Tag: 100-200

Dependence of the antimicrobial activity of chemical preservatives in suspensions on several pharmaceutical factors was written by Pertsev, I. M.;Khokhlova, L. N.;Dmitrievskii, D. I.. And the article was included in Khimiko-Farmatsevticheskii Zhurnal in 1984.Name: rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate This article mentions the following:

The adsorption of chem. preservatives such as nipagin  [99-76-3], nipazol  [94-13-3], sorbic acid  [110-44-1], benzoic acid  [65-85-0], benzalkonium chlorides and ethonium  [21954-74-5] by solid phase drug-suspensions was studied. The suspensions contained Al₂O₃, BaSO₄, Ca glycerophosphate [27214-00-2], MgCO₃, MgO, menthol  [1490-04-6], talc, terpin hydrate  [2451-01-6], phenyl salicylate  [118-55-8] and phthalazole  [85-73-4] in 1, 2.5 and 5% concentrations The quantity of the adsorbed preservatives increased with the concentration of solid phases up to 2.5% drug concentration Since nipagin and nipazole showed the least adsorption, a combination of these was chosen for preserving the suspensions and their concentration increased to study their adsorption. Since benzoic acid and sorbic acid adsorbed most of the drugs used they should not be used as preservatives. In addition, the effect of stabilizers, Tween 80  [9005-65-6] Me cellulose  [9004-67-5], and gelatose  [52624-15-4] on the adsorption of the preservatives were studied. Tween 80 increased the adsorption degree of all the preservatives studied, gelatose decreased it and Me cellulose also increased the degree of adsorption of all the preservatives except that of sorbic acid. The antimicrobial activity was decreased when the stabilizers were not used, especially with sorbic acid. The stabilizers in general increased the antimicrobial activity. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Name: rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Name: rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Discovery and Characterization of 2-Aminooxazolines as Highly Potent, Selective, and Orally Active TAAR1 Agonists was written by Galley, Guido;Beurier, Angelica;Decoret, Guillaume;Goergler, Annick;Hutter, Roman;Mohr, Susanne;Pahler, Axel;Schmid, Philipp;Turck, Dietrich;Unger, Robert;Zbinden, Katrin Groebke;Hoener, Marius C.;Norcross, Roger D.. And the article was included in ACS Medicinal Chemistry Letters in 2016.Related Products of 926291-77-2 This article mentions the following:

2-Aminooxazolines were discovered as a novel structural class of TAAR1 ligands. Starting from a known adrenergic compound, structural modifications were made to obtain highly potent and selective TAAR1 ligands such as (I) (RO5166017), (II) (RO5256390), RO5203648, and RO5263397. These compounds exhibit drug-like physicochem. properties, have good oral bioavailability, and display in vivo activity in a variety of animal models relevant for psychiatric diseases and addiction. In the experiment, the researchers used many compounds, for example, (R)-2-Amino-2-(3-chlorophenyl)ethanol (cas: 926291-77-2Related Products of 926291-77-2).

(R)-2-Amino-2-(3-chlorophenyl)ethanol (cas: 926291-77-2) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Related Products of 926291-77-2

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Alcohol – Wikipedia,
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Heterogeneous Catalysis for Oxidation of Alcohol via 1-Methyl-2-azaadamanane N-oxyl Immobilized on Magnetic Polystyrene Nanosphere was written by Guo, Xiaqun;Li, Meichao;Wang, Jianli;Li, Chunmei;Hu, Xinquan;Jin, Liqun;Sun, Nan;Hu, Baoxiang;Shen, Zhenlu. And the article was included in ChemistrySelect in 2022.SDS of cas: 873-76-7 This article mentions the following:

A highly promising heterogeneous strategy was describedn in which a catalytic amount of 1-methyl-2-azaadamanane N-oxyl immobilized on magnetic polystyrene nanosphere (1-Me-AZADO/MPNs) was used and a series of carbonyl compounds were obtained from various alcs. in 73-99% isolated yields and high selectivity (>99%) under Anelli conditions, thus offering a greener and more convenient methods in the synthesis of carbonyl compounds The attractive features of convenient magnetic separation (within seconds), good recyclability (up to 20 runs) and fast reaction rates (5-20 min) were very efficient to improve the utility of azaadamantane-type-nitroxyl radicals in the oxygenation. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7SDS of cas: 873-76-7).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.SDS of cas: 873-76-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Stimuli-responsive lipidic cubic phase: Triggered release and sequestration of guest molecules was written by Rahanyan-Kaegi, Nelli;Aleandri, Simone;Speziale, Chiara;Mezzenga, Raffaele;Landau, Ehud M.. And the article was included in Chemistry – A European Journal in 2015.Application In Synthesis of 3-(Hydroxymethyl)-4-nitrophenol This article mentions the following:

New stimuli-responsive nanomaterials, made up of host-guest lipidic cubic phases (LCPs) are presented. These biocompatible, stable, transparent and water-insoluble LCPs are composed of monoolein (MO) as a neutral host, and small amounts of one of three judiciously designed and synthesized designer lipids as guest that preserve the structure and stability of LCPs, but render them specific functionalities. Efficient pH- and light-induced binding, release and sequestration of hydrophilic dyes are demonstrated. Significantly, these processes can be performed sequentially, thereby achieving both temporal and dosage control, opening up the possibility of using such LCPs as effective carriers to be used in drug delivery applications. Specifically, because of the inherent optical transparency and mol. isotropy of LCPs they can be envisaged as light-induced drug carriers in ophthalmol. The results presented here demonstrate the potential of mol. design in creating new functional materials with predicted operating mode. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Application In Synthesis of 3-(Hydroxymethyl)-4-nitrophenol).

3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Application In Synthesis of 3-(Hydroxymethyl)-4-nitrophenol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Intramolecular Pd-Catalyzed Reductive Amination of Enolizable sp³-C-H Bonds was written by Ford, Russell L.;Alt, Isabel;Jana, Navendu;Driver, Tom G.. And the article was included in Organic Letters in 2019.Recommanded Product: (3-Methyl-2-nitrophenyl)methanol This article mentions the following:

A palladium-catalyzed reductive cyclization of nitroarenes has been designed to construct sp³-C-NHAr bonds from sp³-C-H bonds by using an enolizable nucleophile to intercept a nitrosoarene intermediate. Exposure of ortho-substituted nitroarenes to 5 mol % of Pd(OAc)₂ and 10 mol % of phenanthroline under 2 atm of CO constructs partially saturated 5-, 6-, or 7-membered N-heterocycles I (R¹ = H, Cl, Me, etc.; R² = H, F, Me, etc.; R³ = H, Me) using α-pyridyl carboxylates, malonates, 1,3-dimethylbarbituric acid, 1,3-diones, or difurans as the nucleophile. In the experiment, the researchers used many compounds, for example, (3-Methyl-2-nitrophenyl)methanol (cas: 80866-76-8Recommanded Product: (3-Methyl-2-nitrophenyl)methanol).

(3-Methyl-2-nitrophenyl)methanol (cas: 80866-76-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Recommanded Product: (3-Methyl-2-nitrophenyl)methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Biotransformation of 3-Methyl-4-nitrophenol, a Main Product of the Insecticide Fenitrothion, by Aspergillus niger was written by Kanaly, Robert A.;Kim, In Seon;Hur, Hor-Gil. And the article was included in Journal of Agricultural and Food Chemistry in 2005.Recommanded Product: 60463-12-9 This article mentions the following:

Biotransformation of the environmental pollutant 3-methyl-4-nitrophenol (MNP), a newly characterized estrogenic chem., and the primary breakdown product of the heavily used insecticide fenitrothion was investigated using a common soil fungus. In 96 h, daily culture sacrifice, extraction, and anal. showed that the filamentous fungus, Aspergillus niger VKM F-1119, removed more than 85% of the MNP present in solution (original concentration = 25 mg/L), mostly through biodegradation Addnl., in 16-day time-course studies, A. Niger was capable of biotransformation of MNP at concentrations as high as 70 mg/L. Gas chromatog. mass spectroscopy (MS) analyses of culture fluid extracts indicated the formation of four metabolites: 2-methyl-1,4-benzenediol, 4-amino-3-methylphenol, and two singly hydroxylated derivatives of MNP. Culture scale up and metabolite anal. by liquid chromatog. MS resulted in the confirmation of the original metabolites plus the detection of an azo derivative metabolite that has not been previously reported before during MNP biodegradation by any micro-organisms. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Recommanded Product: 60463-12-9).

3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Recommanded Product: 60463-12-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Design, Synthesis, and Evaluation of Trivalent PROTACs Having a Functionalization Site with Controlled Orientation was written by Huang, Yifan;Yokoe, Hiromasa;Kaiho-Soma, Ai;Takahashi, Kazunori;Hirasawa, Yusuke;Morita, Hiroshi;Ohtake, Fumiaki;Kanoh, Naoki. And the article was included in Bioconjugate Chemistry in 2022.Related Products of 111-46-6 This article mentions the following:

Trivalent PROTACs having a functionalization site with controlled orientation were designed, synthesized, and evaluated. Based on the X-ray structure of BRD protein degrader MZ1 (1) in complex with human VHL and BRD4^BD2, we expected that the 1,2-disubstituted Et group near the JQ-1 moiety in MZ1 (1) could be replaced by a planar benzene tether as a platform for further functionalization. To test this hypothesis, we first designed six divalent MZ1 derivatives, 2a-c and 3a-c, by combining three variations of substitution patterns on the benzene ring (1,2-, 1,3-, and 1,4-substitution) and two variations in the number of ethylene glycol units (2 or 1). We then tested the synthesized compounds for the BRD4 degradation activity of each. As expected, we found that 1,2D-EG2-MZ1 (2a)(I), an MZ1 derivative with 1,2-disubstituted benzene possessing two ethylene glycol units, had an activity profile similar to that of MZ1 (1). Based on the structure of 2a, we then synthesized and evaluated four isomeric trivalent MZ1 derivatives, 15a-15d, having a tert-Bu ester unit on the benzene ring as a handle for further functionalization. Among the four isomers, 1,2,5T-EG2-MZ1 (15c)(II) retained a level of BRD4 depletion activity similar to that of 2a without inducing a measurable Hook effect, and its BRD4 depletion kinetics was the same as that of MZ1 (1). Other isomers were also shown to retain BRD4 depletion activity. Thus, the trivalent PROTACs we synthesized here may serve as efficient platforms for further applications. In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6Related Products of 111-46-6).

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Related Products of 111-46-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zinc polyoxometalate immobilized on ionic liquid-modified MCM-41: an efficient reusable catalyst for the selective oxidation of alcohols with hydrogen peroxide was written by Hajian, Robabeh;Jafari, Fereshteh. And the article was included in Journal of the Iranian Chemical Society in 2019.Product Details of 1777-82-8 This article mentions the following:

In this study, Keggin-type polyoxometalate [n-C₄H₉)₄N]_x[PW₁₁ZnO₃₉].nH₂O was successfully immobilized on imidazole-functionalized ionic liquid-modified mesoporous MCM-41 by phys. adsorption. The PW₁₁Zn@MCM-41-Im was characterized by FT-IR, ICP, XRD, SEM, nitrogen adsorption and desorption and DRUV-Vis anal. The results indicated that ZnPW₁₁ could be successfully immobilized on mesoporous MCM-41-Im. This heterogeneous catalyst showed high catalytic performance and excellent selectivity in the oxidation of alcs. to the corresponding carbonyl groups with hydrogen peroxide. Furthermore, the supported ionic liquid catalyst was recovered by simple filtration and reused in four reaction runs with the preserve of the catalytic activity. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Product Details of 1777-82-8).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Product Details of 1777-82-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Theoretical and experimental evidence for the action of terpenes as modulators in lung function was written by Zoenker, K. S.;Bluemel, G.;Probst, J.;Reiterer, W.. And the article was included in Progress in Respiration Research (1963-1994) in 1984.Application of 2451-01-6 This article mentions the following:

The terpenes tested (Pinocarveol  [5947-36-4], Terpin hydrate  [2451-01-6], Myrtenol  [515-00-4], Myrtenal  [564-94-3], Verbenone  [80-57-9], and Trans-verbenol  [1820-09-3]) all decreased the surface tension of a dipalmitoyllecithin monolayer and/or natural rat surfactant, indicating that if they could be placed at the air/water/lipid interface within the alveolar lining layer, they may be able to restore pulmonary function. In rabbits with natural tracheobronchial catarrhal effects, terpenes inhibited mucus secretion, decreased mucus deposition and increased the cilia-mediate mucus transport, indicating that terpenes may change the viscoelasticity of the mucus. In patients with chronic obstructive pulmonary disease, terpenes had variable effects. The use of the terpenes in patients with surfactant/lung function impairment is discussed. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Application of 2451-01-6).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Application of 2451-01-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tris(tetrabutylammonium) hexakis(tert-butanethiolato-κS)hepta-μ₃-chlorido-μ₃-sulfidohexamolybdate dihydrate was written by Petrov, Pavel A.;Naumov, Dmitry Yu.;Konchenko, Sergey N.. And the article was included in Acta Crystallographica, Section E: Structure Reports Online in 2012.Quality Control of Sodium 2-methyl-2-propanethiolate This article mentions the following:

The octahedral cluster core of the anion in the structure of the title compound, (C₁₆H₃₆N)₃[Mo₆(C₄H₉S)₆(μ₃-Cl)₇(μ₃-S)]·2H₂O, has 3̅ site symmetry. Two μ₃-Cl atoms fully occupy positions in the cluster core, while the remaining six positions are statistically occupied by Cl and S atoms in a 1:5 ratio. The fully occupied Cl-atom positions are located on sites with 3 symmetry, and the N atom of tetrabutylammonium cation is located on a site with 2 symmetry. The structure contains also two disordered solvent H₂O mols., one of which is located on a 3-fold rotation axis and the other in a general position, both with an occupancy of 0.25. The H₂O mols. are localized in cavities formed by the tetrabutylammonium cations and the tert-butanethiolate groups. The metal clusters are stacked in a cubic close packing arrangement along [001]. Crystallog. data and at. coordinates are given. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2Quality Control of Sodium 2-methyl-2-propanethiolate).

Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Quality Control of Sodium 2-methyl-2-propanethiolate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts