Tag: 100-200

Wikoff, William R.;Nagle, Megha A.;Kouznetsova, Valentina L.;Tsigelny, Igor F.;Nigam, Sanjay K. published 《Untargeted Metabolomics Identifies Enterobiome Metabolites and Putative Uremic Toxins as Substrates of Organic Anion Transporter 1 (Oat1)》. The research results were published in《Journal of Proteome Research》 in 2011.Safety of 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride The article conveys some information:

Untargeted metabolomics on the plasma and urine from wild-type and organic anion transporter-1 (Oat1/Slc22a6) knockout mice identified a number of physiol. important metabolites, including several not previously linked to Oat1-mediated transport. Several, such as indoxyl sulfate, derive from Phase II metabolism of enteric gut precursors and accumulate in chronic kidney disease (CKD). Other compounds included vitamins (pantothenic acid, 4-pyridoxic acid), urate, and metabolites in the tryptophan and nucleoside pathways. Three metabolites, indoxyl sulfate, kynurenine, and xanthurenic acid, were elevated in the plasma and interacted strongly and directly with Oat1 in vitro with IC50 of 18, 12, and 50 μM, resp. A pharmacophore model based on several identified Oat1 substrates was used to screen the NCI database and candidate compounds interacting with Oat1 were validated in an in vitro assay. Together, the data suggest a complex, previously unidentified remote communication between the gut microbiome, Phase II metabolism in the liver, and elimination via Oats of the kidney, as well as indicating the importance of Oat1 in the handling of endogenous toxins associated with renal failure and uremia. The possibility that some of the compounds identified may be part of a larger remote sensing and signaling pathway is also discussed. The experimental procedure involved many compounds, such as 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride (cas: 148-51-6) .

5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(cas:148-51-6 Safety of 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride) is a strong antagonist of vitamin B6. Deoxypyridoxine hydrochloride has been used as an analytical reference standard for the quantification of the analyte in food samples using high performance liquid chromatography.

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Product Details of 110-03-2《Zn-Mediated Hydrodeoxygenation of Tertiary Alkyl Oxalates》 was published in 2021. The authors were Ye, Yang;Ma, Guobin;Yao, Ken;Gong, Hegui, and the article was included in《Synlett》. The author mentioned the following in the article:

A general, mild, and scalable method for hydrodeoxygenation of readily accessible tertiary alkyl oxalates by Zn/silane under Ni-catalyzed conditions was described. The reduction method was suitable for an array of structural motifs derived from tertiary alcs. that beared diverse functional groups, included the synthesis of a key intermediate en route to estrone. The experimental procedure involved many compounds, such as 2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) .

2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) on heteropoly acid catalyzed dehydration yields cyclic ethers via stereospecific intramolecular SN2 mechanism. It reacts with nitriles in concentrated sulfuric acid to yield Δ1-pyrrolines.Product Details of 110-03-2

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Kang, Jian;Liu, Junjie;Pei, Jingjing published 《The indoor volatile organic compounds (VOCs) characteristics and source identification in a new university campus in Tianjin, China》. The research results were published in《Journal of the Air & Waste Management Association》 in 2017.Name: 4-tert-Amylphenol The article conveys some information:

This study investigates the volatile organic compounds (VOCs) constituents and concentration levels on a new university campus, where all of the buildings including classrooms and student dormitories were newly built and decorated within 1 yr. Investigated indoor environments include dormitories, classrooms, and the library. About 30 dormitory buildings with different furniture loading ratios were measured. The characteristics of the indoor VOCs species are analyzed and possible sources are identified. The VOCs were analyzed with gas chromatog.-mass spectroscopy (GC-MS). It was found that the average total VOC (TVOC) concentration can reach 2.44 mg/m³. Alkenes were the most abundant VOCs in dormitory rooms, contributing up to 86.5% of the total VOCs concentration The concentration of α-pinene is the highest among the alkenes. Unlike the dormitory rooms, there is almost no room with TVOC concentration above 0.6 mg/m³ in classroom and library buildings. Formaldehyde concentration in the dormitory rooms increased about 23.7% after the installation of furniture, and the highest level reached 0.068 mg/m³. Ammonia released from the building antifreeze material results in an average indoor concentration of 0.28 mg/m³, which is 100% over the threshold and should be seriously considered. Further experiments were conducted to analyze the source of the α-pinene and some alkanes in dormitory rooms. The results showed that the α-pinene mainly comes from the bed boards, while the wardrobes are the main sources of alkanes. The contribution of the pinewood bed boards to the α-pinene and TVOC concentration can reach up to above 90%. The same type rooms were sampled 1 yr later and the decay rate of α-pinene is quite high, close to 100%, so that it almost cannot be detected in the sampled rooms. Implications: Anal. of indoor volatile organic compounds (VOCs) in newly built campus buildings in China identified the specific constituents of indoor VOCs contaminants exposed to Chinese college students. The main detected substances α-pinene, β-pinene, and 3-carene originated from solid wood bed boards and should be seriously considered. In addition, the contribution rates of building structure materials and furniture to specific VOCs constituents are quant. calculated Also, the decay rates of these specific constituents within 1 yr are also quant. calculated in this paper. This study can help us to better understand the sources and concentration levels of VOC contaminants in campus buildings, and to help select appropriate materials in buildings. And 4-tert-Amylphenol (cas: 80-46-6) was used in the research process.

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group. Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Methanol, ethanol, and propanol are miscible in water. Butanol, with a four-carbon chain, is moderately soluble.Name: 4-tert-Amylphenol

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Wang, Daoyong;Shuler, William G.;Pierce, Conor J.;Hilinski, Michael K. published 《An Iminium Salt Organocatalyst for Selective Aliphatic C-H Hydroxylation》 in 2016. The article was appeared in 《Organic Letters》. They have made some progress in their research.Safety of 3,7-Dimethyloctan-3-ol The article mentions the following:

The first examples of catalysis of aliphatic C-H hydroxylation by an iminium salt are presented. The method allows the selective organocatalytic hydroxylation of unactivated 3° C-H bonds at room temperature using hydrogen peroxide as the terminal oxidant. Hydroxylation of an unactivated 2° C-H bond is also demonstrated. Furthermore, improved functional group compatibility over other catalytic methods is reported in the form of selectivity for aliphatic C-H hydroxylation over alc. oxidation On the basis of initial mechanistic studies, an oxaziridinium species is proposed as the active oxidant. To complete the study, the researchers used 3,7-Dimethyloctan-3-ol (cas: 78-69-3) .

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Safety of 3,7-Dimethyloctan-3-ol Metabolite observed in cancer metabolism. It has a role as a human metabolite.

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Application of 80-46-6In 2020, Furdikova, Katarina;Machynakova, Andrea;Drtilova, Tereza;Spanik, Ivan published 《Comparison of different categories of Slovak Tokaj wines in terms of profiles of volatile organic compounds》. 《Molecules》published the findings. The article contains the following contents:

The present work deals with the characterization of volatile organic compounds in wines from the Slovak Tokaj wine region. Studied wine samples were divided into 3 groups-varietal wines from registered Tokaj vine varieties, film wines Tokajske samorodne dry, and naturally sweet botrytized wines Tokaj selections. The VOCs from wines were extracted using optimized solid phase microextraction and analyzed by comprehensive two-dimensional gas chromatog. coupled to high-resolution time-of-flight mass spectrometry (HRTOF-MS). In total, 176 VOCs were identified in all 46 studied samples. It was found that the total number of VOCs in varietal wines was generally higher than in botrytized wines. All three studied categories showed characteristic VOC profiles with significant differences. Varietal wines were characterized by higher concentrations of esters and terpenoids originating from grapes. The presence of γ-octalactone, (E)-6-methylhept-2-en-4-one, and lack of benzaldehyde were typical for Tokajske samorodne dry. Tokaj selections expressed the highest concentration of di-Et malate, benzaldehyde, and furfurals. Several interesting trends were also observed The concentration of fermentation products was highest in varietal wines, while long-term matured Tokaj special wines were typified by the presence of compounds related to noble-rotten raisins (2-phenylacetaldehyde, Et 2-phenylacetate, and 2-phenylethanol), wood (cis-whisky lactone), and aging (1,1,6-trimethyl-2H-naphthalene, furfural, and 5-methylfurfural). The experimental procedure involved many compounds, such as 4-tert-Amylphenol (cas: 80-46-6) .

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group.Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Application of 80-46-6

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Formula: C8H18O2In 2021, Tailor, Sanita B.;Manzotti, Mattia;Smith, Gavin J.;Davis, Sean A.;Bedford, Robin B. published 《Cobalt-Catalyzed Coupling of Aryl Chlorides with Aryl Boron Esters Activated by Alkoxides》. 《ACS Catalysis》published the findings. The article contains the following contents:

The cobalt-catalyzed Suzuki biaryl cross-coupling of aryl chloride substrates with aryl boron reagents, activated with more commonly used bases, remained a significant unmet challenge in the race to replace platinum group metal catalysts with Earth-abundant metal alternatives. This highly desirable process can be realized using alkoxide bases, provided the right counterion is employed, strict stoichiometric control of the base is maintained with respect to the aryl boron reagent, and the correct boron ester is selected. Potassium tert-butoxide works well, but any excess of the base first inhibits and then poisons the catalyst. Lithium tert-butoxide performs very poorly, while even catalytic amounts of lithium additives also poison the catalyst. Meanwhile, a neopentane diol-based boron ester is required for best performance. As well as delivering this sought-after transformation, a detailed mechanistic and computational investigations to probe the possible mechanism of the reaction has been discussed and explains the unexpected exptl. observations. To complete the study, the researchers used 2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) .

2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) on heteropoly acid catalyzed dehydration yields cyclic ethers via stereospecific intramolecular SN2 mechanism. It reacts with nitriles in concentrated sulfuric acid to yield Δ1-pyrrolines.Formula: C8H18O2

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Related Products of 224434-01-9《Enantioselective Cu(I)-Catalyzed Cycloaddition of Prochiral Diazides with Terminal or 1-Iodoalkynes》 was published in 2020. The authors were Wang, Cai;Zhu, Ren-Yi;Liao, Kui;Zhou, Feng;Zhou, Jian, and the article was included in《Organic Letters》. The author mentioned the following in the article:

We report an unprecedented highly enantioselective desym. Cu(I)-catalyzed 1,3-dipolar cycloaddition of diazides with terminal alkynes and 1-iodoalkynes, affording tertiary alcs. bearing a 1,2,3-triazole moiety in high yield and excellent ee value. PYBOX ligands with a C4 shielding group once again show the promising ability to achieve higher enantioselectivity.(S)-2-Amino-2-(4-fluorophenyl)ethanol (cas: 224434-01-9) were involved in the experimental procedure.

(S) – 2-amino-2 – (4-fluorophenyl) ethanol (cas: 224434-01-9) has the characteristics of alcohol. In general, the hydroxyl group makes alcohols polar. Those groups can form hydrogen bonds to one another and to most other compounds. Related Products of 224434-01-9

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Cruz, Rodrigo A. S.;Botas, Gisele da S.;Fernandes, Caio P.;Santos, Marcelo G.;Rocha, Leandro published 《Chemical Constituents of Essential Oils from Leaves of Two Erythroxylum Species》. The research results were published in《Chemistry of Natural Compounds》 in 2018.Quality Control of 3,7-Dimethyloctan-3-ol The article conveys some information:

In this context, the aim of the present study was to describe for the first time the chem. composition of essential oils obtained from leaves of these two Erythroxylum species. The present study contributes to the phytochem. studies of this genus, especially concerning volatile substances. Moreover, these are the first chem. investigations performed with Erythroxylum ovalifolium and Erythroxylum subsessile. The experimental procedure involved many compounds, such as 3,7-Dimethyloctan-3-ol (cas: 78-69-3) .

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Quality Control of 3,7-Dimethyloctan-3-ol Metabolite observed in cancer metabolism. It has a role as a human metabolite.

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Related Products of 80-46-6《Study on capillary GC fingerprint of Guominxing Biyan Granules》 was published in 2016. The authors were Hu, Jun-hua;Ren, Ji-hua;Wang, Xue;Li, Jia-chun;Huang, Wen-zhe;Wang, Zhen-zhong;Xiao, Wei, and the article was included in《Zhongcaoyao》. The author mentioned the following in the article:

Objective To establish the capillary GC fingerprint of Guominxing Biyan Granules and give a new method for quality control. Methods The capillary GC was used. The ingredients of common peaks were analyzed by FID and MS. The HP-5 Ph Me Siloxane (30 m×0.32 mm, 0.25 μm) was used for capillary column. The chromatog. conditions were as follows: the temperature of inlet was 200 degree C in splitless sampling, the detector temperature was 250 degree C, the column initial temperature was 50 degree C, 3 degree C/min rose to 140 degree C, keeping 2 min and 10 degree C/min rose to 200 degree C, keeping 2 min. Results Capillary GC fingerprint of volatile oil in Allergic Rhinitis Particles was established. Twelve peaks were selected as the fingerprint peaks of Allergic Rhinitis Particles. The ingredients of common peaks were designated by GC-MS. The similarity between the fingerprint of 10 batches of Allergic Rhinitis Particles Samples were 0.90. Conclusion The established capillary GC fingerprint has desirable precision, reproducibility, and stability, and can be applied to the quality control of Guominxing Biyan Granules.4-tert-Amylphenol (cas: 80-46-6) were involved in the experimental procedure.

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group. Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Methanol, ethanol, and propanol are miscible in water. Butanol, with a four-carbon chain, is moderately soluble.Related Products of 80-46-6

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Product Details of 110-03-2In 2012, Siebert, Joerg Max;Baier, Grit;Landfester, Katharina published 《Thermal and acid labile polyurethanes as a new class of responsive materials in polymeric nanoparticles and nanocapsules》. 《Journal of Polymer Science, Part A: Polymer Chemistry》published the findings. The article contains the following contents:

A new class of polyurethanes has been designed, containing tertiary carbamate groups in the main chain of the polymer, which enable the resulting polymer to degrade completely under acid and thermal treatment. The decomposition temperatures of the polymers were determined by measuring the evolution of carbon dioxide and other decomposition products using TGA-MS. Until decomposition of the polymer, no glass transition was found. The polymers exhibit excellent solubility in common organic solvents like chloroform and THF, making them to suitable materials for film formation. From the obtained polymers, nanoparticles were synthesized by the solvent evaporation method combined with the miniemulsion technique. The resulting nanoparticles can be used as intelligent fillers in films and sensors, since they degrade at temperatures of above 180°, which can be detected by a color change reaction with ninhydrin. Polymeric nanocapsules were prepared by an interfacial polyaddition reaction from 2,4-toluene diisocyanate and tertiary diols performed at the droplet’s interface in inverse (water-in-oil) miniemulsions. These nanocapsules with an encapsulated photoacid generator can act as a release system, whereby an acidic release through irradiation with UV light can be triggered. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011. And 2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) was used in the research process.

2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) was used in the synthesis of six- and seven-membered heterocyclic boron compounds containing intramolecular N-B bond.Product Details of 110-03-2

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