Tag: 200-300

Zarraga O., M.; Darouch, M.; Lisboa, E.; Arroyo P., P.; Miranda M., A. published an article in 2021, the title of the article was Synthesis of 6-tert-octyl and 6,8-ditert-butyl coumarins, two coumarins of biological interest.Product Details of 96-76-4 And the article contains the following content:

In this study, the synthesis of new coumarins with aliphatic chains is discussed. The incorporation of the 6-tert-octyl and 6,8-ditert-Bu chains into a coumarin structure from alkylphenols, allows obtaining hydrophobic coumarins with good yields. These coumarins can be potential modulators of TRPV1 receptors. Synthesis and spectroscopic data of these new coumarins are analyzed. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Product Details of 96-76-4

The Article related to tert octyl ditert butyl coumarin preparation, Heterocyclic Compounds (One Hetero Atom): Benzopyrans (Including Coumarins, Isocoumarins, Chromones, Benzopyrones, Dibenzopyrans, and Other Arenopyrans) and other aspects.Product Details of 96-76-4

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On December 31, 2021, Bhanderi, Khushboo; Ghalsasi, Prasanna S.; Inoue, Katsuya published an article.Computed Properties of 96-76-4 The title of the article was Nonconventional driving force for selective oxidative C-C coupling reaction due to concurrent and curious formation of Ag0. And the article contained the following:

Herein, reduction of [Ag(NH3)2]+ to Ag0 with concurrent oxidation of different phenols/naphthols to biphenyls was undertaken. The work was originated during careful observation of an undergraduate experiment-Tollen’s test-where silver mirror film deposition takes place on the walls of borosilicate glass test tube. When the same reaction was carried out in polypropylene (plastic-Eppendorf) tube, aggregation of Ag0 leading to floating Ag-particles was observed but not silver film deposition. This prompted to carry out challenging cross-coupling reaction by only changing the surface of the reaction flask from glass to plastic to silicones. Surprisingly, good selective oxidative homo-coupling on Teflon surface while cross-coupling in Eppendorf vial was observed Thus, the formation of biphenyl is driven by the macroscopic growth of Ag0 into [Ag-particle] orchestrated by Ag…Ag cohesive interaction was proposed. To validate results, experiments were also performed on gram scale. More importantly, oxidation of β-naphthol carried out in quartz (chiral) tube which yielded slight enantioselective excess of BINOL. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Computed Properties of 96-76-4

The Article related to phenol silver ammonia complex catalyst regieoselective oxidative coupling, biphenyl preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Phenols, Thiophenols, and Derivatives Including Phenol and Thiophenol Ethers and Esters and other aspects.Computed Properties of 96-76-4

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On April 30, 2020, Vol’eva, V. B.; Zhorin, V. A.; Ovsyannikova, M. N.; Kurkovskaya, L. N. published an article.Computed Properties of 96-76-4 The title of the article was Solid-Phase ortho-Hydroxylation of 2,4-Di-tert-butylphenol and Its Derivatives. And the article contained the following:

Direct phenol-catechol conversion was realized as a result of the solid-phase reaction of 2,4-di-tert-butylphenol with cuprous oxide under high pressure and shear deformation on the Bridgman anvils. The yield of 3,5-di-tert-butylcatechol in this reaction was about 85%. When cupric oxide was used in the solid-phase process, oxidative coupling of the starting phenol took place, resulting in quant. formation of tetra-tert-butyl-ortho-bisphenol. The reaction of 6-substituted derivatives of 2,4-di-tert-butylphenol with cuprous oxide was used as an example to demonstrate the possibility of substitutive ortho-hydroxylation yielding 7-20% of pyrocatechols. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Computed Properties of 96-76-4

The Article related to hydroxy ditertiary butylphenol preparation, ditertiary butylphenol ortho hydroxylation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Phenols, Thiophenols, and Derivatives Including Phenol and Thiophenol Ethers and Esters and other aspects.Computed Properties of 96-76-4

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On September 9, 2011, Layton, Mark E.; Kelly, Michael J.; Hartingh, Timothy J. published a patent.Application In Synthesis of [4-Fluoro-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol The title of the patent was Preparation of benzothiadiazole and thiadiazolopyridine dioxides as positive allosteric modulators of mGluR2. And the patent contained the following:

The present invention is directed to 5-substituted 1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide and 1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridine 2,2,-dioxide derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurol. and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The compounds of the invention have general formula I, wherein X is C or N; Y is C1-6 alkyl; R1 is (un)substituted benzyl, (un)substituted C2-8 alkyl, etc.; each R2 is independently halo, OH, C1-4 alkyl, etc.; A is (un)substituted aryl or (un)substituted heteroaryl. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved. Synthetic procedures for preparing I are exemplified. Example compound II, prepared in a 5-step synthesis that culminated in reaction of III with 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile, potentiated mGluR2 activity in a FLIPR assay with an EC50 of 5.0 nM. The experimental process involved the reaction of [4-Fluoro-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol(cas: 1333264-06-4).Application In Synthesis of [4-Fluoro-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol

The Article related to benzothiadiazole thiadiazolopyridine dioxide preparation allosteric mglur2 modulator therapy, neurol psychiatric disorder treatment benzothiadiazole thiadiazolopyridine dioxide and other aspects.Application In Synthesis of [4-Fluoro-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol

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On August 17, 2021, Lowe, Charles N.; Phillips, Katherine A.; Favela, Kristin A.; Yau, Alice Y.; Wambaugh, John F.; Sobus, Jon R.; Williams, Antony J.; Pfirrman, Ashley J.; Isaacs, Kristin K. published an article.Related Products of 96-76-4 The title of the article was Chemical Characterization of Recycled Consumer Products Using Suspect Screening Analysis. And the article contained the following:

Recycled materials are found in many consumer products as part of a circular economy; however, the chem. content of recycled products is generally uncharacterized. A suspect screening anal. using two-dimensional gas chromatog. time-of-flight mass spectrometry (GC x GC-TOFMS) was applied to 210 products (154 recycled, 56 virgin) across seven categories. Chems. in products were tentatively identified using a standard spectral library or confirmed using chem. standards A total of 918 probable chem. structures identified (112 of which were confirmed) in recycled materials vs. 587 (110 confirmed) in virgin materials. Identified chems. were characterized in terms of their functional use and structural class. Recycled paper products and construction materials contained greater numbers of chems. than virgin products; 733 identified chems. had greater occurrence in recycled compared to virgin materials. Products made from recycled materials contained greater numbers of fragrances, flame retardants, solvents, biocides, and dyes. The results were clustered to identify groups of chems. potentially associated with unique chem. sources, and identified chems. were prioritized for further study using high-throughput hazard and exposure information. While occurrence is not necessarily indicative of risk, these results can be used to inform the expansion of existing models or identify exposure pathways currently neglected in exposure assessments. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Related Products of 96-76-4

The Article related to chem recycled consumer product suspect screening, expocast, consumer exposure, consumer products, human exposure modeling, nontargeted analysis, recycling, suspect screening and other aspects.Related Products of 96-76-4

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On January 15, 2022, Sun, Nan; Gao, Zhiyi; Li, Shiqi; Chen, Xiaowen; Guo, Jing published an article.Reference of 2,4-Di-tert-butylphenol The title of the article was Assessment of chemical constitution and aroma properties of kiwi wines obtained from pure and mixed fermentation with Wickerhamomyces anomalus and Saccharomyces cerevisiae. And the article contained the following:

To improve the aroma of kiwi wine through the utilization of Wickerhamomyces anomalus, kiwi juice was fermented using a selected W. anomalus strain in pure culture and mixed fermentations with Saccharomyces cerevisiae, which was inoculated simultaneously and sequentially. The physicochem. indexes, volatile compounds and aroma properties of the kiwi wines were assessed. The study suggested that the ethanol, color indexes and organic acids of the wines were closely related to the method of inoculation. Compared with the pure S. cerevisiae fermentation, the mixed fermentations produced more varieties and concentrations of volatiles. The sequential fermentations increased the concentrations of esters and terpenes, improving the flower and sweet fruit notes of the wines. The simultaneous inoculation enhanced the contents of esters and aldehydes, intensifying the flower, sweet and sour fruit of the wines. Partial least-squares regression anal. showed that esters and terpenes contributed greatly to the flower and sweet fruit aroma, whereas aldehydes were the major contributors to the sour note. Based on our results, the mixed fermentations not only enriched the types and concentrations of volatiles, but also had better sensory properties. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Reference of 2,4-Di-tert-butylphenol

The Article related to ester aldehyde terpene kiwi wine aroma wickerhamomyces saccharomyces fermentation, wickerhamomyces anomalus, kiwi wine, mixed fermentations, partial least squares regression and other aspects.Reference of 2,4-Di-tert-butylphenol

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On January 31, 2022, Vahdati, Saeed Niazi; Lashkari, Ali; Navasatli, Sepideh Aliniaye; Ardestani, Susan Kabudanian; Safavi, Maliheh published an article.Electric Literature of 96-76-4 The title of the article was Butylated hydroxyl-toluene, 2,4-Di-tert-butylphenol, and phytol of Chlorella sp. protect the PC12 cell line against H2O2-induced neurotoxicity. And the article contained the following:

Oxidative stress is considered the main cause of cellular damage in a number of neurodegenerative disorders. One suitable ways to prevent cell damage is the use of the exogenous antioxidant capacity of natural products, such as microalgae. In the present study, four microalgae extracts, isolated from the Persian Gulf, were screened to analyze their potential antioxidant activity and free radical scavenging using ABTS, DPPH, and FRAP methods. The methanolic extracts (D1M) of green microalgae derived from Chlorella sp. exhibited potent free radical scavenging activity. In order to characterize microalgae species, microscopic observations and anal. of the expression of 18S rRNA were performed. The antioxidant and neuroprotective effects of D1M on H2O2-induced toxicity in PC12 cells were investigated. The results demonstrated that D1M significantly decreased the release of nitric oxide (NO), formation of intracellular reactive oxygen species (ROS), and the level of malondialdehyde (MDA), whereas it enhanced the content of glutathione (GSH), and activity of heme oxygenase 1 (HO-1), NAD(P)H: quinone oxidoreductase 1 (NQO1), and catalase (CAT) in PC12 cells exposed to H2O2. The pretreatment of D1M improved cell viability as measured by the MTT assay and invert microscopy, reduced cell apoptosis as examined by flow cytometry anal., increased mitochondrial membrane potential (MMP), and diminished caspase-3 activity. The GC/MS anal. revealed that D1M ingredients have powerful antioxidant and anti-inflammatory compounds, such as butylated hydroxytoluene (BHT), 2,4-di-tert-butyl-phenol (2,4-DTBP), and phytol. These results suggested that Chlorella sp. extracts have strong potential to be applied as neuroprotective agents, for the treatment of neurodegenerative disorders. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Electric Literature of 96-76-4

The Article related to phytol butylated hydroxyl toluene hydrogen peroxide butylphenol chlorella neurotoxicity, anti-inflammatory, antioxidant, chlorella sp, microalgae, neuroprotective, pc12 cell and other aspects.Electric Literature of 96-76-4

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Canuto, Andre V. S.; Echevarria, Aurea published an article in 2014, the title of the article was 1H NMR for quantifying sulfide trapping efficiency by using 1,3,5-tris(2-hydroxyethyl)-1,3,5-triazinane.Application of 4719-04-4 And the article contains the following content:

H2S is an extremely toxic colorless gas; it is corrosive and denser than air. It usually happens in oil and natural gas fields, refineries, coal mines, and in some industrial effluent treatment systems. This work presents an alternative method of monitoring and quantifying H2S trapping efficiency using 1,3,5-tris(2-hydroxyethyl)-1,3,5-triazinane as a sequestering agent, and Na sulfide as a source of sulfide ion, through 1H NMR spectroscopy. The results proved that the reaction occurs very quickly at 20° at pH 7 and 10. here, 3,5-di(2-hydroxyethyl)-1,3,5-thiodiazinane and 5-(2-hydroxyethyl)-1,3,5-dithiozinane were observed and quantified; it was evidenced that 1H NMR spectroscopy can be applied as a fast and effective method to quantify H2S trapping efficiency. Copyright © 2014 John Wiley & Sons, Ltd. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).Application of 4719-04-4

The Article related to proton nmr quantification sulfide trapping efficiency hydroxyethyltriazinane, 1,3,5-triazinane, 1,3,5-tris(2-hydroxyethyl)-1,3,5-triazinane, 1h, h2s sequestering agent, nmr and other aspects.Application of 4719-04-4

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On September 7, 2020, Kraszewski, Karol; Tomczyk, Ireneusz; Drabinska, Aneta; Bienkowski, Krzysztof; Solarska, Renata; Kalek, Marcin published an article.Name: 2,4-Di-tert-butylphenol The title of the article was Mechanism of Iodine(III)-Promoted Oxidative Dearomatizing Hydroxylation of Phenols: Evidence for a Radical-Chain Pathway. And the article contained the following:

The oxidative dearomatization of phenols with the addition of nucleophiles to the aromatic ring induced by hypervalent iodine(III) reagents and catalysts has emerged as a highly useful synthetic approach. However, exptl. mechanistic studies of this important process have been extremely scarce. In this report, we describe systematic investigations of the dearomatizing hydroxylation of phenols using an array of exptl. techniques. Kinetics, EPR spectroscopy, and reactions with radical probes demonstrate that the transformation proceeds by a radical-chain mechanism, with a phenoxyl radical being the key chain-carrying intermediate. Moreover, UV and NMR spectroscopy, high-resolution mass spectrometry, and cyclic voltammetry show that before reacting with the phenoxyl radical, the water mol. becomes activated by the interaction with the iodine(III) center, causing the Umpolung of this formally nucleophilic substrate. The radical-chain mechanism allows the rationalization of all existing observations regarding the iodine(III)-promoted oxidative dearomatization of phenols. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Name: 2,4-Di-tert-butylphenol

The Article related to phenol iodine oxidative dearomatization kinetics mechanism, hypervalent iodine, mechanistic investigations, phenol dearomatization, radical-chain pathway, synthetic methods and other aspects.Name: 2,4-Di-tert-butylphenol

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Razali, Shakirah; Khan, Al’aina Yuhainis Firus; Khatib, Alfi; Ahmed, Qamar Uddin; Abdul Wahab, Ridhwan; Zakaria, Zainul Amiruddin published an article in 2021, the title of the article was An in vitro anticancer activity evaluation of Neolamarckia cadamba (Roxb.) bosser leaves’ extract and its metabolite profile.Application of 96-76-4 And the article contains the following content:

The leaves of Neolamarckia cadamba (NC) (Roxb.) Bosser (family: Rubiaceae) are traditionally used to treat breast cancer in Malaysia; however, this traditional claim is yet to be scientifically verified. Hence, this study was aimed to evaluate the anticancer effect of NC leaves ethanol extract against breast cancer cell line (MCF-7 cells) using an in vitro cell viability, cytotoxicity, and gene expression assays followed by the gas chromatog. anal. to further confirm active principles. Results revealed 0.2 mg/mL as the half maximal inhibitory concentration (IC50) against MCF-7. The extract exerted anticancer effect against MCF-7 cells in a dose- and time-dependent manner. The cell cycle assay showed that the extract arrested MCF-7 cells in the G0/G1 phase, and apoptosis was observed after 72 h by the Annexin-V assay. The gene expression assay revealed that the cell cycle arrest was associated with the downregulation of CDK2 and subsequent upregulation of p21 and cyclin E. The extract induced apoptosis via the mediation of the mitochondrial cell death pathways. A chromatog. anal. revealed the contribution of D-pinitol and myo-inositol as the two major bioactive compounds to the activity observed Overall, the study demonstrated that NC leaves ethanol extract exerts anticancer effect against MCF-7 human breast cancer cells through the induction of apoptosis and cell cycle arrest, thereby justifying its traditional use for the treatment of breast cancer in Malaysia. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Application of 96-76-4

The Article related to neolamarckia leaf extract anticancer agent breast cancer, neolamarckia cadamba, breast cancer, gas chromatography, gene expression assay, in vitro anticancer, mechanisms of action and other aspects.Application of 96-76-4

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