Tag: 100-200

Senthilkumar, Samuthirarajan; Zhong, Wei; Natarajan, Mookan; Lu, Chunxin; Xu, Binyu; Liu, Xiaoming published an article in 2021. The article was titled 《A green approach for aerobic oxidation of benzylic alcohols catalysed by CuI-Y zeolite/TEMPO in ethanol without additional additives》, and you may find the article in New Journal of Chemistry.Computed Properties of C7H7BrO The information in the text is summarized as follows:

An efficient and green protocol for aerobic oxidation of benzylic alcs. in ethanol using CuI-Y zeolite catalysts assisted by TEMPO (TEMPO = 2,2,6,6-tetramethyl-1-piperidine-N-oxyl) as the radical co-catalyst in the presence of atm. air under mild conditions is reported. The CuI-Y zeolite prepared via ion exchange between CuCl and HY zeolite was fully characterized by a variety of spectroscopic techniques including XRD, XPS, SEM, EDX and HRTEM. The incorporation of Cu(I) into the 3D-framework of the zeolite rendered the catalyst with good durability. The results of repetitive runs revealed that in the first three runs, there was hardly a decline in activity and a more substantial decrease in yield was observed afterwards, while the selectivity remained almost unchanged. The loss in activity was attributed to both the formation of CuO and the bleaching of copper into the liquid phase during the catalysis, of which the formation of CuO was believed to be the major contributor since the bleaching loss for each run was negligible (<2%). In this catalytic system, except TEMPO, no other additives were needed, either a base or a ligand, which was essential in some reported catalytic systems for the oxidation of alcs. The aerobic oxidation proceeded under mild conditions (60°C, and 18 h) to quant. and selectively convert a wide range of benzylic alcs. to corresponding aldehydes, which shows great potential in developing green and environmentally benign catalysts for aerobic oxidation of alcs. The system demonstrated excellent tolerance against electron-withdrawing groups on the Ph ring of the alcs. and showed sensitivity to steric hindrance of the substrates, which is due to the confinement of the pores of the zeolite in which the oxidation occurred. Based on the mechanism reported in the literature for homogenous oxidation, a mechanism was analogously proposed for the aerobic oxidation of benzylic alcs. catalyzed by this Cu(I)-containing zeolite catalyst. The experimental part of the paper was very detailed, including the reaction process of (4-Bromophenyl)methanol(cas: 873-75-6Computed Properties of C7H7BrO)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Computed Properties of C7H7BrO It undergoes oxidation reaction in the presence of polyvinylpolypyrrolidone-supported hydrogen peroxide, silica sulfuric acid and ammonium bromide to yield 4-bromobenzaldehyde.

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Manandhar, Erendra; Johnson, Ashley D. G.; Watson, William M.; Dickerson, Shelby D.; Sahukhal, Gyan S.; Elasri, Mohamed O.; Fronczek, Frank R.; Cragg, Peter J.; Wallace, Karl J. published an article in 2021. The article was titled 《Detection of ferric ions in a gram-positive bacterial cell: Staphylococcus aureus》, and you may find the article in Journal of Coordination Chemistry.Related Products of 1195-59-1 The information in the text is summarized as follows:

A rhodamine-based chemosensor was synthesized and found to selectively bind ferric ions over other metal ions (Na+, K+, Ca2+, Mg2+, Fe2+, Zn2+, Cd2+, Co2+, Hg2+ Cr3+, Al3+) in an organic-aqueous mixture (CH3CN-MES). Upon addition of ferric ions, the spirolactam ring opens, producing a visual color change and a fluorescence intensity increase, i.e. a turn on optical response at 577 nm is observed The chemosensor coordinates to ferric ions in 1:1 stoichiometry with a calculated Ka = 3.5 × 104 mol dm-3 by fluorescence spectroscopy and a LoD of 27 ppb. The chemosensor was reversible upon addition of the Fe3+ chelator desferrioxamine. One- and two-dimensional NMR experiments with Al3+ ions aided in understanding of the coordination environment of the ferric ion with the chemosensor, which were confirmed by mol. modeling calculations X-ray quality crystals of the chemosensor were obtained, and the solid-state structure is reported. Confocal microscopy was used to detect free ferric ions in Staphylococcus aureus. In the experiment, the researchers used 2,6-Pyridinedimethanol(cas: 1195-59-1Related Products of 1195-59-1)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Related Products of 1195-59-1

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《Iron(0)-Catalyzed Transfer Hydrogenative Condensation of Nitroarenes with Alcohols: A Straightforward Approach to Benzoxazoles, Benzothiazoles, and Benzimidazoles》 was written by Putta, Ramachandra Reddy; Chun, Simin; Choi, Seung Hyun; Lee, Seok Beom; Oh, Dong-Chan; Hong, Suckchang. Recommanded Product: 100-55-0 And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

The iron-catalyzed hydrogen transfer strategy has been applied to the redox condensation of o-hydroxynitrobenzene with alc., leading to the formation of benzoxazole derivatives A wide range of 2-substituted benzoxazoles were synthesized in good to excellent yields without the addition of an external redox agent. A series of control experiments provided a plausible mechanism. Furthermore, the reaction system was successfully extended to the synthesis of benzothiazoles and benzimidazoles. The results came from multiple reactions, including the reaction of 3-Pyridinemethanol(cas: 100-55-0Recommanded Product: 100-55-0)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Recommanded Product: 100-55-0

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《Synthesis and structure-activity relationship studies of LLY-507 analogues as SMYD2 inhibitors》 was written by Zhang, Bin; Liao, Liping; Wu, Fan; Zhang, Fengcai; Sun, Zhongya; Chen, Haijun; Luo, Cheng. Recommanded Product: 2-Hydroxyphenylboronic acid And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020. The article conveys some information:

SET and MYND domain-containing protein 2 (SMYD2), a lysine methyltransferase, is reported to catalyze the methylation of lysine residues on histone and non-histone proteins. As a potential target for cancer therapy, there are several SMYD2 inhibitors are reported, LLY-507 as a cell-active inhibitor exhibits submicromolar potency against SMYD2 in several cancer cell lines. To know which structural fragment of LLY-507 is suitable for chem. modification, three sites are chosen for structure-activity relationship studies (SARs). Among our focused library, compounds 43 and 44 with amide link on site C showed reasonably improved potency indicating that modification on this fragment is more flexible and introduction of electrophilic warheads in this position might provide lysine-targeting covalent inhibitors for SMYD2. The experimental part of the paper was very detailed, including the reaction process of 2-Hydroxyphenylboronic acid(cas: 89466-08-0Recommanded Product: 2-Hydroxyphenylboronic acid)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Recommanded Product: 2-Hydroxyphenylboronic acid

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Alcohol – Wikipedia,
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《Structural reorganization and crack-healing properties of hydrogels based on dynamic diselenide linkages》 was written by Xu, Hao; Suzuki, Nao; Takahashi, Akira; Ohishi, Tomoyuki; Goseki, Raita; Xie, Xu-Ming; Otsuka, Hideyuki. Recommanded Product: 1195-59-1 And the article was included in Science and Technology of Advanced Materials in 2020. The article conveys some information:

We report the dynamic behavior of diselenide-containing hydrophilic polyurethanes and hydrogels based on diselenide exchange reactions in an aqueous media. Diselenide-containing linear and crosslinked polyurethanes were synthesized via polyaddition reactions using diselenide-containing diol in combination with pyridinium diol that enhances the hydrophilicity of the polymer chains. The obtained linear polyurethanes underwent photo-induced diselenide exchange reactions with small diselenide compounds and degraded to smaller fragments, confirming the dynamicity of the obtained hydrophilic polyurethanes. The prepared hydrogels displayed characteristic large swelling behavior based on the structural reorganization through diselenide exchange either under photo-irradiation at 365 nm or even in the dark at room temperature The diselenide-containing hydrogels also showed crack-healing behavior under the same exchanging conditions, presenting the utility of diselenide linkages as simple and useful units to offer high dynamicity to hydrogels. In addition to this study using 2,6-Pyridinedimethanol, there are many other studies that have used 2,6-Pyridinedimethanol(cas: 1195-59-1Recommanded Product: 1195-59-1) was used in this study.

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Recommanded Product: 1195-59-1

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Alcohol – Wikipedia,
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《Elucidating the promotional effect of a covalent triazine framework in aerobic oxidation》 was published in Applied Catalysis, B: Environmental in 2020. These research results belong to Abednatanzi, Sara; Gohari Derakhshandeh, Parviz; Tack, Pieter; Muniz-Miranda, Francesco; Liu, Ying-Ya; Everaert, Jonas; Meledina, Maria; Vanden Bussche, Flore; Vincze, Laszlo; Stevens, Christian V.; Van Speybroeck, Veronique; Vrielinck, Henk; Callens, Freddy; Leus, Karen; Van Der Voort, Pascal. Application In Synthesis of 3-Pyridinemethanol The article mentions the following:

Synergistic catalysis holds great promise to enhance the catalytic performance of heterogeneous catalysts suffering from sluggish reaction kinetics. Much effort has been dedicated to the development of bimetallic systems in which the two promoter elements display synergistic benefits compared to monometallic counterparts. However, the use of bimetallic catalysts inescapably raises the cost of preparation and environmental issues. This study discovers a synergistic effect when using a bipyridine covalent triazine framework (bipy-CTF) as support for an IrIII complex in the aerobic oxidation reaction. The detailed mechanistic study provides insights into the function of the bipy-CTF in this synergistic catalysis. The EPR and in-situ XANES analyses confirm the applicability of bipy-CTF to activate oxygen and alc., resulting in an enhancement of the performance of the IrIII complex to exceed the activity of the homogeneous counterpart. This is an unprecedented report on promoting the activity of a heterogeneous catalyst through its solid support. The experimental part of the paper was very detailed, including the reaction process of 3-Pyridinemethanol(cas: 100-55-0Application In Synthesis of 3-Pyridinemethanol)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Application In Synthesis of 3-Pyridinemethanol

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Aminothiazolones as potent, selective and cell active inhibitors of the PIM kinase family》 was published in Bioorganic & Medicinal Chemistry in 2020. These research results belong to Quevedo, Camilo E.; Bataille, Carole J. R.; Byrne, Simon; Durbin, Matthew; Elkins, Jon; Guillermo, Abigail; Jones, Alan M.; Knapp, Stefan; Nadali, Anna; Walker, Roderick G.; Wilkinson, Isabel V. L.; Wynne, Graham M.; Davies, Stephen G.; Russell, Angela J.. Formula: C6H7BO3 The article mentions the following:

We have previously reported the discovery of a series of rhodanine-based inhibitors of the PIM family of serine/threonine kinases. Here we described the optimization of those compounds to improve their physicochem. and ADME properties as well as reducing their off-targets activities against other kinases. Through mol. modeling and systematic structure activity relationship (SAR) studies, advanced mols. with high inhibitory potency, reduced off-target activity and minimal efflux were identified as new pan-PIM inhibitors. One example of an early lead, I, was found to inhibit PIMs with nanomolar potency (15 nM for PIM1), inhibit proliferation of two PIM-expressing leukemic cancer cell lines, MV4-11 and K562, and to reduce intracellular phosphorylation of a PIM substrate in a concentration dependent manner. The experimental part of the paper was very detailed, including the reaction process of 2-Hydroxyphenylboronic acid(cas: 89466-08-0Formula: C6H7BO3)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Formula: C6H7BO3

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Alcohol – Wikipedia,
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《Highly Productive α-Alkylation of Ketones with Alcohols Mediated by an Ir-Oxalamidato/Solid Base Catalyst System》 was published in Organic Process Research & Development in 2020. These research results belong to Shimizu, Hideo; Maeda, Hironori; Nara, Hideki. Recommanded Product: 5-Hexen-1-ol The article mentions the following:

An Ir-oxalamidato complexes I [R = Ph, 2-MeC6H4, 2-Me-4-OH-5-t-BuC6H2, etc.] were synthesized and examined for their catalytic activity in the synthesis of alkylated ketones R1C(O)R2 [R1 = Me, n-hexyl, CH2CH2C6H5, etc.; R2 = n-hexyl, CH2CH2C6H5, 4-OMeC6H4CH2CH2, etc.]. Synthesized Ir-oxalamidato complex I [R = 2-Me-4-OH-5-t-BuC6H2] in combination with a solid base (e.g., magnesium aluminometasilicate/Ca(OH)2) significantly improved the catalyst productivity in α-alkylation of Me ketones with primary alcs. Optimization through systematic variation of the oxalamidato ligand led to a practical turnover number (TON) of 10 000-40 000. In the experimental materials used by the author, we found 5-Hexen-1-ol(cas: 821-41-0Recommanded Product: 5-Hexen-1-ol)

5-Hexen-1-ol(cas: 821-41-0) is a volatile organic compound. Further, it is used to prepare 6-bromo-hex-1-ene by reaction with phosphorus tribromide.Recommanded Product: 5-Hexen-1-ol

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Alcohol – Wikipedia,
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《Allylic Amination of Alkenes with Iminothianthrenes to Afford Alkyl Allylamines》 was published in Journal of the American Chemical Society in 2020. These research results belong to Cheng, Qiang; Chen, Junting; Lin, Songyun; Ritter, Tobias. HPLC of Formula: 821-41-0 The article mentions the following:

Allylic C-H amination is currently accomplished with (sulfon)amides or carbamates. Here we show the first allylic amination that can directly afford alkyl allylamines, enabled by the reactivity of thianthrene-based nitrogen sources that can be prepared from primary amines in a single step. In the experiment, the researchers used many compounds, for example, 5-Hexen-1-ol(cas: 821-41-0HPLC of Formula: 821-41-0)

5-Hexen-1-ol(cas: 821-41-0) is a volatile organic compound. Further, it is used to prepare 6-bromo-hex-1-ene by reaction with phosphorus tribromide.HPLC of Formula: 821-41-0

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Alcohol – Wikipedia,
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The author of 《Ligand-Promoted Iron(III)-Catalyzed Hydrofluorination of Alkenes》 were Xie, Yongtao; Sun, Peng-Wei; Li, Yuxin; Wang, Siwei; Ye, Mengchun; Li, Zhengming. And the article was published in Angewandte Chemie, International Edition in 2019. Category: alcohols-buliding-blocks The author mentioned the following in the article:

An iron-catalyzed hydrofluorination of unactivated alkenes has been developed. The use of a multidentate ligand and the fluorination reagent N-fluorobenzenesulfonimide (NFSI) proved to be critical for this reaction, which afforded various fluorinated compounds in up to 94 % yield. In the experiment, the researchers used 5-Hexen-1-ol(cas: 821-41-0Category: alcohols-buliding-blocks)

5-Hexen-1-ol(cas: 821-41-0) is used in cyclization to a tetrahydropyran by phenylselenoetherification. It is also used as a building block in synthetic chemistry.Category: alcohols-buliding-blocks

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Alcohol – Wikipedia,
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