Tag: 100-200

Dryzhakov, Marian;Moran, Joseph published 《Autocatalytic Friedel-Crafts Reactions of Tertiary Aliphatic Fluorides Initiated by B(C₆F₅)₃·H₂O》. The research results were published in《ACS Catalysis》 in 2016.Name: 3,7-Dimethyloctan-3-ol The article conveys some information:

The C-F bond is the strongest single bond to carbon, constituting an intrinsic challenge for selective catalytic activation in the presence of other functional groups. Existing methods for the activation of tertiary aliphatic fluorides involve stoichiometric abstraction with fluorophilic Lewis acids or by Lewis-acid-catalyzed trapping with Si reagents. Herein, we describe a B(C₆F₅)₃·H₂O-catalyzed Friedel-Crafts reaction of tertiary alkyl fluorides that proceeds rapidly at room temperature without trapping reagents. The method is completely selective for F^– over traditionally better leaving groups and displays an autocatalytic kinetic profile. The experimental procedure involved many compounds, such as 3,7-Dimethyloctan-3-ol (cas: 78-69-3) .

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Name: 3,7-Dimethyloctan-3-ol Metabolite observed in cancer metabolism. It has a role as a human metabolite.

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Category: alcohols-buliding-blocks《Inhibition of colitis by ring-modified analogues of 6-acetamido-2,4,5-trimethylpyridin-3-ol》 was published in 2020. The authors were Chaudhary, Chhabi Lal;Chaudhary, Prakash;Dahal, Sadan;Bae, Dawon;Nam, Tae-gyu;Kim, Jung-Ae;Jeong, Byeong-Seon, and the article was included in《Bioorganic Chemistry》. The author mentioned the following in the article:

6-Aminopyridin-3-ol scaffold has shown an excellent anti-inflammatory bowel disease activity. Various analogs with the scaffold were synthesized in pursuit of the diversity of side chains tethering on the C(6)-position. SAR among the analogs was investigated to understand the effects of the side chains and their linkers on their anti-inflammatory activities. In this study, structural modification moved beyond side chains on the C(6)-position and reached to pyridine ring itself. It expedited to synthesize diverse ring-modified analogs of a representative pyridine-3-ol, 6-acetamido-2,4,5-trimethylpyridin-3-ol. In the evaluation of compounds on their inhibitory actions against TNF-α-induced adhesion of monocytic cells to colonic epithelial cells, an in vitro model mimicking colon inflammation, the effects of compounds I , II, and III were greater than tofacitinib, an orally available anti-colitis drug, and compound dehydroxylated analog II exhibit the greatest activity. In addition, TNF-α-induced angiogenesis, which permits more inflammatory cell migration into inflamed tissues, was significantly blocked by compounds I and II in a concentration-dependent manner. In the comparison of in vivo therapeutic effects of compounds I , II, and III on dextran sulfate sodium (DSS)-induced colitis in mice, compound dehydroxylated analog II was the most potent and efficacious, and compound demethylated analog III was better than compound I which exhibited a similar degree of inhibitory effect to tofacitinib. And 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride (cas: 148-51-6) was used in the research process.

5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(cas:148-51-6 Category: alcohols-buliding-blocks) is a strong antagonist of vitamin B6. Deoxypyridoxine hydrochloride has been used as an analytical reference standard for the quantification of the analyte in food samples using high performance liquid chromatography.

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Formula: C8H12ClNO2《Biological radiation protection. LIX. The meaning of radiation-caused changes in the content of metabolites to the survival rate of mice》 was published in 1964. The authors were Melching, Hans Joachim;Abe, Mitsuyuki;Streffer, Christian, and the article was included in《Strahlentherapie》. The author mentioned the following in the article:

After radiation, changes occur in albumin metabolism, especially in the case of tryptophan and cysteine. The changes reflect a curbing of the activity of amino acid decarboxylase with pyridoxal 5-phosphate as coenzyme. The following compounds increased the mortality rate when given with an x-ray dose of 505 r. (L.D._16/30): 4-deoxypyridoxine-HCl, isonicotinic acid hydrazide,DL-tryptophan, DL-kynurenine, and L-kynurenine. Taurine, given with 590 r. (L.D._64/30), increased the survival rate. To complete the study, the researchers used 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride (cas: 148-51-6) .

5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(cas:148-51-6 Formula: C8H12ClNO2) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine , pyridoxal, and pyridoxamine in and reduces growth of S. carlsbergensis cells. DOP inhibits sphingosine-1-phosphate (S1P) lyase and reduces cyclic stretch-induced apoptosis in alveolar epithelial MLE-12 cells.

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Zhou, Binghua;Zhou, Ying;Lai, Lujie;Chen, Ziling;Li, Jiajia;Jiang, Yunliang;Liu, Jian;Wang, Zhipeng;Xue, Zhigang published 《Fabrication of Borate-Based Porous Polymer Electrolytes Containing Cyclic Carbonate for High-Performance Lithium Metal Batteries》 in 2021. The article was appeared in 《ACS Applied Energy Materials》. They have made some progress in their research.Name: 2,5-Dimethyl-2,5-hexanediol The article mentions the following:

A series of borate-based porous polymer electrolytes (B-PPEs) is prepared by incorporating the copolymers containing cyclic boroxine and cyclic carbonate groups into poly(vinylidene fluoride) (PVDF) through the phase inversion method. The dense and well-interconnected pores are obtained in the polymer matrix when the content of the copolymer reached 40 wt %. The ethylene-oxygen chain segments in the copolymer can facilitate the mobility of polymer chains and form the uniform distribution of pores in the B-PPEs. The B-PPEs show an enhanced ionic conductivity of 1.32 x 10^-3 S cm^-1 at 30 °C, which is due to the uniform well-interconnected pores in the polymer host. The cyclic carbonate units interact with the liquid electrolyte, which could improve the electrolyte uptake capacity of the polymer matrix. Benefited from the Lewis acid-base interactions between boron moieties and the anions of the lithium salt, the lithium-ion transference number of B-PPEs is also significantly improved. Compared to the pure PVDF-based electrolyte, the Li/B-PPEs/Li cell displays a very stable polarization voltage and the long-time cycling for 1000 h at a c.d. of 0.2 mA cm^-2. Moreover, the Li/B-PPEs/LiFePO₄ cells deliver a higher capacity of 143.0 mAh g^-1 at 0.2 C and 86% capacity retention after 150 cycles. The B-PPEs could be a promising candidate for enhancing the safety and electrochem. properties of lithium metal batteries.2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) were involved in the experimental procedure.

2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) was used in the synthesis of six- and seven-membered heterocyclic boron compounds containing intramolecular N-B bond.Name: 2,5-Dimethyl-2,5-hexanediol

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Hamada, Yoshio;Ohta, Hiroko;Miyamoto, Naoko;Sarma, Diganta;Hamada, Takashi;Nakanishi, Tomoya;Yamasaki, Moe;Yamani, Abdellah;Ishiura, Shoichi;Kiso, Yoshiaki published 《Significance of interactions of BACE1-Arg235 with its ligands and design of BACE1 inhibitors with P₂ pyridine scaffold. [Erratum to document cited in CA151:049158]》 in 2009. The article was appeared in 《Bioorganic & Medicinal Chemistry Letters》. They have made some progress in their research.Category: alcohols-buliding-blocks The article mentions the following:

On page 2438, Table 2 is incorrect; the correct version of the table is given. And (S)-2-Amino-2-(4-fluorophenyl)ethanol (cas: 224434-01-9) was used in the research process.

(S) – 2-amino-2 – (4-fluorophenyl) ethanol (cas: 224434-01-9) has the characteristics of alcohol. In general, the hydroxyl group makes alcohols polar. Those groups can form hydrogen bonds to one another and to most other compounds. Category: alcohols-buliding-blocks

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Quality Control of 3,7-Dimethyloctan-3-ol《Ruthenium nanoparticle-intercalated montmorillonite clay for solvent-free alkene hydrogenation reaction》 was published in 2015. The authors were Upadhyay, Praveenkumar;Srivastava, Vivek, and the article was included in《RSC Advances》. The author mentioned the following in the article:

Well-characterized, ruthenium nanoparticle-intercalated montmorillonite clay was used as a catalyst in solvent-free alkene hydrogenation reactions and the corresponding products were obtained in good yields. The catalytic activity of ruthenium nanoparticle-intercalated montmorillonite clay was successfully tested with 16 different functionalized and non-functionalized alkenes. Apart from alkene reduction, the ruthenium nanoparticle-intercalated montmorillonite clay was also tested in Wittig-type reactions for obtaining dehydrobrittonin A, an important intermediate for the synthesis of brittonin A. Ruthenium nanoparticle-intercalated montmorillonite clay was found to be active in the synthesis of dehydrobrittonin A and brittonin A. The ability to recycle the catalyst nine times, together with low catalyst loading, high catalytic activity and catalytic selectivity were noteworthy advantages of the proposed protocol.3,7-Dimethyloctan-3-ol (cas: 78-69-3) were involved in the experimental procedure.

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Quality Control of 3,7-Dimethyloctan-3-ol Metabolite observed in cancer metabolism. It has a role as a human metabolite.

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Shabani, Mahtab;Keshavarz, Seyed Tahmoures;Farahmandghavi, Farhid;Imani, Mohammad published 《Long-lasting adsorption of golden flower oil on polyvinyl alcohol/clinoptilolite (PVA/CP) xerogel particles》 in 2020. The article was appeared in 《Applied Clay Science》. They have made some progress in their research.Synthetic Route of C10H22O The article mentions the following:

The present work aimed to study the adsorption and desorption characteristics of Golden Flower Oil (GFO) on xerogel particles made of Clinoptilolite (CP), a natural zeolite and polyvinyl alc. (PVA). Firstly, chem. composition and phys. characteristics of GFO (by GC/MS) and CP (by SEM and BET) were thoroughly characterized. PVA/CP xerogel was synthesized then and characterized by SEM, BET, TGA, and DSC techniques. Adsorption of the 12 GFO components on the CP and PVA/CP xerogel surface was investigated in different concentrations of GFO components. Both adsorbents showed concentration-independent and selective adsorption for GFO components. The selective adsorption index showed a direct relationship with polarity (δ_P) of the components and inversely correlated with their molar volume (V_m). Adsorption isotherms of the components were fitted by Langmuir, Freundlich, and Temkin equations. Maximum monolayer GFO adsorption on PVA/CP surface was equal to 231.93 mg g^-1 compared to 198.73 mg g^-1 for CP as an adsorbent. The maximum desorbed amount for each of the components was directly related to the V_m parameter and the weight percentage of each GFO component in the oil and inversely related to δ_P. Multilayer desorbed amount from PVA/CP xerogel particles (366.03 mg g^-1) was less than that for CP particles (573.36 mg g^-1) supporting PVA/CP for retaining GFO for longer periods. To complete the study, the researchers used 3,7-Dimethyloctan-3-ol (cas: 78-69-3) .

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Synthetic Route of C10H22O Metabolite observed in cancer metabolism. It has a role as a human metabolite.

Reference:
Alcohol – Wikipedia,
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Computed Properties of C11H16OIn 2020, Bub, Christina L.;Thoennissen, Vinzenz;Patureau, Frederic W. published 《Benzophenothiazine and Its Cr(III)-Catalyzed Cross Dehydrogenative Couplings》. 《Organic Letters》published the findings. The article contains the following contents:

In stark contrast to phenothiazines and their prevalence for cross-dehydrogenative amination reactions, benzophenothiazine has a pronounced preference for cross-dehydrogenative C-C bond-forming reactions. Moreover, the substrate is very versatile, leading to several new classes of C-C bond-forming reactions and many new oxidative coupling product architectures, including unprecedented indole fused paddlewheel-like structures. To complete the study, the researchers used 4-tert-Amylphenol (cas: 80-46-6) .

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group. Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Methanol, ethanol, and propanol are miscible in water. Butanol, with a four-carbon chain, is moderately soluble.Computed Properties of C11H16O

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Hughes-Oliver, Jacqueline M.;Xu, Guangning;Baynes, Ronald E. published 《Skin permeation of solutes from metalworking fluids to build prediction models and test A partition theory》. The research results were published in《Molecules》 in 2018.Synthetic Route of C11H16O The article conveys some information:

Permeation of chem. solutes through skin can create major health issues. Using the membrane-coated fiber (MCF) as a solid phase membrane extraction (SPME) approach to simulate skin permeation, we obtained partition coefficients for 37 solutes under 90 treatment combinations that could broadly represent formulations that could be associated with occupational skin exposure. These formulations were designed to mimic fluids in the metalworking process, and they are defined in this manuscript using: one of mineral oil, polyethylene glycol-200, soluble oil, synthetic oil, or semi-synthetic oil; at a concentration of 0.05 or 0.5 or 5 percent; with solute concentration of 0.01, 0.05, 0.1, 0.5, 1, or 5 ppm. A single linear free-energy relationship (LFER) model was shown to be inadequate, but extensions that account for exptl. conditions provide important improvements in estimating solute partitioning from selected formulations into the MCF. The benefit of the Expanded Nested-Solute-Concentration LFER model over the Expanded Crossed-Factors LFER model is only revealed through a careful leave-one-solute-out cross-validation that properly addresses the existence of replicates to avoid an overly optimistic view of predictive power. Finally, the partition theory that accompanies the MCF approach is thoroughly tested and found to not be supported under complex exptl. settings that mimic occupational exposure in the metalworking industry.4-tert-Amylphenol (cas: 80-46-6) were involved in the experimental procedure.

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group.Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Synthetic Route of C11H16O

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Reinisch, Jens;Klamt, Andreas published 《Correction to “Predicting Flash Points of Pure Compounds and Mixtures with COSMO-RS” [Erratum to document cited in CA164:106271]》 in 2016. The article was appeared in 《Industrial & Engineering Chemistry Research》. They have made some progress in their research.SDS of cas: 80-46-6 The article mentions the following:

The final conversion within eq 4 in the original manuscript is incorrect; The correct equation has been given. There is an analog error in eq 11; The corrected equation has been given. To complete the study, the researchers used 4-tert-Amylphenol (cas: 80-46-6) .

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group.Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. SDS of cas: 80-46-6

Reference:
Alcohol – Wikipedia,
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