Tag: 100-200

Category: alcohols-buliding-blocksIn 2021, Kundra, Milan;Grall, Tom;Ng, Derrick;Xie, Zongli;Hornung, Christian H. published 《Continuous Flow Hydrogenation of Flavorings and Fragrances Using 3D-Printed Catalytic Static Mixers》. 《Industrial & Engineering Chemistry Research》published the findings. The article contains the following contents:

A new type of additively manufactured catalytic static mixer, coated with alumina-supported metal catalysts, has been used for the hydrogenation of various model compounds commonly employed in the flavoring and fragrance industries. These heterogeneous catalytic reactions were performed inside an intensified tubular flow reactor housing several catalytic static mixers. In addition to electroplated and cold-sprayed catalyst coatings, which were presented by our group in earlier work, we herein demonstrate a series of alumina-supported metal catalysts for the first time, namely Pd, Pt, Ru, and Ni, supported on alumina and deposited on stainless-steel static mixers. The continuous flow hydrogenation of (-)-isopulegol at 24 bar and 130°C produced the high value product (-)-menthol at full conversion with a 98.8% purity and a space-time yield of 2.66 kg L^-1 h^-1.3,7-Dimethyloctan-3-ol (cas: 78-69-3) were involved in the experimental procedure.

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Category: alcohols-buliding-blocks Metabolite observed in cancer metabolism. It has a role as a human metabolite.

Reference:
Alcohol – Wikipedia,
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Cui, Wei-chan;Wang, Bing;Guo, Meng-bo;Liu, Yang;Jacquin-Joly, Emmanuelle;Yan, Shan-chun;Wang, Gui-rong published 《A receptor-neuron correlate for the detection of attractive plant volatiles in Helicoverpa assulta (Lepidoptera: Noctuidae)》. The research results were published in《Insect Biochemistry and Molecular Biology》 in 2018.SDS of cas: 78-69-3 The article conveys some information:

Plant volatiles are vital cues in the location of hosts for feeding and oviposition for Lepidoptera moths. The noctuid Helicoverpa assulta is a typical polyphagous moth, regarded as a good model for studying the olfactory reception of plant volatiles. In this study, four full-length genes encoding odorant receptors HassOR24, HassOR40, HassOR41, and HassOR55 expressed in antenna in H. assulta were functionally characterized. The highly expressed HassOR40 was narrowly tuned to a few structurally-related plant volatiles: geranyl acetate, geraniol and nerolidol. By systematically analyzing responses of single neuron in both trichoid sensilla and basiconic sensilla using single sensillum recording, the specific neuron B in one type of short trichoid sensilla was found to be mainly activated by the same chems. as HassOR40 with high sensitivity, and with no significant difference between male and female neurons. Thus, a clear “receptor-neuron” relationship in H. assulta was demonstrated here, suggesting that HassOR40/HassOrco are expressed in neuron B of short trichoid sensilla. The active tobacco volatile nerolidol, recognized by this receptor-neuron line, elicits significant behavioral attraction of both sexes in H. assulta adults. The results indicate that we identified a receptor-neuron route for the peripheral coding of a behaviorally relevant host volatile in H. assulta. To complete the study, the researchers used 3,7-Dimethyloctan-3-ol (cas: 78-69-3) .

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.SDS of cas: 78-69-3 Metabolite observed in cancer metabolism. It has a role as a human metabolite.

Reference:
Alcohol – Wikipedia,
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Reeves, Richard E.;Meleney, Henry E.;Frye, William W. published 《Cultivation of Entamoeba histolytica with penicillin-inhibited Bacteroides symbiosus cells. I. Pyridoxine requirement》. The research results were published in《American Journal of Hygiene》 in 1959.SDS of cas: 148-51-6 The article conveys some information:

In a modified Shaffer-Frye culture system it was found that the multiplication of Entamoeba histolytica is strongly inhibited by low concentrations of deoxypyridoxol. The effect of this substance is reversed by the addition of pyridoxal, pyridoxylamine, pyridoxol or pyridoxal phosphate. The last substance was shown to be more effective than pyridoxol in reversing the action of desoxypyridoxol. Conditions were found which allowed the determination of the concentrations of desoxypyridoxol required to reduce to half-maximum the multiplication of E. histolytica. These half-maximum concentrations were reproducible for given stains of amebae, but significant differences were found among 5 strains examined. The F-22 and a newly isolated strain (JH) were more sensitive, the DKB, 200 and K-9 strains were less sensitive to the anti-metabolite. Neither the F-22 nor the DKB strain developed the ability to tolerate larger amounts of anti-metabolite upon continued cultivation in media containing it. Desoxypyridoxol was also effective in preventing the growth of E. histolytica in Cleveland-Collier cultures in the presence of a multiplying mixed-bacterial flora. These results show that there is a pyriodoxine requirement for the multiplication of E. histolytica in the MS-F system. It is not definitely established whether the action of the anti-metabolite is directly on the ameba or upon some phase of the residual metabolism of the accompanying penicillin-inhibited bacterial cells.5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride (cas: 148-51-6) were involved in the experimental procedure.

5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(cas:148-51-6 SDS of cas: 148-51-6) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine , pyridoxal, and pyridoxamine in and reduces growth of S. carlsbergensis cells. DOP inhibits sphingosine-1-phosphate (S1P) lyase and reduces cyclic stretch-induced apoptosis in alveolar epithelial MLE-12 cells.

Reference:
Alcohol – Wikipedia,
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Computed Properties of C8H10FNOIn 2017, Guo, Jing;Zhu, Mingyue;Wu, Tianxiao;Hao, Chenzhou;Wang, Kai;Yan, Zizheng;Huang, Wanxu;Wang, Jian;Zhao, Dongmei;Cheng, Maosheng published 《Discovery of indolin-2-one derivatives as potent PAK4 inhibitors: Structure-activity relationship analysis, biological evaluation and molecular docking study》. 《Bioorganic & Medicinal Chemistry》published the findings. The article contains the following contents:

Utilizing a pharmacophore hybridization approach, a novel series of substituted indolin-2-one derivatives were designed, synthesized and evaluated for their in vitro biol. activities against p21-activated kinase 4. Three compounds including I exhibited the most potent inhibitory activity against PAK4 (IC₅₀ = 22 nM, 16 nM and 27 nM, resp.). Among them, compound I showed the highest antiproliferative activity against A549 cells (IC₅₀ = 0.83 μM). Apoptosis anal. in A549 cells suggested that compound I delayed cell cycle progression by arresting cells in the G2/M phase of the cell cycle, retarding cell growth. Further investigation demonstrated that compound I strongly inhibited migration and invasion of A549 cells. Western blot anal. indicated that compound I potently inhibited the PAK4/LIMK1/cofilin signaling pathways. Finally, the binding mode between compound I with PAK4 was proposed by mol. docking. A preliminary ADME profile of the compound I was also drawn on the basis of QikProp predictions.(S)-2-Amino-2-(4-fluorophenyl)ethanol (cas: 224434-01-9) were involved in the experimental procedure.

(S) – 2-amino-2 – (4-fluorophenyl) ethanol (cas: 224434-01-9) has the characteristics of alcohol. In general, the hydroxyl group makes alcohols polar. Those groups can form hydrogen bonds to one another and to most other compounds. Computed Properties of C8H10FNO

Reference:
Alcohol – Wikipedia,
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Ling, Xiaoxi;Masson, Eric published 《Cucurbituril Slippage: Cations as Supramolecular Lubricants》 in 2012. The article was appeared in 《Organic Letters》. They have made some progress in their research.COA of Formula: C8H18O2 The article mentions the following:

The dethreading rate of a polyaminated axle flanked by two benzo-15-crown-5 stoppers from the cavity of Cucurbit[7]uril (CB[7]) was enhanced by up to 500 times in the presence of aqueous metallic and organic cations. Cations likely stabilize the highest energy transition state of the dethreading process by interacting with both crown ether and CB[7] units.2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) were involved in the experimental procedure.

2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) is used as an intermediate in the preparation of 2.5-Dimethyl-2.5-bis(tertbutyl-peroxy)hexane. It is also used in the synthesis of six- and seven-membered heterocyclic boron compounds.COA of Formula: C8H18O2

Reference:
Alcohol – Wikipedia,
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Diler, Fatma;Burhan, Hakan;Genc, Hayriye;Kuyuldar, Esra;Zengin, Mustafa;Cellat, Kemal;Sen, Fatih published 《Efficient preparation and application of monodisperse palladium loaded graphene oxide as a reusable and effective heterogeneous catalyst for suzuki cross-coupling reaction》 in 2020. The article was appeared in 《Journal of Molecular Liquids》. They have made some progress in their research.Reference of 3,7-Dimethyloctan-3-ol The article mentions the following:

A homogeneously dispersed graphene oxide supported palladium nanomaterial (Pd@GO) has been successfully synthesized and used as a catalyst in cross-coupling reactions at room temperature Various anal. techniques such as X-ray Diffraction (XRD), XPS, transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HR-TEM) were used to characterize the monodisperse Pd@GO. Monodisperse Pd@GO nanomaterials were used for the cross-coupling reactions which brought together organic mols. with functional significance. This catalyst showed superior catalytic activity and stability for these coupling reactions. High product yields, short reaction times and mild reaction conditions, obtained by the using of developed catalysts. Importantly, the catalyst can be used at least five experiments successfully without losing its efficiency. And 3,7-Dimethyloctan-3-ol (cas: 78-69-3) was used in the research process.

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Reference of 3,7-Dimethyloctan-3-ol Metabolite observed in cancer metabolism. It has a role as a human metabolite.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of C11H16O《Catalytic and enantioselective bromoetherification of olefinic 1,3-diols: mechanistic insight》 was published in 2016. The authors were Ke, Zhihai;Tan, Chong Kiat;Liu, Yi;Lee, Keefe Guang Zhi;Yeung, Ying-Yeung, and the article was included in《Tetrahedron》. The author mentioned the following in the article:

How can high enantioselectivity be achieved when the racemic background reaction proceeds at a rate comparable to that of the catalytic asym. reaction. We attempted to rationalize this counterintuitive observation by studying the effect of (1) catalyst structure, (2) temperature and addition sequence of components, (3) catalyst loading, and (4) Bronsted acid additives. In the course of our investigation, it was found that increasing the amount of catalyst used led to inhibition of the stoichiometric reaction. Olefinic 1,3-diol 1, 5 mol % of catalyst 3a, 1 equiv of MsOH, and NBS were added at low temperature in a specific sequence to provide the best performance for the enantioselective bromoetherification. And 4-tert-Amylphenol (cas: 80-46-6) was used in the research process.

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Electric Literature of C11H16O

Reference:
Alcohol – Wikipedia,
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Kosower, Nechama S.;Rock, Rica A. published 《Seizures in experimental porphyria》. The research results were published in《Nature (London, United Kingdom)》 in 1968.Application In Synthesis of 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride The article conveys some information:

Rats made porphyric by allylisopropylacetamide (I) are susceptible to induced convulsions. Female Sprague-Dawley rats (150-160 g.) were injected daily with 400 mg. I/kg. in 0.15M NaCl for 8-10 days. Controls received NaCl. Twenty-four hrs. after the last injection, control and exptl. animals were injected with isonicotinoylhydrazide (II) or 4-methoxymethylpyridoxol-HCl (III) at pH 7, or deoxypyridoxol-HCl (IV) at pH 7. Other animals were given pyridoxal-HCl (V) 15 min. prior to injection of the compounds At 0.75 millimoles II/kg., clonic-tonic convulsions occurred in 60% of porphyric rats and in none of the controls; at 1.12 millimoles/kg., 90% of the porphyric rats convulsed, and 20% of controls. At 0.5-2 millimoles/kg., V did not alter the convulsions induced by II. Following III at 0.25 millimoles/kg., 70% of porphyric rats convulsed, and all convulsed at 0.75 millimoles/kg. (but no controls convulsed). No difference was noted between controls and animals injected with IV. These compounds may act by interfering with pyridoxal 5-phosphate in the nervous system.5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride (cas: 148-51-6) were involved in the experimental procedure.

5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(cas:148-51-6 Application In Synthesis of 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine , pyridoxal, and pyridoxamine in and reduces growth of S. carlsbergensis cells. DOP inhibits sphingosine-1-phosphate (S1P) lyase and reduces cyclic stretch-induced apoptosis in alveolar epithelial MLE-12 cells.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Recommanded Product: 78-69-3In 2019, Fu, Yu;Bak, Kathrine H.;Liu, Jing;De Gobba, Cristian;Toestesen, Marie;Hansen, Erik T.;Petersen, Mikael A.;Ruiz-Carrascal, Jorge;Bredie, Wender L. P.;Lametsch, Rene published 《Protein hydrolysates of porcine hemoglobin and blood: Peptide characteristics in relation to taste attributes and formation of volatile compounds》. 《Food Research International》published the findings. The article contains the following contents:

The objective of this study was to investigate the impact of endo- and exo-peptidase treatment on certain structural characteristics of peptides and volatile compounds of porcine Hb and whole blood hydrolyzates. Porcine Hb and whole blood were hydrolyzed by endo- and exo-peptidases. The presence of exopeptidases reduced the bitterness and altered the volatile profiles of protein hydrolyzates. Exopeptidase treatment can release terminal amino acids from peptides, which in turn may contribute to formation of volatile compounds by Maillard reactions. In contrast, endopeptidases conferred a slightly bitter taste and different volatile profiles. For Hb hydrolyzates, principal component anal. revealed that proteases were categorized into three groups based on endo- or exo-peptidase activity. Whole blood is a more complex raw material, yet the proteases were still categorized in a similar fashion. This work contributes to understanding structural characteristics responsible for taste and volatile profiles of protein hydrolyzates. To complete the study, the researchers used 3,7-Dimethyloctan-3-ol (cas: 78-69-3) .

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Recommanded Product: 78-69-3 Metabolite observed in cancer metabolism. It has a role as a human metabolite.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sangjan, Worasit;Marzougui, Afef;Mattinson, D. Scott;Schroeder, Brenda K.;Bates, Austin A.;Khot, Lav R.;Sankaran, Sindhuja published 《Identification of volatile biomarkers for high-throughput sensing of soft rot and Pythium leak diseases in stored potatoes》 in 2022. The article was appeared in 《Food Chemistry》. They have made some progress in their research.Electric Literature of C10H22O The article mentions the following:

Soft rot and Pythium leak are postharvest storage diseases of potato tubers that can cause substantial crop losses in the US. This study focused on detecting volatile organic compounds (VOCs) associated with rot inoculated tubers during storage (up to 21 days) using headspace solid-phase microextraction (SPME) coupled to gas chromatog. (GC) with mass spectrometry (MS) and flame ionization detector (FID) anal. Russet Burbank and Ranger Russet tubers were inoculated with the rot pathogens. Static sampling with 50 min trapping time followed by GC-MS and GC-FID anal. identified 23 and 30 common VOCs from the pathogen inoculated tubers. Overall, n,n-dimethylmethylamine, acetone, 1-undecene, and styrene, occurred frequently and repeatability in inoculated samples based on GC-MS anal., with the latter two found using GC-FID anal. as well. Identification of such biomarkers can be useful in developing high-throughput VOC sensing systems for early disease detection in potato storage facilities. And 3,7-Dimethyloctan-3-ol (cas: 78-69-3) was used in the research process.

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Electric Literature of C10H22O Metabolite observed in cancer metabolism. It has a role as a human metabolite.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts