Tag: 200-300

Coletta, Marco; Tziotzi, Thomais G.; Gray, Mark; Nichol, Gary S.; Singh, Mukesh K.; Milios, Constantinos J.; Brechin, Euan K. published an article in 2021, the title of the article was A [Mn18] wheel-of-wheels.Quality Control of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol And the article contains the following content:

A [Mn18] wheel of wheels is obtained from the reaction of MnBr2·4H2O and LH3 in MeOH. The metallic skeleton reveals two asym. [MnIII6MnII2] square wheels connected into a larger wheel via two MnII ions. Magnetic susceptibility and magnetization data reveal competing exchange interactions, supported by computational studies. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).Quality Control of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol

The Article related to manganese trihydroxyethyltriazacyclohexane oxo hydroxide methanol complex preparation, crystal structure manganese trihydroxyethyltriazacyclohexane oxo hydroxide methanol complex and other aspects.Quality Control of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol

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On June 24, 2004, Groppi, Vincent Edward, Jr.; Jacobsen, Eric Jon; Myers, Jason Kenneth; Piotrowski, David Walter; Rogers, Bruce Nelsen; Walker, Daniel Patrick; Wishka, Donn Gregory published a patent.Product Details of 280752-78-5 The title of the patent was Preparation of N-(quinuclidinyl)heteroarylamides as nicotinic acetylcholine receptor agonists for use in combination therapy for the treatment of ADHD. And the patent contained the following:

Title N-(1-azabicyclo[2.2.2]octyl)heteroarylamides I and analogs [wherein X = o, S; R1 = H, (halo)alkyl, cycloalkyl, substituted Ph, naphthyl; R2 = independently halo, cycloalkyl, aryl, (un)substituted alkyl; m = 0-1; n = 0-1; with the proviso that m + n = 1; W = (un)substituted Ph, heterocyclyl, heteroaryl; or pharmaceutically acceptable salts, racemic mixtures, or pure enantiomers thereof] were prepared as α7 nicotinic acetylcholine receptor (nAChR) full agonists (no data). For example, reaction of phosgene with 4-bromopyrazole in EtOAc, followed by coupling with (+)-3-aminoquinuclidine•2HCl provided II•HCl (25%). The invention provides for compositions of I with psychostimulants and/or monoamine reuptake inhibitors for the treatment of attention deficit hyperactivity disorder (ADHD). The experimental process involved the reaction of (6-Bromo-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol(cas: 280752-78-5).Product Details of 280752-78-5

The Article related to quinuclidinyl heteroarylamide preparation nicotinic acetylcholine receptor agonist adhd treatment, azabicyclooctyl heteroarylamide preparation composition nachr agonist adhd treatment and other aspects.Product Details of 280752-78-5

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On May 31, 2005, Kuramshin, A. I.; Asafyeva, E. V.; Cherkasov, R. A. published an article.Formula: C9H21N3O3 The title of the article was Preparation of Complexes η4-4-(1,3-Diphenyl-2-propen-1-one)-η3-3-(1,3,5-triorganyl-1,3,5-triazacyclohexane)carbonyltungsten(0) and Their Reactions with Diethyl Phosphite. And the article contained the following:

New W complexes were prepared of a composition η3-[(1,3,5-triorganyl)-1,3,5-triazacyclohexane]tricarbonyltungsten(0) where a tridentate coordination of the triazinane fragment to the metal center was found. The reaction of tricarbonyl triazinane W complexes with 1,3-diphenyl-2-propen-1-one (chalcone) under thermochem. activation resulted in replacement of two CO mols. in the coordination sphere of W by a chalcone mol. linked to the transition metal atom through a system of π-bonds C:C and C:O. The phosphorylation of η4-(1,3-diphenyl-2-propen-1-one)-η3-[(1,3,5-triphenyl)-1,3,5-triazacyclohexane]monocarbonyltungsten(0) with di-Et phosphite occurred at the carbonyl group of the coordinated heterodiene; the phosphonate thus formed underwent intra-complex phosphonate-phosphate rearrangement affording an organometallic phosphate. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).Formula: C9H21N3O3

The Article related to tungsten carbonyl triazacyclohexane preparation coordinative substitution chalcone phosphorylation, regioselective phosphorylation tungsten carbonyl triazacyclohexane chalcone complex and other aspects.Formula: C9H21N3O3

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On November 1, 2020, Tsochatzis, Emmanouil D.; Mieth, Anja; Alberto Lopes, Joao; Simoneau, Catherine published an article.Formula: C14H22O The title of the article was A Salting-out Liquid-Liquid extraction (SALLE) for the analysis of caprolactam and 2,4-di-tert butyl phenol in water and food simulants. Study of the salinity effect to specific migration from food contact materials. And the article contained the following:

Caprolactam and 2,4-di-tert-Bu phenol (2,4-DTBP) are substances typically found in some food contact materials (FCMs). They are known to often migrate into food, and are difficult to analyze in liquid food simulants using GC. In this work a simple salting-out Liquid-Liquid Extraction (SALLE) for the anal. of both substances in water and the official food simulant A (10% volume/volume ethanol, Regulation (EU) Number 10/2011) is presented. The method, which included anal. determination by GC-MS, was optimized and validated to ensure sufficient anal. quality. The method’s LOQs allowed the proper quantification of caprolactam at its EU legislative limit (15 mg kg-1). For 2,4-DTBP the method also revealed good sensitivity, although no official limits have been established yet. Linear regression coefficients (R2) were in all cases higher than 0.999, and recoveries ranged from 87% and 95% for caprolactam and 2,4-DTBP, resp. Precision was also acceptable, with the RSDs (%) below 12%. The method proved to be adequate to be used for routine anal. The presence of salt during migration of caprolactam and 2,4-DTBP was also investigated in this work. Polyamide/polyethylene FCM multilayer films have been tested with water and simulant A, containing different amounts of NaCl (up to 15% m/v), and applying different migration conditions (temperature and time). The results indicated that salinity plays an important effect on the migration of caprolactam, with the presence of salt reducing its migration in case of water and increasing it in case of simulant A. These preliminary results seem to indicate that migration testing should consider not only the well-known fatty content of a food, but also its salinity content, as it may end up affecting drastically the migration of polar substances. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Formula: C14H22O

The Article related to caprolactam 24 dtbp food contact material, food contact materials, gc-ms, method validation, migration testing and food simulants, salle – salt assisted liquid extraction, salinity effect and other aspects.Formula: C14H22O

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On February 28, 2022, Gautam, Veer Singh; Singh, Arti; Kumari, Puja; Nishad, Jay Hind; Kumar, Jitendra; Yadav, Monika; Bharti, Rajnish; Prajapati, Priyanka; Kharwar, Ravindra Nath published an article.Formula: C14H22O The title of the article was Phenolic and flavonoid contents and antioxidant activity of an endophytic fungus Nigrospora sphaerica (EHL2), inhabiting the medicinal plant Euphorbia hirta (dudhi) L.. And the article contained the following:

Since endophytic fungi are pivotal sources of various bioactive natural compounds, the present study is aimed to investigate the antioxidant compounds of the endophytic fungus Nigrospora sphaerica isolated from a pantropical weed, Euphorbia hirta L. The fungus was fermented in four different media and each filtered broth was sequentially extracted in various solvents. Crude extracts collected from different solvents were subjected to phytochem. anal. and antioxidant activity. The total phenolic content (TPC) and total flavonoid content (TFC) were maximal in Et acetate crude extract (EtOAcE) of endophyte fermented in potato dextrose broth (PDB) medium (77.74 ± 0.046mgGAE/g and 230.59 ± 2.0 mgRE/g) with the highest 96.80% antioxidant activity. However, TPC and TFC were absent in hexane extract of Czapek Dox broth (CDB) medium exhibiting the lowest 4.63 ± 2.75% activity. The EtOAcE (PDB) showed a pos. correlation between TFC and antiradical activity (R2 = 0.762; P < 0.05), whereas a high pos. correlation was noticed between TPC and antioxidant activity (R2 = 0.989; P < 0.05). Furthermore, to determine the antioxidant activity, EtOAcE (PDB) was subjected to TLC bioautog.-based partial purification, while GC/MS anal. of the partial purified extract was done to confirm the presence of phenolics along with antioxidant compounds that resulted in the detection of 2,4-Di-tert-butylphenol (13.83%), a phenolic compound accountable for the antioxidant potential. Conclusively, N. sphaerica is a potential candidate for natural antioxidant. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Formula: C14H22O

The Article related to nigrospora sphaerica euphorbia hirta phenolic flavonoid antioxidant, antioxidant activity, compounds purification, gc–ms analysis, n. sphaerica, phytochemical analysis, tlc bioautography and other aspects.Formula: C14H22O

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On August 4, 2020, Behm, Kira; Fazekas, Eszter; Paterson, Martin J.; Vilela, Filipe; McIntosh, Ruaraidh D. published an article.Formula: C14H22O The title of the article was Discrete Ti-O-Ti Complexes: Visible-Light-Activated, Homogeneous Alternative to TiO2 Photosensitisers. And the article contained the following:

A series of novel bimetallic TiIV amine bis(phenolate) complexes was synthesized and fully characterised. X-ray crystallog. studies revealed distorted octahedral geometries around the Ti centers with single or double oxo-bridges connecting the two metals. These robust, air- and moisture-stable complexes were employed as photosensitizers generating singlet oxygen following irradiation with visible light (420 nm) LED module in a com. flow reactor. All five complexes showed high activity in the photo-oxygenation of α-terpinene and achieved complete conversion to ascaridole in four hours at ambient temperature The excellent selectivity of these photosensitizers towards ascaridole (vs. transformation to p-cymene) was demonstrated with control experiments using a traditional TiO2 catalyst. Further comparative studies employing the free pro-ligands as well as a monometallic analog highlighted the importance of the ′TiO2-like′ moiety in the polymetallic catalysts. Computational studies were used to determine the nature of the ligand to metal charge transfer (LMCT) states and singlet-triplet gaps for each complex, the calculated trends in the UV-vis absorption spectra across the series agreed well with the exptl. results. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Formula: C14H22O

The Article related to discrete tioti complex visible light activated photosensitizers, crystal structure discrete tioti complex, amine bis(phenolate), flow chemistry, photosensitiser, singlet oxygen, titanium and other aspects.Formula: C14H22O

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Li, Tianpeng; Fan, Jing; Sun, Tingting published an article in 2021, the title of the article was Effective removal of methylene blue dye from water with nanocomposite ceramsites in a fixed-bed column.Application of 96-76-4 And the article contains the following content:

The study aims to remove methylene blue dye from water with a fixed-bed column packed with Cu2O nanocomposite ceramsites. The column showed the advantages of fixed-bed column adsorption and photocatalytic oxidation The Cu2O nanocomposite ceramsites with strong photocatalytic oxidation activity and well-developed porous structure were successfully prepared with the chem. vapor deposition process, which also met with the China’s industrial standard of CJ/T 299-2008 and China’s national standard of GB 5085.3-2007. The breakthrough time and saturation time under UV radiation were 36.0% and 26.83% longer than those under the conditions without UV radiation, because the micro-pore structure of ceramsite was closely related to optical excitation properties of nano-Cu2O. The Yoon-Nelson and Adams-Bohart models were applied to describe the obtained breakthrough curves using non-linear regression, in which the Yoon-Nelson model gave the better prediction results for breakthrough curves, with R2>0.98. Besides, amines were the dominant intermediates at saturation point and final products were inorganic anions. This study confirmed that the fixed-bed column packed with Cu2O nanocomposite ceramsites could efficiently treat methylene blue dye wastewater, due to the structure-function relationship between ceramsite and nano-Cu2O. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Application of 96-76-4

The Article related to methylene blue adsorption photocatalytic oxidation copper oxide ceramsite nanocomposite, ceramsite, breakthrough curves, kinetic analysis, nanocomposite, structure-function relationship and other aspects.Application of 96-76-4

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On August 31, 2022, Ghamry, Mohamed; Ghazal, Ahmed Fathy; Al-Maqtqri, Qais Ali; Li, Li; Zhao, Wei published an article.HPLC of Formula: 96-76-4 The title of the article was Impact of a novel probiotic Lactobacillus strain isolated from the bee gut on GABA content, antioxidant activity, and potential cytotoxic activity against HT-29 cell line of rice bran. And the article contained the following:

Rice bran was fermented with Lactobacillus apis, isolated from the bee gut as a novel probiotic strain, and Saccharomyces cerevisiae to investigate the relationship between its metabolites and antioxidant activity, nutraceutical value, and cytotoxic activity against the HT-29 cell line. The findings showed that L. apis improved the antioxidant activity (DPPH of 37.73%) and antioxidant capacity (ABTS of 37.62 mg Trolox/g,), as well as, hydroxyl radical-scavenging activity (91.55%) of rice bran compared to S. cerevisiae. The metabolic anal. of volatile compounds revealed an increase of alcs. and lactones in the samples fermented with S. cerevisiae. While the samples fermented with L. apis displayed an increase of ketones, esters, and thiazoles. On the other hand, L. apis and S. cerevisiae exhibited a significant ability to increase γ-aminobutyric acid during different fermentation times. Compared with non-fermented samples (18.54%), L. apis increased the cytotoxic activity of rice bran against the HT-29 cell line to 34.17%, and S. cerevisiae to 31.34%. These results suggest that the fermentation of rice bran with S. cerevisiae and L. apis provides a promising strategy to improve the antioxidant activity and nutraceuticals of rice bran, and a potential source for plant-based pharmaceutical products. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).HPLC of Formula: 96-76-4

The Article related to lactobacillus apis saccharomyces cerevisiae fermentation antioxidant nutraceutical cytotoxic activity, antioxidants, cytotoxic activity, lactobacillus apis, rice bran, saccharomyces cerevisiae and other aspects.HPLC of Formula: 96-76-4

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On December 1, 2018, Guo, Bin; Guo, Shimeng; Huang, Jing; Li, Jingya; Li, Jia; Chen, Qian; Zhou, Xianli; Xie, Xin; Yang, Yushe published an article.Product Details of 280752-78-5 The title of the article was Design and optimization of 2,3-dihydrobenzo[b][1,4]dioxine propanoic acids as novel GPR40 agonists with improved pharmacokinetic and safety profiles. And the article contained the following:

GPR40 has become a new potential therapeutic target for the treatment of diabetes due to its role in mediating the enhancement of glucose-stimulated insulin secretion in pancreatic β cells with a low risk of hypoglycemia. As an effort to extend the chem. space and identify structurally distinct GPR40 agonists with improved liver safety, a novel series of fused-ring Ph propanoic acid analogs were designed. Comprehensive structure-activity relationship studies around novel scaffolds were conducted and led to several analogs exhibited potent GPR40 agonistic activities and high selectivity against other fatty acid receptors. Further evaluation of pharmacokinetic (PK) profiles and in vivo efficacy identified compound I with excellent PK properties and significant glucose-lowering efficacy during an oral glucose tolerance test. In addition, compound I displayed lower hepatobiliary transporter inhibition and favorable druggability. All results indicate that compound I is a promising candidate for further development. The experimental process involved the reaction of (6-Bromo-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol(cas: 280752-78-5).Product Details of 280752-78-5

The Article related to dihydrobenzodioxine propanoic acid preparation gpr40 agonist antidiabetic pharmacokinetic profile, 2,3-dihydrobenzo[b][1,4]dioxine, gpr40 agonist, insulin secretion, type 2 diabetes mellitus and other aspects.Product Details of 280752-78-5

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On December 31, 2020, Fagbohun, Oladapo F.; Olawoye, Babatunde; Ademakinwa, Adedeji N.; Jolayemi, Kehinde A.; Msagati, Titus A. M. published an article.Synthetic Route of 96-76-4 The title of the article was Metabolome modulatory effects of Kigelia africana (Lam.) Benth. fruit extracts on oxidative stress, hyperlipidaemic biomarkers in STZ-induced diabetic rats and antidiabetic effects in 3T3 L1 adipocytes. And the article contained the following:

The management of diabetes is considered a global problem, and a cure is yet to be discovered. This study investigated the modulatory effect of Kigelia africana fruit on oxidative stress and hyperlipidemic biomarkers in STZ-induced diabetic rats, profiled phytoconstituents using GC-TOF-MS and evaluated antidiabetic effects on 3T3 L1 adipocytes. Thirty male Wistar rats (120-150 g) were divided into six groups (n = 5). Diabetes was induced by a single i.p. injection of STZ (60 mg/kg) and treated with 100, 200 and 400 of hexane fraction of KA for 28 days. Immunohistochem. evaluation was carried out using avidin-biotin immunoperoxidase (ABI) method. Catalase and SOD activities as well as the levels of total protein, albumin, bilirubin, triglyceride, cholesterol, and high-d. lipoprotein were measured. The expressions of oxidative stress and hyperlipidemic biomarkers alongside fasting blood glucose concentrations were remarkedly decreased in KA-treated diabetic rats. Moreover, there was a significant increase in endocrine cell distribution, area covered with increase in β-cell mass, composition and morphol. of KA-treated animals. Addnl., there was constant up-regulation in 3T3 L1 adipocytes due to the presence of phytoconstituents. Kigelia africana fruit can act as a modulatory agent due to its ameliorative effects against oxidative stress. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Synthetic Route of 96-76-4

The Article related to metabolome modulatory effect kigelia africana oxidative stress hyperlipidemic biomarker, kigelia africana , diabetes mellitus , gc-tof-ms, antioxidant enzymes, avidin-biotin immunoperoxidase and other aspects.Synthetic Route of 96-76-4

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