Tag: 100-200

In 2018,Danon, Jonathan J.; Leigh, David A.; Pisano, Simone; Valero, Alberto; Vitorica-Yrezabal, Inigo J. published 《A Six-Crossing Doubly Interlocked [2]Catenane with Twisted Rings, and a Molecular Granny Knot》.Angewandte Chemie, International Edition published the findings.Safety of 2,6-Pyridinedimethanol The information in the text is summarized as follows:

A mol. 623 link (a six crossing, doubly interlocked, [2]catenane with twisted rings) and a 31#31 granny knot (a composite knot made up of two trefoil tangles of the same handedness) were constructed by ring-closing olefin metathesis of an Fe(II)-coordinated 2×2 interwoven grid. The connections were directed by pendant Ph groups to be between proximal ligand ends on the same faces of the grid. The 623 link was separated from the topoisomeric granny knot by recycling size-exclusion chromatog. The identity of each topoisomer was determined by tandem mass spectrometry and the structure of the 623 link confirmed by x-ray crystallog., which revealed two 82-membered macrocycles, each in figure-of-eight conformations, linked through both pairs of loops. In addition to this study using 2,6-Pyridinedimethanol, there are many other studies that have used 2,6-Pyridinedimethanol(cas: 1195-59-1Safety of 2,6-Pyridinedimethanol) was used in this study.

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Safety of 2,6-Pyridinedimethanol

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In 2018,El Awamy, Moustafa; Mohammad, Haroon; Hussien, Abdelrahman; Abutaleb, Nader S.; Hagras, Mohamed; Serya, Rabah A. T.; Taher, Azza T.; Abouzid, Khaled A. M.; Seleem, Mohamed N.; Mayhoub, Abdelrahman S. published 《Alkoxyphenylthiazoles with broad-spectrum activity against multidrug-resistant gram-positive bacterial pathogens》.European Journal of Medicinal Chemistry published the findings.Product Details of 18621-18-6 The information in the text is summarized as follows:

With the continued rise of antibiotic resistance and reduced susceptibility to almost all front-line antibiotics, multidrug-resistant Gram-pos. bacterial infections represent an incessant threat to healthcare providers. This study presents a new series of phenylthiazole compounds where two active moieties were combined into one scaffold. The antibacterial activity of the hybrid structures extended to include several clin.-relevant multi-drug resistant pathogens including methicillin-resistant and vancomycin-resistant Staphylococcus aureus, methicillin-resistant Staphylococcus epidermidis, vancomycin-resistant enterococci, cephalosporin-resistant and methicillin-resistant Streptococcus pneumoniae, and Listeria monocytogenes. In addition, the most potent compounds, 16a and 17a, exhibited a fast bactericidal mode of action in vitro with low susceptibility to induce bacterial resistance. In addition to its potent spectrum of activity against Gram-pos. bacterial pathogens, compound 17a was found to be metabolically stable in rats, with a half-life of 4h. In the experimental materials used by the author, we found Azetidin-3-ol hydrochloride(cas: 18621-18-6Product Details of 18621-18-6)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Product Details of 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

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Product Details of 54-17-1On March 31, 2019, Ashraf, Muhammad; Ahmad, Manzoor; Ahmad, Hanif; Ahmad, Shujaat published an article in Pakistan Journal of Pharmaceutical Sciences. The article was 《Phytochemical investigation of Hyoscyamus albus》. The article mentions the following:

The work presented in this paper illustrates the isolation and structure elucidation of secondary metabolites of Hyoscyamus albus. Two new natural source and three known compounds were isolated from the Hyoscyamus albus. Among the isolated compounds, grivilloside H (1) and betulaplatoside (2) were isolated for the first time while scopolamine (3), β-sitosterol (4) and stigmasterol (5) have been reported previously from the same plant. The structures of all the isolated compounds were established by using modern spectroscopic technique (UV, IR, NMR, and EI-MS) and by comparing with those available in literature. In the experiment, the researchers used many compounds, for example, rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1Product Details of 54-17-1)

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is oxidized in various tissues under either aerobic or anaerobic conditions through glycolysis; the oxidation reaction produces carbon dioxide, water, and ATP.Product Details of 54-17-1

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SDS of cas: 54-17-1On October 15, 2020 ,《Microwave-assisted synthesis of nutgall tannic acid-based salecan polysaccharide hydrogel for tunable release of β-lactoglobulin》 was published in International Journal of Biological Macromolecules. The article was written by Hu, Xinyu; Yan, Linlin; Wang, Yongmei; Xu, Man. The article contains the following contents:

The low stability of β-lactoglobulin (βlg) under gastric conditions decreases the protein amount reaching the small intestine. Thus, it is crucial to develop a vehicle that can protect βlg from the stomach harsh acidity and enable its sustained and prolonged release in the small intestine. Herein, a fresh hydrogel composed of salecan-g-poly(N,N-dimethylaminoethyl acrylate) (PDMAEA) and nutgall tannic acid (TA) was fabricated by microwave-assisted polymerization The incorporation of salecan into hydrogels markedly affected the hydrogels thermal stability, microstructure, and mech. strength. Particularly, the multiple phenolic groups of TA can form complexes with βlg, and this enables the highly effective loading of proteins. As expected, βlg not only achieved effective entrapment into the hydrogels but also achieved a tunable and pH-controlled release. Such a release profile will enable βlg protection in the stomach and its targeted release in the small intestine. Increasing the salecan content dramatically enhanced the βlg release in simulated intestinal fluid (SIF). Furthermore, the βlg release was driven by Fickian diffusion in simulated gastric fluid (SGF), but the mechanism changed to non-Fickian diffusion in SIF. The release mechanism excellently matched Ritger-Peppas model. Overall, these results indicate that TA/salecan-g-PDMAEA hydrogels hold great potential for protein delivery in the gastrointestinal tract. The results came from multiple reactions, including the reaction of rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1SDS of cas: 54-17-1)

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is oxidized in various tissues under either aerobic or anaerobic conditions through glycolysis; the oxidation reaction produces carbon dioxide, water, and ATP.SDS of cas: 54-17-1

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Reference of rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraolOn September 15, 2019 ,《A polysaccharide found in Dendrobium nobile Lindl stimulates calcium signaling pathway and enhances tobacco defense against TMV》 was published in International Journal of Biological Macromolecules. The article was written by Li, Zhurui; Shi, Jing; Hu, Deyu; Song, Baoan. The article contains the following contents:

A neutral polysaccharide separated from Dendrobium nobile Lindl was designated as DNPE6(4). It was structurally characterized using a combination of spectral and chem. anal. Its average mol. weight was 99.2 kDa. The monosaccharide composition was Araf, Glcp, Galp, and Manp in a molar ratio of 2.5:0.9:0.3:0.8. Their linkage types were (→1)-L-Araf-(3→, →1)-D-Glcp-(4→, →1)-D-Galp-(3→, →1)-D-Galp-(6→, →1)-D-Manp-(3, 6→), and T-D-Manp. The polysaccharide was found to have anti-TMV and anti-CMV activities for the first time in vivo. Notably, DNPE6(4) exhibited excellent protective activity against TMV. Furthermore, several proteins related to calcium signaling pathway and pathogen related proteins were up-regulated, and we also found expression levels of EDS1, ICS1, and PR1 involved in SA pathway up-regulated after DNPE6(4) treatment. In addition, some defense enzymes increased in the same condition. All these findings revealed DNPE6(4) was an elicitor to stimulate calcium signaling pathway to enhance the tobacco defense against TMV. This study therefore revealed that DNPE6(4) was a promising antiviral agent for future study. In the experiment, the researchers used rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1Reference of rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol)

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is oxidized in various tissues under either aerobic or anaerobic conditions through glycolysis; the oxidation reaction produces carbon dioxide, water, and ATP.Reference of rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol

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Synthetic Route of C3H8ClNOIn 2020 ,《Design, optimization, and study of small molecules that target tau pre-mRNA and affect splicing》 was published in Journal of the American Chemical Society. The article was written by Chen, Jonathan L.; Zhang, Peiyuan; Abe, Masahito; Aikawa, Haruo; Zhang, Liying; Frank, Alexander J.; Zembryski, Timothy; Hubbs, Christopher; Park, Ha Jeung; Withka, Jane; Steppan, Claire; Rogers, Lucy; Cabral, Shawn; Pettersson, Martin; Wager, Travis T.; Fountain, Matthew A.; Rumbaugh, Gavin; Childs-Disney, Jessica L.; Disney, Matthew D.. The article contains the following contents:

Approx. 95% of human genes are alternatively spliced, and aberrant splicing events can cause disease. One pre-mRNA that is alternatively spliced and linked to neurodegenerative diseases is tau (microtubule-associated protein tau), which can cause frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) and can contribute to Alzheimer′s disease. Here, we describe the design of structure-specific lead small mols. that directly target tau pre-mRNA from sequence. This was followed by hit expansion and analog synthesis to further improve upon these initial lead mols. The emergent compounds were assessed for functional activity in a battery of assays, including binding assays and an assay that mimics mol. recognition of tau pre-mRNA by a U1 small nuclear ribonucleoprotein (snRNP) splicing factor. Compounds that emerged from these studies had enhanced potency and selectivity for the target RNA relative to the initial hits, while also having significantly improved drug-like properties. The compounds are shown to directly target tau pre-mRNA in cells, via chem. crosslinking and isolation by pull-down target profiling, and to rescue disease-relevant splicing of tau pre-mRNA in a variety of cellular systems, including primary neurons. More broadly, this study shows that lead, structure-specific compounds can be designed from sequence and then further optimized for their physicochem. properties while at the same time enhancing their activity. The results came from multiple reactions, including the reaction of Azetidin-3-ol hydrochloride(cas: 18621-18-6Synthetic Route of C3H8ClNO)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Synthetic Route of C3H8ClNO Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

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Application of 627-18-9In 2022 ,《Stimuli-Responsive Polydiacetylene Based on the Self-Assembly of a Mercury-Bridged Macrocyclic Diacetylene Dimer》 was published in Macromolecules (Washington, DC, United States). The article was written by Bae, Kwangmin; Lee, Dong Geol; Khazi, Mohammed Iqbal; Kim, Jong-Man. The article contains the following contents:

The metal-mediated self-assembly process allows the well-directed and controlled construction of supramol. architectures, and the assembled metal-ligand complexes display diverse functionalities depending on the composition of the complex template. Through the deliberate introduction of a metal-binding nucleobase, cytosine, to the macrocyclic diacetylene (MCDA), a macrocyclic ligand, CytMCDA, was synthesized. On account of the metal affinity of cytosine and the π-π interaction of the diacetylene template, a Hg-coordinated unidirectional columnar self-assembly of CytMCDA was generated that formed into organic nanotubes. The monomeric CytMCDA-Hg is covalently crosslinked to the blue-phase macrocyclic polydiacetylene nanotubes (CytMCPDA-Hg) via UV-induced topochem. polymerization CytMCPDA-Hg displayed a naked-eye-detectable sensing response toward heat and solvents with a brilliant blue-red chromatic transition. Moreover, owing to the high affinity of the mercury complex toward sulfur, CytMCPDA-Hg displayed a high sensitivity against thiols. The results came from multiple reactions, including the reaction of 3-Bromopropan-1-ol(cas: 627-18-9Application of 627-18-9)

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Application of 627-18-9

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Synthetic Route of C6H7BO3In 2021 ,《Synthesis of Pyrroles via Consecutive 6π-Electrocyclization/Ring-Contraction of Sulfilimines》 appeared in Journal of the American Chemical Society. The author of the article were Haut, Franz-Lucas; Feichtinger, Niklas J.; Plangger, Immanuel; Wein, Lukas A.; Mueller, Mira; Streit, Tim-Niclas; Wurst, Klaus; Podewitz, Maren; Magauer, Thomas. The article conveys some information:

Authors present a modular, synthetic entry to polysubstituted pyrroles employing readily available 2,5-dihydrothiophenes. Ring-opening of the heterocycle provides access to a panel of 1,3-dienes which underwent pyrrole formation in the presence of inexpensive chloramine-T trihydrate. The transformation is conducted in an open flask and proceeds at ambient temperatures (23°) in nondry solvents. A careful adjustment of the electronics and sterics of the 1,3-diene precursor allows for the isolation of key intermediates. DFT studies identified a reaction mechanism that features a 6π-electrocyclization of a sulfilimine intermediate followed by spontaneous ring-contraction to reveal the pyrrole skeleton. In the part of experimental materials, we found many familiar compounds, such as 2-Hydroxyphenylboronic acid(cas: 89466-08-0Synthetic Route of C6H7BO3)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Synthetic Route of C6H7BO3

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In 2022,Plaza-Pedroche, Rodrigo; Fernandez-Liencres, M. Paz; Jimenez-Pulido, Sonia B.; Illan-Cabeza, Nuria A.; Achelle, Sylvain; Navarro, Amparo; Rodriguez-Lopez, Julian published an article in ACS Applied Materials & Interfaces. The title of the article was 《Excited-State Intramolecular Proton Transfer in 2-(2′-Hydroxyphenyl)pyrimidines: Synthesis, Optical Properties, and Theoretical Studies》.Safety of 2-Hydroxyphenylboronic acid The author mentioned the following in the article:

The development of fluorescence materials with switched on/off emission has attracted great attention owing to the potential application of these materials in chem. sensing. In this work, the photophys. properties of a series of original 2-(2′-hydroxyphenyl)pyrimidines were thoroughly studied. The compounds were prepared by following well-established and straightforward methodologies and showed very little or null photoluminescence both in solution and in the solid state. This absence of emission can be explained by a fast proton transfer from the OH group to the nitrogen atoms of the pyrimidine ring to yield an excited tautomer that deactivates through a nonradiative pathway. The key role of the OH group in the emission quenching was demonstrated by the preparation of 2′-unsubstituted derivatives, all of which exhibited violet or blue luminescence. Single crystals of some compounds suitable for an X-ray diffraction anal. could be obtained, which permitted us to investigate inter- and intramol. interactions and mol. packing structures. The protonation of the pyrimidine ring by an addition of trifluoroacetic acid inhibited the excited-state intramol. proton transfer (ESIPT) process, causing a reversible switch on fluorescence response detectable by the naked eye. This acidochromic behavior allows 2-(2′-hydroxyphenyl)pyrimidines to be used as solid-state acid-base vapor sensors and anticounterfeiting agents. Extensive d. functional theory and its time-dependent counterpart calculations at the M06-2X/6-31+G** level of theory were performed to rationalize all the exptl. results and understand the impact of protonation on the different optical transitions. In the experiment, the researchers used many compounds, for example, 2-Hydroxyphenylboronic acid(cas: 89466-08-0Safety of 2-Hydroxyphenylboronic acid)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Safety of 2-Hydroxyphenylboronic acid

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In 2022,Nicolai, Stefano; Waser, Jerome published an article in Angewandte Chemie, International Edition. The title of the article was 《(4+3) Annulation of Donor-Acceptor Cyclopropanes and Azadienes: Highly Stereoselective Synthesis of Azepanones》.SDS of cas: 126456-43-7 The author mentioned the following in the article:

Herein, the Lewis acid catalyzed (4+3) annulative addition of aryl and amino donor-acceptor cyclopropanes with 2-aza-1,3-dienes were reported. Densely substituted azepane derivatives were obtained in good to excellent yields and with high diastereoselectivity. The reaction occurred under mild conditions with ytterbium triflate as the catalyst. The use of copper triflate with a trisoxazoline (Tox) ligand led to an enantioselective transformation. The obtained cycloadducts were convenient substrates for a series of further modifications, showing the synthetic utility of these compounds In the experimental materials used by the author, we found (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7SDS of cas: 126456-43-7)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.SDS of cas: 126456-43-7

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