Tag: 100-200

Nickel-Catalyzed Phosphine Free Direct N-Alkylation of Amides with Alcohols was written by Das, Jagadish;Banerjee, Debasis. And the article was included in Journal of Organic Chemistry in 2018.Electric Literature of C7H6Cl2O This article mentions the following:

Herein, we developed an operational simple, practical, and selective Ni-catalyzed synthesis of secondary amides. Application of renewable alcs., earth-abundant and nonprecious nickel catalyst facilitates the transformations, releasing water as byproduct. The catalytic system is tolerant to a variety of functional groups including nitrile, allylic ether, and alkene and could be extended to the synthesis of bis-amide, antiemetic drug Tigan, and dopamine D2 receptor antagonist Itopride. Preliminary mechanistic studies revealed the participation of a benzylic C-H bond in the rate-determining step. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Electric Literature of C7H6Cl2O).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Electric Literature of C7H6Cl2O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hydrogen, a good partner for rhodium-catalyzed hydrosilylation was written by Balan, Cedric;Pop, Roxana;Comte, Virginie;Poinsot, Didier;Ratovelomanana-Vidal, Virginie;Le Gendre, Pierre. And the article was included in Applied Organometallic Chemistry in 2014.Name: (S)-1-(2-Fluorophenyl)ethanol This article mentions the following:

The influence of hydrogen pressure on the hydrosilylation of ketones catalyzed by [((S)-SYNPHOS)Rh(nbd)]OTf was studied. The authors notably demonstrated that hydrogen significantly affected the outcome of the reaction while not being consumed as stoichiometric reducing agent. In THF, di-Et ether or toluene, the hydrogen pressure exceedingly accelerated the hydrosilylation reaction and preserved or even improved the enantioselectivity of the process. In CH₂Cl₂, the Rh catalyst also showed generally higher catalytic activity under hydrogen pressure. Most serendipitously, several ketones were found to give products of absolute opposite configuration upon performing the hydrosilylation under argon atm. or under hydrogen pressure. Copyright © 2014 John Wiley & Sons, Ltd. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Name: (S)-1-(2-Fluorophenyl)ethanol).

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Name: (S)-1-(2-Fluorophenyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Characterisation of the probiotic potential of Lactiplantibacillus plantarum K16 and its ability to produce the postbiotic metabolite γ-aminobutyric acid was written by Diez-Gutierrez, Lucia;San Vicente, Leire;Saenz, Jessica;Barron, Luis Javier R.;Chavarri, Maria. And the article was included in Journal of Functional Foods in 2022.COA of Formula: C4H10O4 This article mentions the following:

Lactiplantibacillus plantarum has been widely studied due to its beneficial effects on health such as protect against pathogens, enhance the immune system, or produce metabolites like γ-aminobutyric acid (GABA). The objective of this study was the evaluation of the GABA-producer L. plantarum K16 isolated from kimchi. The safety and probiotic characterization of this strain was performed by analyzing carbohydrates fermentation, enzymic activity, antibiotics susceptibility, and haemolytic and antimicrobial activity. Likewise, GABA production was optimized following a one-factor-at-a-time procedure by changing relevant fermentation parameters like incubation temperature, yeast extract concentration and fermentation time. The results indicated that L. plantarum K16 has the potential to stimulate the digestion and absorption of several nutrients and it could have an inhibitory effect against pathogenic bacteria. The best results for GABA production by this strain was around 1000 mg/L, using 12 g/L of yeast extract, 34 °C of incubation temperature and 96 h of fermentation time. In the experiment, the researchers used many compounds, for example, (2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6COA of Formula: C4H10O4).

(2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.COA of Formula: C4H10O4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Preparation of combined cross-linked enzyme aggregates and its application in synthesis of chiral alcohols by the asymmetric reduction of carbanyl group was written by Yang, Meng;Jiang, Huijuan;Ning, Chenxi;Wei, Dongzhi;Su, Erzheng. And the article was included in Gaodeng Xuexiao Huaxue Xuebao in 2018.Formula: C8H9ClO This article mentions the following:

Using ketoreductase KRED 30 from Corynebacterium sp. and the D-glucose dehydrogenase from Bacillus subtilis as the model enzymes, a combined cross-linked enzyme aggregates (combi-CLEAs) with high activity was prepared by optimization of the precipitant type, glutaraldehyde concentration, crosslinking temperature and time. Characterization of the combi-CLEAs showed that the stability and substrate tolerance of free enzymes mixture were significantly improved after combined crosslinking. Investigation of catalytical performance showed that combi-CLEAs could effectively catalyze the reduction of Et 4-chloroacetoacetate (COBE) and 3′-chloroacetophenone (CPO) for the synthesis of corresponding chiral alcs. in aqueous system. Only a little cofactor was needed to start the reactions. The catalytical activity could retain more than 70% after continuously catalyzing for 10 batches. The result showed that catalytical performance of combi-CLEAs in the biphasic system was much better than that in aqueous system. The total turnover number (TTN) for catalyzing COBE could attend 6595, and TTN for catalyzing CPO could attend 7500. Thus, cofactor regeneration by combi-CLEAs is feasible. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Formula: C8H9ClO).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Formula: C8H9ClO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Crystal structures of tetrakis-(4-chlorophenylthio)-butatriene and tetrakis-(tert-butylthio)-butatriene was written by Ibis, Cemil;Sayil, Cigdem;Deniz, N. Gulsah. And the article was included in Spectroscopy Letters in 2006.Formula: C4H9NaS This article mentions the following:

Tetrakis-(4-chlorophenylthio)-butatriene (3a) and tetrakis-(tert-butylthio)-butatriene (3b) were synthesized, and their crystal structures were determined The compound 3a is monoclinic, space group P2₁/c, a = 6.9785(8), b = 8.6803(9), c = 22.884(2) Å, β = 93.887(6)°, Z = 2. The compound 3b is monoclinic, space group P2₁/n, a = 11.0615(6), b = 10.8507(4), c = 11.2717(6) Å, β = 116.427(2)°, Z = 4. The title compounds 3a and 3b reside on an inversion center so that only half of the mol. is crystallog. unique. Both compounds are not planar. The crystal structures of 3a and 3b have cumulated double bonds. The C7-C8-C8ⁱ and C5-C6-C6ⁱ angles that show the linearity in both structures, resp., are 176.4(3)° in 3a and 175.6(2)° in 3b. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2Formula: C4H9NaS).

Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Formula: C4H9NaS

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tandem oxidative amidation of benzylic alcohols by copper(II) supported on metformin-graphitic carbon nitride nanosheets as an efficient catalyst was written by Ghafuri, Hossein;Ghafori Gorab, Mostafa;Dogari, Haniyeh. And the article was included in Scientific Reports in 2022.Recommanded Product: (4-Chlorophenyl)methanol This article mentions the following:

In this research, an efficient heterogeneous catalyst based on graphitic carbon nitride nanosheets (CN) was reported. The CN was functionalized by 1,3-dibromopropane as a linker (CN-Pr-Br) and subsequently modified with metformin (CN-Pr-Met). Furthermore, the copper(II) was coordinated on modified CN (CN-Pr-Met-Cu(II)) and during this process, 7.94% copper(II) was loaded into the catalyst structure. The synthesized catalyst was evaluated by various techniques including fourier-transform IR spectroscopy (FT-IR), energy dispersive X-ray spectroscopy (EDS), field emission SEM (FE-SEM), thermogravimetric anal. (TGA), X-ray diffraction (XRD), and inductively coupled plasma at. emission spectroscopy (ICP-OES). CN-Pr-Met-Cu(II) was used as a catalyst in the synthesis of amides via the oxidation of benzyl alcs. The conditions of this reaction were optimized in terms of temperature, time, amount of catalyst, type of base, oxidant, and solvent. Moreover, a variety of amides with an efficiency of 75-95% were synthesized. The reaction was carried out in the presence of benzyl alcs., amine hydrochloride salts, tert-Bu hydroperoxide (TBHP), CaCO₃, and CN-Pr-Met-Cu(II) at 80°C of acetonitrile solvent. The synthesized catalyst can be easily separated from the reaction medium and reused for 7 consecutive runs without a significant reduction in reaction efficiency. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Recommanded Product: (4-Chlorophenyl)methanol).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Recommanded Product: (4-Chlorophenyl)methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Light-Triggered, Self-Immolative Nucleic Acid-Drug Nanostructures was written by Tan, Xuyu;Li, Ben B.;Lu, Xueguang;Jia, Fei;Santori, Clarissa;Menon, Priyanka;Li, Hui;Zhang, Bohan;Zhao, Jean J.;Zhang, Ke. And the article was included in Journal of the American Chemical Society in 2015.Synthetic Route of C7H7NO4 This article mentions the following:

The simultaneous intracellular delivery of multiple types of payloads, such as hydrophobic drugs and nucleic acids, typically requires complex carrier systems. Herein, we demonstrate a self-deliverable form of nucleic acid-drug nanostructure that is composed almost entirely of payload mols. Upon light activation, the nanostructure sheds the nucleic acid shell, while the core, which consists of prodrug mols., disintegrates via an irreversible self-immolative process, releasing free drug mols. and small mol. fragments. We demonstrate that the nanostructures exhibit enhanced stability against DNase I compared with free DNA, and that the model drug (camptothecin) released exhibits similar efficacy as free, unmodified drugs toward cancer cells. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Synthetic Route of C7H7NO4).

3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Synthetic Route of C7H7NO4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

One dimensional chemical shift modulated correlation spectroscopy of single-crystals was written by Iuliucci, Robbie J.;Grant, David M.. And the article was included in Solid State Nuclear Magnetic Resonance in 1996.Computed Properties of C6H14O6 This article mentions the following:

A simple 1-dimensional modulation method is presented for determining the spatial correlation of chem. shifts in two different single-crystal orientations. This proposed chem. shift modulated correlation (CSMC) spectroscopy uses a Jeener pulse sequence to give 1-dimensional spectra containing peaks that are amplitude modulated by the chem. shifts associated with the single-crystal’s evolution orientation. Conversely, the spectral frequencies in these 1-dimensional CSMC spectra designate the shifts in the crystal’s orientation during the detection period. By observing the amplitude modulation of these spectral frequencies, the spatial correlation between the two chem. environments can be established for a specific nucleus from a single 1-dimensional spectrum. The CSMC procedure finishes by acquiring a normal 1-dimensional static spectrum for the crystal oriented in the evolution direction, thereby providing very accurate evolution frequencies approximated by the amplitude modulation in the CSMC spectra. The CSMC method improves the time efficiency over both the traditional goniometer method and the 2-dimensional chem. shift-chem. shift correlation method, and therefore is beneficial for the study of samples with longer T₁ values. In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0Computed Properties of C6H14O6).

(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Computed Properties of C6H14O6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Borane evolution and its application to organic synthesis using the phase-vanishing method was written by Soga, Nene;Yoshiki, Tomo;Sato, Aoi;Kawamoto, Takuji;Ryu, Ilhyong;Matsubara, Hiroshi. And the article was included in Tetrahedron Letters in 2021.Safety of 2-(4-(Trifluoromethyl)phenyl)ethanol This article mentions the following:

Although borane is a useful reagent, it is difficult to handle. In this study, borane was generated in situ from NaBH₄ or ⁿBu₄NBH₄ with several oxidants (H₂SO₄, I₂, or EtI) using a phase-vanishing (PV) method using a mixture of a fluorinated solvent (Galden HT-135, Galden HT-200, or FC-72) and a nonfluorinated solvent (DME or THF). The borane generated was directly reacted with alkenes, affording the desired alcs. in good yields after oxidation with H₂O₂ under basic conditions. The selective reduction of carboxylic acids with the evolved borane was examined The organoboranes generated by the PV method successfully underwent Suzuki-Miyaura coupling. Using this PV system, reactions with borane can be carried out easily and safely in a common test tube. In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6Safety of 2-(4-(Trifluoromethyl)phenyl)ethanol).

2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Safety of 2-(4-(Trifluoromethyl)phenyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The α-alkylation of ketones with alcohols in pure water catalyzed by a water-soluble Cp*Ir complex bearing a functional ligand was written by Meng, Chong;Xu, Jing;Tang, Yawen;Ai, Yao;Li, Feng. And the article was included in New Journal of Chemistry in 2019.COA of Formula: C7H6Cl2O This article mentions the following:

A water-soluble dinuclear Cp*Ir complex bearing 4,4′,6,6′-tetrahydroxy-2,2′-bipyrimidine as a bridging ligand was found to be a highly effective catalyst for the α-alkylation of ketones with alcs. in pure water. In the presence of catalyst (0.5 mol%), a series of desirable products were obtained with high reaction economy under environmentally benign conditions. The importance of the hydroxy group in the ligand for catalytic hydrogen transfer was confirmed by mechanism experiments Furthermore, the application of this catalytic system for the synthesis of a biol. active mol. donepezil in pure water was accomplished. Notably, this research would facilitate the progress of C-C bond-forming reactions in water catalyzed by water-soluble metal-ligand bifunctional catalysts. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8COA of Formula: C7H6Cl2O).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.COA of Formula: C7H6Cl2O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts