Tag: 100-200

Organocatalytic Chlorination of Alcohols by P(III)/P(V) Redox Cycling was written by Longwitz, Lars;Jopp, Stefan;Werner, Thomas. And the article was included in Journal of Organic Chemistry in 2019.Recommanded Product: 2-(Trifluoromethyl)phenethyl alcohol This article mentions the following:

A catalytic system for the chlorination of alcs. under Appel conditions was developed. Benzotrichloride was used as a cheap and readily available chlorinating agent in combination with trioctylphosphine as the catalyst and phenylsilane as the terminal reductant. The reaction has several advantages over other variants of the Appel reaction, e.g., no addnl. solvent is required and the phosphine reagent was used only in catalytic amounts In total, 27 different primary, secondary, and tertiary alkyl chlorides were synthesized in yields up to 95%. Under optimized conditions, it was also possible to convert epoxides and an oxetane to the dichlorinated products. In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5Recommanded Product: 2-(Trifluoromethyl)phenethyl alcohol).

2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Recommanded Product: 2-(Trifluoromethyl)phenethyl alcohol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ruthenium olefin metathesis catalysts with modified styrene ethers: influence of steric and electronic effects was written by Zaja, Mirko;Connon, Stephen J.;Dunne, Aideen M.;Rivard, Michael;Buschmann, Nicole;Jiricek, Jan;Blechert, Siegfried. And the article was included in Tetrahedron in 2003.Product Details of 15777-70-5 This article mentions the following:

A series of olefin metathesis catalysts with modified isopropoxybenzylidene ligands were synthesized, and the effects of ligands on the rate of metathesis was investigated. Increased steric hindrance ortho to the isopropoxy group enhanced reaction rates. In the case of N-heterocyclic carbene complexes, decreasing electron d. at both the chelating oxygen atom and the Ru:C bond accelerated reaction rates appreciably. In an example reaction, CH₂:CHCH₂N(Ts)CH₂CH:CH₂ underwent ring-closing metathesis in the presence of (4,5-dihydroIMes)Cl₂Ru:CH(2-OⁱPr)(4-CN)C₆H₃ giving N-tosyl-2,5-dihydropyrrole in 96% yield. Catalysts containing a tricyclohexylphosphine ligand, such as (PCy₃)Cl₂Ru:CH(2-OⁱPr)(5-CF₃)C₃H₆, followed the same trend with regard to benzylidene electrophilicity, while higher electron d. at oxygen enhanced reaction rates. In the experiment, the researchers used many compounds, for example, 4-Hydroxy-3-methylbenzonitrile (cas: 15777-70-5Product Details of 15777-70-5).

4-Hydroxy-3-methylbenzonitrile (cas: 15777-70-5) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Product Details of 15777-70-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Enantioselective dialkylzinc addition to aldehydes catalyzed by chiral Zn(II)-BINOLates bearing phosphonates and phosphoramides in the 3,3′-positions was written by Hatano, Manabu;Miyamoto, Takashi;Ishihara, Kazuaki. And the article was included in Synlett in 2006.HPLC of Formula: 120121-01-9 This article mentions the following:

Highly enantioselective dialkylzinc addition to a series of aldehydes was developed based on chiral Zn(II)-BINOLate catalysts bearing phosphonates [P(:O)(OR)₂] and phosphoramides [P(:O)(NMe₂)₂] at the 3,3′-positions. The reactions proceeded smoothly and showed reductions in the amounts of both catalysts and dialkylzinc reagents to be loaded. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9HPLC of Formula: 120121-01-9).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.HPLC of Formula: 120121-01-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Design of New Photoactivatable Amino Acids: Stereoselective Synthesis of N-Protected Phenylalanine Derivatives as Precursors of p-Diazocyclohexadienone-Containing Peptides was written by Dugave, C.. And the article was included in Journal of Organic Chemistry in 1995.Electric Literature of C7H7NO4 This article mentions the following:

4-Diazocyclohexa-2,5-dienone-based amino acids I were designed for building up photoactivatable peptides. Their stable precursors II [R = Me₃CO₂C (Boc), 9-fluorenylmethoxycarbonyl (Fmoc)] were synthesized by stereoselective alkylation of the corresponding benzyloxynitrobenzyl iodides by a chiral glycine equivalent Alkylation was carried out using either butyllithium in dry organic solvents or a phase transfer procedure. Alkylation, hydrolysis of the adduct, and protection as Boc and Fmoc derivatives were achieved in 57-73% overall yields and led to 97-99% optically pure material. II were inserted in model dipeptides by a homogeneous solution procedure and by solid-phase peptide synthesis. Deprotection and diazotization of the resulting p-hydroxyanilines gave the corresponding photoactivatable 4-diazocyclohexa-2,5-dienone-containing peptides in quant. yields. Such photoprobes are stable for several hours in the dark but are rapidly photolyzed at 350 nm or at 295 nm by a tryptophan-mediated energy transfer activation process. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Electric Literature of C7H7NO4).

3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Electric Literature of C7H7NO4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reactivity-based one-pot synthesis of the tumor-associated antigen N3 minor octasaccharide for the development of a photo-cleavable DIOS-MS sugar array was written by Lee, Jinq-Chyi;Wu, Chung-Yi;Apon, Junefredo V.;Siuzdak, Gary;Wong, Chi-Huey. And the article was included in Angewandte Chemie, International Edition in 2006.Quality Control of 3-(Hydroxymethyl)-4-nitrophenol This article mentions the following:

Readily available thioglycosides with defined relative reactivity values were used as building blocks in a one-pot strategy to synthesize the tumor-associated oligosaccharide antigen N3 minor. The target mol. was attached covalently to a porous silicon surface through a photo-cleavable linker for direct characterization in a mass spectrometer equipped with a laser source. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Quality Control of 3-(Hydroxymethyl)-4-nitrophenol).

3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Quality Control of 3-(Hydroxymethyl)-4-nitrophenol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Universal strategy for sugar replacement in foods was written by van der Sman, R. G. M.;Jurgens, A.;Smith, A.;Renzetti, S.. And the article was included in Food Hydrocolloids in 2022.HPLC of Formula: 149-32-6 This article mentions the following:

In this paper we present a sugar replacements strategy, derived from phys. theory, which we think is applicable for a wide range of food categories. The strategy is based on the hypothesis that reformulated foods must mimic the values of two phys. characteristic numbers, related to the plasticizing and hygroscopic properties of sugar, to reproduce the texture of a sugar-rich product. We will show the validity of the strategy for reformulated biscuits, using exptl. determination of phys. properties of dough and baked biscuits, as well as sensorial evaluation by a trained panel. Our investigations shown that the majority of these phys. and sensorial attributes correlate with the two phys. characteristic numbers Furthermore, multiple reformulations can be defined which are close to the reference product (in terms of the two phys. characteristic numbers), which are indeed scored similar by the trained sensory panel. Hence, our strategy also leaves room for further optimization of the reformulated food towards dietary fiber content, laxative properties or sweetness. In the experiment, the researchers used many compounds, for example, (2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6HPLC of Formula: 149-32-6).

(2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.HPLC of Formula: 149-32-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Metal-free visible light-promoted synthesis of isothiazoles: a catalytic approach for N-S bond formation from iminyl radicals under batch and flow conditions was written by Cabrera-Afonso, Maria Jesus;Cembellin, Sara;Halima-Salem, Adnane;Berton, Mateo;Marzo, Leyre;Miloudi, Abdellah;Maestro, M. Carmen;Aleman, Jose. And the article was included in Green Chemistry in 2020.HPLC of Formula: 29364-29-2 This article mentions the following:

A sustainable synthesis of isothiazoles was developed using an α-amino-oxy acid auxiliary and applying photoredox catalysis. This simple strategy features mild conditions, broad scope and wide functional group tolerance represented a new environmentally friendly option to prepare these highly valuable heterocycles. Furthermore, the synthetic value of the method was highlighted by the preparation of a natural product derivative and the implementation of the reaction in a continuous flow setup. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2HPLC of Formula: 29364-29-2).

Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.HPLC of Formula: 29364-29-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Highly soluble sulfur-rich [Ni(L)(^siS₃)] complexes containing the new ligand bis(2-mercapto-3-trimethylsilylphenyl) sulfide(2-) (^siS₃^2-) was written by Sellmann, Dieter;Prakash, Raju;Geipel, Franz;Heinemann, Frank W.. And the article was included in European Journal of Inorganic Chemistry in 2002.Recommanded Product: 29364-29-2 This article mentions the following:

The new organosulfur ligands ^siS₃-H₂ [^siS₃^2- = bis(2-mercapto-3-trimethylsilylphenyl) sulfide(2-)] and ^caS₃-H₂ [^caS₃^2- = bis(2-mercapto-3-carboxyphenyl) sulfide(2-)] were synthesized from ^HS₃-H₂ [^HS₃^2- = bis(2-mercaptophenyl) sulfide(2-)], BuLi, and Me₃SiCl or CO₂/H⁺. Reaction of ^siS₃-H₂ with Ni(acac)₂·4H₂O gave the air-stable and well-soluble trinuclear complex I, [Ni(^siS₃)]₃ (1), whose structure was determined by x-ray crystallog. Reactions of complex 1 with nucleophiles L [L = PR₃ (R = Pr, Ph, Cy), N₂H₄, S^tBu^–, and Cl^–] yielded the corresponding neutral or anionic complexes, which were isolated as [Ni(PR₃)(^siS₃)] [R = Pr (2), Ph (3), Cy (4)], Bu₄N[Ni(Cl)(^siS₃)] (5), Bu₄N[Ni(StBu)(^siS₃)] (6), and [Ni(N₂H₄)(^siS₃)] (8). The azido complex Et₄N[Ni(N₃)(^siS₃)] (7) was prepared from Me₃SiN₃ and the precursor chloro complex Et₄N[Ni(Cl)(^siS₃)] formed in situ. Reaction of 1 with NH₃ yielded labile [Ni(NH₃)(^siS₃)] (9), which was characterized in solution by ¹H and ¹³C NMR spectroscopy. Analogously, 1 reacts with nicotinamide (NA) or diethylnicotinamide (NAEt₂) to give, from equilibrium reactions, the corresponding mononuclear [Ni(L)(^siS₃)] complexes with L = NA, NAEt₂. X-ray structure determinations showed that 1, 3, 4, 5, and 7 all exhibit tetrahedrally distorted planar [Ni(L)(^siS₃)] fragments. Complex 7 is the first structurally characterized azidonickel complex with a coligand having exclusively S donors. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2Recommanded Product: 29364-29-2).

Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Recommanded Product: 29364-29-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

De Novo Asymmetric Bio- and Chemo-Catalytic Synthesis of Saccharides – Stereoselective Formal O-Glycoside Bond Formation Using Palladium Catalysis was written by Comely, Alex C.;Eelkema, Rienk;Minnaard, Adriaan J.;Feringa, Ben L.. And the article was included in Journal of the American Chemical Society in 2003.Quality Control of 3-(Hydroxymethyl)-4-nitrophenol This article mentions the following:

A novel integrated bio- and chemo-catalytic approach to the de novo catalytic asym. synthesis of saccharides has been developed. Acetoxypyranones obtained enantiopure by enzymic resolution have been shown to undergo highly stereoselective palladium-catalyzed formal O-glycoside bond formation. The combination of these protocols can be applied to asym. catalytic synthesis of saccharides. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Quality Control of 3-(Hydroxymethyl)-4-nitrophenol).

3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Quality Control of 3-(Hydroxymethyl)-4-nitrophenol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Characterization of key odor-active compounds in pure chicken powder and the effect of yeast extract, using instrumental and sensory techniques was written by Shen, Dong-Yu;Li, Meng-Ke;Zhao, Mu;Li, Jie;Cui, Xinyue;Zou, Ting-Ting;Song, Huan-Lu;Xiong, Jian;Li, Ku. And the article was included in Journal of Food Composition and Analysis in 2023.Recommanded Product: 3391-86-4 This article mentions the following:

Pure chicken powder (PCP) is a reliable source of mellow chicken soup flavor in seasoning, but it has some unstable compounds and is prone to lipid oxidation, which leads to unpleasant odor. Adding yeast extract (YE) can reduce the off-odor intensity of PCP. Based on the results of gas chromatog.-olfactometry-mass spectrometry (GC-O-MS), two-dimensional comprehensive gas chromatog.-olfactometry-mass spectrometry (GCxGC-O-MS) and combined aroma extract dilution anal. (AEDA), 14 key odor-active compounds were identified. Internal standard curve method was used for quant. anal., and the odor activity value (OAV) was calculated Octanal, 1-octen-3-ol and hexanal were found to be the most vital odor-active compounds in PCP. The odor-active compounds of YE were studied by the same method, and di-Me trisulfide was identified as the most important odor-active compound of YE. Addnl., recombination and omission experiments were carried out with PCP. Finally, it was found that a low concentration of di-Me trisulfide had masking effect on the odor of PCP. In the experiment, the researchers used many compounds, for example, Oct-1-en-3-ol (cas: 3391-86-4Recommanded Product: 3391-86-4).

Oct-1-en-3-ol (cas: 3391-86-4) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Recommanded Product: 3391-86-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts