Tag: 200-300

Rheological Properties of Zirconium Oxide Suspensions in Acrylate Monomers For Use In 3D Printing was written by Sokolov, P. S.;Komissarenko, D. A.;Dosovitskii, G. A.;Shmeleva, I. A.;Slyusar, I. V.;Dosovitskii, A. E.. And the article was included in Glass and Ceramics in 2018.Quality Control of Diethyleneglycoldiacrylate This article mentions the following:

The rheol. properties of highly concentrated suspensions consisting of nanocrystalline powders of zirconium oxide with monoclinic, tetragonal, and cubic modification (stabilized at molar content of yttrium oxide 4 and 8%) and liquid UV-photocured monomers of different nature were studied. The dynamic viscosity of the suspensions with the highest filling to 32% by volume was equal to 3 Pa · sec at shear rate 10 s ^-1 and of the order of 1 Pa · sec at 100 s ^-1 and 20°C. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Quality Control of Diethyleneglycoldiacrylate).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Quality Control of Diethyleneglycoldiacrylate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Copper-Catalyzed Protoboration of 1,3-Diynes as a Platform for Iterative Functionalization was written by Ghosh, Suman;Chakrabortty, Rajesh;Kumar, Shailendra;Das, Aniruddha;Ganesh, Venkataraman. And the article was included in ACS Catalysis in 2022.Electric Literature of C16H20B2N2O2 This article mentions the following:

This paper presents the protoboration of 1,3-diynes as a platform for the iterative functionalization of various groups on enynes and dienes. Synthetic approaches to targets with high complexity are directed toward using small, modular building blocks similar to a Lego construction using iterative chem. and automated synthesis. Organoboron compounds are currently in the spotlight for achieving these goals. Here, the authors report an operationally simple, regioselective protoboration of 1,3-diynes using a mixed diboron reagent and Cu(I)/phosphine catalyst to provide enynylboronates in good yields. Under similar conditions, diprotoboration of 1,3-diynes was also achieved to access bench-stable 1,4-diboryl-1,3-dienes in good yields and regioselectivities. The iterative coupling capabilities of the products were demonstrated along with other downstream transformations offering a range of value-added skeletons. In the experiment, the researchers used many compounds, for example, 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-naphtho[1,8-de][1,3,2]diazaborinine (cas: 1214264-88-6Electric Literature of C16H20B2N2O2).

2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-naphtho[1,8-de][1,3,2]diazaborinine (cas: 1214264-88-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Electric Literature of C16H20B2N2O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hybrid collagen/pNIPAAM hydrogel nanocomposites for tissue engineering application was written by Tatiana, Nistor Manuela;Cornelia, Vasile;Tatia, Rodica;Aurica, Chiriac. And the article was included in Colloid and Polymer Science in 2018.Computed Properties of C10H14O5 This article mentions the following:

The present work explores new hybrid bioactive, enzymically degradable hydrogel nanocomposites. They are composed by stimuli-sensitive semi-interpenetrating collagen/poly(N-iso-Pr acrylamide) polymeric matrix, Dellite 67G and Cloisite 93A nanoclays, and hydroxyapatite particles. Morphol. of the hybrid hydrogel nanocomposites was examined by near IR chem. imaging, X-ray diffraction, SEM, and transmission electron microscopy techniques. It has been found that the porous hydrogel nanocomposites showed a mix between intercalated and exfoliated structure, with interconnected pores and the inorganic material was evenly distributed in the polymeric matrix because of specific interactions between components. The collagen resistance against enzymic degradation and the thermal stability were improved due to the protein encapsulation in the synthetic polymer matrix. The hydrogel nanocomposites showed suitable swelling characteristics for tissue engineering. In vitro cytocompatibility and cell viability revealed that the hybrid nanocomposites were non-cytotoxic for rat osteoblasts. These hybrid nanocomposites were designed as potential synthetic bone tissue engineering. [Figure not available: see fulltext.]. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Computed Properties of C10H14O5).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Computed Properties of C10H14O5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Phytochemical characterization of raw and cooked traditionally consumed alimurgic plants was written by Monari, Stefania;Ferri, Maura;Montecchi, Beatrice;Salinitro, Mirko;Tassoni, Annalisa. And the article was included in PLoS One in 2021.Recommanded Product: 10083-24-6 This article mentions the following:

In the past, wild edible alimurgic plants became an important alternative food source when poverty, wars or drought made it difficult to access crops. These plants were considered rich in highly nutritional compounds and also frequently used as food-medicine given their health-promoting properties. With the aim of improving our knowledge on the content of beneficial or detrimental compounds in relation with past local dietary and curative traditions, 12 wild food plant species were collected from two study areas selected for their very different degree of industrialization, urbanization, and conservation of local past traditions among the population: the Bologna province (Northern Italy) and the Middle Agri Valley (Southern Italy). Protein, polyphenol flavonoid and biogenic amine (both free and conjugated) contents and antioxidant activity of raw and boiled wild food plant extracts, and of cooking water were analyzed by means of spectrophotometric and high-performance liquid chromatog. methods. The results demonstrated that most of the phenolic compounds were released in the cooking water which also showed the highest antioxidant activity. Seventeen different phenolic compounds were identified, of which the health-related luteolin, luteolin-7-glucoside and rutin were the most abundant (e.g., S. pratensis L. and C. intybus L.). On the other hand, biogenic amines were absent or present at very low levels in cooking water of those very same species (e.g., S. pratensis L., T. officinalis Weber, C. vesicaria subsp. taraxacifolia and C. intybus L.) of which traditionally a decoction is used for therapeutic purposes. Free and conjugated spermidine and spermine were generally the most abundant biogenic amines, while none of the known detrimental monoamines (e.g., histamine) was detected. In conclusion, the present results seem to support past local popular traditions which indicated beneficial medical properties of some wild edible plant, as well as of their cooking water. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Recommanded Product: 10083-24-6).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Recommanded Product: 10083-24-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Copper-catalyzed B(dan)-installing carboboration of alkenes was written by Kageyuki, Ikuo;Osaka, Itaru;Takaki, Ken;Yoshida, Hiroto. And the article was included in Organic Letters in 2017.HPLC of Formula: 1214264-88-6 This article mentions the following:

Carboboration of alkenes was found to occur readily with an unsym. diboron [(pin)B-B(dan)] (H₂dan = 1,8-naphthalenediamine) and alkyl halides under copper catalysis, leading to the direct formation of protected alkylboron compounds via synchronous C-C and C-B bond-forming processes. The B(dan) moiety was solely installed into the organic frameworks with the regioselective attachment to a terminal carbon of alkenes employed. In the experiment, the researchers used many compounds, for example, 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-naphtho[1,8-de][1,3,2]diazaborinine (cas: 1214264-88-6HPLC of Formula: 1214264-88-6).

2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-naphtho[1,8-de][1,3,2]diazaborinine (cas: 1214264-88-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.HPLC of Formula: 1214264-88-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cleavage of C(aryl)-CH₃ Bonds in the Absence of Directing Groups under Transition Metal Free Conditions was written by Dai, Peng-Fei;Ning, Xiao-Shan;Wang, Hua;Cui, Xian-Chao;Liu, Jie;Qu, Jian-Ping;Kang, Yan-Biao. And the article was included in Angewandte Chemie, International Edition in 2019.Application of 68716-49-4 This article mentions the following:

Organic chemists now can construct C-C σ-bonds selectively and sequentially, whereas methods for the selective cleavage of C-C σ-bonds, especially for unreactive hydrocarbons, remain limited. Activation by ring strain, directing groups, or in the presence of a carbonyl or a cyano group is usually required. By using a sequential strategy site-selective cleavage and borylation of C(aryl)-CH₃ bonds was developed under directing group free and transition metal free conditions. Me groups of various arenes are selectively cleaved and replaced by boryl groups. Mechanistic anal. suggests that it proceeds by a sequential intermol. oxidation and coupling of a transient aryl radical, generated by radical decarboxylation, involving a pyridine-stabilized persistent boryl radical. In the experiment, the researchers used many compounds, for example, 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4Application of 68716-49-4).

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Application of 68716-49-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dynamic surface properties of aqueous media imparted by a sugar-modified organosiloxane surfactant was written by Zhi, Li-Fei;Yao, Shu-Shan;Li, Xiao-Ming;Xue, Yong-Bing;Zhang, Yue-Zhong;Zhang, Qing-Hua. And the article was included in Journal of Dispersion Science and Technology in 2019.Formula: C10H14O5 This article mentions the following:

A novel tetrasiloxane-tailed surfactant bearing oligo(ethylene oxide) Me ether and sugar moieties (TGA-2) has been evaluated. The dynamic surface tension (DST) and spreading properties imparted to water by TGA-2 have been investigated. DST parameters, namely effective diffusion coefficient, activation barrier, and contact angle have been calculated and analyzed. A general diffusion mechanism of surfactant TGA-2 has been delineated. DST analyses yielded significantly different long-term (D_L) and short-term (D_S) diffusion coefficients, implying that the adsorption process involves a mixed diffusion-kinetic mechanism. Adsorption activation energies (E_a) of the surfactant TGA-2 have been measured as 9.14 kJ/mol at 4 × 10^-5 M and 19.37 kJ/mol at 4 × 10^-4 M. These small E_a values suggest that the tetrasiloxane group is favorable for adsorption. A polytetrafluoroethylene (PTFE) membrane was chosen as a solid substrate to demonstrate the spreading ability imparted by TGA-2. At a TGA-2 concentration of 0.5% in water, the contact angle decreased from 57° to 7.8° in 60 s, such that the droplets became almost flat. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Formula: C10H14O5).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Formula: C10H14O5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode was written by Wang, Aoli;Li, Xixiang;Wu, Hong;Zou, Fengming;Yan, Xiao-E.;Chen, Cheng;Hu, Chen;Yu, Kailin;Wang, Wenchao;Zhao, Peng;Wu, Jiaxin;Qi, Ziping;Wang, Wei;Wang, Beilei;Wang, Li;Ren, Tao;Zhang, Shanchun;Yun, Cai-Hong;Liu, Jing;Liu, Qingsong. And the article was included in Journal of Medicinal Chemistry in 2017.Computed Properties of C11H21NO3 This article mentions the following:

On the basis of Ibrutinib’s core pharmacophore, which was moderately active to EGFR T790M mutant, we discovered novel epidermal growth factor receptor (EGFR) inhibitor compound 19 (CHMFL-EGFR-202), which potently inhibited EGFR primary mutants (L858R, del19) and drug-resistant mutant L858R/T790M. Compound 19 displayed a good selectivity profile among 468 kinases/mutants tested in the KINOMEscan assay (S score (1) = 0.02). In particular, it did not exhibit apparent activities against INSR and IGF1R kinases. The X-ray crystal structure revealed that this class of inhibitors formed a covalent bond with Cys797 in a distinct “DFG-in-C-helix-out” inactive EGFR conformation. Compound 19 displayed strong antiproliferative effects against EGFR mutant-driven nonsmall cell lung cancer (NSCLC) cell lines such as H1975, PC9, HCC827, and H3255 but not the wild-type EGFR expressing cells. In the H1975 and PC9 cell-inoculated xenograft mouse models, compound 19 exhibited dose-dependent tumor growth suppression efficacy without obvious toxicity. Compound 19 might be a potential drug candidate for EGFR mutant-driven NSCLC. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-hydroxycyclohexyl)carbamate (cas: 224309-64-2Computed Properties of C11H21NO3).

tert-Butyl (4-hydroxycyclohexyl)carbamate (cas: 224309-64-2) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Computed Properties of C11H21NO3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Analytical methodology to evaluate potential migration in coatings and inks was written by Roqueta, C.;Fournier, F.;Hutchinson, I.;Dulongpont, H.;Cavalie, H.. And the article was included in Pitture e Vernici, European Coatings in 2009.Application of 4074-88-8 This article mentions the following:

Testing methods were evaluated to monitor leaching and migration of acrylate compounds from coatings and inks, into the environment, especially for food packaging applications. The techniques for quantification of the monomers include gas chromatog. with flame ionization detector, GC/FID; the monitoring of alcs. leading to acrylate monomers are ethylene glycol, diethylene glycol, triethylene glycol, and trimethylolpropane, for ethylene glycol diacrylate, diethylene glycol diacrylate, triethylene glycol diacrylate, and trimethylolpropane triacrylate. Model coatings from UV cured compositions were tested by solvent extraction and liquid chromatog./mass spectroscopy. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Application of 4074-88-8).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Application of 4074-88-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Controlling Chemoselectivity of Catalytic Hydroboration with Light was written by Bergamaschi, Enrico;Lunic, Danijela;McLean, Liam A.;Hohenadel, Melissa;Chen, Yi-Kai;Teskey, Christopher J.. And the article was included in Angewandte Chemie, International Edition in 2022.Product Details of 59960-32-6 This article mentions the following:

The ability to selectively react one functional group in the presence of another underpins efficient reaction sequences. Despite many designer catalytic systems being reported for hydroboration reactions, which allow introduction of a functional handle for cross-coupling or act as mild method for reducing polar functionality, these platforms rarely deal with more complex systems where multiple potentially reactive sites exist. Here authors demonstrate, for the first time, the ability to use light to distinguish between ketones and carboxylic acids in more complex mols. By taking advantage of different activation modes, a single catalytic system can be used for hydroboration, with the chemoselectivity dictated only by the presence or absence of visible light. In the experiment, the researchers used many compounds, for example, 2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid (cas: 59960-32-6Product Details of 59960-32-6).

2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid (cas: 59960-32-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Product Details of 59960-32-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts