Tag: 100-200

A Fully Biobased Aromatic Polyester Polyol for Polyisocyanurate Rigid Foams: Poly(diethylene furanoate) was written by Rhein, Michael;Demharter, Anton;Felker, Benjamin;Meier, Michael A. R.. And the article was included in ACS Applied Polymer Materials in 2022.Reference of 111-46-6 This article mentions the following:

Aromatic polyester polyols are often used in polyurethane rigid foam (PUR) and polyisocyanurate (PIR) synthesis, since they offer higher rigidity than polyether polyols. Herein, a route toward fully biobased aromatic polyester polyols was investigated using sugar-based 2,5-furandicarboxylic acid (FDCA) and diethylene glycol (DEG), enabling a direct one-step synthesis of a fully biobased aromatic polyester polyol, poly(diethylene furanoate) (PDEF), for applications in PIR rigid foam. Therefore, reaction conditions were optimized to obtain PDEF as a processable polyol with OH values and remaining unreacted DEG similar to a com., petroleum-based polyol. The processability was improved by either copolymerizing 10-20 mol % of a biobased aliphatic dicarboxylic acid, like succinic acid (SA) or adipic acid (AA), maintaining the fully biobased character of the polyol, or copolymerization with phthalic acid. The fully biobased polyester polyols were successfully prepared on a 100 g scale of dicarboxylic acids. Subsequent application in PIR rigid foam showed similar d., thermal conductivity, flame behavior, and compressive strength if compared to the rigid foam obtained from a com. polyol. Thus, fully biobased PDEF can substitute petroleum-based aromatic polyester polyols in PIR applications. In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6Reference of 111-46-6).

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Reference of 111-46-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

1-(Heteryloxy)silatranes was written by Iovel, I.;Golomba, L.;Popelis, J.;Grinberga, S.;Lukevics, E.. And the article was included in Chemistry of Heterocyclic Compounds (New York)(Translation of Khimiya Geterotsiklicheskikh Soedinenii) in 2000.Safety of 6-Methyl-2-pyridinemethanol This article mentions the following:

Novel heterocyclic 1-derivatives I of silatranes were obtained [R = Et, PhCH₂, 2-tetrahydrofurfuryl, 3-pyridinyl, and (6-methyl-2-pyridyl)methyl -]. The optimal synthetic method for these compounds is transesterification of tetraethoxysilane by an equimolar mixture of triethanolamine and a heterocyclic (or aromatic) hydroxyl-containing compound E.g., heating 0.01 mol each PhCH₂OH, N(CH₂CH₂OH)₃ and Si(OEt)₄ in 14 mL xylene containing 0.2 g KOH at (120-130°) gave 1-benzyloxysilatrane I (R = PhCH₂) in 75% yield. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Safety of 6-Methyl-2-pyridinemethanol).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Safety of 6-Methyl-2-pyridinemethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ruthenium Catalyzed N-Alkylation of Cyclic Amines with Primary Alcohols was written by Savela, Risto;Vogt, Dieter;Leino, Reko. And the article was included in European Journal of Organic Chemistry in 2020.SDS of cas: 1777-82-8 This article mentions the following:

A robust alc. amination protocol using common saturated amines and primary alcs. as starting materials is described. The reactions are catalyzed by combination of dichloro(p-cymene)ruthenium(II) dimer precatalyst with triphenylphosphine ligand, with the excess alc. substrate or toluene functioning as the solvent. The catalyst and ligand residues can be precipitated from the reaction media by addition of hexane or cold di-Et ether, followed by precipitation and isolation of the product as a hydrochloride salt. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8SDS of cas: 1777-82-8).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.SDS of cas: 1777-82-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Structural hybridization of pyrrolidine-based T-type calcium channel inhibitors and exploration of their analgesic effects in a neuropathic pain model was written by Son, Woo Seung;Jeong, Kyu-Sung;Lim, Sang Min;Pae, Ae Nim. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2019.Recommanded Product: 2-(4-(Trifluoromethyl)phenyl)ethanol This article mentions the following:

Highly effective and safe drugs for the treatment of neuropathic pain are urgently required and it was shown that blocking T-type calcium channels can be a promising strategy for drug development for neuropathic pain. We have developed pyrrolidine-based T-type calcium channel inhibitors by structural hybridization and subsequent assessment of in vitro activities against Ca_v3.1 and Ca_v3.2 channels. Profiling of in vitro ADME properties of compounds was also carried out. The representative compound 17h showed comparable in vivo efficacy to gabapentin in the SNL model, which indicates T-type calcium channel inhibitors can be developed as effective therapeutics for neuropathic pain. In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6Recommanded Product: 2-(4-(Trifluoromethyl)phenyl)ethanol).

2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Recommanded Product: 2-(4-(Trifluoromethyl)phenyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

An Improved Synthesis of 4-O-Benzoyl-2,2-difluorooleandrose from L-Rhamnose. Factors Determining the Synthesis of 2,2-Difluoro-Carbohydrates from 2-Uloses was written by Barrena, M. Isabel;Matheu, M. Isabel;Castillon, Sergio. And the article was included in Journal of Organic Chemistry in 1998.COA of Formula: C6H14O6 This article mentions the following:

4-O-Benzoyl-2,2-difluorooleandrose I has been synthesized from L-rhamnose via DAST difluorination of ulose II followed by chemoselective etherification. In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0COA of Formula: C6H14O6).

(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.COA of Formula: C6H14O6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Halobenzyl alcohols as structurally simple organogelators was written by Prathap, Annamalai;Ravi, Arthi;Pathan, Javed R.;Sureshan, Kana M.. And the article was included in CrystEngComm in 2019.Recommanded Product: 1777-82-8 This article mentions the following:

We report 11 simple halobenzyl alcs., each comprising of only 16 atoms, as organogelators for aliphatic hydrocarbon solvents. Comparison of PXRD profiles of wet gels and xerogels with the simulated profiles from the single crystal XRD data confirmed that the mol. packing in gels and crystals are identical. Therefore single crystal X-ray structures were analyzed to understand the mol. level interactions involved in the self-assembly in gel state. Each of these compounds undergoes a faster linear assembly along the crystallog. direction associated with the OH···O hydrogen bond and a supplementary non-covalent interaction (NCI). In directions perpendicular to the direction of OH···O Hydrogen bonding, mols. associate through various relatively weaker NCIs. Notably, halogen bonds, X···X, C-H···X interactions play major role in the lateral growth. In the case of gels, the linear growth is faster than lateral growth leading to the formation of long fibers, which entangles to a 3D fibrous network. This study reveals that halogen atoms in halobenzyl alcs. impart mol. features that contribute to their self-assembly in solution and hence in gelation. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Recommanded Product: 1777-82-8).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Recommanded Product: 1777-82-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Presence of polarization bonds in some copper(II) complexes was written by Hall, D.;McKinnon, A. J.;Waters, J. M.;Waters, T. N.. And the article was included in Nature (London, United Kingdom) in 1964.SDS of cas: 1122-71-0 This article mentions the following:

The structures of bis(N-methyl-2-hydroxy-1-naphthaldiminato)copper(II) (I) and a second crystal modification of bis(salicylaldehydrato)copper(II) (II) were determined by space group requirements and 3-dimensional Fourier syntheses. The space group of I is P2₁/n with Z = 2, a 3.86, b 19.55, c 12.57, and β = 91.1°. II belongs to space group P2₁/c with Z = 2, a 11.75, b 4.00, c 12.42, and β = 90.3°. I and II are essentially sq. planar but the mols. pack so that there is an axial approach of 2.94 and 3.15 A., resp., to the hydroxy O of neighboring mols. and thus a deviation from overall mol. planarity. Within one mol. the 2 ligands are individually planar but mean planes through them are separated by 1.16 A. and 0.36 A. The distortions indicate that definite weak interactions exist; polarization bonding is suggested. The polarization bonds can involve different regions of the ligand, being to the O of the chelated ring in II and to a C of the benzene ring in the previously reported modification of II. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0SDS of cas: 1122-71-0).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.SDS of cas: 1122-71-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Design and synthesis of phenethyl benzo[1,4]oxazine-3-ones as potent inhibitors of PI3Kinaseγ was written by Lanni, Thomas B.;Greene, Keri L.;Kolz, Christine N.;Para, Kimberly S.;Visnick, Melean;Mobley, James L.;Dudley, David T.;Baginski, Theodore J.;Liimatta, Marya B.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.Recommanded Product: 2-(4-(Trifluoromethyl)phenyl)ethanol This article mentions the following:

The Type 1 PI3-Kinases comprise a family of enzymes, which primarily phosphorylate PIP2 to give the second messenger PIP3, a key player in many intracellular signaling processes. Of the four type 1 PI3Ks, the γ-isoform, which is expressed almost exclusively in leukocytosis of particular interest with respect to its role in inflammatory diseases such as rheumatoid arthritis (RA) and chronic obstructive pulmonary disease (COPD). Investigation of a series of 4,6-disubstituted-4H-benzo[1,4]oxazin-3-ones, e.g., I, has led to the identification of single-digit nanomolar inhibitors of PI3Kγ, several of which had good cell based activity and were shown to be active in vivo in an aspectic peritonitis model of inflammatory cell migration. In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6Recommanded Product: 2-(4-(Trifluoromethyl)phenyl)ethanol).

2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Recommanded Product: 2-(4-(Trifluoromethyl)phenyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chokeberry Pomace as a Component Shaping the Content of Bioactive Compounds and Nutritional, Health-Promoting (Anti-Diabetic and Antioxidant) and Sensory Properties of Shortcrust Pastries Sweetened with Sucrose and Erythritol was written by Raczkowska, Ewa;Nowicka, Paulina;Wojdylo, Aneta;Styczynska, Marzena;Lazar, Zbigniew. And the article was included in Antioxidants in 2022.Quality Control of (2R,3S)-rel-Butane-1,2,3,4-tetraol This article mentions the following:

In this study, an attempt was made to develop shortcrust pastries containing different amounts of chokeberry pomace (0%, 10%, 30%, 50%), modulating their degree of sweetness via the application of sucrose or erythritol. The obtained products were assessed for their nutritional value (energy value, protein, fats, dietary fiber, sugars, minerals). Bioactive compounds, as well as antioxidant and anti-diabetic properties in an in vitro model and sensory attributes, were also analyzed. Increasing the proportion of chokeberry pomace in shortcrust pastries improved their nutritional value, especially their energy value (reduction of nearly 30% for shortcrust pastries with 50% pomace sweetened with erythritol), nutritional fiber content (10-fold higher in shortcrust pastries with the highest proportion of pomace) and potassium, calcium, magnesium, and iron content. Chokeberry pomace was also a carrier of 14 bioactive compounds The most beneficial antioxidant and anti-diabetic effect was shown for shortcrust pastries containing 50% chokeberry pomace. In addition, it was shown that the use of erythritol as a sweetener has a beneficial effect on the perception of sensory attributes. Finally, it was shown that the developed products could be excellent alternatives to traditional shortcrust pastries and, at the same time, be a good way to utilize waste from the fruit industry. In the experiment, the researchers used many compounds, for example, (2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6Quality Control of (2R,3S)-rel-Butane-1,2,3,4-tetraol).

(2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Quality Control of (2R,3S)-rel-Butane-1,2,3,4-tetraol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Varenicline: An α4β2 Nicotinic Receptor Partial Agonist for Smoking Cessation was written by Coe, Jotham W.;Brooks, Paige R.;Vetelino, Michael G.;Wirtz, Michael C.;Arnold, Eric P.;Huang, Jianhua;Sands, Steven B.;Davis, Thomas I.;Lebel, Lorraine A.;Fox, Carol B.;Shrikhande, Alka;Heym, James H.;Schaeffer, Eric;Rollema, Hans;Lu, Yi;Mansbach, Robert S.;Chambers, Leslie K.;Rovetti, Charles C.;Schulz, David W.;Tingley, F. David III;O’Neill, Brian T.. And the article was included in Journal of Medicinal Chemistry in 2005.Application of 230615-52-8 This article mentions the following:

Herein we describe a novel series of compounds from which varenicline (1, 6,7,8,9-tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine) has been identified for smoking cessation. Neuronal nicotinic acetylcholine receptors (nAChRs) mediate the dependence-producing effects of nicotine. We have pursued α4β2 nicotinic receptor partial agonists to inhibit dopaminergic activation produced by smoking while simultaneously providing relief from the craving and withdrawal syndrome that accompanies cessation attempts. Varenicline displays high α4β2 nAChR affinity and the desired in vivo dopaminergic profile. In the experiment, the researchers used many compounds, for example, 2,3,4,5-Tetrahydro-1H-1,5-methanobenzo[d]azepine hydrochloride (cas: 230615-52-8Application of 230615-52-8).

2,3,4,5-Tetrahydro-1H-1,5-methanobenzo[d]azepine hydrochloride (cas: 230615-52-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Application of 230615-52-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts