Tag: 100-200

Related Products of 26153-38-8In 2022 ,《Alkyne Metathesis with d2 Re(V) Alkylidyne Complexes Supported by Phosphino-Phenolates: Ligand Effect on Catalytic Activity and Applications in Ring-Closing Alkyne Metathesis》 appeared in Journal of the American Chemical Society. The author of the article were Cui, Mingxu; Sung, Herman H. Y.; Williams, Ian D.; Jia, Guochen. The article conveys some information:

A family of d2 Re(V) alkylidyne complexes bearing two decorated phosphino-phenolates (POs) and a labile pyridine ligand were prepared that can efficiently promote alkyne metathesis reactions in toluene. The relative activity of these complexes varies with the PO ligands. Complexes with an electron-rich metal center have a higher activity. Ligand exchange experiments suggest that the pyridine ligands of the Re(V) alkylidynes with more electron-donating PO ligands are more labile and are more easily released to generate catalytically active species. However, complexes with electron-withdrawing PO ligands are more air-stable than those with electron-donating PO ligands. These Re(V) alkylidyne catalysts can promote the homometathesis of functionalized internal alkyl- and aryl-alkynes, as well as ring-closing alkyne metathesis (RCAM) of Me-capped diynes, forming macrocycles with a ring size ≥12 efficiently for concentrations ≤5 mM. These reactions represent the 1st examples of RCAM mediated by nond0 alkylidyne complexes. The Re(V) alkylidyne catalysts tolerate a wide range of functional groups including ethers, esters, ketones, aldehydes, alcs., phenols, amines, amides, and heterocycles. Also, the catalytic RCAM reactions promoted by robust Re(V) alkylidyne catalysts could also proceed normally in wet toluene. In the experimental materials used by the author, we found 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Related Products of 26153-38-8)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Related Products of 26153-38-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Han, Xiang-Bin; Zu, Hui-Yuan; Chai, Chao-Yang; Liang, Bei-Dou; Fan, Chang-Chun; Zhang, Wen published an article in Journal of Physical Chemistry Letters. The title of the article was 《cis/trans-Isomeric Cation Tuning Photoluminescence and Photodetection in 2D Perovskites》.Application of 27489-62-9 The author mentioned the following in the article:

Cationic components in the organic-inorganic hybrid perovskites (OIHPs) play an important role in the arrangement and tilting of the inorganic part that is responsible for semiconducting, luminescent, and photoelectronic properties. Herein, we report two 2D OIHP compounds, (cis-4ACHO)2(H3OBr)PbBr4 (1) and (trans-4ACHO)2(H3OCl)PbBr4 (2) (4ACHO = 4-aminocyclohexanol), showing both photoluminescence (PL) and photodetection (PD) that are tuned by the cis- and trans configurational isomerism of 4ACHO. Crystals of 1 and 2 exhibit similar packing structures but with different crystallog. symmetries. Compound 2 displays a broadband white-light emission with a higher PL efficiency (6.6%) than 1 (2.1%) that emits narrow band blue light while the PD property of 1 is better than 2 with a higher on/off ratio under the same conditions. The PL and PD of the two compounds show a seesaw relationship, which provides a new perspective for understanding the PL and PD properties in OIHPs. The experimental process involved the reaction of trans-4-Aminocyclohexanol(cas: 27489-62-9Application of 27489-62-9)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Application of 27489-62-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Cleveland, Jacob W.; Choi, Ji Il; Sekiya, Ryoh-Suke; Cho, Jinwon; Moon, Hyun June; Jang, Seung Soon; Jones, Christopher W. published an article in ACS Applied Materials & Interfaces. The title of the article was 《Cooperativity in the Aldol Condensation Using Bifunctional Mesoporous Silica-Poly(styrene) MCM-41 Organic/Inorganic Hybrid Catalysts》.Synthetic Route of C6H12O The author mentioned the following in the article:

This work explores the efficacy of silica/organic hybrid catalysts, where the organic component is built from linear aminopolymers appended to the silica support within the support mesopores. Specifically, the role of mol. weight and polymer chain composition in amine-bearing atom transfer radical polymerization-synthesized poly(styrene-co-2-(4-vinylbenzyl)isoindoline-1,3-dione) copolymers is probed in the aldol condensation of 4-nitrobenzaldehyde and acetone. Controlled polymerization produces protected amine-containing poly(styrene) chains of controlled mol. weight and dispersity, and a grafting-to thiol-ene coupling approach followed by a phthalimide deprotection step are used to covalently tether and activate the polymer hybrid catalysts prior to the catalytic reactions. Site-normalized batch kinetics are used to assess the role of polymer mol. weight and chain composition in the cooperative catalysis. Lower-mol.-weight copolymers are demonstrated to be more active than catalysts built from only mol. organic components or from higher-mol.-weight chains. Mol. dynamics simulations are used to probe the role of polymer flexibility and morphol., whereby it is determined that higher-mol.-weight hybrid structures result in congested pores that inhibit active site cooperativity and the diffusivity of reagents, thus resulting in lower rates during the reaction.5-Hexen-1-ol(cas: 821-41-0Synthetic Route of C6H12O) was used in this study.

5-Hexen-1-ol(cas: 821-41-0) is a volatile organic compound. Further, it is used to prepare 6-bromo-hex-1-ene by reaction with phosphorus tribromide.Synthetic Route of C6H12O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Li, Xue-Lian; Wu, Dong-En; Qiao, Qiwei; Guo, Qing-Hui; Cai, Yu-Jie published an article in Journal of the Iranian Chemical Society. The title of the article was 《The isomeric effect on structure and photophysical property of organic fluorescent material: synthesis, structures, and photophysical properties of two novel D-π-π-A prototype fluorescent material》.Recommanded Product: 3,5-Dihydroxybenzaldehyde The author mentioned the following in the article:

Two novel D-π-π-A prototype organic fluorescent compounds, namely (E)-2-(3-([1,1′-biphenyl]-4-yl)-1-(naphthalen-2-yl)allylidene)malononitrile (3-BNM) and (E)-2-(1-([1,1′-biphenyl]-4-yl)-3-(naphthalen-2-yl)allylidene)malononitrile (1-BNM) were synthesized to examine the isomeric effect on their structures and photophys. properties. The results indicated that 3-BNM and 1-BNM display different crystal packing and optical properties, because of the differences in substitution position. 3-BNM mols. packed into a 2D layer structure, while a 2D layer structure was formed in 1-BNM. Compared to that of 1-BNM, red-shifted emissions were observed in the crystal and dilute solution of 3-BNM. The structure-property relationship of the two isomers showed that it is the differences in electronic structures that lead to their different emission behaviors. The obvious isomeric effect indicated that subtle manipulation of substitution position is indeed a feasible and efficient way for tuning the structures and photophys. properties of D-π-π-A prototype organic fluorescent materials. The experimental process involved the reaction of 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Recommanded Product: 3,5-Dihydroxybenzaldehyde)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Recommanded Product: 3,5-Dihydroxybenzaldehyde

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Mittal, Rupali; Awasthi, Satish Kumar published an article in ACS Sustainable Chemistry & Engineering. The title of the article was 《Bimetallic Oxide Catalyst for the Dehydrogenative Oxidation Reaction of Alcohols: Practical Application in the Synthesis of Value-Added Chemicals》.Synthetic Route of C6H7NO The author mentioned the following in the article:

This work demonstrates the preparation of zinc cobalt oxide materials (ZCO-1, ZCO-2, and ZCO-3) via thermal annealing of novel zinc cobalt acetate hydroxide precursors prepared in three different Co/Zn molar ratios (2:1, 1:1, and 1:2). Among these, the ZCO-1 sample displayed superior catalytic activity for the dehydrogenative oxidation of alcs. to carboxylic acids, exhibiting wide substrate applicability and high yield output with concomitant evolution of hydrogen gas (latent fuel) under oxidant-free conditions. The high catalytic activity of ZCO-1 can be accredited to synergistic effects arising from a balanced molar ratio of Co/Zn (2:1), which led to the formation of pure spinel-structured zinc cobalt oxide and a sufficiently high surface area capable of furnishing copious active sites, resulting in faster reaction kinetics and higher productivity. Moreover, the practical utility of the current protocol was displayed via ZCO-1-catalyzed gram-scale synthesis of value-added chems. like nicotinic acid, terephthalic acid, and succinic acid. In the part of experimental materials, we found many familiar compounds, such as 3-Pyridinemethanol(cas: 100-55-0Synthetic Route of C6H7NO)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Synthetic Route of C6H7NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bellenie, Benjamin R.; Hall, Edward; Bruce, Ian; Spendiff, Matthew; Culshaw, Andrew; McDonald, Sarah; Ambarkhane, Ameet; Chinn, Colin; Thomas, Matthew; Rosner, Elisabeth; Bracher, Marguerite; Nicklin, Paul; Marshall, Stephen; Coote, Julie; Cullen, Eva; Tessier, Clemence; Wuersch, Kuno; Lal, Ajay; Wallis, Gillian; Hollingworth, Gregory J.; Neef, James published an article in 2021. The article was titled 《Discovery and Toxicological Profiling of Aminopyridines as Orally Bioavailable Selective Inhibitors of PI3-Kinase γ》, and you may find the article in Journal of Medicinal Chemistry.Reference of trans-4-Aminocyclohexanol The information in the text is summarized as follows:

Using a novel physiol. relevant in vitro human whole blood neutrophil shape change assay, an aminopyrazine series of selective PI3Kγ inhibitors was identified and prioritized for further optimization. Severe solubility limitations associated with the series leading to low oral bioavailability and poor exposures, especially at higher doses, were overcome by moving to an aminopyridine core. Compound 33, with the optimal balance of on-target activity, selectivity, and pharmacokinetic parameters, progressed into in vivo studies and demonstrated good efficacy (10 mg/kg) in a rat model of airway inflammation. Sufficient exposures were achieved at high doses to support toxicol. studies, where unexpected inflammatory cell infiltrates in cardiovascular tissue prevented further compound development. In addition to this study using trans-4-Aminocyclohexanol, there are many other studies that have used trans-4-Aminocyclohexanol(cas: 27489-62-9Reference of trans-4-Aminocyclohexanol) was used in this study.

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Reference of trans-4-Aminocyclohexanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xu, Shicheng; Guo, Anping; Chen, Nan-nan; Dai, Wei; Yang, Huan-aoyu; Xie, Wenqin; Wang, Mengjie; You, Qi-Dong; Xu, Xiao-Li published an article in 2021. The article was titled 《Design and synthesis of Grp94 selective inhibitors based on Phe199 induced fit mechanism and their anti-inflammatory effects》, and you may find the article in European Journal of Medicinal Chemistry.Category: alcohols-buliding-blocks The information in the text is summarized as follows:

Glucose-regulated protein 94 (Grp94), a member of the Heat shock protein 90 (Hsp90) family, is implicated in many human diseases, including cancer, neurodegeneration, inflammatory, and infectious diseases. Here, we describe our effort to design and develop a new series of Grp94 inhibitors based on Phe199 induced fit mechanism. Using an alkynyl-containing inhibitor as a starting point, we developed compound 4 (I), which showed potent inhibitory activity toward Grp94 in a fluorescence polarization-based assay. With improved physicochem. properties and suitable pharmacokinetic properties, compound 4 was advanced into in vivo bioactivity evaluation. In a dextran sulfate sodium (DSS)-induced mouse model of ulcerative colitis (UC), compound 4 showed anti-inflammatory property and reduced the levels of pro-inflammatory cytokines (TNF-α and IL-6). Together, these findings provide evidence that this approach may be promising for further Grp94 drug development efforts. In the experimental materials used by the author, we found trans-4-Aminocyclohexanol(cas: 27489-62-9Category: alcohols-buliding-blocks)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Davies, Jacob; Janssen-Muller, Daniel; Zimin, Dmitry P.; Day, Craig S.; Yanagi, Tomoyuki; Elfert, Jonas; Martin, Ruben published their research in Journal of the American Chemical Society in 2021. The article was titled 《Ni-Catalyzed carboxylation of aziridines en route to β-amino acids》.Electric Literature of C6H12O The article contains the following contents:

A Ni-catalyzed reductive carboxylation of N-substituted aziridines with CO2 at atm. pressure is disclosed. The protocol is characterized by its mild conditions, exptl. ease, and exquisite chemo- and regioselectivity pattern, thus unlocking a new catalytic blueprint to access β-amino acids, important building blocks with considerable potential as peptidomimetics. In the experiment, the researchers used many compounds, for example, 5-Hexen-1-ol(cas: 821-41-0Electric Literature of C6H12O)

5-Hexen-1-ol(cas: 821-41-0) is a volatile organic compound. Further, it is used to prepare 6-bromo-hex-1-ene by reaction with phosphorus tribromide.Electric Literature of C6H12O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Palladium-Catalyzed Selective Reduction of Carbonyl Compounds》 was written by Sarkar, Nabin; Mahato, Mamata; Nembenna, Sharanappa. Recommanded Product: 1195-59-1 And the article was included in European Journal of Inorganic Chemistry in 2020. The article conveys some information:

Two new examples of structurally characterized β-diketiminate analogs i.e., conjugated bis-guanidinate (CBG) supported palladium(II) complexes, [LPdX]2; [L= {(ArHN)(ArN)-C=N-C=(NAr)(NHAr)}; Ar = 2,6-Et2-C6H3], X = Cl (1), Br (2) were reported. The synthesis of complexes 1-2 was achieved by two methods. Method A involves deprotonation of LH by nBuLi followed by the treatment of LLi (insitu formed) with PdCl2 in THF, which afforded compound 1 in good yield (75%). In Method B, the reaction between free LH and PdX2 (X = Cl or Br) in THF allowed the formation of complexes 1 (Yield 73%) and 2 (Yield 52%), resp. Moreover, these complexes were characterized thoroughly by several spectroscopic techniques (1H, 13C NMR, UV/Vis, FT-IR, and HRMS), including single-crystal X-ray structural and elemental analyses. In addition, we tested the catalytic activity of these complexes 1-2 for the hydroboration of carbonyl compounds with pinacolborane (HBpin). We observed that compound 1 exhibits superior catalytic activity when compared to 2. Compound 1 efficiently catalyzes various aldehydes and ketones under solvent-free conditions. Furthermore, both inter- and intramol. chemoselectivity hydroboration of aldehydes over other functionalities have been established. In the experiment, the researchers used many compounds, for example, 2,6-Pyridinedimethanol(cas: 1195-59-1Recommanded Product: 1195-59-1)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Recommanded Product: 1195-59-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Catalyst-controlled doubly enantioconvergent coupling of racemic alkyl nucleophiles and electrophiles》 was written by Huo, Haohua; Gorsline, Bradley J.; Fu, Gregory C.. Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol And the article was included in Science (Washington, DC, United States) in 2020. The article conveys some information:

Stereochem. control in the construction of carbon-carbon bonds between an alkyl electrophile and an alkyl nucleophile is a persistent challenge in organic synthesis. Classical substitution reactions via SN1 and SN2 pathways are limited in their ability to generate carbon-carbon bonds (inadequate scope, due to side reactions such as rearrangements and eliminations) and to control stereochem. when beginning with readily available racemic starting materials (racemic products). Here, we report a chiral nickel catalyst that couples racemic electrophiles (propargylic halides) with racemic nucleophiles (β-zincated amides) to form carbon-carbon bonds in doubly stereoconvergent processes, affording a single stereoisomer of the product from two stereochem. mixtures of reactants. In the experiment, the researchers used many compounds, for example, (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts