Tag: 100-200

Morisawa, Yasuhiro;Kataoka, Mitsuru;Watanabe, Taiichiro;Kitano, Noritoshi;Matsuzawa, Toshiaki published 《Anticoccidal agents. IV. Modification at the 5-position of 4-deoxypyridoxol and α4-norpyridoxol》. The research results were published in《Agricultural and Biological Chemistry》 in 1975.Formula: C8H12ClNO2 The article conveys some information:

In an attempt to relate structure to anticoccidial activity, a number of 5-modified analogs of 4-deoxypyridoxol (I) and α4-norpyridoxol (II) have been synthesized and their biol. activities examined The compounds prepared include the 5-(3-hydroxypropyl), 5-(2-hydroxyethyl), 5-(1-hydroxyethyl), formyl and acetyl analogs of I, and 5-(3-hydroxypropyl), formyl, ethoxycarbonyl, carbamoyl and hydroxyl analogs of II. Among these compounds, 4-deoxyisopyridoxal (III) and α4-norisopyridoxal (IV) exhibited anticoccidil activity. To complete the study, the researchers used 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride (cas: 148-51-6) .

5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(cas:148-51-6 Formula: C8H12ClNO2) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine , pyridoxal, and pyridoxamine in and reduces growth of S. carlsbergensis cells. DOP inhibits sphingosine-1-phosphate (S1P) lyase and reduces cyclic stretch-induced apoptosis in alveolar epithelial MLE-12 cells.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Singh, R. P.;Korytnyk, W. published 《Pyridoxine chemistry. VII. Some modifications in the 4-position of pyridoxol》. The research results were published in《Journal of Medicinal Chemistry》 in 1965.Synthetic Route of C8H12ClNO2 The article conveys some information:

cf. preceding abstract Derivatives of I were prepared by treatment of 2,2,8-trimethyl-4H-m-dioxino[4,5-c]pyridine-5-methanol benzoate with HCl. I (R = OH) refluxed with SOCl₂ and the residue treated with EtOH produced I (R = Cl). The catalytic (C) hydrogenation of I (R = Cl) afforded I (R = H). I (R = H) refluxed in KOH gave 4-deoxypyridoxine (II). I (R = Cl) stirred with Na₂S₂O₅ produced I (R = SO₃H). KCNS refluxed with I (R = Cl) gave I (R = SCN). Similarly, I (R = Cl) stirred with NaHS gave I (R = SH). I (R = H) was as active and I (R = SO₃H) one-half as active as II in depressing lymphocyte count in rats fed a pyridoxine deficient diet, while the other reported derivatives were inactive. None of the other compounds inhibited the growth of Saccharomyces carlsbergensis. Cf. Schmidt, and Giesselmann, CA 58, 1429d. The experimental procedure involved many compounds, such as 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride (cas: 148-51-6) .

5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(cas:148-51-6 Synthetic Route of C8H12ClNO2) is a strong antagonist of vitamin B6. Deoxypyridoxine hydrochloride has been used as an analytical reference standard for the quantification of the analyte in food samples using high performance liquid chromatography.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

SDS of cas: 148-51-6In 1940, Harris, Stanton A. published 《Vitamin B₆. II. Reactions and derivatives》. 《Journal of the American Chemical Society》published the findings. The article contains the following contents:

Vitamin B₆-HCl (I) in an equal mixture of C₅H₅N and Ac₂O, allowed to stand overnight and then heated on a steam bath for 20 min., gives vitamin B₆ triacetate-HCl [2-methyl-3-acetoxy-4,5-bis(acetoxymethyl)-pyridine-HCl], m. 157°; it is stable in 0.01 N HCl but is slowly hydrolyzed in 0.01 N alkali at 37°. Vitamin B₆ dibromide-HBr (II) and 3 equivalents AcOAg in a 22% solution of AcOK in AcOH, heated on the steam bath for 0.5 hrs., give 25% of vitamin B₆ diacetate-HCl [2-methyl-3-hydroxy-4,5-bis(acetoxymethyl) pyridine-HCl], m. 160-1°; the aqueous solution gives a good FeCl₃ test; it has the same relative stability as the tri-Ac derivative Reduction of II with a PdBaSO₄ catalyst in EtOH gives 40% of 2,4,5-trimethyl-3-hydroxypyridine, m. 178°; HCl salt, m. 216°. Catalytic reduction of I with the Adams catalyst gives 2,4-dimethyl-3-hydroxy-5-hydroxymethylpyridine-HCl, m. 267-8°; this is weakly active for the growth and promotion of acid formation by Streptobacterium plantarum, whereas III is inactive. I, exactly neutralized with 1 equivalent of MeONa in MeOH and heated at 125° for 4 hrs., gives a small yield of 2-methyl-3-hydroxy-4-methoxymethyl-5-hydroxymethylpyridine-HCl (III), m. 181°. To complete the study, the researchers used 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride (cas: 148-51-6) .

5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(cas:148-51-6 SDS of cas: 148-51-6) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine , pyridoxal, and pyridoxamine in and reduces growth of S. carlsbergensis cells. DOP inhibits sphingosine-1-phosphate (S1P) lyase and reduces cyclic stretch-induced apoptosis in alveolar epithelial MLE-12 cells.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhu, Fen;Song, Yaqin;Liu, Shaohui;Nie, Jun;He, Yong published 《Preparation of polymerizable thermal initiator and its application in photo-induced thermal frontal polymerization》 in 2019. The article was appeared in 《European Polymer Journal》. They have made some progress in their research.Related Products of 110-03-2 The article mentions the following:

Photo-induced frontal polymerization has been growing interesting in the recent decades. However, the conflict among the frontal starting temperature, the storage stability and the high leachability remain problems to be solved. A new polymerizable methacrylate functionalized aliphatic peroxide thermal initiator (named as IEM-HDHP) through modifying methacrylate group into the 2,5-dihydroperoxy-2,5-dimethylhexane (HDHP) was successfully prepared In the photo-induced frontal polymerization investigated, IEM-HDHP showed medium photo-induced frontal polymerization starting temperature, frontal velocity and best storage stability compared with two com. thermal initiators (benzoyl peroxide (BPO) and 1-(2-hydroperoxypropan-2-yl) benzene) (CHP). What’s more, the lowest amount of small mol. leachability makes it outstanding from the two competitors. At the same time, IEM-HDHP is the only one to lead to the sample stick with complete and smooth appearance in this work. The experimental procedure involved many compounds, such as 2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) .

2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) on heteropoly acid catalyzed dehydration yields cyclic ethers via stereospecific intramolecular SN2 mechanism. It reacts with nitriles in concentrated sulfuric acid to yield Δ1-pyrrolines.Related Products of 110-03-2

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Today I want to share an article with you. The article is 《Impact of crossflow microfiltration on aroma and sensory profiles of a potential functional citrus-based food》,you can find this article in 《Journal of the Science of Food and Agriculture》. The following contents are mentioned:

Citrus juices can be cold-concentrated by crossflow microfiltration (CMF) in order to obtain functional foods enriched in carotenoids, flavonoids and pectins. The work aimed to characterize the organoleptic quality of this type of micronutrient-dense foods through their aroma profile and sensory anal. Two citrus concentrates with and without a diafiltration step were compared. Both citrus products were very different, linked to aroma compound, sugar and organic acid contents. Due to its sugar/acidity balance and its better aromatic profile responsible for the citrus-floral flavor, the concentrate without diafiltration was preferred by the sensory panel. Thanks to a simple transfer model, we showed that retention of volatiles clearly varied from one aroma compound to another. The terpene hydrocarbons were the most retained by the membrane during CMF, probably because they were strongly associated with insoluble solids by adsorption. Even though the process modified their organoleptic profiles, both citrus-based products were well rated and can be consumed directly as pleasant functional drinks.3,7-Dimethyloctan-3-ol (cas: 78-69-3) were involved in the experimental procedure.

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Recommanded Product: 3,7-Dimethyloctan-3-ol Metabolite observed in cancer metabolism. It has a role as a human metabolite.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gurkan-Alp, A. Selen;Mumcuoglu, Mine;Andac, Cenk A.;Dayanc, Emre;Cetin-Atalay, Rengul;Buyukbingol, Erdem published 《Synthesis, anticancer activities and molecular modeling studies of novel indole retinoid derivatives》. The research results were published in《European Journal of Medicinal Chemistry》 in 2012.HPLC of Formula: 110-03-2 The article conveys some information:

In this study, novel (E)-3-(5-substituted-1H-indol-3-yl)-1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-2-en-1-one derivatives were synthesized and their anticancer effects were determined in vitro. Novel indole retinoid compounds have anti-proliferative capacity in liver, breast, and colon cancer cell lines. This anti-proliferative effect was further analyzed in breast cancer cell line panel by using the most potent compound The latter can inhibit proliferation at very low IC₅₀ concentrations in all of the breast cancer cell lines. Here, we present some evidence on apoptotic termination of cancer cell proliferation which may be primarily driven by the inhibition of RXRα and, to a lesser extent, RXRγ. And 2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) was used in the research process.

2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) is used as an intermediate in the preparation of 2.5-Dimethyl-2.5-bis(tertbutyl-peroxy)hexane. It is also used in the synthesis of six- and seven-membered heterocyclic boron compounds.HPLC of Formula: 110-03-2

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 3,7-Dimethyloctan-3-olIn 2018, Malysheva, A. G.;Kozlova, N. Yu.;Yudin, S. M. published 《The unaccounted hazard of processes of substances transformation in the environment in the assessment of the effectiveness of the application of technologies》. 《Gigiena i Sanitariya》published the findings. The article contains the following contents:

To solve environmental problems in the current economic conditions, the use of achievements in scientific and technol. progress acquires the special significance. This primarily concerns the creation, optimization, and improvement of environmentally friendly technologies for purification and neutralization of industrial emissions, new technologies for purification and disinfection of drinking water, development and implementation of environment improving phytotechnologies and many other environmental and health-improving measures. The present system of environmental and anal. monitoring of the state of environmental objects exposed to various technologies for its recovery, based on the use of phys. and chem. or biol. factors, requires the control of chem. safety, taking into account the possibility of formation of byproducts of transformation with respect to their harmlessness for use. The studies were performed using a chromatog.-mass spectrometric system including a gas chromatograph with full electronic control of gas flows and a digital pressure and flow control mode with automatic determination of column parameters, mass spectrometric detector with a quadrupole mass analyzer that provides measurements in the range of mass numbers from 1 to 1050, and a thermal desorber with a gas sample cryo-focusing. Examples of assessing the effectiveness and chem. safety of the application of new environmental protection technologies for cleaning air emissions from a number of enterprises and measures for improving the air environment of enclosed spaces show that their application, on the one hand, is aimed at directly addressing their specific purpose, i.e., a significant reduction in the qual. and quant. composition of pollutants in production emissions has been established, including an important component in terms of environmental aspects, such as the smell and on the other hand – a neg. side effect associated with the formation of toxic and dangerous products of transformation is simultaneously established, even for substances of natural origin, a significant part of which does not have hygienic standards, and consequently their impact on public health remains unaccounted. The side effect was often manifested by a change in the direction of deterioration in the chem. composition of the environment object that is phys. and chem. affected by the use of the new technol. For an adequate assessment of the quality of the environment and chem. safety of public health, an important condition is to take into account the multicomponent nature of the composition of chem. contaminants and to take into account the transformation products of substances affecting humans under real environmental conditions. Studies focused on identification with a quant. assessment of air emission components before and after the application of a new environmental technol. or a better environmental and health improvement measure allow to monitor environmental objects taking into account the actual content and changes in the group and component composition under the influence of the chem. impact of new technol. and to make recommendations for further improvement of the new technol. from the point of view of environmental aspects, which, in turn, is aimed at preserving the health of the population. And 3,7-Dimethyloctan-3-ol (cas: 78-69-3) was used in the research process.

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Reference of 3,7-Dimethyloctan-3-ol Metabolite observed in cancer metabolism. It has a role as a human metabolite.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Zong-yan;Wu, Xiao-lan;Ma, Jun;Xiao, Li;Wang, Tao;Lu, Hui-yi published 《Preparation of high quality tetrachloroethylene by impurity removal method》 in 2018. The article was appeared in 《Huaxue Shiji》. They have made some progress in their research.Application In Synthesis of 4-tert-Amylphenol The article mentions the following:

The purification process of tetrachloroethylene was investigated. The methods of extraction, adsorption, distillation separation and purification of tetrachloroethylene feasibility, and the parameters are optimized. The purity of tetrachloroethylene is improved because of the reduction of p-tert-amylphenol and other impurities. And 4-tert-Amylphenol (cas: 80-46-6) was used in the research process.

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group.Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Application In Synthesis of 4-tert-Amylphenol

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Abd-Alla, Howaida I.;Taie, Hanan A. A.;Abd-Elmotaleb, Marwa M. published 《Comparative phytochemical and biological investigation of five Glycine max (L.) Merrill genotypes》 in 2019. The article was appeared in 《Asian Journal of Pharmaceutical and Clinical Research》. They have made some progress in their research.COA of Formula: C8H18O2 The article mentions the following:

Soybean (Glycine max L. Merrill) is the world′s most important consumed seed legume. The objectives of the present study were to determine the variability in phytochem. composition and biol. activities between five genotypes of G. maximum Lipoidal matters were determined using glucose (GLC). Amino acids were detected by the amino acid analyzer. The phytoconstituents present within each ethanol extract was investigated by gas chromatog.-mass spectrometry. The amount of total phenolics, flavonoids, and tannins was analyzed using a spectrophotometric technique, based on Folin-Ciocalteu reagent, aluminum chloride colorimetric assay, and the modified vanillin hydrochloric acid method, resp. Quercetin, catechin, and gallic acid were used as standard compounds, resp. Isoflavones content were detected by high-performance liquid chromatog. (HPLC)/photodiode array (PDA). The radical scavenging and antioxidant capacity of the genotypes using different in vitro anal. assays such as 2,2-di-Ph,1-picryl hydrazyl, 2,2′-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid), reducing power, metal chelating, and ferric reducing anti-oxidant power. Bu hydroxyl toluene and trolox were used as the reference antioxidant radical scavenger compounds Antitumor activity was evaluated by detecting the viability of Ehrlich ascites carcinoma cells on four different concentrations (1-5 mg/mL). GLC anal. showed the high value of total unsaturated fatty acids and 16 amino acids including glutamic acid with the highest concentration The variation between genotypes according to their chem. composition of the aldehydes, esters, ketones, alcoholics, and carboxylic content were reported. HPLC/PDA referred to the presence of daidzein, genistein, and in all genotypes. The results confirm the higher value of phytoconstituents of the genotype Giza 35 and Giza 21 as well as their better bioactivity. The experimental procedure involved many compounds, such as 2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) .

2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) is used as an intermediate in the preparation of 2.5-Dimethyl-2.5-bis(tertbutyl-peroxy)hexane. It is also used in the synthesis of six- and seven-membered heterocyclic boron compounds.COA of Formula: C8H18O2

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wakayama, Hideki;Sakasai, Mitsuyoshi;Yoshikawa, Keiichi;Inoue, Michiaki published 《Method for Predicting Odor Intensity of Perfumery Raw Materials Using Dose-Response Curve Database》. The research results were published in《Industrial & Engineering Chemistry Research》 in 2019.Quality Control of 3,7-Dimethyloctan-3-ol The article conveys some information:

The main purpose of this study is to facilitate fragrance development on the basis of scientific knowledge. To this end, data on 314 perfumery raw materials (PRMs) showing the relationship between PRM odor intensity and gas concentration were obtained, and a calculation model for the data was then developed with the following features: (1) maximum PRM coverage, (2) calculating values implying odor intensity from only arbitrary gas concentration, and (3) estimating odor intensity from the calculated values directly and easily. To verify the prediction accuracy of this model, the predicted odor intensity was compared with the evaluated value for both single component and a mixture, and the same degree of root mean square error (RMSE) was confirmed. RMSE in the single component was 6.22 while that in the mixture was 6.69. Thus, the odor intensity of a PRM or mixture can be predicted from arbitrary gas concentrations And 3,7-Dimethyloctan-3-ol (cas: 78-69-3) was used in the research process.

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Quality Control of 3,7-Dimethyloctan-3-ol Metabolite observed in cancer metabolism. It has a role as a human metabolite.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts