Tag: 100-200

A Homochiral Microporous Hydrogen-Bonded Organic Framework for Highly Enantioselective Separation of Secondary Alcohols was written by Li, Peng;He, Yabing;Guang, Jie;Weng, Linghong;Zhao, John Cong-Gui;Xiang, Shengchang;Chen, Banglin. And the article was included in Journal of the American Chemical Society in 2014.Application of 120121-01-9 This article mentions the following:

A homochiral microporous hydrogen-bonded organic framework (HOF-2) based on a BINOL derivative was synthesized and structurally characterized to be a uninodal 6-connected {3³5⁵6⁶7} network. This new HOF exhibits not only a permanent porosity with the BET of 237.6 m² g^-1 but also, more importantly, a highly enantioselective separation of chiral secondary alcs. with ee value up to 92% for 1-phenylethanol. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Application of 120121-01-9).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Application of 120121-01-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis of cobalt single atom catalyst by a solid-state transformation strategy for direct C-C cross-coupling of primary and secondary alcohols was written by Li, Zhijun;Chen, Yuying;Lu, Xiaowen;Li, Honghong;Leng, Leipeng;Zhang, Tinglei;Horton, J. Hugh. And the article was included in Nano Research in 2022.Name: (4-Chlorophenyl)methanol This article mentions the following:

Atomic engineering of single atom catalysts (SACs) with high-d. available active sites and optimized electronic properties can substantially boost catalytic efficacy. Herein, we report a solid-state transformation strategy to access Co SACs by introducing Co species from com. Co₂O₃ powders into nitrogen-doped carbon support. The catalyst exhibited excellent catalytic activity, with a turnover frequency (TOF) of 2,307 h^-1 and yield of 95%, in the direct C-C cross-coupling of benzyl alc. and 1-phenylethanol (1 atm O₂@80 °C) to yield chalcone. D. functional theory (DFT) calculations demonstrate the coordination environment and electronic metal-support interaction impact the catalytic pathway. In particular, a wide substrate scope and a broad functional-group tolerance of this SAC were validated, and the employment of this strategy for large-scale synthesis was also shown to be feasible. This work might shed light on the facile and scalable synthesis of highly active, selective, and stable SACs for heterogeneous catalysis. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Name: (4-Chlorophenyl)methanol).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Name: (4-Chlorophenyl)methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Comprehensive chocolate aroma characterization in beverages containing jackfruit seed flours and cocoa powder was written by Spada, Fernanda Papa;de Alencar, Severino Matias;Purgatto, Eduardo. And the article was included in Future Foods in 2022.Reference of 3391-86-4 This article mentions the following:

Jackfruit (Artocarpus heterophyllus Lam) occurs abundantly in Brazil, but its seeds are often underutilized in food nutrition. Previously, we showed that roasted jackfruit seeds are an innovative source of chocolate aroma. In this study, we characterized the volatile content of exptl. beverages containing jackfruit seed flours as compared to non-alk. cocoa powder. The three key results of this study were that (i) the fermented jackfruit seed flour beverage (FJSBev) was similar to the non-alk. cocoa powder beverage (CTRLBev); (ii) similar volatile groups (acids, alcs., aldehydes, ester, furans, and pyrazines) were identified in the samples (FJSBev and CTRLBev); (iii) the beverages contained volatile compounds with a low threshold of cocoa attributes (butter, cocoa, coffee, floral, fruit, green, honey, mushroom, nut, and roasted). To conclude, the beverage formulation containing fermented jackfruit seeds had more volatile compounds and odor-active constituents than that with non-alk. cocoa powder. Collectively, our data demonstrate that fermentation is critical to producing a chocolate aroma. Fermented jackfruit seed flours could be used as a partial or total additive to improve chocolate aroma in food formulations. In the experiment, the researchers used many compounds, for example, Oct-1-en-3-ol (cas: 3391-86-4Reference of 3391-86-4).

Oct-1-en-3-ol (cas: 3391-86-4) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Reference of 3391-86-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Orange peel fermentation using Lactiplantibacillus plantarum: microbiological analysis and physico-chemical characterisation was written by Deba-Rementeria, Shuyana;Estrada, Olaia;Issa-Issa, Hanan;Vazquez-Araujo, Laura. And the article was included in International Journal of Food Science and Technology in 2022.Related Products of 149-32-6 This article mentions the following:

Summary : To find an innovative use for orange peels discarded in the orange juice-making process, a fermentative process was assessed using a Lactiplantibacillus plantarum strain. Blanched or rinsed peels were submerged in a 5% NaCl-3% inoculated sucrose brine for 10 days. Total soluble solids, pH, sugars and total aerobic and anaerobic counts were determined in the brines to characterize the process. The final products were characterised by instrumental texture, color and volatile composition The blanching pretreatment had a significant effect on the whole process and the final product characteristics. Anaerobic bacteria total counts were significantly higher in the blanched samples during the whole fermentation, and pH decreased significantly slower in these samples than in the rinsed ones. Rinsed samples were characterised by higher aerobic total counts, higher sucrose consumption and higher glucose, fructose and polyalcs. production The texture was softer in the pretreated samples, probably due to the blanching process rather than the fermentation The volatile composition was quite similar between samples, although it was different from one of the raw orange peels due to a significant decrease in various volatile compounds In the experiment, the researchers used many compounds, for example, (2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6Related Products of 149-32-6).

(2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Related Products of 149-32-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis of some new sulfonylureas was written by Loev, Bernard;Snader, Kenneth M.;Walz, Donald T.. And the article was included in Journal of Medicinal Chemistry in 1963.SDS of cas: 2968-93-6 This article mentions the following:

The sulfonamides were prepared by treating the sulfonyl chlorides with anhydrous NH₃. The styrene sulfonamides were prepared according to Bordwell, et al. (CA 40, 1466⁵, 7176¹). The sulfonylureas were prepared by treating the sulfonamide with BuNCO in aqueous Me₂CO and the amino-substituted sulfonylurea was prepared by treating the isocyanate with the aminosulfonamide and by reduction of the nitrosulfonylurea. The following I were prepared (X, A, and m.p. given): 4-Cl, CH₂, 180-1°; 4-NO₂, CH₂ (II), 193.5-4.5°; H, CH₂CH₂, 159-61°; 4-NO₂, CH₂CH₂, 153-5°; 2-NO₂, CH₂CH₂, 154-6°; 4-NH₂, CH₂CH₂, 129-31°; 4-AcNH, CH₂CH₂, 206° (decomposition); 4-CN, CH₂CH₂ (III), 143-8° (decomposition); 4-CONH₂, CH₂CH₂, 197-9° (decomposition); 4-CO₂Et, CH₂CH₂, 127-30° (decomposition). 4-CO₂H, CH₂CH₂, 172-4° (decomposition); 4-CF₃, CH₂CH₂, 158-9°; H, CH:CH, 128-30°; 4-NO₂, CH:CH, 190-90.5°. The following IV were also prepared (X, A, and m.p. given): 4-NO₂, CH₂CH₂, 118-21°; 2-NO₂, CH₂CH₂, 125-7°; 4-CN, CH₂CH₂, 105-8°; 4-AcNH, CH₂CH₂, 159-60°; 4-CONH₂, CH₂CH₂, 197-9°; 4-CO₂Et, CH₂CH₂, 103-10°; 4-CO₂H, CH₂CH₂, 232-5° (decomposition); 4-CF₃, CH₂CH₂, 110-13°; 4-NO₂, CH:CH, 188-90°. II and III were found to have hypoglycemic activity equal to chlorpropamide when tested by the modified method of Hoffman (CA 31, 8583⁴). In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6SDS of cas: 2968-93-6).

2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.SDS of cas: 2968-93-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ice-forming activity of organic crystal hydrates was written by Chesha, I. I.;Tovbin, M. V.;Nikeshina, I. V.;Shcherbina, L. S.;Kolomiets, N. A.. And the article was included in Fizika Aerodispersnykh Sistem in 1982.Name: rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate This article mentions the following:

The ice-forming activity was studied of 2,4-dioxybenzoic acid (I) [89-86-1], the mol. of which crystallizes with 3 H₂O mols. The specific yield of ice crystals ranges (1.7-8.8) × 10⁹/1 g, in relation to the amount of I added (0.45-1.25 mL) to the solution The anhydrous form of I has a better ice-forming activity than the crystal-hydrates. Comparative data are also obtained for cis-terpin and its crystal hydrate. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Name: rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Name: rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Metabolic shifts during fruit development in pungent and non-pungent peppers was written by Rodrigues-Salvador, Acacio;Lana-Costa, Jaciara;Omena-Garcia, Rebeca Patricia;Batista-Silva, Willian;Scossa, Federico;Rosado-Souza, Laise;Perez-Diaz, Jorge Luis;Menezes-Silva, Paulo Eduardo;DaMatta, Fabio M.;Sulpice, Ronan;Araujo, Wagner L.;Zsogon, Agustin;Fernie, Alisdair R.;Nunes-Nesi, Adriano. And the article was included in Food Chemistry in 2022.Synthetic Route of C4H10O4 This article mentions the following:

Fruit pungency is caused by the accumulation of capsaicinoids, secondary metabolites whose relation to primary metabolism remains unclear. We have selected ten geog. diverse accessions of Capsicum chinense Jacq with different pungency levels. A detailed metabolic profile was conducted in the fruit placenta and pericarp at 20, 45, and 60 days after anthesis aiming at increasing our understanding of the metabolic changes in these tissues across fruit development and their potential connection to capsaicin metabolism Overall, despite the variation in fruit pungency among the ten accessions, the composition and metabolite levels in both placenta and pericarp were uniformly stable across accessions. Most of the metabolite variability occurred between the fruit developmental stages rather than among the accessions. Interestingly, different metabolite adjustments in the placenta were observed among pungent and non-pungent accessions, which seem to be related to differences in the genetic background. Furthermore, we observed high coordination between metabolites and capsaicin production in C. chinense fruits, suggesting that pungency in placenta is adjusted with primary metabolism In the experiment, the researchers used many compounds, for example, (2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6Synthetic Route of C4H10O4).

(2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Synthetic Route of C4H10O4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Organic solvent free, high performance and cleaning reactive dye ink using hydroxypropyl methyl cellulose for inkjet printing was written by Zhang, Kun;Fang, Kuanjun;Song, Yawei;Sun, Fuyun. And the article was included in Journal of Cleaner Production in 2022.Quality Control of 2,2′-Oxybis(ethan-1-ol) This article mentions the following:

Organic solvents adjusting the surface tension and viscosity of reactive dye inks for good droplet formation has resulted in low dye utilization and serious environmental pollution. Hydroxypropyl Me cellulose (HPMC) has advantages of biocompatibility, renewability and excellent surface tension and viscosity. Here, an organic solvent free dye ink was developed using HPMC and the printability of HPMC/dye inks was compared with diethylene glycol (DEG)/dye inks and com. inks. Only adding 0.6 wt% of HPMC could obtain good droplet formation, while DEG needed to be added by 50 wt%. The HPMC/dye ink printed patterns exhibited much deeper color than the DEG/dye ink and the com. ink due to the less diffusion of HPMC/dye ink to the back of the fabric. Moreover, as the small dosage of HPMC and the poor reactivity between HPMC and reactive dye, the coloring effluent of the HPMC/dye ink was less than the DEG/dye ink and the com. ink. According to the data of World Textile Information Network, HPMC adjusting the jetting performance will save 1.4 billion ¥ than DEG in 2025. The HPMC/dye ink is a clean ink with advantages of high performance and low pollution and cost. In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6Quality Control of 2,2′-Oxybis(ethan-1-ol)).

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Quality Control of 2,2′-Oxybis(ethan-1-ol)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Effect of dilution of sulfuric acid, phosphoric acid and oxalic acid on the production of α-terpineol from terpin hydrate was written by Kullaj, S.. And the article was included in Buletin i Shkencave Natyrore in 1983.Reference of 2451-01-6 This article mentions the following:

Terpin hydrate(I) was dehydrated to α-terpineol(II) by boiling with 0.01-1% H₂SO₄, H₃PO₄, or oxalic acid. H₃PO₄ (0.025%) gave maximum yields of II (98.8%); the reaction mixture contained 72.1% of II. After distillation at 20 mm Hg through a column with 5 distillation plates, a crystalline II was obtained in a fraction boiling at 113-118°. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Reference of 2451-01-6).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Reference of 2451-01-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Scutellarein attenuates atopic dermatitis by selectively inhibiting transient receptor potential vanilloid 3 channels was written by Wang, Yujing;Tan, Liaoxi;Jiao, Kejun;Xue, Chu;Tang, Qinglian;Jiang, Shan;Ren, Younan;Chen, Hao;El-Aziz, Tarek Mohamed Abd;Abdelazeem, Khalid N. M.;Yu, Ye;Zhao, Fang;Zhu, Michael X.;Cao, Zhengyu. And the article was included in British Journal of Pharmacology in 2022.HPLC of Formula: 499-75-2 This article mentions the following:

Background and Purpose : Atopic dermatitis (AD) is one of the most common chronic inflammatory cutaneous diseases with unmet clin. needs. As a common ingredient found in several medicinal herbs with efficacy on cutaneous inflammatory diseases, Scutellarein (Scu) has been shown to possess anti-inflammatory and anti-proliferative activities. We aimed to evaluate the therapeutic efficacy of Scu against AD and its underlying mol. mechanism. Exptl. Approach : Efficacy of Scu on AD was evaluated in 2,4-dinitrofluorobenzene (DNFB) and carvacrol-induced dermatitis mouse models. Cytokine mRNA and serum IgE levels were examined using qPCR and ELISA, resp. Voltage clamp recordings were used to measure currents mediated by transient receptor potential (TRP) channels. In silico docking, site-direct mutagenesis, and covalent modification were used to explore the binding pocket of Scu on TRPV3. Key Results : S.c. administration of Scu efficaciously suppresses DNFB and carvacrol-induced pruritus, epidermal hyperplasia and skin inflammation in wild type mice but has no addnl. benefit in Trpv3 knockout mice in the carvacrol model. Scu is a potent and selective TRPV3 channel allosteric neg. modulator with an apparent affinity of 1.18 μM. Mol. docking coupled with site-direct mutagenesis and covalent modification of incorporated cysteine residues demonstrate that Scu targets the cavity formed between the pore helix and transmembrane helix S6. Moreover, Scu attenuates endogenous TRPV3 activity in human keratinocytes and inhibits carvacrol-induced proliferative and proinflammatory responses. Conclusion and Implications : Collectively, these data demonstrate that Scu ameliorates carvacrol-induced skin inflammation by directly inhibiting TRPV3, and TRPV3 represents a viable therapeutic target for AD treatment. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2HPLC of Formula: 499-75-2).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.HPLC of Formula: 499-75-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts