Tag: 100-200

Regio- and stereoselective hydroxylation of some nitrogen heterocyclic compounds by microorganisms was written by Zefirov, N. S.;Terent’ev, P. B.;Modyanova, L. V.;Dovgilevich, E. V.. And the article was included in Indian Journal of Chemistry in 1993.Formula: C7H9NO This article mentions the following:

Microbial hydroxylation of pyridine and alkylpyridines, as well as of some saturated monocyclic compounds, provides an efficient regio- and stereoselective route to biol. active and synthetically useful hydroxy derivatives Thus, the picolines I (R = 2-, 3-, 4-Me) are converted by fungi, such as Aspergillus and Penicillium, into the corresponding pyridinemethanols I (R = 2-, 3-, 4-CH₂OH) in up to 45% yields. Transformation of condensed polycyclic N-heterocycles, however proceeds in a different manner. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Formula: C7H9NO).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Formula: C7H9NO

Referemce:
Alcohol – Wikipedia,
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Excited-State Palladium-Catalyzed Radical Migratory Mizoroki-Heck Reaction Enables C2-Alkenylation of Carbohydrates was written by Yao, Wang;Zhao, Gaoyuan;Wu, Yue;Zhou, Lin;Mukherjee, Upasana;Liu, Peng;Ngai, Ming-Yu. And the article was included in Journal of the American Chemical Society in 2022.Safety of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol This article mentions the following:

Excited-state palladium catalysis has emerged as a promising strategy for developing novel and valuable reactions. Herein, we report the first excited-state Pd-catalyzed 1,2-radical migratory Mizoroki-Heck reaction that enables C2-alkenylation of carbohydrates using readily available 1-bromosugars and alkenes. The reaction tolerates a wide variety of functional groups and complex mol. architectures, including derivatives of natural products and marketed drugs. Preliminary mechanistic studies and DFT calculations suggest the involvement of visible-light-induced photoexcitation of Pd species, 1,2-spin-centered-shift (SCS) process, and Heck-type cross-coupling reaction. The reaction expands the reactivity profile of excited-state Pd catalysis and provides a streamlined protocol for the preparation of a wide variety of C2-alkenylated carbohydrate mimetics to aid the discovery and development of new therapeutics, agrochems., and materials. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Safety of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Safety of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Polymeric organometallic architectures of novel P-Se anions was written by Shi, Weifeng;Shafaei-Fallah, Maryam;Zhang, Le;Anson, Christopher E.;Matern, Eberhard;Rothenberger, Alexander. And the article was included in Chemistry – A European Journal in 2007.Recommanded Product: Sodium 2-methyl-2-propanethiolate This article mentions the following:

The characterization of compounds obtained from Woollins’ reagent (W.R., PhP(Se)(μ-Se)₂P(Se)Ph) offers a novel approach to organometallic coordination polymers. The syntheses were achieved by nucleophilic ring-opening reactions of W.R. with metal salts and crystallization using solvent-diffusion techniques. One-dimensional coordination polymers are formed as a result, and the dimensionality of the polymers can be influenced by using hydrated metal salts or by the construction of heterometallic arrangements. Compounds prepared and characterized by x-ray crystallog. include [K₂(PhP(Se)(O^tBu)Se)₂(THF)]_n, [Na₂(SePhP(Se)-P(Se)PhSe)(THF)₃]_n, [K₂(PhP(:Se)(Se^–)Se-SeP(:Se)(Se^–)Ph)(THF)₄], [Na₂(PhP(O)Se₂)(H₂O)₄(THF)], [Ni{Na(PhPSe₃)(THF)}₂]_n, and discrete cluster [Cu₄(PhSeP-O-PSePh)₂(PPh₃)₄]. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2Recommanded Product: Sodium 2-methyl-2-propanethiolate).

Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Recommanded Product: Sodium 2-methyl-2-propanethiolate

Referemce:
Alcohol – Wikipedia,
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Formation of coumarins from β-diketones and the structure of Kostanecki-Robinson acetylation product of γ-orcacetophenone and its 6-O-methyl ether was written by Ahluwalia, V. K.;Kumar, Devendra. And the article was included in Indian Journal of Chemistry in 1976.Computed Properties of C9H10O3 This article mentions the following:

Cyclization of 4,2,6-Me(MeO)2C6H2COCH2COMe (I) with HBr-Ac2O yields 4,7-dimethyl-5-methoxycoumarin (II). Coumarin (II) was obtained by similar cyclization of 6,2,4-Me(MeO)2C6H2COCH2COMe (III). A mechanism for the formation of II from I and III is indicated. Kostanecki-Robinson acetylation of γ-orcacetophenone and its 6-O-methyl ester gave IV (R = Ac, Me, resp). In the experiment, the researchers used many compounds, for example, 2′,6′-Dihydroxy-4′-methylacetophenone (cas: 1634-34-0Computed Properties of C9H10O3).

2′,6′-Dihydroxy-4′-methylacetophenone (cas: 1634-34-0) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Computed Properties of C9H10O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Empirical Analysis Revealing Privileged Chemical Space of Cosmetic Preservatives was written by Storz, Michael P.;Holsten, Lea. And the article was included in Cosmetics in 2021.Electric Literature of C7H6Cl2O This article mentions the following:

Most cosmetic products require preservation to prevent microbial contamination and to ensure consumer safety. Due to regulatory restrictions and rejection by consumers, preservative options have become limited and the development of novel solutions is needed. This search can be guided by knowledge about favorable chem. space for cosmetic preservatives. Therefore, we used preservatives allowed in the EU as training set and calculated various mol. properties. Empirical anal. revealed two separated areas of privileged chem. space with the net charge as distinctive property. The first area comprises the group of neutral and anionic preservatives and is characterized by low mol. size as well as limited hydrogen-bonding capacity, polarity, and flexibility. The second area includes cationic preservatives, which are rather diffusely distributed regarding mol. weight and hydrogen-bonding, however, all members share high flexibility. Both groups significantly differ from antibiotics, reflecting the specific requirement of cosmetic preservation. The mol. properties defining the privileged chem. space are easy to calculate, and thus, can provide guidance for the development of novel preservatives. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Electric Literature of C7H6Cl2O).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Electric Literature of C7H6Cl2O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Near-Zero Hysteresis Ionic Conductive Elastomers with Long-Term Stability for Sensing Applications was written by Borayek, Ramadan;Foroughi, Firoozeh;Xin, Xu;Mohamed, Ayman Mahmoud;Abdelrahman, Mahmoud M.;Zedan, Mostafa;Zhang, Danwei;Ding, Jun. And the article was included in ACS Applied Materials & Interfaces in 2022.Computed Properties of C4H10O3 This article mentions the following:

Soft conductive elastomers with low hysteresis over a wide range of stretchability are desirable in various applications. Such applications include soft sensors with a long measurement range, motion recognition, and electronic skin, just to name a few. Even though the measurement capability of the sensors based on soft materials has been greatly improved compared to the traditional ones in recent years, hysteresis in the loading and unloading states has limited the applications of these sensors, thereby neg. affecting their accuracy and reliability. In this work, conductive elastomers with near-zero hysteresis have been formulated and fabricated using 3D printing. These elastomers are made by combining highly stretchable dielec. elastomer formulations with a polar hydrophobic ionic liquid and polymerizing under UV light. High-performance piezoresistive sensors have been fabricated and characterized, with a 10-fold stretchability and low hysteresis (1.2%) over long-term stability (more than 10 000 cycles under cyclic stress) with a 20 ms response time. Addnl., the current elastomers displayed fast mech. and elec. self-healing properties. Using 3D printing in conjunction with some of our structural innovations, we have fabricated smart gloves to show this material’s wide range of applications in soft robots, motion detection, wearable devices, and medical care. In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6Computed Properties of C4H10O3).

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Computed Properties of C4H10O3

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Evaluation of insecticidal activity of Lavandula coronopifolia essential oil against the Mediterranean fruit fly Ceratitis capitata Wiedemann. (Diptera: Tephritidae) was written by Ouarhach, Aicha;Ait Said, Loubna;Aboussaid, Houda;Ghalbane, Ichrak;El Messoussi, Said;Romane, Abderrahmane. And the article was included in South African Journal of Botany in 2022.Product Details of 3391-86-4 This article mentions the following:

The present investigation was aimed to assess the toxicity of Lavandula coronopifolia (Lamiaceae) essential oil (EO) against adult Mediterranean fruit fly. Ceratitis capitata (Wiedemann) (Diptera Tephritidae) is one of the most destructive fruit pests in Morocco. Essential oil was extracted from leaves of lavender (L. coronopifolia) by hydrodistillation and analyzed by GC and GC/MS. The main compound is carvacrol (48.9%) followed by E-caryophyllene (10.8%) and caryophyllene oxide (7.7%). The EO was examined in the laboratory for 7 days to assess their activity against Ceratitis capitata (Wiedemann) (Diptera: Tephritidae) adults by ingestion toxicity. We also conducted oviposition bioassay in the laboratory, testing the oviposition deterrence of essential oils. The oil showed 75% mortality of adults at the concentration of 150μl/g after 24 h of exposure. Great differences in insect mortality were observed depending on the sex of the insects, oil concentrations and exposure time. The ingestion toxicity potential of L. coronopifolia on adults was higher (LC 50 = 86.34μl/g, LC 95 = 236.07μl/g) and also, deterred significantly the oviposition by C. capitata, reducing the number of eggs laid by about 94% compared with the controls for the concentration of 55μl/g. The results suggested that L. coronopifolia EOs may have potential as a control agent against this major stored product insect. In the experiment, the researchers used many compounds, for example, Oct-1-en-3-ol (cas: 3391-86-4Product Details of 3391-86-4).

Oct-1-en-3-ol (cas: 3391-86-4) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Product Details of 3391-86-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A rapid and practical catalytic esterification for the preparation of caffeic acid esters was written by Xie, Dongsheng;Yang, Fengzhi;Xie, Jin;Zhang, Man;Liu, Wenlu;Fu, Lei. And the article was included in Journal of Chemical Research in 2014.Name: 2-(4-(Trifluoromethyl)phenyl)ethanol This article mentions the following:

A convenient and practical catalytic method for the preparation of caffeic acid esters is reported. This esterification was carried out with high efficiency in the presence of ytterbium triflate in nitromethane without any other auxiliary reagents. The wide scope of application and especially the higher reactivity and more convenient procedure than previous methods make it a valuable application for the synthesis of caffeic acid esters and other cinnamic acid esters. In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6Name: 2-(4-(Trifluoromethyl)phenyl)ethanol).

2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Name: 2-(4-(Trifluoromethyl)phenyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple synthesis of 7-formylindole was written by Uchil, Vinod;Gund, Machhindra;Satyam, Apparao. And the article was included in Synthetic Communications in 2006.Quality Control of (3-Methyl-2-nitrophenyl)methanol This article mentions the following:

A simple route to 7-formylindole is described in which appropriately functionalized o-nitrotoluenes are converted to 7-hydroxymethylindole (I) using the Batcho-Leimgruber process. Condensation of 3-methyl-2-nitrobenzyl alc. with N,N-dimethylformamide di-Me acetal yields the enamine, which upon catalytic hydrogenation affords I in 22% yield. When the hydroxyl function in functionalized o-nitrotoluenes is protected with pivaloyl or tetrahydropyranyl group, the yields of I are increased to 39% and 48%, resp. Finally, I is oxidized with pyridinium chlorochromate (PCC) to afford 7-formylindole in 86% yield. In the experiment, the researchers used many compounds, for example, (3-Methyl-2-nitrophenyl)methanol (cas: 80866-76-8Quality Control of (3-Methyl-2-nitrophenyl)methanol).

(3-Methyl-2-nitrophenyl)methanol (cas: 80866-76-8) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Quality Control of (3-Methyl-2-nitrophenyl)methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

N-Heterocyclic Carbene C,S Palladium(II) π-Allyl Complexes: Synthesis, Characterization, and Catalytic Application In Allylic Amination Reactions was written by Krishnan, Deepa;Wu, Meiyi;Chiang, Minyi;Li, Yongxin;Leung, Pak-Hing;Pullarkat, Sumod A.. And the article was included in Organometallics in 2013.HPLC of Formula: 29364-29-2 This article mentions the following:

Five-membered N-heterocyclic carbene C,S Pd(II) π-allyl complexes were successfully developed from the transmetalation of carbene silver complexes and characterized. Structural analyses of these complexes revealed that the organopalladium chelates adopt a skew-envelope conformation with a trans disposition of the substituents on the metal chelate rings. Using these C,S Pd(II) π-allyl complexes as catalysts, a catalytic system for the allylic amination reaction was developed. C-N bond formations between amines and unsym. substituted allylic carbonates could be catalyzed efficiently by complex (±)-9 in a regioselective manner. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2HPLC of Formula: 29364-29-2).

Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.HPLC of Formula: 29364-29-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts