Tag: 100-200

The versatile, efficient, and stereoselective self-assembly of transition-metal helicates by using hydrogen-bonds was written by Telfer, Shane G.;Kuroda, Reiko. And the article was included in Chemistry – A European Journal in 2005.Electric Literature of C7H9NO This article mentions the following:

A diverse range of dinuclear double-stranded helicates in which the ligand strand is built up by using H-bonding was synthesized. The helicates, formulated as [Co₂(L)₂(L-H)₂X₂], readily self-assemble from a mixture of a suitable pyridine-alc. compound (L; for example, 6-methylpyridine-2-methanol, 1), and a CoX₂ salt in the presence of base. Nine such helicates were characterized by x-ray crystallog. For helicates derived from the same pyridine-alc. precursor, a remarkable regularity was found for both the mol. structure and the crystal packing arrangements, regardless of the nature of the ancillary ligand (X). A notable exception was observed in the solid-state structure of [Co₂(1)₂(1-H)₂(NCS)₂] for which intermol. nonbonded contacts between the S atoms (S···S = 3.21 Å) give 1-dimensional chains. Helicates derived from (R)-6-methylpyridine-2-methanol (2) are soluble in solvents such as MeCN and CH₂Cl₂, and their self-assembly could be monitored in solution by ¹H NMR, UV/visible, and CD titrations No intermediate complexes form in a significant concentration at any point throughout these titrations The global thermodn. stability constant of [Co₂(2)₂(2-H)₂(NO₃)₂] was calculated from spectrophotometric data to be logβ = 8.9(8). The stereoisomerism of these helicates was studied in some detail and the self-assembly process is highly stereoselective. The chirality of the ligand precursors can control the absolute configuration of the metal centers and thus the overall helicity of the dinuclear assemblies. Also, the enantiomers of rac-6-methylpyridine-2-methanol (3) undergo a self-recognition process to form exclusively homochiral helicates in which the four pyridine-alc. units possess the same chirality. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Electric Literature of C7H9NO).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Electric Literature of C7H9NO

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Identification of a series of PPARγ/δ dual agonists via solid-Phase parallel synthesis was written by Liu, Kevin G.;Lambert, Millard H.;Leesnitzer, Lisa M.;Oliver, William;Ott, Ronda J.;Plunket, Kelli D.;Stuart, Ludwig W.;Brown, Peter J.;Willson, Timothy M.;Sternbach, Daniel D.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2001.Name: 6-Methyl-2-pyridinemethanol This article mentions the following:

The authors have developed a general solid-phase synthesis for identification of PPAR (peroxisome proliferator-activated receptors) ligands. Synthesis of a 480-member library led to the identification of a potent PPARγ/δ dual agonist 23. Compound I showed good plasma exposure in rats and demonstrated antihyperglycemic and antihyperlipidemic efficacy in diabetic fatty Zucker rats. Compounds with PPARγ/δ dual activity may be useful in the treatment of metabolic syndrome X. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Name: 6-Methyl-2-pyridinemethanol).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Name: 6-Methyl-2-pyridinemethanol

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Analysis of sugar components related to heartwood formation in young Swietenia mahagoni (L.) Jacq trees was written by Arisandi, Rizki;Marsoem, Sri Nugroho;Lukmandaru, Ganis;Sutapa, Johanes Pramana Gentur. And the article was included in Journal of Wood Chemistry and Technology in 2022.HPLC of Formula: 149-32-6 This article mentions the following:

This study aims to investigate the sugar components which play an important role in the process of heartwood formation in young Swietania mahagoni. The methanol-water (70/30, volume/volume) extract was analyzed by GC-MS to determine sugar constituents. The content of methanol-water extract ranged from 3.7 to 7.8% based on dried wood. After a 4-5 yr duration of heartwood formation in the sapwood, monosaccharide and alditol fractions doubly increased. This was followed by almost five times the content of cyclitols. In a radial variation, the content of major monosaccharides including fructose, glucose, mannose and xylose decreased from sapwood to heartwood, while arabinose, galactose, and sucrose in the age 5 years were only found in the sapwood. Meanwhile, the main content of cyclitols and alditols (arabitol) significantly decreased from sapwood to heartwood. The main monosaccharides and disaccharides represented by sucrose played a key role in the process of heartwood formation. Further studies are required to investigate the phenolic and lipophilic components as both are involved in heartwood formation. In addition, similar studies on alditol and cyclitol regarding their role in tropical wood are necessary. In the experiment, the researchers used many compounds, for example, (2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6HPLC of Formula: 149-32-6).

(2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.HPLC of Formula: 149-32-6

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Synthesis and Catalytic Activity of Iron Hydride Ligated with Bidentate N-Heterocyclic Silylenes for Hydroboration of Carbonyl Compounds was written by Qi, Xinghao;Zheng, Tingting;Zhou, Junhao;Dong, Yanhong;Zuo, Xia;Li, Xiaoyan;Sun, Hongjian;Fuhr, Olaf;Fenske, Dieter. And the article was included in Organometallics in 2019.Product Details of 1777-82-8 This article mentions the following:

We report the synthesis of a novel bidentate N-heterocyclic silylene (NHSi) ligand, N-(LSi:)-N-methyl-2-pyridinamine (1) (L = PhC(N^tBu)₂), and the first bischelate disilylene iron hydride I, [(Si,N)(Si,C)Fe(H)(PMe₃)] (2, R = ^tBu), and monosilylene iron hydride, [(Si,C)Fe(H)(PMe₃)₃] (2‘), through C_sp²-H activation of the NHSi ligand. Compounds 1 and 2 were fully characterized by spectroscopic methods and single-crystal X-ray diffraction anal. D. functional theory calculations indicated the multiple-bond character of the Fe-Si bonds and the π back-donation from Fe(II) to the Si(II) center. Moreover, the strong donor character of ligand 1 enables 2 to act as an efficient catalyst for the hydroboration reaction of carbonyl compounds at room temperature Chemoselective hydroboration is attained under these conditions. This might be the first example of hydroboration of ketones and aldehydes catalyzed by a silylene hydrido iron complex. A catalytic mechanism was suggested and partially exptl. verified. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Product Details of 1777-82-8).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Product Details of 1777-82-8

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Activation of Remote meta-C-H Bonds in Arenes with Tethered Alcohols: A Salicylonitrile Template was written by Zhang, Lanlan;Zhao, Chaoyue;Liu, Yang;Xu, Jiancong;Xu, Xiufang;Jin, Zhong. And the article was included in Angewandte Chemie, International Edition in 2017.Application of 94022-96-5 This article mentions the following:

Palladium-catalyzed activation of remote meta-C-H bonds in arenes containing tethered alcs. was achieved with high regioselectivity by using a nitrile template. Computational studies on the macrocyclic transition state of the regioselectivity-determining C-H activation steps revealed that both the C-N-Ag angles and gauche conformations of Ph ether play an extremely important role in the meta selectivity. In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5Application of 94022-96-5).

2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Application of 94022-96-5

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Alcohol – Wikipedia,
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The protective effects of thymol and carvacrol against di (2-ethylhexyl) phthalate-induced cytotoxicity in HEK-293 cells was written by Amara, Ines;Timoumi, Rim;Annabi, Emna;Ben Othmene, Yosra;Abid-Essefi, Salwa. And the article was included in Journal of Biochemical and Molecular Toxicology in 2022.Name: 5-Isopropyl-2-methylphenol This article mentions the following:

The protective effects of thymol and carvacrol, two phenolic monoterpenes with a wide spectrum of pharmacol. effects, against the oxidative stress produced by the di (2-ethylhexyl) phthalate (DEHP) in human embryonic kidney cells 293 cells (HEK-293 cells) were investigated in this study. The cytotoxicity was monitored by cell viability, while oxidative stress generation was assessed by reactive oxygen species (ROS) quantification, antioxidant enzyme activities measurement, glutathione concentration, and malondialdehyde (MDA) quantification. The genotoxicity was evaluated by the measurement of DNA fragmentation through the Comet assay. Our results demonstrated that the pretreatment of HEK-293 cells with thymol or carvacrol, 2 h before DEHP exposure, significantly increased the cell viability, decreased the ROS overproduction, modulated catalase (CAT), and superoxide dismutase (SOD) activities, restored the reduced glutathione content, and reduced the MDA level. The DNA fragmentation was also decreased by thymol and carvacrol pretreatment. These findings suggest that thymol and carvacrol could protect HEK-293 cells from DEHP-induced oxidative stress. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Name: 5-Isopropyl-2-methylphenol).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Name: 5-Isopropyl-2-methylphenol

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Determination of Volatile Flavour Profiles of Citrus spp. Fruits by SDE-GC-MS and Enantiomeric Composition of Chiral Compounds by MDGC-MS was written by Hong, Joon Ho;Khan, Naeem;Jamila, Nargis;Hong, Young Shin;Nho, Eun Yeong;Choi, Ji Yeon;Lee, Cheong Mi;Kim, Kyong Su. And the article was included in Phytochemical Analysis in 2017.Category: alcohols-buliding-blocks This article mentions the following:

Introduction : Citrus fruits are known to have characteristic enantiomeric key compounds biosynthesised by highly stereoselective enzymic mechanisms. In the past, evaluation of the enantiomeric ratios of chiral compounds in fruits has been applied as an effective indicator of adulteration by the addition of synthetic compounds or natural components of different botanical origin. Objective : To analyze the volatile flavor compounds of Citrus junos Sieb. ex Tanaka (yuzu), Citrus limon BURM. f. (lemon) and Citrus aurantifolia Christm. Swingle (lime), and determine the enantiomeric ratios of their chiral compounds for discrimination and authentication of extracted oils. Methodol. : Volatile flavor compounds of the fruits of the three Citrus species were extracted by simultaneous distillation extraction and analyzed by gas chromatog.-mass spectrometry. The enantiomeric composition (ee%) of chiral camphene, sabinene, limonene and β-phellandrene was analyzed by heart-cutting multidimensional gas chromatog.-mass spectrometry. Results : Sixty-seven (C. junos), 77 (C. limon) and 110 (C. aurantifolia) volatile compounds were identified with limonene, γ-terpinene and linalool as the major compounds Stereochem. anal. (ee%) revealed 1S,4R-(-) camphene (94.74, 98.67, 98.82), R-(+)-limonene (90.53, 92.97, 99.85) and S-(+)-β-phellandrene (98.69, 97.15, 92.13) in oil samples from all three species; R-(+)-sabinene (88.08) in C. junos; and S-(-)-sabinene (81.99, 79.74) in C. limon and C. aurantifolia, resp. Conclusion : The enantiomeric composition and excess ratios of the chiral compounds could be used as reliable indicators of genuineness and quality assurance of the oils derived from the Citrus fruit species. Copyright © 2017 John Wiley & Sons, Ltd. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Category: alcohols-buliding-blocks).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Category: alcohols-buliding-blocks

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Highly Efficient and Chemoselective Zinc-Catalyzed Hydrosilylation of Esters under Mild Conditions was written by Kovalenko, Oleksandr O.;Adolfsson, Hans. And the article was included in Chemistry – A European Journal in 2015.Reference of 2968-93-6 This article mentions the following:

A mild and highly efficient catalytic hydrosilylation protocol for room-temperature ester reductions has been developed using diethylzinc as the catalyst. The methodol. is operationally simple, displays high functional group tolerance and provides for a facile access to a broad range of different alcs. in excellent yields. In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6Reference of 2968-93-6).

2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Reference of 2968-93-6

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Derivatives of Amino Alcohols. I. Esters or Derivatives Acylated at the Oxygen was written by Fourneau, E.. And the article was included in Journal de Pharmacie et de Chimie in 1911.COA of Formula: C6H15NO This article mentions the following:

The esters of amino alcs. were prepared by mixing C₆H₆ solutions of the alcs. and the acid chlorides or bromides; the ester salts crystallize out almost immediately. With certain amino alcs. like diethylamino alcohol it was necessary to use no solvent in order to obtain the benzoate. Amino alcs. in which both functions are tertiary form esters with ClCO₂Et, as with other acid chlorides, differing thus from the simple tertiary alcs. In this case the tertiary NH₂ acts like pyridine in acylation. The amino alc. esters are nearly odorless liquids, which are more easily hydrolyzed by strong mineral acids than by alkalies. Derivatives of dimethylaminotrimethylcarbinol, Me₂NCH₂CMe₂OH: Benzoate hydrochloride, cubes, m. 202° cinnamate hydrochloride, large plates, m. 208°, isovalerate hydrochloride, hygroscopic, unctuous leaflets, m. 125°. Derivatives of dimethylaminodimethylethylcarbinol: Benzoate, syrupy liquid, b₁₃ 150°, benzoate hydrochloride is stovaine, diethylcarbamate derivative, Me₂NCH₂C(O₂CNEt₂)MeEt, limpid liquid with peculiar odor b₄₁ 136°. Hydrochloride, hygroscopic needles from acetone, m. 142° (decompose), hydrobromide, sedative, needles, m. 148°, chloroaurate, long orange-red needles m. 98°, “valerate” derivative, b₂₃ 128°, very stable to alkalies, hydrochloride, anesthetic, hygroscopic, unctuous plates, m. 151°, hydrobromide, similar, but not hygroscopic, m. 126°. Bromovalerate hydrochloride, strongly anesthetic, fine needles, m. 158°. Diethylacetate hydrobromide, brilliant needles, m. 169°. Bromodiethylacetate hydrochloride, leaflets, m. 160°. Caproate derivative, b. (in vacuo) 152°. Hydrochloride, slender needles. The compounds with the aliphatic acids heavier than caproic are strongly modified by the acyl group and acquire the properties of soaps like the polypeptides of the higher aliphatic acids. Bromocaproate hydrochloride, slender hygroscopic needles, m. 130°. Aqueous solution gives lather. Bromo-oenanthylate hydrochloride, white leaflets, m. 128° anesthetic. Bromolaurate hydrochloride, slender needles. m. 99°. Aqueous solution gives lather. Dimethylaminomethyldiethylcarbinyl benzoate hydrochloride, Et₂C(OBz)CH₂NMe₂.HCl, quadrangular plates, m. 180°. Dimethylaminodimethylpropylcarbinyl benzoate hydrochloride, isomeric with the preceding compound, brilliant needles, m. 146°. Dimethylaminodimethylisoamylcarbinyl benzoate hydrochloride, anesthetic, long needles, m. 142°. Chloroplatinate, m. 178°. Cinnamate hydrochloride, slender needles, m. 110°. Diethylaminodimethylethylcarbinyl benzoate hydrochloride, tufts of slender needles, m. 140°. In the experiment, the researchers used many compounds, for example, 1-(Dimethylamino)-2-methylpropan-2-ol (cas: 14123-48-9COA of Formula: C6H15NO).

1-(Dimethylamino)-2-methylpropan-2-ol (cas: 14123-48-9) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.COA of Formula: C6H15NO

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Organocatalytic Enantioselective Synthesis of Bicyclo[2.2.2]octenones via Oxaziridinium Catalysed ortho-Hydroxylative Phenol Dearomatization was written by D’Arcy, Tom D.;Elsegood, Mark R. J.;Buckley, Benjamin R.. And the article was included in Angewandte Chemie, International Edition in 2022.Related Products of 499-75-2 This article mentions the following:

Hydroxylative dearomatization reactions of phenols (HPD) offer an efficient way to assemble complex, biol. relevant scaffolds. Despite this, enantioselective hydroxylative phenol dearomatizations for the construction of bicyclo[2.2.2]octenones are classically limited to stoichiometric chiral reagents, and a practical, enantioselective catalytic method has remained elusive. Herein, authors describe a highly enantioselective, organocatalytic tandem o-HPD-[4+2] reaction. Authors methodol. utilizes a chiral oxaziridinium organocatalyst, that is available in both enantiomeric forms, to afford dearomatized products in high enantioselectivity over a range of phenol substitution patterns. This approach was applied to the highly enantioselective synthesis of (+)-biscarvacrol (99 : 1 e.r.) and (-)-bis(2,6-xylenol) (94 : 6 e.r.). The practicality of authors conditions was demonstrated at gram-scale, using an amine precatalyst, accessible in a single synthetic step. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Related Products of 499-75-2).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Related Products of 499-75-2

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