Tag: 200-300

On April 7, 2020, Grashow, Rachel; Bessonneau, Vincent; Gerona, Roy R.; Wang, Aolin; Trowbridge, Jessica; Lin, Thomas; Buren, Heather; Rudel, Ruthann A.; Morello-Frosch, Rachel published an article.Electric Literature of 96-76-4 The title of the article was Integrating Exposure Knowledge and Serum Suspect Screening as a New Approach to Biomonitoring: An Application in Firefighters and Office Workers. And the article contained the following:

Firefighters (FF) are exposed to recognized and probable carcinogens, yet there are few chem. exposure studies and associated health concerns for women firefighters, e.g., breast cancer. Biomonitoring often requires a-priori selection of compounds to be measured, and may not detect relevant, lesser known, exposures. The women firefighters biomonitoring collaborative (WFBC) created a biol. sample archive and conducted a general suspect screen (GSS) to address this data gap. Using liquid chromatog./quadrupole time-of-flight tandem mass spectrometry, candidate chems. of interest were identified in serum samples from 83 women (FF) and 79 women office workers (OW) in San Francisco, California. Chem. peaks were identified by matching accurate mass from serum samples to a custom chem. database of 722 slightly polar phenolic and acidic compounds, including many relevant to firefighting or breast cancer etiol. Collected tentatively identified chems. were selected for confirmation based on: detection frequency or peak area differences between OW and FF; evidence of mammary carcinogenicity, estrogenicity, or genotoxicity; and not currently measured in large biomonitoring studies. In total 620 chems. were detected which matched 300 mol. formulas in the WFBC database, including phthalate and phosphate flame retardant metabolites, phenols, pesticides, nitro- and nitroso-compounds, and per- and polyfluoroalkyl substances. Of 20 suspect chems. selected for validation, eight were confirmed (two alkylphenols, Et paraben, BPF, PFOSAA, benzophenone-3, benzyl p-hydroxybenzoate, tri-Ph phosphate) by running a matrix spike of reference standards and using m/z, retention time, and the confirmation of at least two fragment ions as matching criteria. GSS provided a powerful high-throughput approach to identify and prioritize novel chems. for biomonitoring and health studies. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Electric Literature of 96-76-4

The Article related to occupational health hazard women firefighter office worker chem exposure, risk assessment women firefighter office worker cancer chem exposure, carcinogen understudied compound biomonitoring women firefighter office worker and other aspects.Electric Literature of 96-76-4

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On June 17, 2004, Gunawardana, Indrani W. published a patent.Computed Properties of 280752-78-5 The title of the patent was Preparation of 2- or 4-(phenylthio)cinnamides as cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds. And the patent contained the following:

The title compounds (I) [wherein R1-R5 = independently H, halo, (halo)alkyl, alkoxy, cyano, NO2, CHO, and least one of R1 or R3 is an (un)substituted cis- or trans-cinnamide; Ar = (un)substituted (hetero)aryl] were prepared as cell adhesion inhibitors for the treatment of inflammatory and immune diseases and cerebral vasospasm. Examples include syntheses for 445 invention compounds and data for 3 bioassays. For instance, a mixture of 2-[(2,4-dichlorophenyl)thio]benzaldehyde (preparation given), malonic acid, piperidine in anhydrous pyridine was heated at 110°C for 2 h and then treated with aqueous HCl to give trans-2-[(2,4-dichlorophenyl)thio]cinnamic acid (91%). Conversion to the acid chloride followed by amidation with 6-amino-1-hexanol gave (E)-II (90%). In an integrin LFA-1/ICAM-1 biochem. interaction assay, I demonstrated inhibition at 4 μM. In cell-based adhesion assays which measure the ability of test compounds to block adherence of JY-8 cells (a human EBV-transformed B cell line expressing LFA-1 on its surface) to immobilized ICAM-1 or ICAM-3, I exhibited blocking activity at 4 μM and 0.6 μM, resp. The pharmaceutical composition comprising the compound I is claimed. The experimental process involved the reaction of (6-Bromo-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol(cas: 280752-78-5).Computed Properties of 280752-78-5

The Article related to phenylthio cinnamide preparation cell adhesion inhibitor, aminocarbonylethenylphenyl phenyl sulfide preparation antiinflammatory immunosuppressant, cerebral vasospasm sulfide aminocarbonylethenylphenyl phenyl preparation and other aspects.Computed Properties of 280752-78-5

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On September 30, 2013, Friis, Ulrik F.; Menne, Torkil; Flyvholm, Mari-Ann; Bonde, Jens Peter E.; Johansen, Jeanne D. published an article.Related Products of 4719-04-4 The title of the article was Occupational allergic contact dermatitis diagnosed by a systematic stepwise exposure assessment of allergens in the work environment. And the article contained the following:

Background. Information on the presence of contact allergens and irritants is crucial for the diagnosis of occupational contact dermatitis. Ingredient lists and Material Safety Datasheets (MSDSs) may be incomplete. Objectives. To evaluate the workability of a systematic exposure assessment in consecutive patients with suspected occupational contact dermatitis, and to study how it could potentially aid correct diagnostic classification. Methods. A tool for systematic stepwise assessment of exposures in the work environment was developed, consisting of six steps spanning medical history and workplace visits. The program included 228 consecutive patients diagnosed with occupational contact dermatitis: all patients underwent a clin. examination, the stepwise exposure assessment, and extensive patch and prick testing. Results. Of the participants. 48.2% were classified as having occupational allergic contact dermatitis. The diagnosis was made at the stepwise exposure assessment for 50.0% of patients at Step 1 (medical history) and for 34.5% at Step 2 (ingredient labeling/MSDS). We found 132 different occupational allergens of relevance to the patients’ eczema of these, 78.0% were allergens not included in the European baseline series. Conclusions. Systematic stepwise exposure assessment provides information that results in the identification of occupational allergies caused by allergens not included in the European baseline series in a substantial number of patients. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).Related Products of 4719-04-4

The Article related to allergic contact dermatitis allergen occupational allergy, allergens, exposure analysis, occupational, occupational allergic contact dermatitis, occupational contact allergy, systematic exposure assessment, systematic stepwise exposure assessment and other aspects.Related Products of 4719-04-4

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On April 30, 2021, Velikorodov, A. V.; Stepkina, N. N.; Osipova, V. P.; Zukhairaeva, A. S.; Shustova, E. A. published an article.HPLC of Formula: 96-76-4 The title of the article was Synthesis of New Functionally Substituted Indenes, Benzofurans and 2,5-Benzodiazocin-1(2H)-ones. And the article contained the following:

The synthesis of new functionally substituted 1H-indene-1,3(2H)-diones, such as I [R = pyridin-2-yl, morpholin-4-yl] indenobenzofurans II [R1 = 1-adamantyl, t-Bu; R2 = Me, t-Bu] and 2,5-benzodiazocines III [R3 = H, t-Bu, NHCO2Me, 1-adamantyl; R4 = H, NHCO2Me; R5 = H, Me, t-Bu, NHCO2Me] was described. The condensations of ninhydrin in concentrated sulfuric acid with 2-(morpholin-4-yl)ethyl and 2-(pyridin-2-yl)ethyl phenylcarbamates at 20°C and with 2,6-di-tert-butylphenol while gradually raising temperature from 0 to 20°C gave corresponding 2,2-disubstituted 1H-indene-1,3(2H)-diones such as I in 62-89% yields. The indeno[1,2-b]benzofuran derivatives II were obtained with high yields (96-98%) by heating ninhydrin with 2-(1-adamantyl)-4-methylphenol and 2,4-di(tert-butyl)phenol, resp., in glacial acetic acid at 60°C. Benzofurans containing an adamantyl, tert-Bu, or carbamate fragment reacted with 99% ethylenediamine at 20°C to afford 80-85% of new 2,5-benzodiazocine derivatives III. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).HPLC of Formula: 96-76-4

The Article related to disubstituted indene dione preparation, phenylcarbamate ninhydrin sulfuric acid condensation, indenobenzofuran preparation, ninhydrin phenol acetic acid condensation, benzodiazocine preparation, ethylenediamine indenobenzofuran condensation and other aspects.HPLC of Formula: 96-76-4

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On August 3, 2022, Tziotzi, Thomais G.; Mavromagoulos, Athanasios; Murrie, Mark; Dalgarno, Scott J.; Evangelisti, Marco; Brechin, Euan K.; Milios, Constantinos J. published an article.Electric Literature of 4719-04-4 The title of the article was Constructing “Closed” and “Open” {Mn8} Clusters. And the article contained the following:

Use of the 1,3,5-tri(2-hydroxyethyl)-1,3,5-triazacyclohexane ligand, LH3, in manganese chem. affords access to two structurally related {Mn8} clusters: a “closed” {MnIII6MnII2} puckered square wheel of formula [Mn8L2(LH)O3(OH)2(MeO)2Br(ImH)(H2O)3](Br)3 (1; imH = imidazole) and an “open” {MnIII8} rod of formula [MnIII8L2O4(aibH)2(aib)2(MeO)6(MeOH)2](NO3)2 (2, aibH = 2-amino-isobutyric acid). In each case the triaza ligands, L/LH, direct the formation of {Mn3} triangles with their N atoms preferentially bonding to the Jahn-Teller axes of the MnIII ions. Subsequent self-assembly is dependent on the anion of the Mn salt and the identity of the organic coligand employed-the terminally bonded imidazole and the chelating/bridging amino acid. The {Mn3} triangles fold up on themselves in 1, forming a wheel. However, the syn, syn-bridging carboxylates in 2 prevent this from happening, instead directing the formation of a linear rod. Magnetic susceptibility and magnetization measurements reveal competing ferro- and antiferromagnetic interactions in both complexes, the exchange being somewhat weaker in 1 due to the presence of MnII ions. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).Electric Literature of 4719-04-4

The Article related to preparation closed open manganese trihydroxyethyltriazacyclohexane cluster, crystal structure closed open manganese trihydroxyethyltriazacyclohexane cluster, magnetic property closed open manganese trihydroxyethyltriazacyclohexane cluster and other aspects.Electric Literature of 4719-04-4

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Nair, Reshma V. R.; Jayasree, Devi Velayudhan; Biju, Prabath Gopalakrishnan; Baby, Sabulal published an article in 2020, the title of the article was Anti-inflammatory and anticancer activities of erythrodiol-3-acetate and 2,4-di-tert-butylphenol isolated from Humboldtia unijuga.Formula: C14H22O And the article contains the following content:

Humboldtia unijuga Bedd., endemic to Agasthyamala in Western Ghats in India, is traditionally used by local Kani tribes for chicken pox, head ache and snake bite. This study reports the isolation of erythrodiol-3-acetate (HU-1) and 2,4-di-tert-butylphenol (HU-2) from H. unijuga roots and their anti-inflammatory and anticancer activities in macrophage, skin and breast cancer cell lines. Effects of HU-1 and HU-2 treatments (50, 100μg/mL) on gene expression profiles of pro-inflammatory cytokines TNFα, IL-6 and IL-1β, and apoptosis genes p53 and caspase 7 were studied. HU-2 exerted a significantly superior anti-inflammatory effect compared to HU-1 in all three pro-inflammatory genes. HU-2 showed a superior dose dependent anticancer effect through activation of p53 gene over HU-1 in MCF-7 cells. HU-1 exhibited a dose dependent effect on caspase 7 gene in both cell lines while HU-2 was more effective in A431. HU-2 has potential for development as a novel anti-inflammatory and anticancer agent. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Formula: C14H22O

The Article related to humboldtia unijuga erythrodiol acetate ditertbutylphenol antiinflammatory anticancer activity apoptosis, humboldtia unijuga , 2,4-di-tert-butylphenol, anti-inflammatory activity, anticancer activity, apoptosis, erythrodiol-3-acetate and other aspects.Formula: C14H22O

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Zhao, Fuqiang; Wang, Ping; Lucardi, Rima D.; Su, Zushang; Li, Shiyou published an article in 2020, the title of the article was Natural sources and bioactivities of 2,4-Di-tert-butylphenol and its analogs.Safety of 2,4-Di-tert-butylphenol And the article contains the following content:

2,4-Di-tert-butylphenol or 2,4-bis(1,1-dimethylethyl)-phenol (2,4-DTBP) is a common toxic secondary metabolite produced by various groups of organisms. The biosources and bioactivities of 2,4-DTBP have been well investigated, but the phenol has not been systematically reviewed. This article provides a comprehensive review of 2,4-DTBP and its analogs with emphasis on natural sources and bioactivities. 2,4-DTBP has been found in at least 169 species of bacteria (16 species, 10 families), fungi (11 species, eight families), diatom (one species, one family), liverwort (one species, one family), pteridiphyta (two species, two families), gymnosperms (four species, one family), dicots (107 species, 58 families), monocots (22 species, eight families), and animals (five species, five families). 2,4-DTBP is often a major component of violate or essential oils and it exhibits potent toxicity against almost all testing organisms, including the producers; however, it is not clear why organisms produce autotoxic 2,4-DTBP and its analogs. The accumulating evidence indicates that the endocidal regulation seems to be the primary function of the phenols in the producing organisms. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Safety of 2,4-Di-tert-butylphenol

The Article related to review 2 4di tert butylphenol analog natural source bioactivity, 2,4-dtbp, 2,4-bis(1,1-dimethylethyl)-phenol (2,4-dtbp), 2,4-di-tert-butylphenol, analogs, animals, autotoxicity, bacteria, bioactivities, fungi, natural source, plants and other aspects.Safety of 2,4-Di-tert-butylphenol

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On August 4, 2020, Wu, Yan; Venier, Marta; Hites, Ronald A. published an article.Formula: C14H22O The title of the article was Broad Exposure of the North American Environment to Phenolic and Amino Antioxidants and to Ultraviolet Filters. And the article contained the following:

This work comprehensively assessed three suites of commonly used synthetic additives: phenolic and amino antioxidants and UV filters. Concentrations of 47 such compounds and their transformation products were measured in 20 atm. particle samples collected at Chicago, Illinois, in 21 Canadian e-waste dust samples, in 32 Canadian and US residential dust samples, and in 10 Chicago Sanitary and Ship Canal sediment samples. Despite their large US production volumes, environmental data on antioxidants and UV filters in North America is limited. These compounds were detected in all samples, indicating their ubiquitous distribution in the North American environment. The most prevalent compounds were 2,6-di-t-butyl-p-benzoquinone, diphenylamine, 4,4′-di-t-octyl diphenylamine, 2,4-dihydroxybenzophenone, and 2-hydroxy-4-methoxybenzophenone. E-waste dust contained significantly greater total concentrations of these compounds than Canadian residential dust; intermediate levels were detected in US residential dust. Sediment had relatively high N,N’-diphenylbenzidine concentrations whose source was unclear, and some benzotriazole UV filters. Daily intake rates via dust ingestion for these compounds were 1-10 ng/kg-day for adults to 10-100 ng/kg-day for toddlers. Due to the wide distribution of these compounds in ambient and built environments, future research on their potential toxic effects on people and ecosystems is important. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Formula: C14H22O

The Article related to environmental pollution phenol compound amino antioxidant uv filter, air water aquatic sediment pollution organic compound north america, atm particulate electronic waste dust contamination organic compound, toxicity human exposure organic environmental pollutant north america and other aspects.Formula: C14H22O

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On October 31, 2021, Aalto-Korte, Kristiina; Pesonen, Maria published an article.Application In Synthesis of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol The title of the article was Patterns of positive patch test reactions to formaldehyde and formaldehyde releasers at the F innish I nstitute of O ccupational H ealth from 2007 to 2020. And the article contained the following:

Formaldehyde is an important contact sensitizer. Formaldehyde releasing substances induce pos. reactions in formaldehyde-allergic patients, but there are also reactions independent of formaldehyde allergy. In an earlier study, stronger formaldehyde reactions led to more pos. reactions to quaternium-15. To analyze patterns of pos. patch test reactions to formaldehyde and different formaldehyde releasers. Patch test files of 1497 patients investigated during the period Nov. 2007-August 2020 were retrospectively reviewed for pos. reactions to formaldehyde and its releasers. During the study period, almost all (≥99.3%) patients were tested with a formaldehyde dilution series and six formaldehyde releasers. Ninety-three patients tested pos. to formaldehyde; 80% of these had pos. reactions to at least one formaldehyde releaser, most often benzylhemiformal. There were only nine independent contact allergies to formaldehyde releasers. There were only two reactions to 2-bromo-2-nitropropane-1,3-diol and they occurred in formaldehyde-neg. patients. In patients with extreme (+++) reactions to formaldehyde, concomitant pos. reactions to any of the other 11 investigated formaldehyde releasers were more common than in patients with milder formaldehyde reactions. Strong formaldehyde reactions were associated with pos. reactions to formaldehyde releasers. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).Application In Synthesis of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol

The Article related to formaldehyde releaser pos patch test reaction, 2-bromo-2-nitropropane-1,3-diol, bioban cs 1135, bioban cs 1246, bioban p 1487, dmdm hydantoin, benzylhemiformal, diazolidinyl urea, hexahydro-1,3,5-tris-(2-hydroxyethyl)triazine, imidazolidinyl urea, quaternium-15 and other aspects.Application In Synthesis of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol

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On September 15, 2021, Stienbarger, Cheyenne D.; Joseph, Jincy; Athey, Samantha N.; Monteleone, Bonnie; Andrady, Anthony L.; Watanabe, Wade O.; Seaton, Pamela; Taylor, Alison R.; Brander, Susanne M. published an article.Product Details of 96-76-4 The title of the article was Direct ingestion, trophic transfer, and physiological effects of microplastics in the early life stages of Centropristis striata, a commercially and recreationally valuable fishery species. And the article contained the following:

Microplastics are ubiquitous in marine and estuarine ecosystems, and thus there is increasing concern regarding exposure and potential effects in com. species. To address this knowledge gap, we investigated the effects of microplastics on larval and early juvenile life stages of the Black Sea Bass (Centropristis striata), a North American fishery. Larvae (13-14 days post hatch, dph) were exposed to 1.0 x 104, 1.0 x 105, and 1.0 x 106 particles L-1 of low-d. polyethylene (LDPE) microspheres (10-20μ) directly in seawater and via trophic transfer from microzooplankton prey (tintinnid ciliates, Favella spp.). We also compared the ingestion of virgin and chem.-treated microspheres incubated with either phenanthrene, a polycyclic aromatic hydrocarbon, or 2,4-di-tert-butylphenol (2,4-DTBP), a plastic additive. Larval fish did not discriminate between virgin or chem.-treated microspheres. However, larvae did ingest higher numbers of microspheres through ingestion of microzooplankton prey than directly from the seawater. Early juveniles (50-60 dph) were directly exposed to the virgin and chem.-treated LDPE microspheres, as well as virgin LDPE microfibers for 96 h to determine physiol. effects (i.e., oxygen consumption and immune response). There was a significant pos. relationship between oxygen consumption and increasing microfiber concentration, as well as a significant neg. relationship between immune response and increasing virgin microsphere concentration This first assessment of microplastic pollution effects in the early life stages of a com. finfish species demonstrates that trophic transfer from microzooplankton can be a significant route of microplastic exposure to larval stages of C. striata, and that multi-day exposure to some microplastics in early juveniles can result in physiol. stress. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Product Details of 96-76-4

The Article related to direct ingestion trophic transfer physiol effect microplastic, centropristis striata fishery species, black sea bass, commercial fishery, concentration-response, contaminated prey, immune response, microfibers, microspheres, north america, respiration and other aspects.Product Details of 96-76-4

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