Tag: 200-300

On November 30, 2021, Wang, Xiaoyu; Wang, Aimin; Chen, Zhiyi; Wei, Lihui published an article.Application In Synthesis of 2,4-Di-tert-butylphenol The title of the article was Phytotoxin of rice aggregate sheath spot pathogen Rhizoctonia oryzae-sativae and its biological activities. And the article contained the following:

Rice aggregate sheath spot disease occurs in many countries and causes serious yield losses. In China, the disease-causing fungus Rhizoctonia oryzae-sativae was reported in 1985, and since then, it has rarely been reported in major rice-growing areas after almost 30 years. Compared with Rhizoctonia solani, R. oryzae-sativae has a significantly different physiol. morphol. and growth status, although both fungi affect rice leaves in very similar ways. The optimum temperature for the suitable growth of R. oryzae-sativae is 31°C, which is consistent with previous reports. We extracted phytotoxins from R. oryzae-sativae and analyzed its biol. activity via the detached leaf and radicle inhibition methods. Rhizoctonia solani and R. oryzae-sativae exhibit differences in terms of pathogenicity and toxin activity, which indicates that these fungi may produce different toxin components. Based on gas chromatog.-mass spectrometry data, esters, phenols, and other components were present in the crude toxin extract of R. oryzae-sativae. Our research provides a new method for studying the phytotoxins of R. oryzae-sativae. However, further studies are needed to elucidate the pathogenic mechanisms responsible for aggregate sheath spot disease in rice. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Application In Synthesis of 2,4-Di-tert-butylphenol

The Article related to phytotoxin rice aggregate sheath spot pathogen rhizoctonia oryzae sativae, activité biologique, aggregate sheath spot, biological activity, chromatographie en phase gazeuse–spectrométrie de masse, gas chromatography–mass spectrometry, phytotoxines, phytotoxins, tache de la gaine and other aspects.Application In Synthesis of 2,4-Di-tert-butylphenol

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On February 7, 2022, Bouchey, Caitlin J.; Tolman, William B. published an article.Synthetic Route of 96-76-4 The title of the article was Involvement of a Formally Copper(III) Nitrite Complex in Proton-Coupled Electron Transfer and Nitration of Phenols. And the article contained the following:

A unique high-valent copper-nitrite species, LCuNO2, was accessed via the reversible one-electron oxidation of [M][LCuNO2] (M = NBu4+ or PPN+). The complex LCuNO2 reacts with 2,4,6-trit-butylphenol (TTBP) via a typical proton-coupled electron transfer (PCET) to yield LCuTHF and the 2,4,6-trit-butylphenoxyl radical. The reaction between LCuNO2 and 2,4-di-t-butylphenol (DTBP) was more complicated. It yielded two products: the coupled bisphenol product expected from a hydrogen atom abstraction and 2,4-di-t-butyl-6-nitrophenol, the product of an unusual anaerobic nitration. Various mechanisms for this latter transformation were considered. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Synthetic Route of 96-76-4

The Article related to preparation copper pyridinylamide nitrite complex, crystal structure copper pyridinylamide nitrite complex, epr spectra copper pyridinylamide nitrite complex, raman spectra copper pyridinylamide nitrite complex, cyclic voltammetry copper pyridinylamide nitrite complex, proton coupled electron transfer reaction copper pyridinylamide nitrite complex and other aspects.Synthetic Route of 96-76-4

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On October 1, 2013, Pizzo, Fabiola; Lombardo, Anna; Manganaro, Alberto; Benfenati, Emilio published an article.Application of 4719-04-4 The title of the article was In silico models for predicting ready biodegradability under REACH: A comparative study. And the article contained the following:

REACH legislation (registration evaluation authorization and restriction of chems.) is an European law to raise the human protection level and environmental health. Under REACH, all manufactured or imported chems. of >1 ton/yr must be evaluated for their ready biodegradability. Ready biodegradability is also used as a screening test for persistent, bioaccumulative, and toxic substances. REACH encourages the use of non-testing methods, e.g.,quant. structure-activity relationship (QSAR) models, to save money and time and reduce the number of animals used for scientific purposes. Some QSAR models are available to predict ready biodegradability. A 722 compound dataset was used to test 4 models: VEGA, TOPKAT, BIOWIN 5 and 6, and START; their performance was compared based on the parameters: accuracy, sensitivity, specificity, and Matthew correlation coefficient Performance was analyzed from different viewpoints. A first calculation was done on the entire dataset; VEGA and TOPKAT had the best accuracy (88% and 87%, resp.). Then compounds inside and outside the training set were considered; BIOWIN 6 and 5 had the best results for accuracy (81%) outside the training set. Another anal. examined the applicability domain (AD); VEGA had the highest value for compounds inside the AD for all parameters considered. Compounds outside the training set and in the model AD were considered to assess predictive ability; VEGA had the best accuracy results (99%) for this group of chems. Generally, the START model had poor results. Since BIOWIN, TOPKAT, and VEGA models performed well, they may be used to predict ready biodegradability. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).Application of 4719-04-4

The Article related to in silico modeling chem ready biodegradability prediction, registration evaluation authorization restriction of chem legislation europe, safety testing manufactured imported chem europe, human environmental safety manufactured imported chem europe, biowin start topkat vega chem ready biodegradability model, in silico methods, miti test, qsar and other aspects.Application of 4719-04-4

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On February 15, 2020, Paudel, Kushal; Hauk, Armin; Maier, Tanja Verena; Menzel, Roberto published an article.Related Products of 96-76-4 The title of the article was Quantitative characterization of leachables sinks in biopharmaceutical downstream processing. And the article contained the following:

This article demonstrates, on a quant. level, that leachables – potentially accumulated during a biopharmaceutical manufacturing process – will be significantly reduced/removed during four key downstream process steps: cell removal using centrifugation or depth filtration, sterile filtration and virus filtration. Eight common leachables model compounds (LMCs) were spiked into typical feed solutions containing buffer and proteins and were analyzed post-processing in the supernatant or filtrates by HPLC-UV. The clearance rates were calculated as the quotient between the scavenged and initially spiked amount of each leachable. High clearance rates were found for hydrophobic LMCs for all investigated downstream operation steps. It is shown that the removal of cells and cell debris from a culture broth reduces the amount of LMCs almost completely after centrifugation or depth filtration. Also, sterilizing-grade and virus filtration provided a high scavenger effect to most of the LMCs. In contrast, only one hydrophilic acid was not significantly scavenged by the described operations. The possibility to include leachables sinks to a process qualification and risk mitigation concept is explained. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Related Products of 96-76-4

The Article related to biopharmaceutical downstream processing leachable depth sterile virus filtration, biopharmaceutical manufacturing, cell removal, downstream processing, extractables and leachables, leachables sink, process equipment-related leachables (perls), single-use system (sus), sterilizing-grade filtration, virus filtration and other aspects.Related Products of 96-76-4

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Product Details of 24388-23-6In 2020 ,《Rh-Catalyzed Base-Free Decarbonylative Borylation of Twisted Amides》 appeared in Journal of Organic Chemistry. The author of the article were Bie, Fusheng; Liu, Xuejing; Shi, Yijun; Cao, Han; Han, Ying; Szostak, Michal; Liu, Chengwei. The article conveys some information:

We report the rhodium-catalyzed base-free decarbonylative borylation of twisted amides. The synthesis of versatile arylboronate esters from aryl twisted amides is achieved via decarbonylative rhodium(I) catalysis and highly selective N-C(O) insertion. The method is notable for a very practical, additive-free Rh(I) catalyst system. The method shows broad functional group tolerance and excellent substrate scope, including site-selective decarbonylative borylation/Heck cross-coupling via divergent N-C/C-Br cleavage and late-stage pharmaceutical borylation. The experimental process involved the reaction of 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6Product Details of 24388-23-6)

4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) also known as boronate ester, is generally used in metal-catalyzed C-C bond formation reactions like Suzuki–Miyaura reaction.Product Details of 24388-23-6

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Formula: C8H9NO5SOn September 3, 2019 ,《Conjugation of Antibodies to Horseradish Peroxidase.》 was published in Cold Spring Harbor protocols. The article was written by Berg, Eric A; Fishman, Jordan B. The article contains the following contents:

Antibodies conjugated with horseradish peroxidase (HRP) are one of the most widely used bioreagents in the biological sciences. This protocol is a basic method for adding HRP to a thiolated antibody and can be adapted for use with different cross-linkers. Conjugation methods usually focus on linking through the lysines on HRP because there are only six of them and their modification does not adversely affect enzyme activity. The experimental process involved the reaction of 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6Formula: C8H9NO5S)

2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6) belongs to pyrrolidine. Pyrrolidine being a good nucleophile easily undergoes electrophilic substitution reactions with different electrophiles such alkyl halides and acyl halides, and forms N-substituted pyrrolidines. N-Alkylpyrrolidine on further reaction with alkyl halide provided quaternary salts.Formula: C8H9NO5S

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Safety of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanolOn October 21, 2021 ,《Metallaphotoredox-enabled deoxygenative arylation of alcohols》 was published in Nature (London, United Kingdom). The article was written by Dong, Zhe; MacMillan, David W. C.. The article contains the following contents:

Metal-catalyzed cross-couplings are a mainstay of organic synthesis and are widely used for the formation of C-C bonds, particularly in the production of unsaturated scaffolds1. However, alkyl cross-couplings using native sp3-hybridized functional groups such as alcs. remain relatively underdeveloped2. In particular, a robust and general method for the direct deoxygenative coupling of alcs. would have major implications for the field of organic synthesis. A general method for the direct deoxygenative cross-coupling of free alcs. must overcome several challenges, most notably the in situ cleavage of strong C-O bonds3, but would allow access to the vast collection of com. available, structurally diverse alcs. as coupling partners4. Authors report herein a metallaphotoredox-based cross-coupling platform in which free alcs. are activated in situ by N-heterocyclic carbene salts for carbon-carbon bond formation with aryl halide coupling partners. This method is mild, robust, selective and most importantly, capable of accommodating a wide range of primary, secondary and tertiary alcs. as well as pharmaceutically relevant aryl and heteroaryl bromides and chlorides. The power of the transformation has been demonstrated in a number of complex settings, including the late-stage functionalization of Taxol and a modular synthesis of Januvia, an antidiabetic medication. This technol. represents a general strategy for the merger of in situ alc. activation with transition metal catalysis. After reading the article, we found that the author used ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Safety of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​.Safety of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol And it is used as chiral auxiliaries in Michael and Aldol addition reactions.

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《Eco-friendly materials for large area piezoelectronics: self-oriented Rochelle salt in wood》 was written by Lemaire, E.; Ayela, C.; Atli, A.. Name: Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrateThis research focused onwood Rochelle salt biodegradable piezoelec composite material mech property. The article conveys some information:

Upgraded biodegradable piezoelec. composite materials elaborated by incorporation of Rochelle salt (RS, sodium potassium tartrate tetrahydrate) in wood were reported. RS crystals, known as the first discovered piezoelec. material, were grown in the micro-cavities of wood, having naturally a tubular structure, by soaking the wood into RS saturated water. Since most of the cavities in wood are oriented in the same direction, the piezoelec. effect was improved when the cavities were filled by RS crystals. The mech., structural and piezoelec. properties of RS incorporated wood composite samples were characterized. Both direct and converse piezoelec. effects are illustrated. The wood-base composite exhibits an effective piezoelec. constant d33 of 11 pC N-1. Also, the flexural strength and modulus of elasticity were enhanced by inserting RS into the wood, nevertheless the samples became more brittle. The wood-based piezoelec. samples prepared in this work can be used as actuators, sensors or energy harvesters. The process developed here permits us to manufacture large area piezoelec. devices which are environmentally and economically unsurpassed.Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Name: Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate) was used in this study.

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Name: Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate It may be used as a constituent to prepare DNS (3,5- dinitrosalicylic acid) reagent and Fehling′s solution B, which are used in the determination of reducing sugar.

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《Asymmetric Total Synthesis of Inthomycins A, B, and C》 was published in Journal of Organic Chemistry in 2020. These research results belong to Kim, Jae Hyun; Song, Yeonghun; Kim, Min Jung; Kim, Sanghee. Application In Synthesis of Bis[(pinacolato)boryl]methane The article mentions the following:

Herein, we report the asym. total syntheses of inthomycin antibiotics containing a methylene-interrupted oxazolyl-triene motif. Utilizing the α,β-unsaturated aldehyde as a common intermediate, all three inthomycins A-C were divergently synthesized. The asym. ynone reduction provided an R-configured secondary alc. as in the natural products with high enantioselectivity. The geometrically different triene units for each inthomycin were stereoselectively established via Me cuprate conjugate addition, isomerization of the α,β-unsaturated aldehyde intermediate, and stereoretentive cross-coupling reactions. The experimental process involved the reaction of Bis[(pinacolato)boryl]methane(cas: 78782-17-9Application In Synthesis of Bis[(pinacolato)boryl]methane)

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds.Application In Synthesis of Bis[(pinacolato)boryl]methane Organoboron compounds have been a cornerstone of synthetic transformations for decades. Areas such as boron-containing catalysts, metalate chemistry, photoredox methods, and boryl anions have brought significant new developments in understanding and provided new reactivity upon.

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In 2014,Kjartansdottir, Cecilia; Caspersen, Michael; Egelund, Sune; Moeller, Per published 《Electrochemical investigation of surface area effects on PVD Al-Ni as electrocatalyst for alkaline water electrolysis》.Electrochimica Acta published the findings.Safety of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate The information in the text is summarized as follows:

A thermo-chem. diffusion of vapor deposited Al onto a Ni substrate, leads to a rapid formation of an Al/Ni intermetallic layer that is particularly acceptable for dissolution of Al in strong alkali. The geometry and the structure of the final skeletal Ni coatings can be manipulated by altering the time interval of the diffusion. In that way the actual electrochem. surface area and, thus, the electrocatalytic activity of the coatings towards HER and OER can be influenced. Cyclic voltammetry (CV) and electrochem. impedance spectroscopy (EIS) studies, display that the electrocatalytic surface area increases in proportion to the thickness of the developed porous Ni structure. In the case of the HER, an increase in roughness factor (Rf) from 1 (for polished Ni) to 800, results in reduction of the H overpotential of 337 mV. When further increasing Rf, up to >2000, addnl. 40 mV are gained. For the OER, smaller roughness values were observed with the same activity trend as for the HER. The electrocatalyst are however found not to be stable in the anodic environment during electrolysis. The corrosion mechanism of a skeletal Ni electrocatalyst during the OER in an alk. environment is briefly discussed. The structure and composition of the electrocatalysts are characterized by SEM and x-ray diffraction. The actual electrocatalytic surface area and the electrocatalytic behavior were studied with potentiodynamic polarization, CV and EIS. In addition to this study using Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate, there are many other studies that have used Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Safety of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate) was used in this study.

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Safety of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate It may be used as a constituent to prepare DNS (3,5- dinitrosalicylic acid) reagent and Fehling′s solution B, which are used in the determination of reducing sugar.

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