Tag: 100-200

Cobo-Golpe, M.;Ramil, M.;Cela, R.;Rodriguez, I. published 《Portable dehumidifiers condensed water: A novel matrix for the screening of semi-volatile compounds in indoor air》. The research results were published in《Chemosphere》 in 2020.Recommanded Product: 3,7-Dimethyloctan-3-ol The article conveys some information:

The comprehensive identification of organic species existing in indoor environments is a key issue to understand their impact in human health. This study proposes the anal. of condensed water samples, collected with portable dehumidifiers, to characterize semi-volatile compounds in the gas phase of confined areas. Water samples are concentrated by solid-phase extraction (SPE). The obtained extracts are analyzed by gas chromatog. (GC) time-of-flight mass spectrometry (TOF-MS), following a non-target screening data mining approach. In first term, spectra of deconvoluted compounds are compared with those in NIST low resolution library; thereafter, tentative identifications are verified using an inhouse database of accurate electron ionization (EI) MS spectra. Chromatog. (retention index) and spectral data are combined for unambiguous species identification. The potential of condensed water samples to reflect changes in the composition of indoor atmospheres, the match between data obtained using different dehumidifiers, and the relative concentration efficiency of condensed water compared to that attained by active sampling of moderate air volumes are discussed. A total of 141 semi-volatile compounds were identified (98 confirmed against authentic standards) in a set of 21 samples obtained from different homes and working places. This list contains more than 40 fragrances (including several potential allergens), solvents and intermediates in the production of polymeric materials, plasticizers and flame retardants. To complete the study, the researchers used 3,7-Dimethyloctan-3-ol (cas: 78-69-3) .

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Recommanded Product: 3,7-Dimethyloctan-3-ol Metabolite observed in cancer metabolism. It has a role as a human metabolite.

Reference:
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Recommanded Product: 3,7-Dimethyloctan-3-olIn 2022, Thaveesangsakulthai, Isaya;Nhujak, Thumnoon;Kulsing, Chadin published 《Two-Phase Electrocoagulation of Perfumes and the Analytical Approach for Investigation of the Odor-Active Compound Changes》. 《ChemistrySelect》published the findings. The article contains the following contents:

In this study, a 2-phase electrocoagulation (EC) system has been applied to treat odor active compounds in perfume extracts The system employed an electrochem. cell using two aluminum electrodes and 2-phase electrolyte containing hexane, NaCl(aq) and the perfume compounds This approach allowed electrochem. reaction of the compounds with the subsequent changes of their profiles in the extracts The volatile compounds in the samples before and after 2-phase EC sampled at different parts of the system were tentatively identified by using solid phase micro extraction (SPME) and gas chromatog. hyphenated with mass spectrometry (GC-MS). The results revealed different types and amounts of the odor active compounds in the samples after the 2-phase EC treatment with the enhanced fruity, floral, sweet, green, minty, herbal and citrus smells. The electrochem. oxidation/reduction and esterification/hydrolysis were proposed as the possible reactions. The developed 2-phase EC technique has a potential for application in the area of cost-effective adjustment of essential oil and perfume quality. The experimental procedure involved many compounds, such as 3,7-Dimethyloctan-3-ol (cas: 78-69-3) .

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Recommanded Product: 3,7-Dimethyloctan-3-ol Metabolite observed in cancer metabolism. It has a role as a human metabolite.

Reference:
Alcohol – Wikipedia,
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Jenke, Dennis published 《Safety Risk Categorization of Organic Extractables Associated with Polymers used in Packaging, Delivery and Manufacturing Systems for Parenteral Drug Products》. The research results were published in《Pharmaceutical Research》 in 2015.Product Details of 80-46-6 The article conveys some information:

Purpose: To develop and justify a Risk Evaluation Matrix for estimating the safety risk associated with extractables from plastic materials used in pharmaceutical applications and to apply that matrix to approx. 510 extractables to assess the risk that they would accumulate in drug products at levels sufficiently high to affect patient safety. The Risk Evaluation Matrix considers toxicol., availability and solubility characteristics of extractables. Safety Risk categories were established based on certain scaled values for these characteristics, Total Risk Scores were calculated for each extractable and the extractables were categorized with respect to their safety risk based on these calculations The Total Risk Scores were normally distributed around a value of 20 to 23, corresponding to safety risk categories of moderate and intermediate risk. The range in Risk Scores defined by the mean ± one standard deviation encompassed the entire region of moderate and intermediate risk. Approx. 15% of the extractables were categorized as lowest risk while 3% of the extractables were categorized as highest risk. Categorization of extractables could facilitate the selection of materials for use in pharmaceutical systems, the anal. testing of extracts and the selection of target extractables. To complete the study, the researchers used 4-tert-Amylphenol (cas: 80-46-6) .

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group. Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Methanol, ethanol, and propanol are miscible in water. Butanol, with a four-carbon chain, is moderately soluble.Product Details of 80-46-6

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Reference of 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride《Convulsive effects of 4-deoxypyridoxine and of bicuculline in photosensitive baboons (Papio papio) and in rhesus monkeys (Macaca mulatta)》 was published in 1971. The authors were Meldrum, B. S.;Horton, R. W., and the article was included in《Brain Research》. The author mentioned the following in the article:

4-Deoxypyridoxine HCl (I) [148-51-6] administered i.v. at 40-100 mg/kg enhanced the natural syndrome of photosynthetic epilepsy in baboons and increased the severity of photically-induced myoclonus so that it progressed to a tonic-clonic seizure. In subconvulsive doses I provoked epileptic afterdischarges in the occipital cortex of monkeys exposed to photic stimulation. In both species I at 100-150 mg/kg induced spontaneous seizures which originated unilaterally in the occipital cortex and began with a horizontal nystagmus. When the occipital discharges no longer generalized, the animals had a normal electroencephalogram. A 4:1 excess of pyridoxine [65-23-6] in baboons blocked the increase in photically-induced responses and drug-induced seizures. Bicuculline (II) [485-49-4] administered i.v. at 0.1-0.4 mg/kg induced generalized seizures in both species, and at 0.3-0.6 mg/kg induced prolonged (150-300 min) seizures characterized by sustained myoclonic activity and relative absence of episodes of postictal silence in baboons. At 0.1-0.3 mg/kg II sometimes caused a brief myoclonic jerk associated with frontorolandic spikes and waves. There seem to be 2 inhibitory systems which differ in their pharmacol. responsiveness but both probably involve γ-aminobutyric acid [56-12-2] as the neurotransmitter. One system seems to be intracortical and its functional failure causes occipital discharges and spontaneous seizures after administration of the pyridoxine antagonists. The other is probably a collateral inhibitory system within the pathways afferent to the somatomotor cortex. To complete the study, the researchers used 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride (cas: 148-51-6) .

5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(cas:148-51-6 Reference of 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride) is a strong antagonist of vitamin B6. Deoxypyridoxine hydrochloride has been used as an analytical reference standard for the quantification of the analyte in food samples using high performance liquid chromatography.

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SDS of cas: 110-03-2《Vitrigel-Eye Irritancy Test Method Using HCE-T Cells》 was published in 2013. The authors were Yamaguchi, Hiroyuki;Kojima, Hajime;Takezawa, Toshiaki, and the article was included in《Toxicological Sciences》. The author mentioned the following in the article:

The authors previously reported that the time-dependent relative changes of transepithelial elec. resistance (TEER) after exposing four different chems. to a human corneal epithelium (HCE) model were well correlated to the potential of ocular irritancy. Meanwhile, the authors recently developed a collagen vitrigel membrane (CVM) chamber possessing a scaffold composed of high-d. collagen fibrils equivalent to connective tissues in vivo as a three-dimensional culture tool. The CVM chamber is useful for biomedical assays and immunohistol. using cryosections that are inappropriate to be performed using the conventional Millicell chamber with a polyethylene terephthalate membrane. In this study, the authors aimed to develop a new eye irritancy test (EIT) method called “Vitrigel-EIT method” that can facilitate to briefly and accurately estimate the widespread irritancy of test chems. by applying the TEER assay system to a HCE model fabricated in the CVM chamber. HCE-T cells (a HCE-derived cell strain) were cultured in the CVM chamber for 6 days, and consequently, the Vitrigel-HCE model possessing the following characteristics of HCE in vivo was formed: six cell layers with specific protein expressions and their barrier function. Time-dependent profiles of TEER values after exposing 30 test chems. to the HCE model were converted into the scores of three indexes (time lag, intensity, and plateau level), and each chem. was successfully classified into irritant or nonirritant category by utilizing the criteria for the indexes, resulting in the excellent correlation with Globally Harmonized System of Classification and Labeling of Chems. (GHS) classification (sensitivity: 100%, specificity: 75%, accuracy: 90%). These data suggest that the widespread eye irritancy of chems. can be predicted without false negatives by the Vitrigel-EIT method. Interestingly, the disruption of tight junctions was immunohistol. observed after exposing not only irritants but also three compounds classified as nonirritant by GHS but found pos. in the authors’ Vitrigel-EIT method confirming a possible mild irritant property. The experimental procedure involved many compounds, such as 2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) .

2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) on heteropoly acid catalyzed dehydration yields cyclic ethers via stereospecific intramolecular SN2 mechanism. It reacts with nitriles in concentrated sulfuric acid to yield Δ1-pyrrolines.SDS of cas: 110-03-2

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Braga, Soraia Cristina Gonzaga Neves;Oliveira, Luciana Fontes;Reis de Andrade Silva, Adriana;Efraim, Priscilla;de Jesus Poppi, Ronei;Augusto, Fabio published 《Harvest influence in volatile composition of chocolates produced with hybrid varieties of Bahia’s cocoa was investigated using GC × GC-QMS and chemometrics》. The research results were published in《BrJAC–Brazilian Journal of Analytical Chemistry》 in 2019.Category: alcohols-buliding-blocks The article conveys some information:

Cocoa varieties are important in Brazil due to their resistance to “witch’s broom” disease. In this work, the chromatog. profiles of chocolates produced from eleven cocoa varieties harvested from two different harvests were analyzed. A total of 22 samples were analyzed by comprehensive two-dimensional gas chromatog. coupled to mass spectrometry (GC × GC-MS), using headspace solid phase microextration (HS-SPME). Multiway principal component anal. (MPCA) were conducted to study the differences between the two harvests. Two principal components were responsible for the separation of the profiles between the harvests and their resp. loadings were evaluated. Hydrocarbons were the principal group responsible for this separation, as some pyrazines and aldehydes. To complete the study, the researchers used 3,7-Dimethyloctan-3-ol (cas: 78-69-3) .

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Category: alcohols-buliding-blocks Metabolite observed in cancer metabolism. It has a role as a human metabolite.

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Alcohol – Wikipedia,
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Wang, Jiabao;Gong, Yuxin;Sun, Deli;Gong, Hegui published 《Nickel-catalyzed reductive benzylation of tertiary alkyl halides with benzyl chlorides and chloroformates》 in 2021. The article was appeared in 《Organic Chemistry Frontiers》. They have made some progress in their research.Recommanded Product: 3,7-Dimethyloctan-3-ol The article mentions the following:

Ni-Catalyzed reductive cross-coupling of tertiary alkyl halides with benzyl chlorides and chloroformates has been developed, which provides an efficient method for the construction of benzylated all-carbon quaternary centers in moderate to excellent yields with high functional group tolerance. The experimental procedure involved many compounds, such as 3,7-Dimethyloctan-3-ol (cas: 78-69-3) .

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Recommanded Product: 3,7-Dimethyloctan-3-ol Metabolite observed in cancer metabolism. It has a role as a human metabolite.

Reference:
Alcohol – Wikipedia,
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Formula: C8H12ClNO2《Synthesis of aflatoxins by the non-growing mycelia of Aspergillus parasiticus and the effect of inhibitors》 was published in 1975. The authors were Gupta, S. R.;Prasanna, H. R.;Viswanathan, L.;Venkitasubramanian, T. A., and the article was included in《Journal of General Microbiology》. The author mentioned the following in the article:

Aflatoxins were synthesized by nongrowing mycelia of A. parasiticus, the amount and type (B or G) being dependent on the buffer used in the suspension medium. Incorporation of acetate-14C into aflatoxin was decreased by compounds that inhibit ATP production or interfere with the utilization of certain amino acids. In contrast, the specific activities of aflatoxins were increased by compounds that diverted acetate from metabolic pathways other than those leading to aflatoxin formation. And 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride (cas: 148-51-6) was used in the research process.

5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(cas:148-51-6 Formula: C8H12ClNO2) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine , pyridoxal, and pyridoxamine in and reduces growth of S. carlsbergensis cells. DOP inhibits sphingosine-1-phosphate (S1P) lyase and reduces cyclic stretch-induced apoptosis in alveolar epithelial MLE-12 cells.

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Yi, Zhi-ying;Feng, Tao;Li, Xiao-bei;Bing, Fang-ling published 《Preliminary study on glycosidically bound aroma compounds from pomegranate juice》. The research results were published in《Xiandai Shipin Keji》 in 2017.HPLC of Formula: 78-69-3 The article conveys some information:

The characteristic absorption peaks of glycosidically bound aroma precursors from pomegranate juice were initially identified from UV-visible spectra. The aglycons and the glycones were determined by HPLC and GC-MS anal. before and after enzymic hydrolysis. The glycosidically bound aroma precursors were analyzed by monitoring the evolution of thephysicochem. properties of pomegranate juice without or with enzymic hydrolysis. Characteristic absorption peaks of the glycosides were obtained using UV-visible spectra. The total soluble solid and reducing sugar content of the pomegranate juice showed significant differences for the samples treated with and without enzymic hydrolysis. Glucose and fructose were determined as sugar moieties of the glycosides in pomegranate juice by HPLC anal. A total of 36 volatile compounds were identified by GC-MS, and the bound aromas detected in the juice were mostly aromatic alcs., terpenes, and aldehydes, which mainly included 1-hexyl alc., cis-3-hexen-1-ol, tetrahydrolinalool, and phenethyl alc. The results provide evidence to further explain the structure of glycosidically bound aroma precursors from pomegranate juice. And 3,7-Dimethyloctan-3-ol (cas: 78-69-3) was used in the research process.

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.HPLC of Formula: 78-69-3 Metabolite observed in cancer metabolism. It has a role as a human metabolite.

Reference:
Alcohol – Wikipedia,
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Serwa, Remigiusz;Nam, Tae-gyu;Valgimigli, Luca;Culbertson, Sean;Rector, Christopher L.;Jeong, Byeong-Seon;Pratt, Derek A.;Porter, Ned A. published 《Preparation and Investigation of Vitamin B₆-Derived Aminopyridinol Antioxidants》. The research results were published in《Chemistry – A European Journal》 in 2010.HPLC of Formula: 148-51-6 The article conveys some information:

3-Pyridinols bearing amine substitution para to the hydroxylic moiety have previously been shown to inhibit lipid peroxidation more effectively than typical phenolic antioxidants, for example, α-tocopherol. We report here high-yielding, large-scale syntheses of mono- and bicyclic aminopyridinols from pyridoxine hydrochloride (i.e., vitamin B₆). This approach provides straightforward, scaleable access to novel, potent, mol. scaffolds whose antioxidant properties have been investigated in homogeneous solutions and in liposomal vesicles. These mol. aggregates mimic cell membranes that are the targets of oxidative damage in vivo. To complete the study, the researchers used 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride (cas: 148-51-6) .

5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(cas:148-51-6 HPLC of Formula: 148-51-6) is a strong antagonist of vitamin B6. Deoxypyridoxine hydrochloride has been used as an analytical reference standard for the quantification of the analyte in food samples using high performance liquid chromatography.

Reference:
Alcohol – Wikipedia,
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