Tag: 200-300

On September 6, 2022, Zhang, Dejin; Sun, Shu; Wu, Qi; Xie, Yong; Liu, Chengcheng; Wang, Cong; Zhang, Keying; Shi, Hongwei; Zhuo, Xin; Wang, Hongyan published an article.HPLC of Formula: 96-76-4 The title of the article was Efficient and Easily Recyclable Catalyst for the Alkylation Reaction of Phenol and tert-Butyl Alcohol. And the article contained the following:

Tert-Butylphenol is widely used as an intermediate in organic synthesis, and the catalyst for the alkylation reaction of phenol and tert-Bu alc. is the key to synthesizing tert-butylphenol. In our work, a catalyst, 1H-imidazole-1-acetic acid tosilate ([HIMA]OTs), was synthesized and characterized, and an efficient and easily recyclable catalytic system of an ionic liquid was established. In addition, the kinetic and thermodn. parameters were calculated; the pos. value of ΔH* indicated the endothermic nature of the alkylation reaction, and the pos. value of ΔS* and neg. value of ΔG* implied that the process of alkylation of phenol and tert-Bu alc. was spontaneous in the current reaction system. The recovery experiments of [HIMA]OTs were performed, and an excellent recycling performance was obtained. This method provides a potential way for the industrial synthesis of tert-butylphenol. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).HPLC of Formula: 96-76-4

The Article related to efficient recyclable catalyst alkylation reaction phenol tert butyl alc, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.HPLC of Formula: 96-76-4

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On September 15, 2021, Xiong, Junping; Zhang, Dejin; Yang, Guoqiang; Zhang, Zhibing published an article.Computed Properties of 96-76-4 The title of the article was Alkylation of Phenol and tert-Butyl Alcohol Catalyzed by Deep Eutectic Solvents under Mild Conditions. And the article contained the following:

Tert-Bu phenol is an important intermediate for organic synthesis and the preparation of tert-Bu phenol under mild conditions is of great significance. In our work, five kinds of deep eutectic solvents were synthesized to catalyze the alkylation of phenol and tert-Bu alc. The deep eutectic solvent consisting of choline bisulfate (ChBf) and p-toluene sulfonic acid (p-TsOH) was proved to be a better catalyst. By employing the response surface methodol. to optimize the reaction conditions, we found that 99.5% conversion of tert-Bu alc. was obtained at a reaction temperature of 30°C. The temperature of alkylation reaction was much milder than those in previous reports. The kinetic model for this reaction was established based on the Runge-Kutta-Fehlberg method and the recycle performance for the catalyst was evaluated. Excellent conversion of tert-Bu alc. can be obtained after recycling eight times. This method provides a potential route for the synthesis of tert-Bu phenol under mild conditions in industry. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Computed Properties of 96-76-4

The Article related to phenol tert butanol alkylation catalyst deep eutectic solvents, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Computed Properties of 96-76-4

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On March 12, 2020, Becker, Christopher; Li, Xiaolin; Lu, Peichao; Rajapaksa, Naomi Samadara; Tully, David Charles; Wang, Xiaojing Michael; Zhao, Qian published a patent.Recommanded Product: 1-[(Dibenzylamino)methyl]cyclopropanol The title of the patent was Preparation of pyridopyrazinedione compounds as antiviral agents for treating particularly herpes viruses. And the patent contained the following:

The invention is related to the preparation of compounds I [Cy = (un)substituted Ph, pyridinyl, pyrimidinyl, or a 5-8 membered cycloalkyl; R1, R2 = independently H, C1-3 alkyl; or R1CR2 = 3-6 membered cycloalkyl ring; R3 = 0-2 optional substituents on the ring to which -L-W is directly attached; R4 = H, halo, C1-3 alkyl; R5 = H, halo, CN, C1-3 alkoxy, etc.; L = C1-C4 straight chain or branched alkylene linker, or L = C1-C4 straight chain or branched alkylene linker or a bond when W is an optionally substituted ring; W = H, OH, an optionally substituted ring selected from 3-6 membered cycloalkyl, Ph, 5-6-membered heterocyclyl containing one or two N, O or S heteroatoms as ring members, and 5-membered heteroaryl containing up to 4 heteroatoms selected from N, O and S as ring members that is optionally fused to Ph, etc.; Y = (CH2)0-2] their pharmaceutically acceptable salts, to pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by herpesviruses. Thus, II (m.p. = 186°) was prepared by reaction of Bu 1,6-dioxo-2,3,4,6-tetrahydro-1H-pyrido[1,2-a]pyrazine-7-carboxylate (preparation given) with [1-(cyclopropylsulfonyl)cyclopropyl]methyl Methanesulfonate (preparation given) in DMF in the presence of NaH, acidulation of III•Na, activation of the acid III with oxalyl chloride, amidation with 4-(aminomethyl)benzonitrile hydrochloride. The exemplified compounds of the invention were studied in an CMV polymerase, CMV-luciferase and HSV polymerase assays (some data given). The activity of I against human herpes viruses CMV HSV-1, VZV and EBV was evaluated [Ec50 values of 24(±7) nM, 32(±12), 20(±8) and 12(±), resp]. The experimental process involved the reaction of 1-[(Dibenzylamino)methyl]cyclopropanol(cas: 428855-17-8).Recommanded Product: 1-[(Dibenzylamino)methyl]cyclopropanol

The Article related to pyridopyrazinedione preparation herpes antiviral, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Recommanded Product: 1-[(Dibenzylamino)methyl]cyclopropanol

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Turkiewicz, Anna; Steliga, Teresa; Kluk, Dorota; Gminski, Zbigniew published an article in 2021, the title of the article was Biomonitoring Studies and Preventing the Formation of Biogenic H2S in the Wierzchowice Underground Gas Storage Facility.Electric Literature of 4719-04-4 And the article contains the following content:

The article discusses the results of biomonitoring research at the Underground Gas Storage (UGS). Hydrogen sulfide, as one of the products of microbiol. reaction and transformation, as well as a product of chem. reactions in rocks, is a subject of interest for global petroleum companies. The materials used in this research work were formation waters and stored natural gas. The biomonitoring of reservoir waters and cyclical analyses of the composition of gas stored at UGS Wierzchowice enabled the assessment of the microbiol. condition of the reservoir environment and individual storage wells in subsequent years of operation. Investigations of the formation water from individual wells of the UGS Wierzchowice showed the presence of sulfate reducing bacteria bacteria (SRB), such as Desulfovibrio and Desulfotomaculum genera and bacteria that oxidize sulfur compounds In the last cycles of UGS Wierzchowice, the content of hydrogen sulfide and sulfides in the reservoir waters ranged from 1.22 to 15.5 mg/dm3. The monitoring of natural gas received from UGS production wells and observation wells, which was carried out in terms of the determination of hydrogen sulfide and organic sulfur compounds, made it possible to observe changes in their content in natural gas in individual storage cycles. In the last cycles of UGS Wierzchowice, the content of hydrogen sulfide in natural gas from production wells ranged from 0.69 to 2.89 mg/dm3, and the content of organic sulfur compounds converted to elemental sulfur ranged from 0.055 to 0.130 mg Sel./Nm3. A higher hydrogen sulfide content was recorded in natural gas from observation wells in the range of 2.02-25.15 mg/Nm3. In order to explain the causes of hydrogen sulfide formation at UGS Wierzchowice, isotopic analyses were performed to determine the isotope composition of δ34SH2S, δ34SSO4, δ18OSO4 in natural gas samples (production and observation wells) and in the deep sample of reservoir water. The results of isotope tests in connection with microbiol. tests, chromatog. analyses of sulfur compounds in natural gas collected from UGS Wierzchowice and an anal. of the geol. structure of the Wierzchowice deposit allow us to conclude that the dominant processes responsible for the formation of hydrogen sulfide at UGS Wierzchowice are microbiol., consisting of microbial sulfate reduction (MSR). The presented tests allow for the control and maintenance of hydrogen sulfide at a low level in the natural gas received from the Wierzchowice Underground Gas Storage facility. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).Electric Literature of 4719-04-4

The Article related to biogenic hydrogen sulfide wierzchowice underground gas storage biomonitoring, Electrochemical, Radiational, and Thermal Energy Technology: Energy Handling, Transport, and Storage and other aspects.Electric Literature of 4719-04-4

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On October 1, 2004, Galvez-Ruiz, Juan Carlos; Jaen-Gaspar, Javier C.; Castellanos-Arzola, Indira G.; Contreras, Rosalinda; Flores-Parra, Angelina published an article.COA of Formula: C9H21N3O3 The title of the article was 2-(1,3,5-Dithiazinan-5-yl)ethanol heterocycles, structure and reactivity. And the article contained the following:

Treatment of 2-(1,3,5-dithiazinan-5-yl)ethanol (1), 2-(1,3,5-dithiazinan-5-yl)-1-phenylethanol (2), 2-(1,3,5-dithiazinan-5-yl)-1-methylethanol (3) and 2-(1,3,5-dithiazinan-5-yl)-2-methyl-1-phenylethanol (4) with TsCl and NEt3 in CH2Cl2 afforded the corresponding 3-tosyl-1,3-oxazolidine derivatives (5-8), whereas tosylation of 1-4 in the presence of NHMe3Cl gave the corresponding O-tosyl-2-(1,3,5-dithiazinan-5-yl)ethanol derivatives (11-14). The direct preparation of 5 and 7 from formaldehyde and N-tosylethanolamine (9) or N-tosyl-2-propanolamine was not successful. Reactions of 1 or 3 with benzylamine furnish 1,3,5-tribenzyl-1,3,5-triazinane. Heating of 1 and 2 affords the corresponding 1,3,5-tri(2-hydroxyethyl)-1,3,5-triazinanes. X-Ray diffraction studies of compounds (1-9 and 11) are reported. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).COA of Formula: C9H21N3O3

The Article related to dithiazinanyl ethanol heterocycle preparation crystal mol structure reactivity, tosyl oxazolidine benzyl hydroxyethyl triazinane preparation, Heterocyclic Compounds (More Than One Hetero Atom): Other 6-Membered Rings, Three Or More Hetero Atoms and other aspects.COA of Formula: C9H21N3O3

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On January 1, 2022, Schultheiss, Nate; Holtsclaw, Jeremy; Zeller, Matthias published an article.Computed Properties of 4719-04-4 The title of the article was An orthorhombic polymorph of 2-(1,3,5-dithiazinan-5-yl)ethanol or MEA-dithiazine. And the article contained the following:

Substituted triazines are a class of compounds utilized for scavenging and sequestering hydrogen sulfide in oil and gas production operations. The reaction of one of these triazines under field conditions resulted in the formation of the title compound, 2-(1,3,5-dithiazinan-5-yl)ethanol, C5H11NOS2, or MEA-dithiazine. Polymorphic form I, in space group I41/a, was first reported in 2004 and its extended structure displays one-dimensional, helical strands connected through O-H···O hydrogen bonds. We describe here the form II polymorph of the title compound, which crystallizes in the orthorhombic space group Pbca as centrosym. dimers through pairwise O-H···N hydrogen bonds from the hydroxyl moiety to the nitrogen atom of an adjacent mol. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).Computed Properties of 4719-04-4

The Article related to dithiazinanyl ethanol monoethanolamine dithiazine orthorhombic polymorph, crystal structure, di­thia­zine, hydrogen bonding, hydrogen sulfide, polymorphism, Crystallography and Liquid Crystals: Polytypism, Polymorphism, Crystal Phase Transitions, Ordering, Amorphization and other aspects.Computed Properties of 4719-04-4

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On January 31, 2007, Hua, Guoxiong; Zhang, Qingzhi; McManus, Derek; Slawin, Alexandra M. Z.; Woollins, J. Derek published an article.SDS of cas: 4719-04-4 The title of the article was Improvement of the Fe-NTA sulfur recovery system by the addition of a hydroxyl radical scavenger. And the article contained the following:

The degradation of nitrilotriacetic acid (NTA), which results from the oxidation of hydroxyl radicals formed in the process, is a major deficiency in the present Fe-NTA system for the oxidation of hydrogen sulfide to sulfur by air. The degradation of NTA can be slowed down considerably by the addition of a hydroxyl radical scavenger. In this study, a series of inorganic and organic materials was tested as scavengers / inhibitors of hydroxyl radicals in attempts to improve the Fe-NTA system. The results showed that N-methylpyrrolidinone and ethylene glycol could be used as potentially powerful scavengers of hydroxyl radicals to improve the Fe-NTA system. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).SDS of cas: 4719-04-4

The Article related to hydrogen sulfide oxidation sulfur recovery nta degradation control, Fossil Fuels, Derivatives, and Related Products: Manufacture Of Gasoline Hydrocarbons (Including Catalysts Used) and other aspects.SDS of cas: 4719-04-4

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Alcohol – Wikipedia,
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On August 31, 2020, Agrawal, D.; De, S. K.; Singh, P. K.; Shrivastava, Y. published an article.Application In Synthesis of 2,4-Di-tert-butylphenol The title of the article was Synthesis of a novel post-metallocene titanium complex of chelating [ONOO]-type ligand and studies on the effect of an extra donor arm on its reactivity in aqueous emulsion polymerization. And the article contained the following:

In the present work, a new Ti complex LTiCl2 {LH2 = 2-(3,5-di-tert-butyl-2-hydroxybenzylamino)-succinic acid}-bearing tetradentate [ONOO] donors has been synthesized and used in the homopolymerization of Me methacrylate and styrene in aqueous emulsion. The effect of co-catalyst NaBPh4 with ion-pair BPh-4 was also studied on the catalytic activity. Moreover, synthesized complex has been characterized by 1H NMR, UV-visible spectroscopy, IR spectroscopy, high-resolution mass spectra and elemental anal. The fabricated polymers have been tested using different characterizations, viz. 1H NMR, 13C NMR, DSC, DLS, XRD and GPC anal. The GPC anal. reveals that polymer product obtained has high mol. weight, and the amorphous behavior of the polymer product was indicated by the XRD and DSC anal. In addition to this, kinetic parameters like activation energy and rate constant for polymethyl methacrylate have also been examined The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Application In Synthesis of 2,4-Di-tert-butylphenol

The Article related to methyl methacrylate styrene polymerization metallocene titanium tetradentate ligand catalyst, Chemistry of Synthetic High Polymers: Polymerization Kinetics, Mechanisms, Thermodynamics, Catalysis, Catalysts and other aspects.Application In Synthesis of 2,4-Di-tert-butylphenol

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On November 23, 2017, Gao, Peng; Xiu, Wenhua; Wang, Shaobao; Liu, Lei; Bao, Rudi published a patent.Category: alcohols-buliding-blocks The title of the patent was FGFR4 inhibitor, preparation method and applications. And the patent contained the following:

The invention disclosed a kind of FGFR4 inhibitor, its preparation method and application. The claimed FGFR4 inhibitor is shown in structure I (X1 = -(CR3R4)m1-; X2 = -(CR5R6)m2-; X3 = -(CR7R8)m3-; Y = O or S; Z = NX4, O or S; X4 = H, C1-8 alkyl or haloalkyl, C3-8 cycloalkyl; R = H, halo, hydroxy, mercapto, cyano, etc.; R1 = H, halo, hydroxy, mercapto, cyano, nitro, C3-8 cycloalkyl, heterocyclo, etc.; R2 = halo, hydroxy, mercapto, cyano, nitro, etc.; R3,R4,R5,R6,R7,R8 = H, D, halo, C1-8 alkyl, C2-8 alkenyl, alkynyl, etc.). The claimed compound is prepared via multiple steps (procedure given). The prepared compound have a very-strong inhibition effect on the activity of FGFR4 kinase, has very-high selectivity, can be widely used in the preparation of drugs for treating cancers, specially liver cancer, stomach cancer, prostate cancer, skin cancer, ovarian cancer, lung cancer, breast cancer or colon cancer, and can be developed into a rnew-generation FGFR4 inhibitor drug. The experimental process involved the reaction of 1-[(Dibenzylamino)methyl]cyclopropanol(cas: 428855-17-8).Category: alcohols-buliding-blocks

The Article related to fgfr4 inhibitor preparation antitumor agent, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Category: alcohols-buliding-blocks

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Alcohol – Wikipedia,
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On August 12, 2022, Liu, Bowen; Wang, Lei; Qin, Yunfei; Xu, Xianxiu; Zhao, Jinbo published an article.Recommanded Product: 2,4-Di-tert-butylphenol The title of the article was Synthesis of Trisubstituted Chromanes by Lewis-Base-Catalyzed Three-Component Electrophilic Thiofunctionalization of Cyclopropene with Phenols via a Formal [3 + 3] Annulation. And the article contained the following:

A Lewis-base-catalyzed three-component electrophilic thiofunctionalization of cyclopropene with phenol is developed to furnish various trisubstituted chromanes in high trans-diastereoselectivity. This metal-free protocol is easy to scale-up, offers a unique 2,2,3-substitution pattern, and delivers chromanes with diversified core substitution patterns. The unprecedented tolerance of strong electron-withdrawing substituents at the phenol renders the protocol indispensable to access the otherwise inaccessible chromane chem. space that is important for medicinal chem. campaigns. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Recommanded Product: 2,4-Di-tert-butylphenol

The Article related to alkyl aryl arylthio chromane preparation diastereoselective triphenylphosphine sulfide antitumor, phenol cyclopropene phenylsulfenyl phthalimide annulation, Heterocyclic Compounds (One Hetero Atom): Benzopyrans (Including Coumarins, Isocoumarins, Chromones, Benzopyrones, Dibenzopyrans, and Other Arenopyrans) and other aspects.Recommanded Product: 2,4-Di-tert-butylphenol

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