Tag: 100-200

Deracemization of 1-phenylethanols in a one-pot process combining Mn-driven oxidation with enzymatic reduction utilizing a compartmentalization technique was written by Sato, Hirofumi;Yamada, Rei;Watanabe, Yomi;Kiryu, Takaaki;Kawano, Shintaro;Shizuma, Motohiro;Kawasaki, Hideya. And the article was included in RSC Advances in 2022.Recommanded Product: (R)-1-(3-Chlorophenyl)ethanol This article mentions the following:

Racemic 1-phenylethanols were converted into enantiopure (R)-1-phenylethanols via a chemoenzymic process in which manganese oxide driven oxidation were coupled with enzymic biotransformation by compartmentalization of the reactions, although the two reactions conducted under mixed conditions were not compatible due to enzyme deactivation by Mn ions. Achiral 1-phenylethanol was oxidized to produce acetophenone in the interior chamber of a polydimethylsiloxane thimble. The acetophenone passes through the membrane into the exterior chamber where enantioselective biotransformation takes place to produce (R)-1-phenylethanol with an enantioselectivity of >99% ee and with 96% yield. The developed sequential reaction could be applied to the deracemization of a wide range of methyl- and chloro-substituted 1-phenylethanols (up to 93%, >99% ee). In addition, this method was applied to the selective hydroxylation of ethylbenzene to afford chiral 1-phenylethanol. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Recommanded Product: (R)-1-(3-Chlorophenyl)ethanol).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Recommanded Product: (R)-1-(3-Chlorophenyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Biocatalytic reduction of ketones by a semi-continuous flow process using supercritical carbon dioxide was written by Matsuda, Tomoko;Watanabe, Kazunori;Kamitanaka, Takashi;Harada, Tadao;Nakamura, Kaoru. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2003.SDS of cas: 171032-87-4 This article mentions the following:

The immobilized resting-cell of Geotrichum candidum was used as a catalyst for the reduction of a ketone in a semi-continuous flow process using supercritical carbon dioxide for the first time; it was also applied for the asym. reduction of a ketone and resulted in excellent enantioselectivity (ee >99%) and a higher volumetric productivity than that of the corresponding batch process. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4SDS of cas: 171032-87-4).

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.SDS of cas: 171032-87-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Qualitative gas chromatographic analysis of drugs was written by Dement’eva, N. N.;Zavrazhnaya, T. A.;Potapova, V. N.. And the article was included in Farmatsiya (Moscow, Russian Federation) in 1982.Formula: C10H22O3 This article mentions the following:

Relative retention volumes and Kovats retention indexes in gas chromatog. are tabulated for several classes of pharmaceuticals including amines, esters, pyridine derivatives, imidazoles, etc. The column materials consisted of 5% SE-30, 5% Apiezon L, and 3% neopentyl glycol succinate on Chromosorb W-AW-DMCS (80-100 mesh). Column behavior of the 30 pharmaceuticals is discussed. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Formula: C10H22O3).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Formula: C10H22O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Concise access to perimidines by palladium (II) complexes via acceptorless dehydrogenative coupling of alcohols was written by Clinton, Savarimuthu Selvan;Ramesh, Rengan;Malecki, Jan Grzegorz. And the article was included in Applied Organometallic Chemistry in 2022.Formula: C7H7ClO This article mentions the following:

A facile protocol for the one-pot synthesis of 2,3-dihydro-1H-perimidines via dehydrogenative coupling of easily exploitable benzyl alcs. supported by new Pd(II) complexes has been reported. To accomplish the construction of perimidines, a new set of palladium(II) complexes [Pd(L)Cl (PPh₃)] encompassing biphenyl benzhydrazone ligands I has been reported as catalysts. Structural characterization by elemental anal., FT-IR, NMR (¹H and ¹³C), and mass spectral analyses confirmed the composition of synthesized complexes. The mol. structures of complexes I(R = H, OCH₃), were unequivocally resolved using single-crystal X-ray diffraction. It reveals that the complex espoused distorted square-planar geometry around Pd(II) ion chelated by azomethine nitrogen and imidolate oxygen of biphenyl benzhydrazone ligands with labile chloride and a triphenylphosphine. Further, the selective synthesis of a broad range of functionalized perimidines has been accomplished via ADC of a variety of alcs. with 1,8-diaminonaphthalene. The palladium complexes mediated catalytic synthesis offered good yields of perimidines up to 86% using only 0.5 mol% catalyst loading. A probable mechanism to the formation of perimidines was postulated from the results of control exptl. investigations. The environmentally compassionate, greener ADC protocol progresses via the generation of aldehyde intermediate and releases only water and hydrogen gas. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Formula: C7H7ClO).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Formula: C7H7ClO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Palladium-catalyzed carbonylative synthesis of indole-3-carboxamides from 2-ethynylanilines and nitroarenes was written by Zhang, Jiangjie;Wang, Shangyuan;Wang, Jian-Shu;Ying, Jun;Wu, Xiao-Feng. And the article was included in Organic Chemistry Frontiers in 2022.Recommanded Product: 2216-51-5 This article mentions the following:

A palladium-catalyzed carbonylative cyclization of 2-ethynylanilines with nitroarenes has been developed for the rapid synthesis of indole-3-carboxamide skeletons. By using nitroarenes as the nitrogen source and Mo(CO)₆ as the CO surrogate, the reaction proceeded smoothly to furnish various indole-3-carboxamide derivatives in moderate to high yields. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Recommanded Product: 2216-51-5).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Recommanded Product: 2216-51-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tuning of the redox potential and catalytic activity of a new Cu(II) complex by o-iminobenzosemiquinone as an electron-reservoir ligand was written by Nasibipour, Mina;Safaei, Elham;Wrzeszcz, Grzegorz;Wojtczak, Andrzej. And the article was included in New Journal of Chemistry in 2020.Recommanded Product: 1777-82-8 This article mentions the following:

The synthesis and characterization of a new Cu(II) complex, L^NIS₂Cu^II (L^NIS = o-iminobenzosemiquinone), are reported. X-ray crystallog. studies showed that two o-iminobenzosemiquinone radicals form a distorted square-planar geometry around the Cu(II) center of L^NIS₂Cu^II. Magnetic measurements revealed the paramagnetic character of the complex caused by the presence of three unpaired electrons located on the o-iminobenzosemiquinonate ligands and the Cu^II center. Magnetochem. experiments, and EPR and DFT studies prove that the ground state of the complex is a doublet, which is consistent with the ferromagnetic coupling between Cu(II) and o-iminobenzosemiquinone centers and stronger antiferromagnetic coupling between the iminobenzosemiquinone moieties. The ligand-centered redox reactions of the complex were studied by cyclic voltammetry. Aerobic oxidation of alcs. to aldehydes with TEMPO was studied in the presence of L^NIS₂Cu^II. Furthermore, L^NIS₂Cu^II is an efficient catalyst in homo-coupling of terminal alkynes. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Recommanded Product: 1777-82-8).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Recommanded Product: 1777-82-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding an essential oil blend to the diet of juvenile Nile tilapia improves growth and alters the gut microbiota was written by Zaminhan-Hassemer, Micheli;Zagolin, Gustavo Botton;Perazza, Caio Augusto;Aciole Barbosa, David;Menegidio, Fabiano B.;Coutinho, Luiz Lehmann;Tizioto, Polyana;Hilsdorf, Alexandre Wagner Silva. And the article was included in Aquaculture in 2022.Safety of 5-Isopropyl-2-methylphenol This article mentions the following:

In aquaculture, essential oils are considered promising supplements that can improve productive performance and modulate the fish′s microbiota. Here we investigate how a blend of essential oils (carvacrol + thymol + cinnamaldehyde acid) affects the productive performance and the intestinal microbiota of juvenile Nile tilapia (Oreochromis niloticus, Thai strain). All fish were randomly distributed into 20 multifilament tanks (10-mm mesh and 2.4 m3 capacity). The exptl. design comprised four treatments and five repetitions, with 20 individuals per exptl. unit, for 60 days. Four diets were evaluated with increasing levels of essential oils (control and 3.3, 6.7, and 10 g kg-1 diet). Supplementation with 3.3 g kg-1 of essential oils improved growth performance compared to the control group. However, no differences were detected among the essential oil-supplemented groups (6.7 and 10 g kg-1). Survival was not different among the four groups. Using a Linear Response Plateau (LRP) model, we calculated maximum levels of 3.4, 3.5, 3.5 and 3.2 g kg-1 of the essential oils blend for final weight, weight gain, daily weight gain, and feed conversion, resp. Verrucomicrobia, Firmicutes, Bacteroidetes, and Proteobacteria accounted for a high proportion of the species observed in tilapia′s gut microbiota in the control and essential oil-supplemented groups. In both treatments, Candidatus xiphinematobacter (Verrucomicrobia) and Cetobacterium (Fusobacteria) were most predominant at the genus level. Cetobacterium somerae and Lactobacillus zeae were the most abundant species. At the species level, the Shannon index diversity value was higher in the control group than in the essential oil-supplemented groups (P = 0.046719; t = 2.0586). The bacterial community beta diversity anal. revealed an effect of diet on the tilapia′s gut microbiota, demonstrating a distinct grouping among treatments. Linear discriminant anal. (LDA) associated with effect size (LEfSe) identified that microbiota′s differential abundance was significant when comparing the control group and the 3.3 g kg-1 essential oil-supplemented group. The genera Candidatus xiphinematobacter, Staphylococcus, Caldilinea, and Synechococcus were more abundant in the microbiota of essential oil-fed juvenile Nile tilapia the control group. Pseudomonas, Acinetobacter, Enterococcus, and Lactobacillus were more predominant in the microbiota of fish from the control group. In conclusion, dietary the carvacrol + thymol + cinnamaldehyde acid blend (3.3 g kg-1) increased the growth performance and modulated the gut microbiota of juvenile Nile tilapia. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Safety of 5-Isopropyl-2-methylphenol).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Safety of 5-Isopropyl-2-methylphenol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Effects of combined carnosine and ultra-high pressure on the inhibition of fishy off-odor of snakehead fillets and the possible mechanism was written by Sun, Liangge;Lv, Jingxiu;Liu, Yu;Zang, Mingwu;Li, Pengpeng;Wang, Daoying;Zhu, Yongzhi;Xu, Weimin. And the article was included in Food Chemistry in 2022.Formula: C8H16O This article mentions the following:

The effects of combined application of ultra-high pressure (300 Mpa, 900 s) and carnosine on the inhibition of fishy off-odor from snakehead meat were investigated. Results showed that the combination effectively inhibited the formation of fishy volatile organic compounds (VOCs) and trimethylamine (TMA-N). Further studies demonstrated that the reduction of VOCs was mainly due to the inhibition of lipids oxidation based on the antioxidant activity of carnosine and the inactivation of lipoxygenase by UHP. Moreover, the reduction of TMA-N was mainly attributed to the ability of UHP processing to reduce bacterial load, which also extended the shelf-life of snakehead fillets by ∼ 6 days and retarded the production of TVB-N. Addnl., the combined application allowed a better retention of pH, color, and textural quality of the fillets compared with the control. Therefore, the current combination is a promising technique in fishy off-odor removing and better preservation of snakehead meat. In the experiment, the researchers used many compounds, for example, Oct-1-en-3-ol (cas: 3391-86-4Formula: C8H16O).

Oct-1-en-3-ol (cas: 3391-86-4) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Formula: C8H16O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Parts-per-million level loading organocatalysed enantioselective silylation of alcohols was written by Park, Sang Yeon;Lee, Ji-Woong;Song, Choong Eui. And the article was included in Nature Communications in 2015.Quality Control of (R)-1-(3-Chlorophenyl)ethanol This article mentions the following:

One p.p.m. loading of a simple 1,1′-bi-2-naphthol-based organocatalyst, I, was enough to achieve highly enantioselective silylation reactions of alcs. RCH(OH)R¹ (R = 4-H₃CC₆H₄, 3-F₃CC₆H₄, naphth-1-yl, etc.; R¹ = CH₃; R = Ph, R¹ = HC=CHC₆H₅). The unprecedented TONs and excellent enantioselectivity are ascribed to the robustness of the catalyst and systematic cooperative hydrogen-bonding organocatalysis in a densely confined chiral space. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Quality Control of (R)-1-(3-Chlorophenyl)ethanol).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Quality Control of (R)-1-(3-Chlorophenyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Removing the Obstacle to (-)-Menthol Biosynthesis by Building a Microbial Cell Factory of (+)-cis-Isopulegone from (-)-Limonene was written by Shou, Chao;Zheng, Yu-Cong;Zhan, Jing-Ru;Li, Chun-Xiu;Xu, Jian-He. And the article was included in ChemSusChem in 2022.Recommanded Product: 2216-51-5 This article mentions the following:

Microbial synthesis of plant-based (-)-menthol is of great interest because of its high demand (≈30 kiloton per yr) as well as unique odor and cooling characteristics. However, this remains a great challenge due to the yet unfilled gap between (-)-limonene and (+)-cis-isopulegone. Herein, the first artificial and effective system was developed for (+)-cis-isopulegone biosynthesis from (-)-limonene by recruiting two bacterial enzymes to replace their inefficient counterparts from Mentha piperita, limonene-3-hydroxylase, and isopiperitenol dehydrogenase. A cofactor self-regenerative recombinant Escherichia coli strain was constructed by introducing a formate dehydrogenase for NADP (NADPH) regeneration and an engineered microbial isopiperitenol dehydrogenase. The production of (+)-cis-isopulegone (up to 281.2 mg L-1) was improved by 36 times compared with that of the initial strain. This work lays a reliable foundation for the microbial synthesis of (-)-menthol. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Recommanded Product: 2216-51-5).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Recommanded Product: 2216-51-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts