Tag: 100-200

Ruthenium(II) Complexes of Monodonor Ligands: Efficient Reagents for Asymmetric Ketone Hydrogenation was written by Xu, Yingjian;Clarkson, Guy C.;Docherty, Gordon;North, Carl L.;Woodward, Gary;Wills, Martin. And the article was included in Journal of Organic Chemistry in 2005.Related Products of 120121-01-9 This article mentions the following:

A series of BINOL-derived ligands have been prepared and incorporated into ruthenium(II) complexes containing a diamine ligand. The complexes have proven to be excellent catalysts for the asym. hydrogenation of ketones, giving reduction products with enantiomeric excesses of up to 99%. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Related Products of 120121-01-9).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Related Products of 120121-01-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Eugenol and carvacrol attenuate brain D-galactose-induced aging-related oxidative alterations in rats was written by El-Far, Ali H.;Mohamed, Hadeer H.;Elsabagh, Doaa A.;Mohamed, Shymaa A.;Noreldin, Ahmed E.;Al Jaouni, Soad K.;Alsenosy, Abdelwahab A.. And the article was included in Environmental Science and Pollution Research in 2022.Computed Properties of C10H14O This article mentions the following:

Aging represents the accumulation of progressive changes in a human being over time and can cover phys., psychol., and social changes. It is an oxidative stress-associated process that progresses with age. The antioxidant activity of either eugenol (EU) or carvacrol (CAR) for aging in rats induced by D-gal for 42 days was investigated in the current study using 10 and 20 mg of EU/kg/day/orally, while CAR was supplemented by 40 and 80 mg /kg/day/orally. Biochem., mRNA expression, and histopathol. assessments of brain samples evaluated the oxidative alterations induced by D-gal and the protective role of EU and CAR. Results showed that D-gal was causing oxidative alternation of the brain that was recognized via upregulation of p53 and p21 mRNA expression levels, as aging markers and Bax mRNA expression level, as an apoptotic marker. Also, the results observed alterations in the levels of biochem. markers as creatine phosphokinase (CPK) and triacylglycerol (TAG), besides, enhancement of brain antioxidant capacity. Finally, these results compared with the groups treated with EU and CAR to observe that the EU and CAR potentially attenuate these aging-related oxidative alterations in a dose-dependent manner. Finally, we can conclude that EU and CAR supplementations are considered promising natural protective compounds that could delay aging and maintain health. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Computed Properties of C10H14O).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Computed Properties of C10H14O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Drug discovery based on the structure of FKBPs: design, synthesis and evaluation of L-1,4-thiazane-3-carboxylic acid derivatives as neuroimmunophilin ligands was written by Nie, Ai Hua;Xiao, Jun Hai;Liu, Hong Ying;Li, Li Wang;Li, Song. And the article was included in Chinese Chemical Letters in 2005.Computed Properties of C9H9F3O This article mentions the following:

Based on the structure of FK506, FKBP12 and calcineurin complex and the interactive characteristics of small mol. ligands with FK-506-binding proteins (FKBPs), a series of L-tetrahydro-1,4-thiazine-3-carboxylic acid derivatives I [X = O, R = PhCH₂NMeCH₂CH₂, PhCH:CHCH₂, 3-cyclohexylpropyl, 4-O₂NC₆H₄CH₂, etc.; X = NH, R = Me₂CHCH₂CH(CO₂Et), PhCH₂CH(CO₂CH₂Ph), etc.] was designed and synthesized as neuroimmunophilin ligands. The results of evaluation show that I [X = O; R = (PhCH₂OCH₂)₂CH] (N308) has a great promise as a candidate of neuroprotective and neuroregenerative agent. In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5Computed Properties of C9H9F3O).

2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Computed Properties of C9H9F3O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Metabolomics analysis of freeze-thaw tolerance enhancement mechanism of ε-poly-L-lysine on industrial yeast was written by Lu, Lu;Zhu, Ke-Xue;Yang, Zhen;Guo, Xiao-Na;Xing, Jun-Jie. And the article was included in Food Chemistry in 2022.Name: (2R,3S)-rel-Butane-1,2,3,4-tetraol This article mentions the following:

Antimicrobial polycationic peptide ε-poly-L-lysine (ε-PL) enhanced the freeze-thaw tolerance of industrial yeast; the enhancement mechanism of ε-PL on yeast was studied. The results showed that a ε-PL coating was observed in ε-PL-treated yeast. After 4 times of freeze-thaw, the cell viability, glycerol content, and CO2 production of 0.6 mg/mL ε-PL-treated yeast were higher than those of untreated yeast, specifically, the cell viability of ε-PL-treated yeast was 87.6%, and that of untreated yeast was 68.5%. Metabolomic results showed that the enhancement mechanism of ε-PL on yeast was related to the promotion of cell membrane-related fatty acid synthesis pathways before freeze-thaw treatment, and the promotion of biosynthesis and glycerophospholipid metabolism pathways after freeze-thaw. Furthermore, ε-PL induced inhibition of the tricarboxylic acid cycle, resulting in a longer stationary phase at the beginning of the freeze-thaw and ultimately providing a higher level of freeze-thaw stress tolerance than untreated yeast. In the experiment, the researchers used many compounds, for example, (2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6Name: (2R,3S)-rel-Butane-1,2,3,4-tetraol).

(2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Name: (2R,3S)-rel-Butane-1,2,3,4-tetraol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Development of an N-Terminal BRD4 Bromodomain-Targeted Degrader was written by Divakaran, Anand;Scholtz, Cole R.;Zahid, Huda;Lin, Wenwei;Griffith, Elizabeth C.;Lee, Richard E.;Chen, Taosheng;Harki, Daniel A.;Pomerantz, William C. K.. And the article was included in ACS Medicinal Chemistry Letters in 2022.Synthetic Route of C10H14O This article mentions the following:

Targeted protein degradation is a powerful induced-proximity tool to control cellular protein concentrations using small mols. However, the design of selective degraders remains empirical. Among bromodomain and extra-terminal (BET) family proteins, BRD4 is the primary therapeutic target over family members BRD2/3/T. Existing strategies for selective BRD4 degradation use pan-BET inhibitors optimized for BRD4:E3 ubiquitin ligase (E3) ternary complex formation, but these result in residual inhibition of undegraded BET-bromodomains by the pan-BET ligand, obscuring BRD4-degradation phenotypes. Using our selective inhibitor of the first BRD4 bromodomain, iBRD4-BD1 (I) (IC₅₀ = 12 nM, 23- to 6200-fold intra-BET selectivity), we developed dBRD4-BD1 to selectively degrade BRD4 (DC₅₀ = 280 nM). Notably, dBRD4-BD1 upregulates BRD2/3, a result not observed with degraders using pan-BET ligands. Designing BRD4 selectivity up front enables anal. of BRD4 biol. without wider BET-inhibition and simplifies designing BRD4-selective heterobifunctional mols., such as degraders with new E3 recruiting ligands or for addnl. probes beyond degraders. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Synthetic Route of C10H14O).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Synthetic Route of C10H14O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Structural Diversities of Silver(I) Coordination Compounds with Flexible Dithioether Ligands Based upon Changing the Ligand Spacers was written by Li, Jian-Rong;Zhang, Ruo-Hua;Bu, Xian-He. And the article was included in Crystal Growth & Design in 2003.SDS of cas: 29364-29-2 This article mentions the following:

To study the influences of ligand spacers of flexible bis(thioether) bridging ligands on the framework formations of their complexes, six new Ag^I coordination compounds with structurally related bis(tert-butylthio)alkane ligands, Lⁿ = Me₃CS-(CH₂)_n-SCMe₃ where n = 1-6, [(AgL¹)ClO₄]_n (1), {[Ag(L²)_1.5]ClO₄}_n (2), [(AgL³)ClO₄]₂ (3), {[Ag(L⁴)_1.5]ClO₄}_n (4), [(AgL⁵)ClO₄]₂ (5), and {[Ag(L⁶)_1.5]ClO₄}_n (6), were synthesized and structurally characterized by elemental anal., IR, ¹H NMR spectra, and x-ray crystallog. In 1, the Ag^I centers are linked by bridging L¹ to form a 1-dimensional (1-D) zigzag chain, and 2 has an extended two-dimensional (2-D) (6,3) topol. array with hexagonal 30-membered macrometallacycles. Complexes 3 and 5 show similar discrete dinuclear structures. Complexes 4 and 6 consist of single-double bridging chains in which dinuclear macrometallacycles are further linked by single bridging L ligands. The differences among these structures indicate that the spacers of ligands have important effects on the framework formation of their Ag^I complexes, and this presents a feasible way for controlling the structures of such complexes by modifying the ligand spacers. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2SDS of cas: 29364-29-2).

Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.SDS of cas: 29364-29-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cryptococcus laurentii as a new biocatalyst for the asymmetric reduction of substituted acetophenones was written by Kurbanoglu, Esabi B.;Zilbeyaz, Kani;Kurbanoglu, Namudar I.. And the article was included in Tetrahedron: Asymmetry in 2011.Quality Control of (S)-1-(2-Fluorophenyl)ethanol This article mentions the following:

Immobilized cells of the yeast Cryptococcus laurentii attached to calcium alginate have been introduced as a biocatalyst in the asym. reduction of substituted acetophenones. Forty isolates of microorganisms belonging to this taxonomical yeast group were isolated from various samples. Immobilized cells of these isolates were screened as reducing agents for acetophenone 1a to its corresponding alc. 1b. The four best isolates were selected and identified as Rhodotorula glutinis, Saccharomyces cerevisiae, Hansenula capsulata and C. laurentii by the VITEK 2 compact system. The use of the first three microorganisms is well known and therefore it was decided to explore C. laurentii as a new biocatalyst in organic reactions. The aim was to determine whether C. laurentii could be used to catalyze the bio-reduction of ketones to obtain the (R)- or (S)-isomer of the alc. with high enantiomeric purity. The isolate C. laurentii EBK-19 was selected for further experiments and studied in detail. More than 70% of the ketones tested were obtained with almost complete conversion (100%), while all the ketones tested were converted to the corresponding (S)-isomer-alcs. in up to > 99% enantiomeric excess (ee) under very mild reaction conditions. Amongst the chiral alcs. obtained, the enantiopure 1b obtained from the complete conversion of 1a using C. laurentii EBK-19 was produced on a large scale (9.3 g) using an immobilized cell reaction system. In conclusion, we have presented C. laurentii as a promising biocatalyst for the production of optically active phenylethanols. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Quality Control of (S)-1-(2-Fluorophenyl)ethanol).

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Quality Control of (S)-1-(2-Fluorophenyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Water-Triggered Metal-Free Synthesis of Pyranopyrazoles via One-Pot Oxidation/Michael Addition/Cyclization/Dehydration Sequence. was written by Dandia, Anshu;Bansal, Sarika;Sharma, Ruchi;Parewa, Vijay. And the article was included in ChemistrySelect in 2018.HPLC of Formula: 1777-82-8 This article mentions the following:

An ”all water” strategy for the catalyst free chemo-selective synthesis of pyranopyrazoles via the reaction of 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one with benzyl alcs. was developed. Water actuated the reaction via ‘electrophile-nucleophile dual activation’ of the reactants through the concerted hydrogen bonding network and impel the reactants for C-C bond formation. Reaction proceeded by metal and catalyst free oxidation-Michael addition-cyclization-dehydration sequence. This method gave pyrano[[2, 3-c:6,5-c’]dipyrazol]-2-ones selectivity over other possible products. Furthermore, this method was also applied on the reaction of the benzyl alcs. and dimedone to give arylmethylene[bis(5,5-dimethyl-3-hydroxy-2-cyclohexene-1-ones)] in good to excellent yields. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8HPLC of Formula: 1777-82-8).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.HPLC of Formula: 1777-82-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Preparation and characterization of discrete mass polyether-based polyurethane oligomers was written by Tomlinson, Ian D.;May, Jody C.;Harris, Rachel A.;Buck, Kevin M.;Rosenthal, Sandra J.;McLean, John A.;Hercules, David M.. And the article was included in Polymer in 2022.Application In Synthesis of 2,2′-Oxybis(ethan-1-ol) This article mentions the following:

Polyurethanes are specialized polymeric materials with a diverse range of applications including foams, insulators, sealants, adhesives and elastomers. Anal. of these materials utilizing mass spectrometry is hampered by the polydispersity and the range of isomeric products produced during the polymerization process. To aid with the mass spectral studies of these materials we have developed methodologies to synthesize discreet polyether-based polyurethane oligomers that may be studied by mass spectrometry and used as standards in the anal. of more complex polymer products. We have synthesized oligomers consisting of polyethylene glycol and poly(tetrahydrofuran) adducts of methylene di-Ph diisocyanate (MDI) and characterized these by NMR and mass spectrometry. These oligomers represent both sym. and asym. polyurethane derivatives In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6Application In Synthesis of 2,2′-Oxybis(ethan-1-ol)).

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Application In Synthesis of 2,2′-Oxybis(ethan-1-ol)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

An outstanding catalyst for asymmetric transfer hydrogenation in aqueous solution and formic acid/triethylamine was written by Matharu, Daljit S.;Morris, David J.;Clarkson, Guy J.;Wills, Martin. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2006.Formula: C8H9ClO This article mentions the following:

A Rh/tetramethylcyclopentadienyl complex containing a tethered functionality has been demonstrated to give excellent results in the asym. transfer hydrogenation of ketones in both aqueous and formic acid/triethylamine media. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Formula: C8H9ClO).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Formula: C8H9ClO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts