Tag: 100-200

(L)- or (D)-Valine tert-butylamide grafted on permethylated β-cyclodextrin derivatives as new mixed binary chiral selectors was written by Stephany, O.;Dron, F.;Tisse, S.;Martinez, A.;Nuzillard, J.-M.;Peulon-Agasse, V.;Cardinael, P.;Bouillon, J.-P.. And the article was included in Journal of Chromatography A in 2009.Product Details of 171032-87-4 This article mentions the following:

This work deals with the synthesis of two mixed binary chiral selectors prepared by grafting L– or D-valine tert-butylamide on permethylated cyclodextrin macrocycle. The enantioselective properties of the new chiral selectors diluted in OV11 polysiloxane (35% phenyl- and 65% methylsiloxane) were studied by injections of 117 racemic mixtures The mixed chiral selectors with L-valine and, to a lesser extent with D-valine, have an improved enantioselectivity toward amino acid derivatives by comparison to permethylated cyclodextrin. The enantioseparation capability of these new chiral selectors proved to be slightly less efficient than Chirasil-L-Val (Alltech) for amino acid derivatives, but it was extended to include terpenes, lactones, esters, aliphatic compounds and aryl alcs. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Product Details of 171032-87-4).

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Product Details of 171032-87-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Traceless Photolabile Linker Expedites the Chemical Synthesis of Complex Oligosaccharides by Automated Glycan Assembly was written by Le Mai Hoang, Kim;Pardo-Vargas, Alonso;Zhu, Yuntao;Yu, Yang;Loria, Mirco;Delbianco, Martina;Seeberger, Peter H.. And the article was included in Journal of the American Chemical Society in 2019.Electric Literature of C7H7NO4 This article mentions the following:

Automated glycan assembly (AGA) aims at accelerating access to synthetic oligosaccharides to meet the demand for defined glycans as tools for mol. glycobiol. The linkers used to connect the growing glycan chain to the solid support play a pivotal role for the synthetic strategy as they determine all chem. conditions used during the synthesis and the form of the glycan obtained at the end of it. Here, we describe a traceless photolabile linker to prepare carbohydrates with a free reducing end. Modification of the o-nitrobenzyl scaffold of the linker is key to high yields and compatibility with the AGA work-flow. The assembly of an asym. bi-antennary N-glycan from oligosaccharide fragments prepared by AGA and linear as well as branched β-oligoglucans are described to illustrate the power of the method. These substrates will serve as standards and biomarkers to examine the unique specificity of glycosyl hydrolases. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Electric Literature of C7H7NO4).

3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Electric Literature of C7H7NO4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Enantioselective C-H bond functionalization of aromatic ketones with 1,6-enynes via photoredox/cobalt dual catalysis was written by Maji, Kakoli;Thorve, Pradip Ramdas;Rai, Pramod;Maji, Biplab. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2022.Formula: C10H20O This article mentions the following:

An enantioselective ortho-C(sp₂)-H functionalization of ketones/esters, e.g., I (R¹ = Me, Et, Ph, OMe; R² = H, 4-F, 3-MeO, 3,4-benzo, etc.) with 1,6-enynes II [Ar = Ph, X = NTs, O, C(COOMe)₂; Ar = 3-ClC₆H₄, 4-MeOC₆H₄, 3,5-Me₂C₆H₃, etc., X = NTs] is demonstrated via photoredox/cobalt dual catalysis. The method provides the corresponding arylmethylene-substituted carbo- and heterocycles III in high yields with functional group tolerance and selectivity. Mechanistic studies suggested the operation of visible-light mediated low-valent cobalt complex generation, intramol. cyclization, ortho-C-H bond insertion, and reductive elimination as the key mechanistic steps. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Formula: C10H20O).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Formula: C10H20O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nonprotein Based Enrichment Method to Analyze Peptide Cross-Linking in Protein Complexes was written by Yan, Funing;Che, Fa-Yun;Rykunov, Dmitry;Nieves, Edward;Fiser, Andras;Weiss, Louis M.;Hogue Angeletti, Ruth. And the article was included in Analytical Chemistry (Washington, DC, United States) in 2009.Computed Properties of C7H7NO4 This article mentions the following:

Crosslinking anal. of protein complexes and structures by tandem mass spectrometry (MS/MS) has advantages in speed, sensitivity, specificity, and the capability of handling complicated protein assemblies. However, detection and accurate assignment of the cross-linked peptides are often challenging due to their low abundance and complicated fragmentation behavior in collision-induced dissociation (CID). To simplify the MS anal. and improve the signal-to-noise ratio of the cross-linked peptides, the authors developed a novel peptide enrichment strategy that utilizes a cross-linker with a cryptic thiol group and using beads modified with a photocleavable cross-linker. The functional cross-linkers were designed to react with the primary amino groups in proteins. Human serum albumin was used as a model protein to detect intra- and intermol. cross-linkages. Use of this protein-free selective retrieval method eliminates the contamination that can result from avidin-biotin based retrieval systems and simplifies data anal. These features may make the method suitable to investigate protein-protein interactions in biol. samples. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Computed Properties of C7H7NO4).

3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Computed Properties of C7H7NO4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

C-H and C-S Bond Cleavage in Uranium(III) Thiolato Complexes was written by Arliguie, Therese;Lescop, Christophe;Ventelon, Lionel;Leverd, Pascal C.;Thuery, Pierre;Nierlich, Martine;Ephritikhine, Michel. And the article was included in Organometallics in 2001.Electric Literature of C4H9NaS This article mentions the following:

Reduction of the uranium(IV) thiolates Cp^*₂U(SR)₂ (Cp^* = η-C₅Me₅, R = Ph, Me, ⁱPr or ^tBu) with sodium amalgam afforded the corresponding U(III) complexes Na[Cp^*₂U(SR)₂] (R = Ph, 2a; Me, 2b; ⁱPr, 2c) or the U(IV) sulfide Na[Cp^*₂U(S^tBu)(S)]. C-S bond cleavage of a thiolate ligand was also observed during the thermal decomposition of 2c into the sulfide Na[Cp^*₂U(SⁱPr)(S)], whereas 2b was transformed in refluxing THF into the thiametallacyclopropane complex Na[Cp^*₂U(SMe)(SCH₂)], resulting from C-H bond activation of a SMe group. The x-ray crystal structures of [Na(18-crown-6)(THF)₂][Cp^*₂U(SⁱPr)₂], [Na(18-crown-6)][Cp^*₂U(S^tBu)(S)], and [Na(18-crown-6)(THF)₂][Cp^*₂U(SMe)(SCH₂)] have been determined In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2Electric Literature of C4H9NaS).

Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Electric Literature of C4H9NaS

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis and structure activity relationships of cyanopyridone based anti-tuberculosis agents was written by Jian, Yanlin;Hulpia, Fabian;Risseeuw, Martijn D. P.;Forbes, He Eun;Munier-Lehmann, Helene;Caljon, Guy;Boshoff, Helena I. M.;Van Calenbergh, Serge. And the article was included in European Journal of Medicinal Chemistry in 2020.Related Products of 2968-93-6 This article mentions the following:

The synthesis of a series of aryl-shifted cyanopyridone analogs I [R = H, 2-Cl, OPh, etc.; R¹ = H, 4-ClC₆H₄O, OBn, etc.; R² = H, 4-Cl, 4-MeC₆H₄O, etc.] was reported. These compounds generally lacked significant MtbTMPK inhibitory potency, but some analogs did exhibit promising antitubercular activity. Analog I [R = H; R¹ = H; R² = 4-Ph] demonstrated a 10-fold increased antitubercular activity. Many analogs with whole-cell antimycobacterial activity were devoid of significant cytotoxicity. In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6Related Products of 2968-93-6).

2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Related Products of 2968-93-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A New Combination Inhibitor Based on Tomato Pomace Extract and Organosilane for Enhanced Anticorrosion Performance of Steel was written by Vorobyova, Viktoria;Skiba, Margarita;Julia, Zaporozhets. And the article was included in Chemistry Africa in 2022.Formula: C10H14O This article mentions the following:

The study aims to assess the effect of extract based inhibiting mixture, i.e., tomato pomace and organosilanes (Vinyltrimethoxysilane (VS)) against corrosion of steel in atm. environment. Such compositions can be used as polymer-type corrosion inhibitors for steel. The developed blend VCI based on tomato pomace extract (TPE) and organosilane provide a long-term protection from corrosion processes under the model conditions of carbon steel. The results show that the protection efficiency of the film reaches 96.97%. The tomato pomace extract chem. composition was analyzed by Head Space-Solid Phase Micro Extraction-Gas Chromatog.-Mass Spectrometry (HS-SPME-GC-MS). The major volatile compounds ot the TPE include alcs., esters, aldehydes, ketones and terpene compounds as described by panelists of HS-SPME-GC-MS. Electrochem. studies reveal decreased corrosion current densities from 4.29 x 10-4 to 0.65 x 10-4 A cm^-2 and increased polarization resistance under the conditions of periodic moisture condensation. FT-IR absorption peak obtained at 954, 1142, 1230 cm^-1 revealed the formation of Fe-O-Si, Si-O-Si and Si-O-C bonds. The protective film consesed of silane and extract offered the highest corrosion resistance since the corrosion protective barrier minimized the oxygen access and prevented corrosion of mild steel to a greater extent where the EDX anal. showed a high intense signal of Si and C. The mixture of phytochem. extract and organosilane were incorporated in a paint coating. The addition of additive increases the inhibitory properties of the final coating while keeping the barrier properties of the coating. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Formula: C10H14O).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Formula: C10H14O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The marked influence of steric and electronic properties of ancillary pyridylthioether ligands on the rate of allene insertion into the palladium-carbon bond was written by Canovese, Luciano;Visentin, Fabiano;Chessa, Gavino;Santo, Claudio;Uguagliati, Paolo;Bandoli, Giuliano. And the article was included in Journal of Organometallic Chemistry in 2002.Application In Synthesis of Sodium 2-methyl-2-propanethiolate This article mentions the following:

Neutral Me chloro complexes (L)Pd(Me)Cl 1 containing 6-R’-2-R-thiomethylpyridine ancillary ligands L (R’N-SR, R’ = H, Me, Cl; R = Me, Et, CHMe₂, CMe₃, Ph) were obtained by reaction of L with (COD)Pd(Me)Cl. Complexes 1 were carbonylated with CO to give corresponding acetyl derivatives 2. Kinetics of insertion of 1,1-dimethylpropadiene and 1,1,3,3-tetramethylpropadiene into the palladium-carbon bond in 1 and 2 was studied by ¹H-NMR and UV-vis techniques. The rate of reaction is strongly dependent on the steric and electronic properties of the ancillary ligand and of the allene. The distortion induced by R’ on the main coordination plane of the complex (allowed by sulfur sp³ hybridization) activates the complex to nucleophilic attack by the allene. Increase of electrophilicity of the palladium core, caused by lowering of the basicity of L results in further enhancement of the rate of allene insertion. The rate constants for complexes with L = 6-chloro-2-phenylthiomethylpyridine (ClN-SPh) are the greatest observed so far for similar reactions. The associative asynchronous mechanism of the insertion reaction is discussed. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2Application In Synthesis of Sodium 2-methyl-2-propanethiolate).

Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Application In Synthesis of Sodium 2-methyl-2-propanethiolate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Exploiting the enzymatic machinery of Arthrobacter atrocyaneus for oxidative kinetic resolution of secondary alcohols was written by Silva, Camila R.;Souza, Juliana C.;Araujo, Lidiane S.;Kagohara, Edna;Garcia, Thais P.;Pelizzari, Vivian H.;Andrade, Leandro H.. And the article was included in Journal of Molecular Catalysis B: Enzymatic in 2012.Recommanded Product: 171032-87-4 This article mentions the following:

We evaluated Arthrobacter atrocyaneus (R1AF57) as producer of oxidoreductases for oxidative kinetic resolution of racemic secondary alcs. via oxidation reaction. This bacterium was isolated from Amazon soil samples using medium enriched with (RS)-1-(4-methylphenyl)ethanol as a carbon source. The kinetic resolution of several secondary alcs. through enantioselective oxidation mediated by resting cells and growing cells of A. atrocyaneus was efficiently achieved for the most alcs. In general, it was possible to obtain only the (S)-enantiomer from (RS)-1-arylethanols. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Recommanded Product: 171032-87-4).

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Recommanded Product: 171032-87-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Second-Generation Palladium Catalyst System for Transannular C-H Functionalization of Azabicycloalkanes was written by Cabrera, Pablo J.;Lee, Melissa;Sanford, Melanie S.. And the article was included in Journal of the American Chemical Society in 2018.Product Details of 230615-52-8 This article mentions the following:

This article describes the development of a second-generation catalyst system for the transannular C-H functionalization of alicyclic amines. Pyridine- and quinoline-carboxylate ligands are shown to be highly effective for increasing the reaction rate, yield, and scope of Pd-catalyzed transannular C-H arylation reactions of azabicyclo[3.1.0]hexane, azabicyclo[3.1.1]heptane, azabicyclo[3.2.1]octane, and piperidine derivatives Mechanistic studies reveal that the pyridine/quinoline-carboxylates play a role in impeding both reversible and irreversible catalyst decomposition pathways. These ligands enable the first reported examples of the transannular C-H arylation of the ubiquitous tropane, 7-azanorbornane, and homotropane cores. Finally, the pyridine/quinoline-carboxylates are shown to promote both transannular C-H arylation and transannular C-H dehydrogenation on a homotropane substrate. In the experiment, the researchers used many compounds, for example, 2,3,4,5-Tetrahydro-1H-1,5-methanobenzo[d]azepine hydrochloride (cas: 230615-52-8Product Details of 230615-52-8).

2,3,4,5-Tetrahydro-1H-1,5-methanobenzo[d]azepine hydrochloride (cas: 230615-52-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Product Details of 230615-52-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts