassembly. Herein, we present several strategies to incorporate therapeutics and other functional cargoes onto the surface of crystalline particles, as this helps to ensure that the crystallinity of the particle core is maintained and the particle morphol. is hence unaffected. As a platform to showcase our strategies, in this study, we used biodegradable and bioactive 2D glycoplatelets prepared by living crystallization-driven self-assembly (CDSA). Specifically, we show that we can incorporate either an anticancer drug, doxorubicin (DOX), or a fluorescent dye, Cyanine5 (Cy5), onto the surface of glycoplatelets by seeded growth of prefunctionalized polymers or via postmodification using polymers with reactive handles. We believe that the strategies presented herein are versatile and should thus be applicable to other CDSA systems. Overall, our findings present new opportunities for crystalline particles to be used in drug delivery application.((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6COA of Formula: C12H20O6) was used in this study.

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​. And it is used as chiral auxiliaries in Michael and Aldol addition reactions.COA of Formula: C12H20O6

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《Expanding the Variety of Zirconium-based Inorganic Building Units for Metal-Organic Frameworks》 was published in Angewandte Chemie, International Edition in 2019. These research results belong to Leubner, Sebastian; Zhao, Haishuang; Van Velthoven, Niels; Henrion, Mickael; Reinsch, Helge; De Vos, Dirk E.; Kolb, Ute; Stock, Norbert. Recommanded Product: 401797-00-0 The article mentions the following:

Two new Zr-based metal-organic frameworks [Zr6O4(OH)4(OAc)6(BDC)3] (CAU-26) and [Zr5O4(OH)4(OAc)4(BDC)2] (CAU-27) are reported, which were synthesized from HOAc, a rarely used but green and sustainable solvent (BDC2-: 1,4-benzenedicarboxylate). Structure determination aided by automated electron diffraction tomog. revealed that CAU-26 [Zr6O4(OH)4(OAc)6(BDC)3] is composed of layers of known {Zr6O8} clusters interconnected by terephthalate ions. In contrast CAU-27 [Zr5O4(OH)4(OAc)4(BDC)2] exhibits a three-dimensional structure with a so far unknown type of 1-dimensional inorganic building unit (IBU), which can be rationalized as condensed polyhedron-sharing chains of {Zr6O8} clusters. CAU-26 occurs as an intermediate of the CAU-27 synthesis and can be isolated easily, when reaction temperature and time are decreased. The authors were also able to synthesize two isoreticular derivatives of CAU-27 with extended linker mols. by implementing 4,4′-biphenyldicarboxylic acid (H2BPDC) and 5,5′-dicarboxy-2,2′-bipyridine (H2BIPY). All materials show high thermal and chem. stability as well as permanent microporosity. The excellent stability of CAU-27-BIPY was exploited to synthesize an Ir-supported heterogeneous MOF-based catalyst for the direct C-H borylation of arenes. In the experimental materials used by the author, we found 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0Recommanded Product: 401797-00-0)

2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.Recommanded Product: 401797-00-0

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《AMG 837: A potent, orally bioavailable GPR40 agonist》 was published in Bioorganic & Medicinal Chemistry Letters in 2012. These research results belong to Houze, Jonathan B.; Zhu, Liusheng; Sun, Ying; Akerman, Michelle; Qiu, Wei; Zhang, Alex J.; Sharma, Rajiv; Schmitt, Michael; Wang, Yingcai; Liu, Jiwen; Liu, Jinqian; Medina, Julio C.; Reagan, Jeff D.; Luo, Jian; Tonn, George; Zhang, Jane; Lu, Jenny Ying-Lin; Chen, Michael; Lopez, Edwin; Nguyen, Kathy; Yang, Li; Tang, Liang; Tian, Hui; Shuttleworth, Steven J.; Lin, Daniel C.-H.. Application In Synthesis of (S)-3-(4-Hydroxyphenyl)hex-4-ynoic acid The article mentions the following:

The discovery that certain long chain fatty acids potentiate glucose stimulated insulin secretion through the previously orphan receptor GPR40 sparked interest in GPR40 agonists as potential antidiabetic agents. Optimization of a series of β-substituted phenylpropanoic acids led to the identification of (S)-3-(4-((4′-(trifluoromethyl)biphenyl-3-yl)methoxy)phenyl)hex-4-ynoic acid (AMG 837) as a potent GPR40 agonist with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. The experimental part of the paper was very detailed, including the reaction process of (S)-3-(4-Hydroxyphenyl)hex-4-ynoic acid(cas: 865233-35-8Application In Synthesis of (S)-3-(4-Hydroxyphenyl)hex-4-ynoic acid)

(S)-3-(4-Hydroxyphenyl)hex-4-ynoic acid(cas: 865233-35-8) belongs to alkynes. The addition of nonpolar E−H bonds across C≡C is general for silanes, boranes, and related hydrides. The hydroboration of alkynes gives vinylic boranes which oxidize to the corresponding aldehyde or ketone. In the thiol-yne reaction the substrate is a thiol.Application In Synthesis of (S)-3-(4-Hydroxyphenyl)hex-4-ynoic acid

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Zhenming Chen; Gui, Chengmei; Wei Yao; Li, Peng published an article in 2022. The article was titled 《Polymer Brush Induced Electroless Copper Plating on PA12 Surface for Tensile Strength Enhancement of Selective Laser Sintering Part》, and you may find the article in Journal of Materials Engineering and Performance.Reference of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate The information in the text is summarized as follows:

Metal particles can be deposited on nylon 12 (PA12) surface with excellent metal/substrate interface and distribution by electroless plating (EP), but the use of noble metal as EP catalyst would enhance the cost of raw materials and restrict its application. In this work, we developed a polymer brush (PB)-induced EP method to prepare Cu particle/PA12 composite powder (CPP) as an enhancing component for improving the strength of the selective laser sintering (SLS) part. The results showed hydrolyzed 3-amino-propyltriethoxysilane attached on the modified PA12 surface, which presented in PB form. The PB effectively reduced the stability of [Cu-EDTA] complex and REDOX barrier, subsequently, PB acted as catalytic site to reduce Cu ion into Cu metal by EP. The deposit consisted of Cu particles (spherical, about 1μm) and a small quantity of Cu2O particles (cubic, about 0.3μm), the ratio of Mplated particle/M(plated particle+PA12) is 15%. The PA12 particles were spheroidized firstly, then formed sintered neck during neighboring particles and sintered body in turn under laser action. Based on the excellent Cu/PA12 interface and dispersion, the tensile strength of the SLS part sintered with 10 W laser energy increased by an average of around 26.2% to 53 MPa.Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Reference of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate) was used in this study.

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Reference of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate Potassium sodium tartrate tetrahydrate has been used in the preparation of Lowry reagent for the determination of microsomal protein concentration in rat hepatic microsomes by Lowry method.

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Guo, Ke; Zhu, Xiaoli; Peng, Lianlian; Fu, Yanghe; Ma, Rui; Lu, Xinqing; Zhang, Fumin; Zhu, Weidong; Fan, Maohong published an article in 2021. The article was titled 《Boosting photocatalytic CO2 reduction over a covalent organic framework decorated with ruthenium nanoparticles》, and you may find the article in Chemical Engineering Journal (Amsterdam, Netherlands).Product Details of 34374-88-4 The information in the text is summarized as follows:

The conversion of CO2 into valuable chems. utilizing solar energy is one of the most promising approaches to solve the problems associated with global warming and energy shortage. Considering more and more covalent organic frameworks (COFs) that have been reported, the great potential of COFs as photocatalysts for CO2 reduction is still appreciated to a limited extent. In the current work, Ru nanoparticles (NPs) loaded ketoamine-based COF (TpPa-1) catalysts, named Ru/TpPa-1, were developed for the photocatalytic reduction of CO2 upon visible-light irradiation for the first time. Compared with TpPa-1, Ru/TpPa-1 catalysts exhibit a significantly enhanced activity for the photoreduction of CO2. In combination with the results from some extensive characterizations, it is found that the interactions between the Ru NPs and TpPa-1 can enhance the visible-light harvesting and create a new way to extend the service life of photo-generated charge carriers via facilitating the electron transfer through the loaded Ru NPs. The current investigation, therefore, provides a photocatalytic approach for CO2 fixation, enriches the theory of photocatalysis, and enlarges the application of COF-based materials. In the experiment, the researchers used many compounds, for example, 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Product Details of 34374-88-4)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives. Regarding monomeric phloroglucinols, this group encompasses acryl phloroglucinols, phloroglucinol-terpene adducts, phloroglucinol glycosides, halogenated phloroglucinols, prenylated phloroglucinols, and cyclicroup polyketides.Product Details of 34374-88-4

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Delabie, Jonas; Ceunen, Ward; Detavernier, Siebe; De Winter, Julien; Gerbaux, Pascal; Verbiest, Thierry; Koeckelberghs, Guy published their research in Macromolecules (Washington, DC, United States) in 2021. The article was titled 《Catechol as a Universal Linker for the Synthesis of Hybrid Polyfluorene/Nanoparticle Materials》.Reference of 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane The article contains the following contents:

The attachment of conjugated polymers (CPs), characterized by their optical and electronic properties and excellent processability, to inorganic nanoparticles (NPs), known for their specialized electronic and photonic properties, has proven to result in unique and promising (hybrid) materials. Although CPs can be functionalized with many different end groups, the process to find a correct match between the desired NP and appropriate functional group on the CP is often tedious and time-consuming. This study aims to solve this problem by investigating the potential of catechol as a universal linker mol. for the synthesis of hybrid CP/NP materials. First, the synthesis of poly(9,9-di((S)-3,7-dimethyloctyl)fluorene) via Suzuki-Miyaura catalyst transfer oxidative polycondensation using an external catechol Pd-initiator is studied. A chain-growth polymerization without transfer reactions for molar masses up to 28.3 kg mol-1 is established without degradation of the catechol in basic environments. These polymers are subsequently used to graft a variety of NP materials, including magnetic- (Fe3O4), plasmonic- (Au), and oxide-type (SiO2) NPs, proving its potential as a universal linker mol. In addition, the influence of the catechol group on the supramol. organization of free polyfluorene is studied by comparison with the well-known o-tolyl end-capped polyfluorenes. From these results, it can be concluded that the catechol group significantly disrupts the formation of well-defined supramol. architectures. Finally, as a preliminary study, the supramol. organization of the hybrid NPs is compared to the free polymer using solvatochromism experiments The results indicate an absence of chiral response upon fixation of the polymer onto a surface. In the experiment, the researchers used many compounds, for example, 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6Reference of 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane)

4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) can be used as a substrate in the study of Suzuki–Miyaura coupling of various aryl iodides over SiliaCat Pd(0).Reference of 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane

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Guo, Honglei; Guo, Qianqian; Lan, Tianyu; Luo, Yongjun; Pan, Xiuhao; Yao, Yifang; Li, Yafei; Feng, Ya; Liu, Yujia; Tao, Ling; Shen, Xiangchun published their research in Journal of Biomaterials Science, Polymer Edition in 2021. The article was titled 《Amphiphilic block versus random copolymer nanoparticles with reactive oxygen species responsiveness as berberine vehicles》.Recommanded Product: 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane The article contains the following contents:

A series of amphiphilic block and random copolymers based on phenylboronic acid pinacol ester were synthesized via reversible addition-fragmentation chain transfer polymerization The obtained copolymers can self-assemble in aqueous solution into stable block copolymer nanoparticles and random nanoparticles with sizes of 116.1-158.6 and 126.3-187.0 nm, resp. All nanoparticles showed hydrogen peroxide (H2O2) sensitivity, and the random copolymer nanoparticles presented faster responsiveness to H2O2 than did those derived from block copolymers. Berberine (BBR) can be effectively encapsulated into block and random copolymer nanoparticles with loading capacity of 7.6%-9.1% and 7.3%-8.9%, resp. The BBR release can be controlled in an H2O2 medium. For the random copolymer nanoparticles, the release rate of BBR was faster and the cumulative release amounts in response to H2O2 were higher over 48 h. The BBR cumulative release amount in the H2O2 medium for the block and random copolymer nanoparticles was 62.2%-70.2% and 68.6%-80.4%, resp. Moreover, good biocompatibility was observed for the BBR-loaded block and random copolymer nanoparticles. BBR and BBR-loaded nanoparticles can improve Glut4 translocation to the cell membrane and promote glucose transport into cells. BBR-loaded nanoparticles can decrease the blood glucose levels in diabetic rats over 15 days. These results imply that the different chain formulation of block and random copolymers affects the H2O2 responsiveness and that the two kinds of nanoparticles exhibit potential application as novel vehicles for BBR delivery to regulate blood glucose levels. The results came from multiple reactions, including the reaction of 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6Recommanded Product: 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane)

4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) can be used as a substrate in the study of Suzuki–Miyaura coupling of various aryl iodides over SiliaCat Pd(0).Recommanded Product: 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane

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《Rational Design of an Iron-Based Catalyst for Suzuki-Miyaura Cross-Couplings Involving Heteroaromatic Boronic Esters and Tertiary Alkyl Electrophiles》 was written by Crockett, Michael P.; Wong, Alexander S.; Li, Bo; Byers, Jeffery A.. Electric Literature of C12H17BO2 And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:

Suzuki-Miyaura cross-coupling reactions between a variety of alkyl halides and unactivated aryl boronic esters using a rationally designed iron-based catalyst supported by β-diketiminate ligands are described. High catalyst activity resulted in a broad substrate scope that included tertiary alkyl halides and heteroaromatic boronic esters. Mechanistic experiments revealed that the iron-based catalyst benefited from the propensity for β-diketiminate ligands to support low-coordinate and highly reducing iron amide intermediates, which are very efficient for effecting the transmetalation step required for the Suzuki-Miyaura cross-coupling reaction. In the part of experimental materials, we found many familiar compounds, such as 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6Electric Literature of C12H17BO2)

4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) can be used to prepare sulfinamide derivatives by reacting with diethylaminosulfur trifluoride (DAST) and potassium phenyltrifluoroborate.Electric Literature of C12H17BO2

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