Tag: 100-200

Polaczek, Krzysztof et al. published their research in Journal of Cleaner Production in 2022 | CAS: 111-46-6

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Name: 2,2′-Oxybis(ethan-1-ol)

Open-cell bio-polyurethane foams based on bio-polyols from used cooking oil was written by Polaczek, Krzysztof;Kuranska, Maria;Prociak, Aleksander. And the article was included in Journal of Cleaner Production in 2022.Name: 2,2′-Oxybis(ethan-1-ol) This article mentions the following:

Used cooking oil is a widely available and inexpensive waste with a high application potential as a feedstock for the bio-based polyurethane production Usually, bio-polyols from vegetable oils have higher viscosity and lower hydroxyl values compared to com. petrochem. polyols, which limits their usefulness. This article reports on the development of open-cell polyurethane foam systems wherein 100% of the polyol components were bio-polyols obtained from used cooking oil. What is particularly considered is the effect of bio-polyol properties (mol. weight, viscosity and hydroxyl value) on the properties of the final open-cell polyurethane systems – apparent d., thermal conductivity coefficient, content of closed cells, mech. strength, brittleness and short-term water absorption. It was found that the key step in the synthesis of bio-polyols designed for open-cell polyurethane foams is the epoxidation reaction. The epoxy value has a significant effect on the occurrence of side reactions (mainly oligomerization) during the oxirane ring-opening process determining the properties of bio-polyols. The resulting open-cell foams were characterized by apparent densities from 12.4 to 13.3 kg/m3, thermal conductivity coefficients from 36.6 to 38.2 mW/m·K, and closed cell contents below 10%, which makes them comparable to com. products. The results demonstrate that used cooking oil-based polyols can provide an alternative starting material for open-cell polyurethane foam production In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6Name: 2,2′-Oxybis(ethan-1-ol)).

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Name: 2,2′-Oxybis(ethan-1-ol)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Neupert, Stefanie et al. published their research in Pest Management Science in 2022 | CAS: 149-32-6

(2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.SDS of cas: 149-32-6

Sugar alcohols have the potential as bee-safe baits for the common wasp was written by Neupert, Stefanie;Jandt, Jennifer M.;Szyszka, Paul. And the article was included in Pest Management Science in 2022.SDS of cas: 149-32-6 This article mentions the following:

Pest insects are often baited with poisoned feeding stimulants, the most common of which are sugars. However, sugars are attractive for most animal species, which makes it difficult to target only a specific pest insect species. Here, we assessed different sugar alcs. for their potential as more species-selective feeding stimulants for pest insects. We tested the attractiveness of the sugar alcs. sorbitol, xylitol and erythritol with a capillary feeder assay in wasps (as potential pest insects, because introduced wasps are a pest in many regions) and bees (as non-target insects). For the common wasp (Vespula vulgaris), sorbitol and xylitol acted as nutritive feeding stimulants, and erythritol acted as a non-nutritive feeding stimulant. For the buff-tailed bumble bee (Bombus terrestris), sorbitol acted as a feeding stimulant, while for the honey bee (Apis mellifera), none of the sugar alcs. acted as feeding stimulant. The species-specific preferences for sugar alcs. suggest their potential as species-selective insect baits. The wasp-specific preference for xylitol suggests its potential as a bee-safe alternative to sugar-containing bait for controlling the common wasp. 2022 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chem. Industry. In the experiment, the researchers used many compounds, for example, (2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6SDS of cas: 149-32-6).

(2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.SDS of cas: 149-32-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Elahi, Mona Ghods et al. published their research in International Journal of Peptide Research and Therapeutics in 2022 | CAS: 499-75-2

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Category: alcohols-buliding-blocks

Evaluation and Efficacy Modified Carvacrol and Anti-cancer Peptide Against Cell Line Gastric AGS was written by Elahi, Mona Ghods;Hekmati, Malak;Esmaeili, Davoud;Ziarati, Parisa;Yousefi, Mohamad. And the article was included in International Journal of Peptide Research and Therapeutics in 2022.Category: alcohols-buliding-blocks This article mentions the following:

Cancer is a complex of malignant cell growth and is one of the most challenging issues worldwide. This study aimed to design, determine, and synthesize a modified carvacrol-containing anticancer peptide sequence and its anti-cancer properties investigated against gastric cancer cell line by Real-Time RT PCR technique. Anticancer peptide sequence designed by ACAN bioinformatics software. Modified carvacrol structure designed by bioinformatics software and the anti-cancer sequence added to it. After determining the chem. and structural properties and modeling by bioinformatics software the compound was synthesized. Then, an MTT test was performed on the gastric cancer cell line. In the next step, the AGS cancer cell is exposed to the MTT concentration of the compound in a culture medium. Then, mRNA is extracted from treatment-exposed cancer cells and treatment-free cell lines, and cDNA was then synthesized from mRNA. The effect of the compound on caspase3 and bcl2 apoptosis genes is investigated by Real-Time RT PCR. Alkylation of o-cresol with isopropanol over AlCl3 as an efficient catalyst leads to the appropriate preparation of carvacrol with proper yields (75.6). Results showed that carvacrol accompanied by Anticancer peptide at a concentration of 2.5 mg/mL had cytotoxic effects on the cervical. The inhibitory effects of carvacrol and anticancer peptide increased against inhibition of the Bax gene by 256-fold and caspase 3 by 32-fold and bcl2 decreased by eightfold. Because of the anti-apoptotic properties of modified carvacrol-containing anticancer peptide, it can be used to inhibit cancer cells as a therapeutic supplement and prevention. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Category: alcohols-buliding-blocks).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Bingqiang et al. published their research in Zhongguo Yiyao Gongye Zazhi in 1993 | CAS: 2451-01-6

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Application In Synthesis of rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate

Synthesis of 1,8-terpine hydrate from by-products of eucalyptus oil was written by Li, Bingqiang;Zhuang, Haiqi. And the article was included in Zhongguo Yiyao Gongye Zazhi in 1993.Application In Synthesis of rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate This article mentions the following:

Treatment of eucalyptus oil byproduct containing 65% α- and β-pinene with 25-40% H2SO4 and tween-80 at room temperature for 16 h gave 82.2% 1,8-terpine hydrate. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Application In Synthesis of rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Application In Synthesis of rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Hehe et al. published their research in Journal of the Science of Food and Agriculture in 2022 | CAS: 149-32-6

(2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Formula: C4H10O4

Metabolomics reveals changes in metabolite composition of duck eggs under the impact of long-term storage was written by Liu, Hehe;Yang, Qinglan;Guo, Rui;Hu, Jiwei;Tang, Qian;Qi, Jingjing;Wang, Jiwen;Han, Chunchun;Zhang, Rongping;Li, Liang. And the article was included in Journal of the Science of Food and Agriculture in 2022.Formula: C4H10O4 This article mentions the following:

Eggs are essential food sources as they provide low cost and high nutritional content of animal protein. The preservation period is one of the apparent factors affecting egg quality. Previous studies based on traditional detection techniques demonstrated that storage period would significantly influence egg weight, eggshell weight, albumen height, haugh unit (HU) and albumen viscosity. Herein, we employed non-targeted metabolome technol. to reveal the comprehensive changes in metabolite composition in duck eggs under the impacts of storage period. The results showed that the primary metabolites in the yolk of duck eggs are amino acids, carbohydrates and lipids. In contrast, the primary metabolites in the albumen are amino acids, benzene and indoles. We screened 43 and 16 different metabolites, resp., in the albumen and yolk of duck eggs with different preservation periods. In addition, kyoto encyclopedia of genes and genomes (KEGG) enrichment was performed, and the results showed that various nutrients were degraded in the egg after preservation, thus affecting the quality of duck eggs. These nutrients included amino acids, fatty acids, nucleotides, sugars and vitamins; meanwhile, ammonia, biogenic amines and some flavor substances were produced, affecting the quality of the eggs. Ourfindings can contribute to a holistic understanding of metabolite composition changes in duck eggs during deterioration in storage. In the experiment, the researchers used many compounds, for example, (2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6Formula: C4H10O4).

(2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Formula: C4H10O4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pereira, Vanessa A. et al. published their research in Polymer in 2022 | CAS: 2216-51-5

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.COA of Formula: C10H20O

L-menthol and thymol eutectic mixture as a bio-based solvent for the “one-pot” synthesis of well-defined amphiphilic block copolymers by ATRP was written by Pereira, Vanessa A.;Mendonca, Patricia V.;Coelho, Jorge F. J.;Serra, Armenio C.. And the article was included in Polymer in 2022.COA of Formula: C10H20O This article mentions the following:

A bio-based eutectic mixture (EM), composed of L-menthol and thymol was used, for the first time, as solvent for the atom transfer radical polymerization (ATRP) of hydrophobic monomers (Me acrylate (MA), Me methacrylate (MMA), 2-(dimethylamino) Et methacrylate (DMAEMA), glycidyl methacrylate (GMA)) and hydrophilic monomers (2-hydroxyethyl acrylate (HEA), hydroxyethyl methacrylate (HEMA) and poly(ethylene glycol) Me ether acrylate (OEOA)). Well-defined homopolymers (1.02 < ETH < 1.47) were obtained using only 225 ppm of copper catalyst and a monomer/EM ratio (volume/volume) of 0.75. As a proof-of-concept, this new polymerization system allowed the preparation of well-defined amphiphilic block copolymers (ABs) of PMA-b-PHEA-Br, PMA-b-POEOA-Br and PDAMEMA-b-PHEA-Br by “one-pot” supplemental activator and reducing agent (SARA) ATRP, as well as a PMA-b-PHEA-b-PBA-Br triblock copolymer, after chain extension of a PMA-b-PHEA-Br diblock copolymer. The use of a unique solvent system opens a new route for the easy synthesis of ABs, with conditions that can be applied in large scale production In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5COA of Formula: C10H20O).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.COA of Formula: C10H20O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xu, Zhou et al. published their research in Catalysis Communications in 2008 | CAS: 120121-01-9

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.HPLC of Formula: 120121-01-9

Inversion of stereochemistry in the asymmetric transfer hydrogenation of ketones performed in tap water and in open-vessel was written by Xu, Zhou;Mao, Jincheng;Zhang, Yawen;Guo, Jun;Zhu, Jinlong. And the article was included in Catalysis Communications in 2008.HPLC of Formula: 120121-01-9 This article mentions the following:

The readily available (1R,2S)-1-amino-2-indanol (I) was employed into the [RuCl2(p-cymene)]2-catalyzed asym. transfer hydrogenation of prochiral ketones performed in tap water. The reaction was conducted in open vessel at room temperature, providing moderate to good conversions and enantioselectivities. In addition, the relationship between the structure of the chiral ligand and the catalytic efficiency was studied. Surprisingly, N-substitution of I led to the inversion of the configuration of the product under the same conditions. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9HPLC of Formula: 120121-01-9).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.HPLC of Formula: 120121-01-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lu, Tsai-Te et al. published their research in Inorganic Chemistry in 2008 | CAS: 29364-29-2

Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.SDS of cas: 29364-29-2

Anionic Roussin’s Red Esters (RREs) syn-/anti-[Fe(μ-SEt)(NO)2]2–: the Critical Role of Thiolate Ligands in Regulating the Transformation of RREs into Dinitrosyl Iron Complexes and the Anionic RREs was written by Lu, Tsai-Te;Tsou, Chih-Chin;Huang, Hsiao-Wen;Hsu, I.-Jui;Chen, Jin-Ming;Kuo, Ting-Shen;Wang, Yu;Liaw, Wen-Feng. And the article was included in Inorganic Chemistry in 2008.SDS of cas: 29364-29-2 This article mentions the following:

The anionic syn-/anti-[Fe(μ-SEt)(NO)2]2– (2a) were synthesized and characterized by IR, UV-vis, EPR, and X-ray diffraction. The geometry of the [Fe(μ-S)2Fe] core is rearranged in going from [{Fe(NO)2}9-{Fe(NO)2}9] Roussin’s red ester [Fe(μ-SEt)(NO)2]2 (1a) (Fe···Fe distance of 2.7080(5) Å) to the [{Fe(NO)2}9-{Fe(NO)2}10] complex 2a (Fe···Fe distance of 2.8413(6) Å) to minimize the degree of Fe···Fe interaction to stabilize complex 2a. On the basis of X-ray absorption (Fe K- and L-edge), EPR and SQUID, complex 2a is best described as the anionic [{Fe(NO)2}9-{Fe(NO)2}10] Roussin’s red ester with the fully delocalized mixed-valence core. The complete bridged-thiolate cleavage yielded DNIC [(EtS)2Fe(NO)2]– (3a) in the reaction of 2 equiv of [EtS]– and complex 1a, whereas reaction of 2 equiv of [tBuS]– with [Fe(μ-StBu)(NO)2]2 (1b) gave DNIC [(tBuS)2Fe(NO)2]– (3b) and the anionic Roussin’s red ester [Fe(μ-StBu)(NO)2]2– (2b) through bridged-thiolate cleavage in combination with reduction In contrast to the inertness of DNIC 3b toward complex 1b, nucleophile DNIC 3a induces the reduction of complex 1a to produce the anionic Roussin’s red ester 2a. Interestingly, dissolution of complex 3a in MeOH at 298 K finally led to the formation of a mixture of complexes 2a and 3a, in contrast to the dynamic equilibrium of complexes 3b and 1b observed in dissolution of complex 3b in MeOH. These results illustrate the aspect of how the steric structures of nucleophiles ([EtS]– vs. [tBuS]– and [(EtS)2Fe(NO)2]– vs. [(tBuS)2Fe(NO)2]–) function to determine the reaction products. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2SDS of cas: 29364-29-2).

Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.SDS of cas: 29364-29-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Pei Nian et al. published their research in Chemical Communications (Cambridge, United Kingdom) in 2004 | CAS: 120121-01-9

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Related Products of 120121-01-9

Highly efficient and recyclable heterogeneous asymmetric transfer hydrogenation of ketones in water was written by Liu, Pei Nian;Deng, Jin Gen;Tu, Yong Qiang;Wang, Shao Hua. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2004.Related Products of 120121-01-9 This article mentions the following:

A highly efficient heterogeneous asym. transfer hydrogenation of ketones in water, was developed, which exhibited excellent enantioselectivities, distinct acceleration effect, and remarkably high recyclabilities. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Related Products of 120121-01-9).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Related Products of 120121-01-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Terui, Hitoshi et al. published their research in Journal of Drug Delivery Science and Technology in 2022 | CAS: 111-46-6

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Name: 2,2′-Oxybis(ethan-1-ol)

Intradermal vaccination via electroosmotic injection from a porous microneedle patch was written by Terui, Hitoshi;Kimura, Natsumi;Segawa, Reiji;Kusama, Shinya;Abe, Hiroya;Terutsuki, Daigo;Yamasaki, Kenshi;Nishizawa, Matsuhiko. And the article was included in Journal of Drug Delivery Science and Technology in 2022.Name: 2,2′-Oxybis(ethan-1-ol) This article mentions the following:

The feasibility of the electroosmotic flow (EOF)-promoted intradermal vaccination via a porous microneedle (PMN) has been demonstrated by in-vitro and in-vivo experiments with mice. The EOF-promoted directional transport of ovalbumin (OVA) through a neg. charged PMN was quant. evaluated by experiments using a side-by-side Franz cell. The preloading of the OVA solution into a PMN chip and its effective injection into mouse skin pieces were examined by microscope observations. By using mice, the immunol. effect of the PMN-based intradermal vaccination has been proved by ELISA anal. of serum OVA-specific Igs (IgG1 and IgE). Although the passive diffusion-based release of OVA from PMN was too slow for effective vaccination, the EOF-assisted injection was found to be fast enough to effectively induce production of Igs. In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6Name: 2,2′-Oxybis(ethan-1-ol)).

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Name: 2,2′-Oxybis(ethan-1-ol)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts