Tag: 100-200

Design, synthesis and human carbonic anhydrase I, II, IX and XII inhibitory properties of 1,3-thiazole sulfonamides was written by Erigur, Esra Caner;Altug, Cevher;Angeli, Andrea;Supuran, Claudiu T.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2022.Synthetic Route of C4H10O3 This article mentions the following:

A series of novel 1,3-thiazole sulfonamides I [R = i-Pr, n-Bu, HOCH₂CH₂, Ph(CH₂)₄, etc.] has been designed, synthesized and studied their carbonic anhydrase (CA) inhibitory properties. The inhibition property of four human CA isoforms was investigated: hCA I, II, IX, and XII using the standard drug acetazolamide (AAZ) for comparison. The compounds I showed a wide range of inhibition potency towards the cytosolic enzyme hCA I. Nevertheless, the compounds I (R = n-Pr, i-Pr, HOCH₂CHMe, HOCHMeCH₂, MeOCH₂CH₂) have shown higher inhibition potential as compared to acetazolamide (KI = 250 nM). The abundant human cytosolic isoform, hCA II, was strongly inhibited by the most compounds in low nanomolar range (KI < 12.1 nM). On the other hand, almost all novel synthesized compounds have shown weaker inhibition potential as compared to acetazolamide against the tumor membrane- associated isoform hCA IX. Finally, the second tumor membrane-associated isoform, hCA XII, showed a wide range of potency that spanned from 9.3 to 729.6 nM. In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6Synthetic Route of C4H10O3).

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Synthetic Route of C4H10O3

Referemce:
Alcohol – Wikipedia,
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Fluoro- or trifluoromethyl-substituted benzyl and phenethyl alcohols: Substrates for metal-mediated site-selective functionalization was written by Marzi, Elena;Spitaleri, Andrea;Mongin, Florence;Schlosser, Manfred. And the article was included in European Journal of Organic Chemistry in 2002.Computed Properties of C9H9F3O This article mentions the following:

It was possible to functionalize the three fluorobenzyl alcs. and the three 2-(fluorophenyl)ethanols by metalation and subsequent carboxylation, the prototype electrophilic trapping reaction. Triisopropylsilyl (TIPS) outperformed methoxymethyl (MOM) as an O-protective group making seven new fluorobenzoic acids, including I and II, accessible in 63% average yield. The TIPS group tolerates weakly basic and acidic media and may facilitate further structural elaboration. The unprotected alcs. reacted more sluggishly and were unable to provide two of the targeted products. The yield averaged only 46% in the five other cases. The direct metalation of fluorinated benzyl and phenethyl alcs. remains nevertheless an attractive option because of its operational simplicity. All three (trifluoromethyl)benzyl alcs. and two of the three (trifluoromethyl)phenethyl alc. isomers were successfully submitted to the metalation/functionalization sequence. These five starting materials gave rise to a total nine new benzoic acids or lactones, e.g. III. Despite the poor yields (31% on average), the employed organometallic methods are extremely regioselective, economical and easy to perform. In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6Computed Properties of C9H9F3O).

2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Computed Properties of C9H9F3O

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Alcohol – Wikipedia,
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Changes of the particle size in suspension type medicines was written by Mersich-Vetsey-Kormendi, Agnes. And the article was included in Gyogyszereszet in 1972.Electric Literature of C10H22O3 This article mentions the following:

Medicinal suspensions containing terpine hydrate, norcaine, salicylamide, Bi salicylate in aqueous medium, norcaine, Na salicylate, amidopyrine, caffeine and Na benzoate, phenobarbital and Na noramidopyrine methanesulfonate in soft or solid fatty medium were examined for stability based on the initial parameters. No generalization could be made, hence the elaboration of new formulations of medicinal suspensions, the optimum conditions should be determined individually. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Electric Literature of C10H22O3).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Electric Literature of C10H22O3

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Alcohol – Wikipedia,
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Fractional hydrodistillation of Citronella (Cymbopogon winterianus Jowitt) was written by Rout, P. K.;Jena, K. S.;Rao, Y. R.. And the article was included in Fafai Journal in 2001.Safety of rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate This article mentions the following:

Fractional hydro-distillation of Citronella Grass (C. winterianus Jowitt) and anal. of the decanted oil fractions showed that citronellal-rich fractions and sesquiterpenoid-rich fractions can be separated at the hydrodistillation stage itself. About 6% essential oil is lost in the aqueous layer. Further, 4 constituents, 6-methyl-5-hepten-2-one, benzyl alc., 2-[2-hydroxy-2-propyl]-5-menthylcyclohexanol and terpin hydrate present in significant quantities in the aqueous layer are not detected in any of the decanted oil fractions. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Safety of rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Safety of rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate

Referemce:
Alcohol – Wikipedia,
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A catalytic stereo- and chemo-selective method for the reduction of substituted aromatics was written by Fache, Fabienne;Lehuede, Stephan;Lemaire, Marc. And the article was included in Tetrahedron Letters in 1995.Application In Synthesis of 2-(Trifluoromethyl)phenethyl alcohol This article mentions the following:

Various substituted aromatics have been reduced using colloidal ruthenium under H₂ pressure with good stereoselectivity (cis/trans up to 60). Interesting chemoselectivities are also observed In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5Application In Synthesis of 2-(Trifluoromethyl)phenethyl alcohol).

2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Application In Synthesis of 2-(Trifluoromethyl)phenethyl alcohol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

New insights into the thermal degradation behavior of Hydroxypropyl-beta-cyclodextrin inclusion complexes containing carvacrol essential oil via thermogravimetric analysis was written by Li, Zhe;Jiang, Xiaoxia;Zhu, Lin;Chen, Fucai;Liu, Hongning;Ming, Liangshan. And the article was included in Journal of Thermal Analysis and Calorimetry in 2022.Formula: C10H14O This article mentions the following:

The physicochem. properties and thermodn. parameters of cyclodextrin inclusion complexes (ICs) containing essential oil were investigated by thermogravimetric anal. It is necessary to understand the ICs thermal decomposition behavior and kinetics to control and elucidate the inclusion complexation mechanisms. Carvacrol essential oil was encapsulated with hydroxypropyl-beta-cyclodextrin (HP-β CD) using the freeze-drying method. The IC was characterized by SEM, FT-IR, and phase solubility, which confirmed that there were mol. interactions between the carvacrol essential oil and HP-β CD. Moreover, thermal experiments were carried out by a thermogravimetric analyzer at different heating rates (10-40 °C min-1). In addition, three different models, i.e., FOW, KAS, and Starink, were used to calculate the kinetic energy. The FOW was a more proficient model for the calculation of activation energy (Ea). Further, the average values of Ea varied from conversion, and for carvacrol, HP-β CD, and carvacrol/HP-β CD IC, they were found to be 70.56, 162.15, and 152.57 kJ mol-1 based on the FOW model, resp. In general, carvacrol encapsulated into HP-β CD as an IC showed high thermal stability. The kinetic results could be useful in predicting the thermal performance of IC and in helping optimize exptl. procedures for the encapsulation of essential oils in cyclodextrins. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Formula: C10H14O).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Formula: C10H14O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Aminations of Aryl Bromides in Water at Room Temperature was written by Lipshutz, Bruce H.;Chung, David W.;Rich, Brian. And the article was included in Advanced Synthesis & Catalysis in 2009.Name: 2-(Trifluoromethyl)phenethyl alcohol This article mentions the following:

Unsym. diarylamines and triarylamines R¹C₆H₄NR²R³ [R¹ = H, 4-NC, 4-O₂N, etc.; R² = H, Me, Ph; R³ = 4-FC₆H₄, 1-naphthyl, 2,4-(MeO)₂C₆H₃, etc.] were obtained via palladium-catalyzed amination at ambient temperatures in water. In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5Name: 2-(Trifluoromethyl)phenethyl alcohol).

2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Name: 2-(Trifluoromethyl)phenethyl alcohol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tuning Triplet Energy Transfer of Hydroxamates as the Nitrene Precursor for Intramolecular C(sp³)-H Amidation was written by Jung, Hoimin;Keum, Hyeyun;Kweon, Jeonguk;Chang, Sukbok. And the article was included in Journal of the American Chemical Society in 2020.Electric Literature of C9H9F3O This article mentions the following:

Reported herein is the design of a photosensitization strategy to generate triplet nitrenes and its applicability for the intramol. C-H amidation reactions. Substrate optimization by tuning phys. organic parameters according to the proposed energy transfer pathway led us to identify hydroxamates as a convenient nitrene precursor. While more classical nitrene sources, representatively organic azides, were ineffective under the current photosensitization conditions, hydroxamates, which are readily available from alcs. or carboxylic acids, are highly efficient in accessing synthetically valuable 2-oxazolidinones and γ-lactams by visible light. Mechanism studies supported our working hypothesis that the energy transfer path is mainly operative. In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6Electric Literature of C9H9F3O).

2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Electric Literature of C9H9F3O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reaction of 2,6-lutidine 1-oxide with acetic anhydride was written by Kobayashi, Goro;Furukawa, Sunao;Kawada, Yuitsu. And the article was included in Yakugaku Zasshi in 1954.Application of 1122-71-0 This article mentions the following:

2,6-Lutidine 1-oxide (4 g.) in 15 ml. Ac₂O heated 2 hrs. at 130-40°, the Ac₂O removed in vacuo, the residue with water concentrated in vacuo, made alk. with K₂CO₃, extracted with CHCl₃ and distilled, gave 4 g. oil, b₄ 100-5°. The oil in 10 ml. 10% HCl refluxed 30 min., the product concentrated in vacuo, made alk. with K₂CO₃, extracted with CHCl₃ and distilled, gave 1.8 g. oil, and oxidation of the oil with KMnO₄ gave 6,2-Me(HOH₂C)C₅H₃N (I), m. 96°; picrate, m. 129-32°. I in C₆H₆ treated with PCl₃ gave 6,2-Me(ClH₂C)C₅H₃N (picrate, m. 162-3°). The residue after distillation of I recrystallized from AcOEt gave 0.2 g. 2,6,3-Me₂(HO)C₅H₂N, columns, m. 210-12°. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Application of 1122-71-0).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Application of 1122-71-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Modified WO₃ nanorod with Pt nanoparticle as retrievable materials in catalytic and photocatalytic aerobic oxidation of alcohols was written by Hosseini, Farnaz;Safaei, Elham;Mohebbi, Sajjad. And the article was included in Journal of Nanoparticle Research in 2017.Recommanded Product: 1777-82-8 This article mentions the following:

Catalytic and photocatalytic oxidation of aromatic alcs. using WO₃ nanorod and a series of Pt/WO₃ nanocomposite Pt nanoparticles was loaded on WO₃ nanorod with several mass ratios 0.1, 0.2 and 0.3 via a photoreduction process (PRP) and characterized by transmissionelectron microscopy (TEM), field emission scanning electron microscope (FE-SEM) imaging, Energy-dispersive X-rayspectroscopy (EDAZ), powder X-ray diffraction (XRD), Steady state diffuse reflectance spectroscopy (DRS), inductivelycoupledplasma (ICP) and XPS. WO₃ nanorods were obtained monodispersed with average 40nm diameter and square cross section without significant size change by the loading of platinum nanoparticles on it. Progress of oxidation reaction was monitored by GC and the yield of aerobic photocatalytic oxidation of alcs. reached up to 98% for Pt/WO₃ and 69% for WO₃ while, no oxidation was detected in the absence of light. The highest photocatalytic performance was obtained for mass ratio 0.2 with the selectivity >99%. This nanocomposite had potentials to be used as high-performance heterogeneous catalyst and photocatalyst under visible light irradiation with advantages of high activity, high selectivity and reusability. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Recommanded Product: 1777-82-8).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Recommanded Product: 1777-82-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts