Tag: 100-200

Novel 1,4-dihydropyridine calcium antagonists. I. Synthesis and hypotensive activity of 4-(substituted pyridyl)-1,4-dihydropyridine derivatives was written by Ashimori, Atsuyuki;Ono, Taizo;Uchida, Takeshi;Ohtaki, Yutaka;Fukaya, Chikara;Watanabe, Masahiro;Yokoyama, Kazumasa. And the article was included in Chemical & Pharmaceutical Bulletin in 1990.Category: alcohols-buliding-blocks This article mentions the following:

A series of 4-(substituted pyridyl)-1,4-dihydropyridine derivatives I (R = H, halo, CF₃, etc.) were synthesized and their hypotensive effects examined Several compounds have a hypotensive activity parallel to that of nicardipine; the 4-(3-trifluoromethyl-2-pyridyl) and 4-(2-trifluoromethyl-3-pyridyl) derivatives, in particular, had approx. twice the duration of nicardipine, and the 4-(4-cyano-2-pyridyl) derivative had the most potent hypotensive activity of all the derivatives synthesized. In the experiment, the researchers used many compounds, for example, (6-(Trifluoromethyl)pyridin-2-yl)methanol (cas: 131747-53-0Category: alcohols-buliding-blocks).

(6-(Trifluoromethyl)pyridin-2-yl)methanol (cas: 131747-53-0) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Category: alcohols-buliding-blocks

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Alcohol – Wikipedia,
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Development of sodium alginate-based antioxidant and antibacterial bioactive films added with IRMOF-3/Carvacrol was written by Ning, Haoyue;Lu, Lixin;Xu, Jing;Lu, Lijing;Pan, Liao;Lin, Zidong. And the article was included in Carbohydrate Polymers in 2022.Synthetic Route of C10H14O This article mentions the following:

The purpose of this study was to compare the effects of different concentrations of the amine-functionalized isoreticular metal-organic framework-3 loaded with carvacrol (IRMOF-3/CA) on the properties of sodium alginate (SA) composite films, thus determining the optimal addition amount and further preparing bioactive packaging film with antibacterial and antioxidant activities. The morphol., structure, phys. properties, antioxidant and antibacterial activities of the films were characterized and analyzed. The results showed that the thermal stability and light barrier property of the films were improved by the addition of IRMOF-3/CA. When the addnl. concentration was 0.4 wt%, the tensile, water vapor barrier and hydrophobic properties of the films were increased by 30.13%, 9.06% and 46.43% resp. compared with those of pure SA film. Moreover, the film added with IRMOF-3/CA had sustained antioxidant and antibacterial activities, and had an apparent fresh-keeping effect on pork, suggesting its application potential in food packaging. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Synthetic Route of C10H14O).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Synthetic Route of C10H14O

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Alcohol – Wikipedia,
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Heteroarylmethoxyphenylalkoxyiminoalkylcarboxylic acids as leukotriene biosynthesis inhibitors was written by Kolasa, Teodozyj;Gunn, David E.;Bhatia, Pramila;Woods, Keith W.;Gane, Todd;Stewart, Andrew O.;Bouska, Jennifer B.;Harris, Richard R.;Hulkower, Keren I.;Malo, Peter E.;Bell, Randy L.;Carter, George W.;Brooks, Clint D. W.. And the article was included in Journal of Medicinal Chemistry in 2000.COA of Formula: C7H7NO4 This article mentions the following:

A novel series of heteroarylmethoxyphenylalkoxyiminoalkylcarboxylic acids was studied as leukotriene biosynthesis inhibitors. The hypothesis of structure-activity optimization by insertion of an oxime moiety was investigated using REV-5901 as a starting point. A systematic structure-activity optimization showed that the spatial arrangement and stereochem. of the oxime insertion unit proved to be important for inhibitory activity. A promising lead inhibited LTB₄ biosynthesis in the intact human neutrophil with IC₅₀ of 8 nM and had superior oral activity in vivo, in a rat pleurisy model (ED₅₀ = 0.14 mg/kg) and rat anaphylaxis model (ED₅₀ = 0.13 mg/kg). Spa. In a model of lung inflammation, the compound blocked LTE₄ biosynthesis (ED₅₀ of 0.1 mg/kg) and eosinophil influx (ED₅₀ of 0.2 mg/kg). In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9COA of Formula: C7H7NO4).

3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.COA of Formula: C7H7NO4

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Diarylmethane synthesis through Re₂O₇-catalyzed bimolecular dehydrative Friedel-Crafts reactions was written by Qin, Qi;Xie, Youwei;Floreancig, Paul E.. And the article was included in Chemical Science in 2018.HPLC of Formula: 220227-37-2 This article mentions the following:

The application of Re₂O₇ for the synthesis of diarylmethanes from benzylic alcs. through solvolysis followed by Friedel-Crafts alkylation was described. The reactions were characterized by broad substrate scope, low catalyst loadings, high chem. yields and minimal waste generation. The intermediate perrhenate esters were superior leaving groups to chlorides and bromides in these reactions. The polarity and water sequestering capacity of hexafluoroisopropyl alc. were critical to the success of these processes. Re₂O₇ was a precatalyst for HOReO₃, which served as a less costly and easily handled promoter for these reactions. Oxorhenium catalysts selectively activate alcs. in the presence of similarly substituted acetates, indicating a unique chemoselectivity and mechanism in comparison to Bronsted acid catalysis. In the experiment, the researchers used many compounds, for example, (3,4,5-Trifluorophenyl)methanol (cas: 220227-37-2HPLC of Formula: 220227-37-2).

(3,4,5-Trifluorophenyl)methanol (cas: 220227-37-2) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.HPLC of Formula: 220227-37-2

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Alcohol – Wikipedia,
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Asymmetric Transfer Hydrogenation of Aryl Ketones Catalyzed by Salt-Free Two Samarium Centers Supported by a Chiral Multidentate Alkoxy Ligand was written by Ohno, Kouji;Kataoka, Yasutaka;Mashima, Kazushi. And the article was included in Organic Letters in 2004.Product Details of 120121-01-9 This article mentions the following:

The authors synthesized a chiral multidentate ligand, (R,R,R,R)-N,N,N’,N’-tetra(2-hydroxy-2-phenylethyl)-1,3-xylylene diamine [(R)-I], which can support two metals at adjacent positions. Asym. transfer hydrogenation of acetophenone and its derivatives was conducted by using salt-free bimetallic lanthanoid complexes of (R)-I, and the combination of two samarium atoms and (R)-I was found to be the best catalyst system for asym. transfer hydrogenation of aryl ketones in high enantioselectivity (up to >99% ee). In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Product Details of 120121-01-9).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Product Details of 120121-01-9

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Alcohol – Wikipedia,
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2-Amino-6-(hydroxymethyl)pyridine was written by Goswami, Shyamaprosad;Dey, Swapan;Fun, Hoong Kun;Chantrapromma, Suchada. And the article was included in Acta Crystallographica, Section E: Structure Reports Online in 2006.Application of 79651-64-2 This article mentions the following:

Crystals of the title compound are monoclinic, space group P2₁/c; Z = 4. The mol. is almost planar; the hydroxymethyl group deviates slightly from the plane of the ring. The mols. are linked into a chain running along the a-axis direction by an O-H…N H bond. N-H…O and N-H…N H bonds connect the chains, forming a mol. layer parallel to the (001) plane. A C-H…π interaction is also observed in the layer. In the experiment, the researchers used many compounds, for example, (6-Aminopyridin-2-yl)methanol (cas: 79651-64-2Application of 79651-64-2).

(6-Aminopyridin-2-yl)methanol (cas: 79651-64-2) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Application of 79651-64-2

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Alcohol – Wikipedia,
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Study on extraction process of root of henry wood betony polysaccharides and their antitumor activity against S180 was written by Feng, Haibo;Tian, Lan. And the article was included in Molecules in 2021.Electric Literature of C6H14O6 This article mentions the following:

We optimized the hot water extraction of polysaccharides from the root of Henry wood betony (RHWPs) using a uniform test and explored their anti-tumor activities in vitro and in vivo. The optimal extraction conditions were as follows: 40 min extraction time, liquid/solid ratio 30 mL/g, 100 min soaking time, two extraction cycles, 100% ethanol concentration, and extraction temperature of 80 degC. The mol. weight distribution of RHWPs with MWs was 228,600 g/mol and 5001 g/mol. The IR spectrum further indicated that RHWPs are acidic polysaccharides containing pyranose and furan rings. The main monosaccharides found in RHWPs were mannose, ribose, l-rhamnose monohydrate, glucuronic acid, galacturonic acid, glucose, galactose, xylose, arabinose, and fucose. RHWPs inhibited the proliferation of S180 tumor cells and induced apoptosis in vitro. Oral administration of RHWPs to tumor-bearing mice significantly inhibited the growth of the S180 xenografts, accelerated apoptosis in tumor cells, and expanded the necrotic regions. Furthermore, RHWPs also markedly increased the levels of TNF-alpha, IFN-gamma, and IL-2 in the sera of tumor-bearing mice, and activated immune cells such as lymphocytes, NK cells, and macrophages, thereby inducing tumor cell apoptosis. Taken together, RHWPs are a promising anti-tumor agent that ought to be explored further. In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0Electric Literature of C6H14O6).

(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Electric Literature of C6H14O6

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Alcohol – Wikipedia,
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Iminophenyl Oxazolinylphenylamine for Enantioselective Cobalt-Catalyzed Hydrosilylation of Aryl Ketones was written by Chen, Xu;Lu, Zhan. And the article was included in Organic Letters in 2016.Product Details of 120121-01-9 This article mentions the following:

A family of chiral iminophenyl oxazolinylphenylamines (IPOPA) was designed and synthesized through three steps from com. available starting materials. An efficient cobalt-catalyzed asym. hydrosilylation of simple ketones with a low catalyst loading of CoCl₂ and IPOPA was developed to afford chiral alcs. in good yields with high enantioselectivities. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Product Details of 120121-01-9).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Product Details of 120121-01-9

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Alcohol – Wikipedia,
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High-throughput profiling volatiles in edible oils by cooling assisted solid-phase microextraction technique for sensitive discrimination of edible oils adulteration was written by Xu, Shengrui;Li, Huimin;Dong, Panlong;Wang, Miaomiao;Chen, Chang-Po;Feng, Suling;Fan, Jing. And the article was included in Analytica Chimica Acta in 2022.Product Details of 3391-86-4 This article mentions the following:

In this study, a cooling assisted solid-phase microextraction technique (CA-SPME) was proposed and used for identifying volatile and semi-volatile compounds in edible oil innovatively coupled to gas chromatog.-mass spectrometry. Compared with regular SPME technique, CA-SPME presented significantly higher extraction efficiencies for analytes in edible oil due to its synergistic effect of heating and cooling. After optimization of the extraction conditions including heating temperature, cooling temperature, extraction time, and added amount of edible oil, thirty-eight, thirty-six, twenty-nine, and thirty-three kinds of compounds in peanut oil, olive oil, canola oil, and soybean oil were successfully identified, resp., using DVB/CAR/PDMS coating with extraction time of 30 min and edible oil amounts of 20 μL. Principal component anal., partial least squares discriminant anal., and hierarchical clustering anal. (HCA) were performed to evaluate the potential of proposed method in discriminating edible oils adulteration (peanut oil adulterated with canola oil, peanut oil adulterated with soybean oil, olive oil adulterated with canola oil) subsequently. Results demonstrated that the method was useful in successful discrimination of pure and adulterated edible oils with adulteration percentages ranging from 0.5 to 10%. Furthermore, volatiles contributing to classifications between pure and adulterated edible oils were also illustrated based on variable importance for the projection anal. and distributions of volatiles in HCA heatmaps. The proposed method provided a novel strategy for sensitive detection of edible oil adulteration without any other sample pretreatment. In the experiment, the researchers used many compounds, for example, Oct-1-en-3-ol (cas: 3391-86-4Product Details of 3391-86-4).

Oct-1-en-3-ol (cas: 3391-86-4) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Product Details of 3391-86-4

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Alcohol – Wikipedia,
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Solubility of terpin hydrate in hydroalcoholic solutions was written by Mascardo, Lydia B.;Barr, Martim. And the article was included in Journal of the American Pharmaceutical Association, Practical Pharmacy Edition in 1953.Quality Control of rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate This article mentions the following:

A table and figure shows the solubility of terpin hydrate in various hydroalcholic solutions making it possible to determine rapidly the percent of alc. required to dissolve a given amount of the compound In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Quality Control of rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Quality Control of rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts