Tag: 100-200

Dang, Xiawei; Williams, Sidney B.; Devanathan, Sriram; Franco, Antonietta; Fu, Lijun; Bernstein, Peter R.; Walters, Daniel; Dorn, Gerald W. II published an article in 2021. The article was titled 《Pharmacophore-Based Design of Phenyl-[hydroxycyclohexyl] Cycloalkyl-Carboxamide Mitofusin Activators with Improved Neuronal Activity》, and you may find the article in Journal of Medicinal Chemistry.Quality Control of trans-4-Aminocyclohexanol The information in the text is summarized as follows:

Mitochondrial fragmentation from defective fusion or unopposed fission contributes to many neurodegenerative diseases. Small mol. mitofusin activators reverse mitochondrial fragmentation in vitro, promising a novel therapeutic approach. The first-in-class mitofusin activator, 2, has a short plasma t1/2 and limited neurol. system bioavailability, conferring “”burst activation””. Here, pharmacophore-based rational redesign generated analogs of 2 incorporating cycloalkyl linker groups. A cyclopropyl-containing linker, 5, improved plasma and brain t1/2, increased nervous system bioavailability, and prolonged neuron pharmacodynamic effects. Functional and single-crystal X-ray diffraction studies of stereoisomeric analogs of 5 containing sulfur as a “”heavy atom””, 14A and 14B, showed that 5 biol. activity resides in the trans-R/R configuration, 5B. Structural anal. revealed stereoselective interactions of 5 associated with its mimicry of MFN2 Val372, Met376, and His380 side chains. Modification of murine ALS phenotypes in vitro and in vivo supports advancement of 5B for neurol. conditions that may benefit from sustained mitofusin activation. In the experimental materials used by the author, we found trans-4-Aminocyclohexanol(cas: 27489-62-9Quality Control of trans-4-Aminocyclohexanol)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Quality Control of trans-4-Aminocyclohexanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Koley, Debasis; De, Sriman; Sivendran, Nardana; Goossen, Lukas J. published an article in 2021. The article was titled 《Isomerization of Functionalized Olefins by Using the Dinuclear Catalyst [PdI(μ-Br)(PtBu3)]2: A Mechanistic Study》, and you may find the article in Chemistry – A European Journal.Recommanded Product: 5-Hexen-1-ol The information in the text is summarized as follows:

In a combined exptl. and computational study, the isomerization activity of the dinuclear palladium(I) complex [PdI(μ-Br)(PtBu3)]2 towards allyl arenes, esters, amides, ethers, and alcs. has been investigated. The calculated energy profiles for catalyst activation for two alternative dinuclear and mononuclear catalytic cycles, and for catalyst deactivation are in good agreement with the exptl. results. Comparison of exptl. observed E/Z ratios at incomplete conversion with calculated kinetic selectivities revealed that a substantial amount of product must form via the dinuclear pathway, in which the isomerization is promoted cooperatively by two palladium centers. The dissociation barrier towards mononuclear Pd species is relatively high, and once the catalyst enters the energetically more favorable mononuclear pathway, only a low barrier has to be overcome towards irreversible deactivation. After reading the article, we found that the author used 5-Hexen-1-ol(cas: 821-41-0Recommanded Product: 5-Hexen-1-ol)

5-Hexen-1-ol(cas: 821-41-0) is used in cyclization to a tetrahydropyran by phenylselenoetherification. It is also used as a building block in synthetic chemistry.Recommanded Product: 5-Hexen-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bora, Aditi; Maiti, Subir Kr; Singh, Anmol; Barman, Pranjit published an article in 2021. The article was titled 《Studies on the effect of remote substituents on the DNA binding activity of novel chiral Schiff bases》, and you may find the article in Journal of Molecular Structure.Formula: C9H11NO The information in the text is summarized as follows:

Three chiral Schiff Bases (1S,2R)-1-(((E)-2-hydroxy-4-methylbenzylidene)amino)-2,3-dihydro-1H-inden-2-ol I (R1 = R3 = H; R2 = Me), (1S,2R)-1-(((E)-3-bromo-5-chloro-2-hydroxybenzylidene)amino)-2,3-dihydro-1H-inden-2-ol I (R1 = Br; R2 = H; R3 = Cl) and (1S,2R)-1-(((E)-2-hydroxy-4-methoxybenzylidene)amino)-2,3-dihydro-1H-inden-2-ol I (R1 = R3 = H; R2 = MeO) were synthesized and characterized by 1H NMR, FT-IR, UV-Vis and elemental anal. (CHN). The crystal structures of I (R1 = R3 = H; R2 = Me) and I (R1 = Br; R2 = H; R3 = Cl) were determined by using single X-ray diffraction crystallog. technique also. It was shown that the remote substituents not only affect the structure of the Schiff bases but also affect the biol. activity. Under physiol. conditions, the interaction of Schiff bases with calf-thymus DNA (CT-DNA) was investigated using fluorescence quenching, UV-Vis spectroscopy and cyclic voltammetry. The order of DNA binding affinity (Kb) calculated from the absorption spectroscopy was: I (R1 = R3 = H; R2 = MeO) > I (R1 = R3 = H; R2 = Me) > I (R1 = Br; R2 = H; R3 = Cl). In the part of experimental materials, we found many familiar compounds, such as (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Formula: C9H11NO)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Formula: C9H11NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Journal of Catalysis included an article by Thiruvengetam, Prabaharan; Chakravarthy, Rajan Deepan; Chand, Dillip Kumar. Application of 100-55-0. The article was titled 《A molybdenum based metallomicellar catalyst for controlled and chemoselective oxidation of activated alcohols in aqueous medium》. The information in the text is summarized as follows:

A surfactant based oxodiperoxo molybdenum complex, which could activate mol. oxygen, has been employed as a catalyst for controlled oxidation of benzylic alcs. to corresponding carbonyls I (R = 4-OMe, 3-Br, 4-NMe2, etc.) and II (R = 4-NO2, 4-SMe, 4-allyloxy, etc.; R’ = Me, Et, Ph, etc.). The oxidation reactions were carried out under aqueous environment, however, in the absence of any extraneous base or co-catalyst. Sensitive/oxidizable functional groups like cyano, sulfide, hydroxyl, aryl-hydroxyl, alkene (internal/terminal), alkyne (internal/terminal), and acetal were tolerated during the transformations. Such selectivity is attributed to the mild nature of the catalyst. The methodol. could also be scaled-up for multi-gram synthesis and the protocol is likely to find practical use since it requires an inexpensive recyclable-catalyst and easily available oxidant (under green conditions). A plausible mechanism is proposed with the help of preliminary computational study. The experimental process involved the reaction of 3-Pyridinemethanol(cas: 100-55-0Application of 100-55-0)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Application of 100-55-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2018,Organic Chemistry Frontiers included an article by Kuriyama, Masami; Nakashima, Sho; Miyagi, Tsubasa; Sato, Kanako; Yamamoto, Kosuke; Onomura, Osamu. SDS of cas: 27489-62-9. The article was titled 《Palladium-catalyzed chemoselective anaerobic oxidation of N-heterocycle-containing alcohols》. The information in the text is summarized as follows:

The palladium-catalyzed anaerobic oxidation for N-heterocycle-containing alcs. has been developed with chloroarenes as oxidants. In this process, primary and secondary alcs. were selectively oxidized even in the presence of cyclic amines as well as heteroarenes, and primary, secondary, and tertiary amino groups were found to be well tolerated. Moreover, a gram-scale chemoselective oxidation was achieved in addition to a double oxidation of a diamino diol. In the experimental materials used by the author, we found trans-4-Aminocyclohexanol(cas: 27489-62-9SDS of cas: 27489-62-9)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.SDS of cas: 27489-62-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2018,Mizojiri, Ryo; Asano, Moriteru; Tomita, Daisuke; Banno, Hiroshi; Nii, Noriyuki; Sasaki, Masako; Sumi, Hiroyuki; Satoh, Yoshihiko; Yamamoto, Yukiko; Moriya, Takeo; Satomi, Yoshinori; Maezaki, Hironobu published 《Discovery of Novel Selective Acetyl-CoA Carboxylase (ACC) 1 Inhibitors》.Journal of Medicinal Chemistry published the findings.Product Details of 18621-18-6 The information in the text is summarized as follows:

The authors initiated structure-activity relationship (SAR) studies for selective ACC1 inhibitors from 1a (N-(1-(2-(3-(3-methylphenoxy)azetidin-1-yl)-1,3-benzoxazol-6-yl)ethyl)acetamide) as a lead compound SAR studies of bicyclic scaffolds revealed many potent and selective ACC1 inhibitors represented by 1f (N-(1-(2-(4-(3-(Cyclopropylmethoxy)phenoxy)phenyl)-1,3-benzoxazol-6-yl)ethyl)acetamide), however most of them had physicochem. issues, particularly low aqueous solubility and potent CYP inhibition. To address these two issues and improve the drug-likeness of this chem. series, the authors converted the bicyclic scaffold into a monocyclic framework. Ultimately, this lead the authors to discover a novel monocyclic derivative 1q (1-((2S)-1-((2-(4-(3-(Cyclopropylmethoxy)phenoxy)phenyl)-1,3-oxazol-5-yl)oxy)propan-2-yl)urea) as a selective ACC1 inhibitor, which showed highly potent and selective ACC1 inhibition as well as acceptable solubility and CYP inhibition profiles. Since compound 1q displayed favorable bioavailability in mouse cassette dosing testing, the authors conducted in vivo PD studies of this compound Oral administration of 1q significantly reduced the concentration of malonyl-CoA in HCT-116 xenograft tumors at doses of more than 30 mg/kg. Accordingly, the authors’ novel series of selective ACC1 inhibitors represents a set of useful orally-available research tools, as well as potential therapeutic agents for cancer and fatty acid related diseases. In the experiment, the researchers used many compounds, for example, Azetidin-3-ol hydrochloride(cas: 18621-18-6Product Details of 18621-18-6)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Product Details of 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2017,Li, Zhao; Tamura, Masamichi; Yazaki, Ryo; Ohshima, Takashi published 《Catalytic chemoselective conjugate addition of amino alcohols to α,β-unsaturated ester: hydroxy group over amino group and conjugate addition over transesterification》.Chemical & Pharmaceutical Bulletin published the findings.Category: alcohols-buliding-blocks The information in the text is summarized as follows:

A highly chemoselective conjugate addition of amino alcs. to α,β-unsaturated ester using a soft Lewis acid/hard Bronsted base cooperative catalyst was developed. This catalysis achieved chemoselective addition of a hydroxy group over an amino group. Moreover, soft metal alkoxide generation enabled chemoselective soft conjugate addition over hard transesterification. Various amino alcs., including unprecedented cyclic β-amino alc., were applicable to the present catalysis. After reading the article, we found that the author used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Category: alcohols-buliding-blocks)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hashimoto, Yuka; Hosokawa, Sasuga; Liang, Fengying; Suzuki, Yuto; Dai, Namin; Tana, Gegen; Eda, Kazuo; Kakiuchi, Toshifumi; Okazoe, Takashi; Harada, Hidefumi; Tsuda, Akihiko published an article in Journal of Organic Chemistry. The title of the article was 《Photo-on-Demand Base-Catalyzed Phosgenation Reactions with Chloroform: Synthesis of Arylcarbonate and Halocarbonate Esters》.Recommanded Product: 3,3,3-Trifluoropropan-1-ol The author mentioned the following in the article:

Carbonate esters are utilized as solvents and reagents for C1 building blocks in organic synthesis. This study reports a novel photo-on-demand in situ synthesis of carbonate esters with CHCl3 solutions containing a mixture of an aromatic or haloalkyl alc. having relatively high acidity, and an organic base. We found that the acid-base interaction of the alc. and base in the CHCl3 solution plays a key role in enabling the photochem. reaction. This reaction allows practical syntheses of di-Ph carbonate derivatives, haloalkyl carbonates, and polycarbonates, which are important chems. and materials in industry. After reading the article, we found that the author used 3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2Recommanded Product: 3,3,3-Trifluoropropan-1-ol)

3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2) is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field.Recommanded Product: 3,3,3-Trifluoropropan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

COA of Formula: C3H5F3OOn March 10, 2022, Empel, Claire; Pei, Chao; He, Feifei; Jana, Sripati; Koenigs, Rene M. published an article in Chemistry – A European Journal. The article was 《Proton or Carbene Transfer? On the Dark and Light Reaction of Diazoalkanes with Alcohols》. The article mentions the following:

A fundamental understanding of the reaction of diazoalkanes with alcs. to made this transformation amenable to a generalized approach towards formal alkylation reactions of alcs. with diazoalkanes was aimed. Exptl. and theor. studies suggested a direct proton transfer only in exceptional cases. In a more general setting, such O-H functionalization proceeded both under dark and photochem. conditions via a key hydrogen-bonded singlet carbene intermediate that underwent a protonation-addition mechanism. Applications of this approach in O-H functionalization reactions of alcs., including simple fluorinated, halogenated and aliphatic alcs. and showcase functional-group tolerance of this method in the reaction of biol. active and pharmaceutically relevant alcs. was concluded. In addition to this study using 3,3,3-Trifluoropropan-1-ol, there are many other studies that have used 3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2COA of Formula: C3H5F3O) was used in this study.

3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2) is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field.COA of Formula: C3H5F3O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 2240-88-2On November 3, 2020 ,《Photochemical O-H Functionalization Reactions of Cyclic Diazoamides》 appeared in Advanced Synthesis & Catalysis. The author of the article were Empel, Claire; Verspeek, Dennis; Jana, Sripati; Koenigs, Rene M.. The article conveys some information:

Herein, the photochem. O-H functionalization reaction of acidic alcs. with cyclic diazoamides were described. The O-H functionalization reaction of different fluorinated and non-fluorinated alcs. to give the corresponding ether products in high yields (43 examples, up to 97% yield) were studied. Furthermore, the evaluation of photoexcited proton transfer reaction pathway in comparison to classic carbene transfer reactions were performed. The results came from multiple reactions, including the reaction of 3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2Application of 2240-88-2)

3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2) is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field.Application of 2240-88-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts