Tag: 100-200

Catalytic activity of SBA-15 supported CuO for selective oxidation of veratryl alcohol to veratraldehyde was written by Dhinagaran, G.;Harichandran, G.;Suvaitha, S. Prashanna;Venkatachalam, K.. And the article was included in Molecular Catalysis in 2022.Reference of 873-76-7 This article mentions the following:

Selective oxidation of veratryl alc. (VAlc) to veratraldehyde (VAld) under mild conditions using heterogeneous catalysts is advantageous for industrial applications. In the present study, newly developed SBA-15 supported copper oxide catalyst designated as CuO(5,10,15 weight%)/SBA-15 was examined for the selective oxidation of VAlc to VAld using tert-Bu hydroperoxide (TBHP) as an oxidant between 40 and 100°C. CuO(10 weight%)/SBA-15 showed high conversion (82.5%) compared to others by forming VAld with 100% selectivity. We examined its selective oxidising power using a substrate possessing both the primary and secondary alc. functions, namely propylene glycol (PG). In this substrate, only the secondary alc. group was oxidized to hydroxyacetone (HA). It suggests preferential adsorption of the primary alc. group of PG on the catalyst surface close to the adsorbed TBHP, thus leaving only the secondary alc. group positionally favorable for oxidation In addition, the catalyst effectively oxidized 2-butanol to 2-butanone. So, the catalyst is verified active against both primary and secondary alcs., but when both of them are present on the adjacent carbons of the same compound, only the secondary alc. function is oxidized. So, the present catalyst could have tremendous applications for selective oxidation in organic synthesis. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Reference of 873-76-7).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Reference of 873-76-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Qualitative and quantitative characterization of monosaccharide components of Salvia miltiorrhiza, liguspyragine hydrochloride, and glucose injection was written by Ge, Fa-huan;Ma, Xian-peng;Ma, Jin-fang;Bi, Chang-qiong;Chen, Tian-ling;Zhang, Xiang-dong;Xiao, Xue. And the article was included in Journal of Analytical Methods in Chemistry in 2017.Application In Synthesis of (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate This article mentions the following:

Salvia miltiorrhiza, liguspyragine hydrochloride, and glucose injection (SLGI) was made of Salvia miltiorrhiza Bge., liguspyragine hydrochloride, glucose, and glycerin. There were many kinds of monosaccharide components in SLGI, which might be from the raw material and Salvia miltiorrhiza Bge. Separation was performed on a Phenomenex Luna C18 anal. column (250mm × 4.6mmi.d., 5 μm, AccuStandard Inc., USA) at 30°C. The mobile phase consisted of two solvents: 0.1 mol/L phosphate-buffered saline (pH 6.7) (solvent A) and acetonitrile (solvent B) with gradient elution. The flow rate was maintained at 1.0 mL/min. Five kinds of monosaccharide components, glucose, D-mannose, L-rhamnose monohydrate, galactose, and xylose, were detected by precolumn derivatization HPLC, and their contents were compared with each other. And finally, concentrations of glucose in SLGI were determined and they were higher than the values of marked amount, which showed that one source of glucose might be from Salvia miltiorrhiza Bge. in SLGI. The average concentration of glucose was 5.18 g/100 mL, which was near the average value at 5.25 g/100mL detected by UV spectrophotometry and also close to the marked amount (5.00 g/100 mL) on the label. In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0Application In Synthesis of (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate).

(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Application In Synthesis of (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Emissive Metallacage-Cored Polyurethanes with Self-Healing and Shape Memory Properties was written by Gao, Kai;Feng, Qian;Zhang, Zeyuan;Zhang, Ruoqian;Hou, Yali;Mu, Chaoqun;Li, Xiaopeng;Zhang, Mingming. And the article was included in Angewandte Chemie, International Edition in 2022.Electric Literature of C4H10O3 This article mentions the following:

The structures of the crosslinks in supramol. polymer networks play an important role on their properties and functions. Herein, emissive metallacages are used as crosslinks to prepare metallacage-cored polyurethanes. The mech. properties including storage modulus, toughness, Young’s modulus and breaking strength of polymers are greatly enhanced with the increase of crosslinking densities. Moreover, such polymers not only exhibit good fluorescence in the solid state, but also show self-healing and shape memory properties owing to the dynamic reversible non-covalent bonds in their structures. This study not only offers a convenient strategy to prepare metallacage-crosslinked networks, but also explores their applications as self-healing and shape memory materials, which will promote the study of metallacage-cored supramol. networks as smart materials. In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6Electric Literature of C4H10O3).

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Electric Literature of C4H10O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

New paracyclophane phosphine for highly enantioselective ruthenium-catalyzed hydrogenation of prochiral ketones was written by Cheemala, Murthy N.;Gayral, Maud;Brown, John M.;Rossen, Kai;Knochel, Paul. And the article was included in Synthesis in 2007.Recommanded Product: (R)-1-(3-Chlorophenyl)ethanol This article mentions the following:

A new unsym. (R)-Phanephos analog, [2.2]paracyclophane diphosphine (R)-(C₂H₄)₂(1,4-C₆H₃-2-PAr₂)(1,4-C₆H₃-3-PPh₂) (2, Ar = 3,5-Me₂C₆H₃) was prepared and tested as ligand for ruthenium-catalyzed asym. hydrogenation of acetophenones. Acetophenones XC₆H₄COMe were hydrogenated into the corresponding (αR)-α-methylbenzenemethanols by [(L₂)RuCl₂(H₂NCR¹R²CR²R¹NH₂)] (6a,b; R¹, R² = H, Ph; L₂ = 2) with 94-97% ee. The ligand 2 was highly efficient in the ruthenium-catalyzed asym. hydrogenation of various aromatic and heteroaromatic ketones. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Recommanded Product: (R)-1-(3-Chlorophenyl)ethanol).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Recommanded Product: (R)-1-(3-Chlorophenyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis and structure-activity relationships of aza- and diazabiphenyl analogues of the antitubercular drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824) was written by Kmentova, Iveta;Sutherland, Hamish S.;Palmer, Brian D.;Blaser, Adrian;Franzblau, Scott G.;Wan, Baojie;Wang, Yuehong;Ma, Zhenkun;Denny, William A.;Thompson, Andrew M.. And the article was included in Journal of Medicinal Chemistry in 2010.Reference of 118289-16-0 This article mentions the following:

New heterocyclic analogs of the potent biphenyl class derived from antitubercular drug I were prepared, aiming to improve aqueous solubility but maintain high metabolic stability and efficacy. The strategy involved replacement of one or both Ph groups by pyridine, pyridazine, pyrazine, or pyrimidine, in order to reduce lipophilicity. For para-linked biaryls, hydrophilicities (ClogP) correlated with measured solubilities, but highly soluble bipyridine analogs displayed weak antitubercular activities. A terminal pyridine or proximal heterocycle allowed retention of potency and provided solubility improvements, particularly at low pH, with examples from the latter classes displaying the better in vivo efficacies, high metabolic stabilities, and excellent pharmacokinetics. Five such compounds were >100-fold better than the parent drug in a mouse model of acute Mycobacterium tuberculosis infection, and two orally bioavailable pyridine analogs (3-4-fold more soluble than the parent at low pH) were superior to antitubercular drug II in a chronic infection model. In the experiment, the researchers used many compounds, for example, 2-Bromopyridine-4-methanol (cas: 118289-16-0Reference of 118289-16-0).

2-Bromopyridine-4-methanol (cas: 118289-16-0) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Reference of 118289-16-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Construction of substituted pyrazolo[4,3-c]quinolines via [5+1] cyclization of pyrazole-arylamines with alcohols/amines in one pot was written by Tang, Dong;Mu, Yangxiu;Iqbal, Zafar;He, Lili;Jiang, Rui;Hou, Jing;Yang, Zhixiang;Yang, Minghua. And the article was included in Journal of Heterocyclic Chemistry in 2022.SDS of cas: 873-76-7 This article mentions the following:

An efficient protocol had been developed for the synthesis of pyrazolo[4,3-c]quinoline derivatives I [R¹ = Me, Ph, 3-pyridyl, etc.; R² = Ph, 4-MeC₆H₄, 4-ClC₆H₄, 4-BrC₆H₄, 4-NCC₆H₄; R³ = Ph, 1-naphthyl, 2-thienyl, etc.], by reacting (1H-pyrazol-5-yl)anilines and readily available alcs./amines. A wide range of substrates with diverse functional groups were smoothly converted to the corresponding products in moderate to good yields, under optimal reaction conditions. Furthermore, the strategy also proceeded well with thiol and amino acid to access pyrazolo[4,3-c]quinoline derivatives In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7SDS of cas: 873-76-7).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.SDS of cas: 873-76-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Enantioselective addition of methyl group to aldehydes catalyzed by titanium complex of fluorous ligand was written by Omote, Masaaki;Tanaka, Naoya;Tarui, Atsushi;Sato, Kazuyuki;Kumadaki, Itsumaro;Ando, Akira. And the article was included in Tetrahedron Letters in 2007.Application In Synthesis of (S)-1-(2-Fluorophenyl)ethanol This article mentions the following:

Titanium complex of fluorous axially dissym. ligand (Ra*)-2,2′-bis[(R*)-perfluoro-1H-1-hydroxyoctyl]biphenyl (I) having perfluoroheptyl carbinol moieties catalyzed enantioselective addition of a Me group to aldehydes. Dimethylzinc prepared in situ by mixing ZnCl₂ and Me magnesium bromide without removal of magnesium salt was more reactive for addition of Me group than dimethylzinc without magnesium salt, and gave up to 99% ee of the products. The high fluorine content of I was recoverable by the selective extraction with perfluorohexane. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Application In Synthesis of (S)-1-(2-Fluorophenyl)ethanol).

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Application In Synthesis of (S)-1-(2-Fluorophenyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A novel polysaccharide from Boletus edulis: Extraction, purification, characterization and immunologic activity was written by Yu, Shasha;Ma, Rongjie;Dong, Xiaodan;Ji, Haiyu;Liu, Anjun. And the article was included in Industrial Crops and Products in 2022.Category: alcohols-buliding-blocks This article mentions the following:

A novel polysaccharide (BEP) was extracted from Boletus edulis, and its structural characteristics and immunol. activity were evaluated. Our findings revealed that BEP (139 kDa) contained Man, Glc, and Gal in the molar ratio of 1:0.15:0.17 with typical characteristic absorption peaks of polysaccharides. Moreover, the results of methylation and 1D/2D NMR spectroscopy indicated that the backbone of BEP was (→6)-α-Manp-(1→ and →3,6)-α-Manp-(1→, with the side chain →3)-β-Manp-(1→, →3)-α-Galp-(1→ and α-Glcp-(1→)). The immunol. activity tests demonstrated that the BEP could enhance phagocytosis of peritoneal macrophages and secrete NO and cytokines in a dose-dependent by activated macrophage. It was noteworthy that the secretions of NO, IL-6 and TNF-α at 400 μg/mL concentration were increased by 25.50%, 191.67% and 196.05% compared with the control group, resp. The results illustrated that BEP was a novel polysaccharide, which may be marked as an immunol. agent in the food, pharmaceutical and cosmetic industries. In the experiment, the researchers used many compounds, for example, (2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6Category: alcohols-buliding-blocks).

(2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A simple and efficient room temperature silylation of diverse functional groups with hexamethyldisilazane using CeO₂ nanoparticles as solid catalysts was written by Anbu, Nagaraj;Vijayan, Chellappa;Dhakshinamoorthy, Amarajothi. And the article was included in Molecular Catalysis in 2019.Reference of 1777-82-8 This article mentions the following:

In this study, a mild and efficient method is developed for the silylation of diverse functional groups using CeO₂ nanoparticles (n-CeO₂) as solid catalysts with hexamethyldisilazane (HMDS) as silylating agent at room temperature Alcs., phenols and acids are silylated to their resp. silyl derivatives with faster reaction rate while amines and thiols required relatively longer reaction time. Moreover, the solid catalyst is easily be separated from the reaction mixture and recycled more than five times without any noticeable decay in its activity. Powder X-ray diffraction (XRD), transmission electron microscope (TEM), UV-vis diffuse reflectance spectra (UV-DRS) and Raman analyses revealed identical structural integrity, particle size, absorption edge and valence state for the reused solid compared to the fresh solid catalyst. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Reference of 1777-82-8).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Reference of 1777-82-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A novel approach for the preparation of core-shell MOF/polymer composites as mixed-mode stationary phase was written by Si, Tiantian;Wang, Licheng;Zhang, Haixia;Liang, Xiaojing;Lu, Xiaofeng;Wang, Shuai;Guo, Yong. And the article was included in Talanta in 2021.Name: (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate This article mentions the following:

The nickel organic framework capped with polyvinylpyrrolidone was prepared and synergistically immobilized onto porous silica surface as the mixed-mode stationary phase for high-performance liquid chromatog. Here, polyvinylpyrrolidone firstly was chosen as functional mols. to change morphol. and size of the metal organic framework. The silica microspheres were then modified by them via a simple bonding method rather than in-situ growth method with the aid of electrostatic interaction commonly used before. The stationary phase showed flexible selectivity for separation of both hydrophilic and hydrophobic compounds, especially for hydrophilic compounds such as carbohydrates, alkaloids and sulfonamides etc. The chromatog. behaviors were evaluated by investigating various factors, and a typical mixed-mode retention feature of the column was observed The composites could be prepared repetitively, and relative standard deviations of retention time of objective compounds among different batches were less than 1.75%. It also showed excellent chromatog. reproducibility, stability and potentiality for application in real samples. In short, the composites can be used for a feasible option for anal. of multiple compounds as the mixed-mode stationary phase and it provides a general approach for preparing MOFs-based composites by changing morphol. and size of MOFs. In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0Name: (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate).

(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Name: (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts