Tag: 100-200

On February 27, 2014, Nakajima, Tatsuo; Goi, Takashi; Kawata, Atsushi; Sugahara, Masakatsu; Yamakoshi, Shuhei published a patent.Name: 1-(5-Chloro-2-methylphenyl)ethanol The title of the patent was Preparation of 1-(7-hydroxy-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-1H-pyrazole-4-carboxylic acid derivatives as hypoxia-inducible factor-prolyl hydroxylase inhibitors. And the patent contained the following:

There are provided pyrazolopyrimidine compounds represented by formula [I; the 7-hydroxypyrazolo[4,3-d]pyrimidine-5-yl group is optionally substituted; X = a simple bond or an optionally substituted straight-chain alkylene; Z = H, R, RO, NRR1; R, R1 = independently each optionally substituted aryl, heteroaryl, alicyclic hydrocarbyl, or non-aromatic heterocyclyl] or pharmaceutically acceptable salts. These compounds have an hypoxia-inducible factor-prolyl hydroxylase (HIF-PDH) inhibitors (HIF-PHD) inhibitory effect, and are useful as stimulating agents for the production of erythropoietin in kidney (erythropoiesis stimulating agents) for the prevention and/or treatment of renal anemia. Thus, benzylation of 1-(7-methoxy-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-1H-pyrazole-4-carboxylic acid Et ester by 4-bromomethyl-1,2-dichlorobenzene in the presence of K2CO3 in MeCN with stirring at 80° for 2 h gave 47% 1-[1-(3,4-dichlorobenzyl)-7-methoxy-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-1H-pyrazole-4-carboxylic acid Et ester (II; R2 = Et, R3 = Me) and 35% 1-[2-(3,4-dichlorobenzyl)-7-methoxy-2H-pyrazolo[4,3-d]pyrimidin-5-yl]-1H-pyrazole-4-carboxylic acid Et ester (III). Saponification of II (R2 = Et, R3 = Me) with a mixture of 2 M aqueous NaOH solution and THF at 60° for 1.5 h followed by concentration and acidification with water and 1 M aqueous HCl solution gave 97% II (R2 = = R3 H). II (R2 = R3 = H) and 1-[1-[2-(6-ethylnaphthalen-3-yl)ethyl]-7-hydroxy-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-1H-pyrazole-4-carboxylic acid (IV) showed IC50 of 0.021 and 0.012 μM, resp., against human HIF-PHD2 and 0.16 and 0.18 μM, resp., against human HIF-PHD3. II (R2 = R3 = H) and IV at 3 μM promoted the production of erythropoietin in Hep38 cells by 4.6 and 168-fold, resp. The experimental process involved the reaction of 1-(5-Chloro-2-methylphenyl)ethanol(cas: 58966-31-7).Name: 1-(5-Chloro-2-methylphenyl)ethanol

The Article related to erythropoiesis (stimulating agents), homo sapiens, human, hypoxia-inducible factors role: bsu (biological study, unclassified), biol (biological study), pyrazoles role: pac (pharmacological activity), spn (synthetic preparation), thu (therapeutic use), biol (biological study), prep (preparation), uses (uses), pyrimidines role: pac (pharmacological activity), spn (synthetic preparation), thu (therapeutic use), biol (biological study), prep (preparation), uses (uses), renal anemia and other aspects.Name: 1-(5-Chloro-2-methylphenyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On August 1, 2020, Yan, Yan; Fu, Cai; Cui, Xiaofang; Pei, Xiangping; Li, Aiping; Qin, Xuemei; Du, Chenhui; Du, Huizhi published an article.Application of 621-37-4 The title of the article was Metabolic profile and underlying antioxidant improvement of Ziziphi Spinosae Folium by human intestinal bacteria. And the article contained the following:

Ziziphi Spinosae Folium, the leaf of Ziziphus jujuba Mill. Var. spinosa (Bunge) Hu ex H. F. Chou (LZJS), is currently used as a healthy tea in China. This study evaluated the chem. components and antioxidant activities of LZJS flavonoid (LZJSF) and fermented LZJSF (FLZJSF) using human intestinal bacteria (HIB) through dynamic fermentation Eighteen flavonoids were simultaneously identified in LZJSF using UHPLC-Q-Orbitrap-MS method, nine of which were targeted for a HIB metabolism study. Seven small phenolic acids were identified in FLZJSF. Not only at chem. level but also at PC12 cell level, FLZJSF samples fermented for 4 and 6 h showed significant pos. correlation between their activities and flavonoid aglycons, which were transformed from LZJSF. However, FLZJSF samples (8 h and longer time) mainly contained phenolic acids and indicated weak activities. Thus, LZJSF was found to result in increased antioxidant activity and could be com. utilized as a novel functional food. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Application of 621-37-4

The Article related to ziziphi spinosae folium tea metabolic profile antioxidant intestine bacteria, 3, 4-dihydroxyphenylacetic acid, antioxidant, flavonoids, human intestinal bacteria, kaempferol, kaempferol-3-o-rutinoside, quercetin, quercetin-3-o-robinobioside, quercetin-3-o-rutinoside, quercetin-3-o-β-d-galactose and other aspects.Application of 621-37-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On December 17, 2009, Knust, Henner; Nettekoven, Matthias; Pinard, Emmanuel; Roche, Olivier; Rogers-Evans, Mark published a patent.Quality Control of (6-(Trifluoromethyl)pyridin-3-yl)methanol The title of the patent was Preparation of heteroaromatic monoamides as orexin receptor antagonists. And the patent contained the following:

The present invention is concerned with novel amides of formula [I; (i) Ar1 = heteroaryl, Ar2 = Ph, and Ar = Ph or heteroaryl; or (ii) Ar1 = Ph, Ar2 = heteroaryl, and Ar = Ph or heteroaryl; or (iii) Ar1 = heteroaryl, Ar2 = heteroaryl, and Ar = Ph or heteroaryl; R1 = H, halogen, lower alkyl, halo-lower alkyl, lower alkoxy; R2 = H, halogen, lower alkyl, halo-lower alkyl, lower alkoxy, halo-lower alkoxy; R3 = H, halogen, lower alkyl, halo-lower alkyl, hydroxy-lower alkyl, cycloalkyl-lower alkyl, C(O)O-lower alkyl, C(O)NH-lower alkyl, (CH2)m-O-lower alkyl, lower alkoxy, etc.; or where Ar2 = Ph and o = 2, R3 optionally is R3 and R3′ which together with the corresponding carbon atoms to which they are attached form a non aromatic ring containing the groups (CH2)4, (CH2)3, CH2S(O)2CH2, N(Me)C(O)N(Me), (CH2)2O, O(CH2)2O, O(CH2)2CH(OH), O(CH2)2, O(CH2)3, etc.; R4, R5 = H, hydroxy, lower alkyl, lower alkoxy, CH2NH2, O-C(O)lower alkyl, or NRR’; or R4 and R5 together are :O; R, R’ = H, S(O)2-lower alkyl, cycloalkyl, (CH2)mOH, (CH2)mO-lower alkyl, C(O)CH(NH2)Ph, or oxetan-3-yl optionally substituted by CH2NH2, or NRR’ together form a heterocycloalkyl ring, optionally containing in addition to the N atom a further heteroatom, selected from the group consisting of N, S and O; n, o, p = 1-3; m = 0-2] or pharmaceutically suitable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. These compounds are orexin receptor antagonists that may be useful in the treatment of disorders, in which orexin pathways are involved, e.g. in arousal, sleep/wakefulness, appetite regulation and their roles in anxiety and stress response, etc. The drugs (or compounds) targeting orexin system will have beneficial therapeutic effects for the treatments of diseases like sleep disorders including sleep apnea, narcolepsy, insomnia, parasomnia, jet lag syndrome, circadian rhythms disorder, restless leg syndrome, psychiatric, neurol. and neurodegenerative disorders, etc. Thus, 500 mg (3,4-dimethylphenyl)[2-(6-trifluoromethylpyridin-3-yl)ethyl]amine > was condensed with 300 mg (4-fluorophenyl)oxoacetic acid using in CH2Cl2 with stirring for 12 h at ambient temperature to give, after workup and silica gel chromatog., N-(3,4-dimethylphenyl)-2-(4-fluorophenyl)-2-oxo-N-[2-(6-trifluoromethylpyridin-3-yl)ethyl]acetamide (527 mg, 70%) (II) as a light yellow. II (515 mg) was reduced by 88 mg NaBH4 in MeOH with stirring for 12 h at ambient temperature to give, after workup and silica gel chromatog., N-(3,4-dimethylphenyl)-2-(4-fluorophenyl)-2-hydroxy-N-[2-(6-trifluoromethylpyridin-3-yl)ethyl]acetamide (501 mg, 97%) which was separated by chromatog. on a chiral column to give (S)-N-(3,4-dimethylphenyl)-2-(4-fluorophenyl)-2-hydroxy-N-[2-(6-trifluoromethylpyridin-3-yl)ethyl]ethanamide (III). III showed inhibited orexin receptor-2 receptor (OX2R) with Kb of 0.0005 μM in an intracellular Ca2+ mobilization assay in Chinese hamster ovary mutant cell line stably expressing human OX2R. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Quality Control of (6-(Trifluoromethyl)pyridin-3-yl)methanol

The Article related to phenylpyridinylethylacetamide preparation orexin receptor antagonist, sleep disorder treatment phenylpyridinylethylacetamide preparation, heteroaromatic monoamide preparation orexin receptor antagonist, psychiatric neurol neurodegenerative disorder treatment heteroaromatic monoamide preparation and other aspects.Quality Control of (6-(Trifluoromethyl)pyridin-3-yl)methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Williams, Alexander F.; White, Andrew J. P.; Spivey, Alan C.; Cordier, Christopher J. published an article in 2020, the title of the article was meta-Selective C-H functionalisation of aryl boronic acids directed by a MIDA-derived boronate ester.SDS of cas: 621-37-4 And the article contains the following content:

N-Methyliminodiacetic acid (MIDA) boronates are boronic acid derivatives which are stable to reduction, oxidation and transmetalation. This has led to their widespread use as boronic acid protecting groups (PGs) and in iterative cross-couplings. authors describe herein the development of a novel MIDA derivative that acts in a dual manner, as a protecting group and a directing group (DG) for meta C(sp2)-H functionalisation of arylboronic acids. Palladium catalyzed C-H alkenylations, acetoxylations and arylations are possible, at room temperature and under aerobic conditions. Deprotection to reveal the functionalized boronic acids is rapid and allows for full recovery of the DG. The technique allows the facile diversification of aryl boronic acids and their subsequent use in a range of reactions or in iterative processes. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).SDS of cas: 621-37-4

The Article related to methyliminodiacetic acid boronate preparation cross coupling, selective carbon hydrogen functionalization methyliminodiacetic acid boronate ester, palladium catalyzed alkenylation acetoxylation arylation protecting directing group, crystal mol structure methyliminodiacetic acid boronate ester and other aspects.SDS of cas: 621-37-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On January 30, 2022, Tamargo, Alba; Cueva, Carolina; Taladrid, Diego; Khoo, Christina; Moreno-Arribas, M. Victoria; Bartolome, Begona; Gonzalez de Llano, Dolores published an article.Safety of 3-Hydroxyphenylacetic acid The title of the article was Simulated gastrointestinal digestion of cranberry polyphenols under dynamic conditions and its impact on antiadhesive activity against uropathogenic bacteria. And the article contained the following:

This study is the first dynamic simulation of gastrointestinal digestion of cranberry polyphenols [1 g cranberry extract per day (206.2 mg polyphenols) for 18 days]. Samples from the simulated ascending, transverse, and descending colon of the dynamic gastrointestinal simulator simgi were analyzed. Results showed that 67% of the total cranberry polyphenols were recovered after simulated gastrointestinal digestion. Specifically, benzoic acids, hydroxycinnamic acids, phenylpropionic acids, phenylacetic acids, and simple phenols were identified. Cranberry feeding modified colonic microbiota composition of Enterococcaceae population significantly. However, increments in microbial-derived short-chain fatty acids, particularly in butyric acid, were observed Finally, the simgi effluent during cranberry feeding showed significant antiadhesive activity against uropathogenic Escherichia coli (13.7 ± 1.59% of inhibition). Understanding the role that gut microbiota plays in cranberry metabolism could help to elucidate its interaction with the human body and explain cranberry protective effects against urinary tract infections. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Safety of 3-Hydroxyphenylacetic acid

The Article related to cranberry polyphenol metabolite antioxidant renoprotectant urinary tract infection, antiadhesive activity, cranberry, gut microbiota, metabolism, phenolic metabolites, polyphenols, short chain fatty acids (scfas), simgi® model, urinary tract infections (utis), uropathogenic escherichia coli and other aspects.Safety of 3-Hydroxyphenylacetic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On October 11, 2001, Muehlman, Anna; Classon, Bjoern; Hallberg, Anders; Samuelsson, Bertil published an article.Application of 72364-46-6 The title of the article was Synthesis of potent C2-symmetric, diol-based HIV-1 protease inhibitors. Investigation of thioalkyl and thioaryl P1/P1′ substituents. And the article contained the following:

The synthesis of novel, potent diol-based HIV-1 protease inhibitors, having either -SAr (Ar = Ph, 2-FC6H4, 2-pyridinyl, 2-thienyl), -SCH2Ar (Ar = Ph, 2-FC6H4), or -SCH2R (R = H2C:CHCH2) groups as P1/P1′ substituents is described. They can be prepared using a straightforward synthesis involving a thiol nucleophilic ring opening of a diepoxide. Inhibitor I, an indanyl(thiophenylsulfanyl)hexanediamide, was found to be a potent inhibitor of HIV-1 PR, showing good antiviral activity in a cell-based assay. The experimental process involved the reaction of (2-Fluorophenyl)methanethiol(cas: 72364-46-6).Application of 72364-46-6

The Article related to thioalkyl hexanediamide indanyl methylcarbamoylpropyl preparation hiv protease inhibitor, thioaryl hexanediamide indanyl methylcarbamoylpropyl preparation hiv protease inhibitor, hiv protease inhibitor thioaryl thioalkyl hexanediamide preparation, aids agent thioaryl thioalkyl hexanediamide and other aspects.Application of 72364-46-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On July 10, 2008, Kim, Young Ah; Sharon, Ashoke; Chu, Chung K.; Rais, Reem H.; Al Safarjalani, Omar N.; Naguib, Fardos N. M.; El Kouni, Mahmoud H. published an article.Recommanded Product: 72364-46-6 The title of the article was Structure-Activity Relationships of 7-Deaza-6-benzylthioinosine Analogues as Ligands of Toxoplasma gondii Adenosine Kinase. And the article contained the following:

Several 7-deaza-6-benzylthioinosine analogs with varied substituents on aromatic ring were synthesized and evaluated against Toxoplasma gondii adenosine kinase (EC.2.7.1.20). Structure-activity relationships indicated that the nitrogen atom at the 7-position does not appear to be a critical structural requirement. Mol. modeling reveals that the 7-deazapurine motif provided flexibility to the 6-benzylthio group as a result of the absence of H-bonding between N7 and Thr140. This flexibility allowed better fitting of the 6-benzylthio group into the hydrophobic pocket of the enzyme at the 6-position. In general, single substitutions at the para or meta position enhanced binding. On the other hand, single substitutions at the ortho position led to the loss of binding affinity. The most potent compounds, 7-deaza-p-cyano-6-benzylthioinosine I (R = CN) (IC50 = 5.3 μM) and 7-deaza-p-methoxy-6-benzylthioinosine I (R = OCH3) (IC50 = 4.6 μM), were evaluated in cell culture to delineate their selective toxicity. The experimental process involved the reaction of (2-Fluorophenyl)methanethiol(cas: 72364-46-6).Recommanded Product: 72364-46-6

The Article related to deazabenzylthioinosine nucleoside asym preparation, ribose stereoselective glycosylation benzylthiol benzylhalide nucleophilic substitution, toxoplasma gondii adenosine kinase binding affinity structure activity relationship, mol modeling toxoplasmosis antitoxoplasmic antiparasitic human and other aspects.Recommanded Product: 72364-46-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On September 4, 2006, Prakash, Raju; Saalfrank, Rolf W.; Maid, Harald; Scheurer, Andreas; Heinemann, Frank W.; Trautwein, Alfred X.; Bottger, Lars H. published an article.Synthetic Route of 2160-93-2 The title of the article was Synthesis and redox properties of mixed-valent octanuclear iron defective hexacubanes and a (CaCl)-capped body-centered six-sided iron(III) polyhedron. And the article contained the following:

Three new oligo nuclear complexes [FeII4FeII4(L3)6Cl4O2] (1; H2L3 = N-(tert-butyl)-diethanolamine), [FeII2FeIII6(L3)6Cl6O2] and Na3[FeIII9(L3)8Cl4O6(CaCl)2] self-assemble from N-tert-Bu-diethanolamine and mixtures of Fe(II) and Fe(III) ions. Depending on the reaction conditions, a compact or linear defective hexacubane, or a body-centered six-sided Fe(III) polyhedron is formed. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).Synthetic Route of 2160-93-2

The Article related to iron diethanolamine octanuclear complex preparation structure, calcium capped iron heterodecanuclear complex preparation structure, crystal structure iron diethanolamine polynuclear complex with without calcium, electrochem iron diethanolamine oligonuclear complex with without calcium and other aspects.Synthetic Route of 2160-93-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Sihuai; Mereacre, Valeriu; Zhao, Zhiying; Zhang, Wanwan; Zhang, Mengsi; He, Zhangzhen published an article in 2018, the title of the article was Targeted replacement: systematic studies of dodecanuclear {MIII6LnIII6} coordination clusters (M = Cr, Co; Ln = Dy, Y).Name: 2,2′-(tert-Butylazanediyl)diethanol And the article contains the following content:

Three dodecanuclear 3d-4f coordination clusters, [CrIII6LnIII6(μ3-OH)8(tbdea)6(C6H5COO)16]·2H2O (Ln = Dy (1), Y (2)) and [CoIII6DyIII6(μ3-OH)8(nbdea)6(m-CH3C6H4COO)16]·2H2O·2CH3CN (3), have been synthesized under solvothermal conditions and characterized. Single-crystal x-ray diffraction anal. revealed that all three compounds possess an analogous {M6IIILnIII6} core (M = Cr, Co; Ln = Dy, Y) and dc magnetic susceptibility studies indicated that the magnetic exchange couplings between DyIII ions are dominant antiferromagnetic, while the CrIII-DyIII interactions are weakly ferromagnetic. Furthermore, the ac magnetic susceptibility measurements showed that both CrIII6DyIII6 compound 1 and CoIIi6DyIII6 compound 3 containing highly anisotropic DyIII ions displayed single-mol. magnetic (SMM) behavior with the energy barrier Ueff increasing from 12.8 K (for 1) to 20.8 K (for 3), indicating that weak 3d-4f exchange couplings enhance the QTM and reduce the energy barrier. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).Name: 2,2′-(tert-Butylazanediyl)diethanol

The Article related to dodecanuclear chromium rare earth metal dithanolamine benzoate cluster preparation, crystal structure dodecanuclear chromium rare earth metal cluster, magnetic property dodecanuclear chromium rare earth metal cluster, thermal stability dodecanuclear chromium rare earth metal cluster and other aspects.Name: 2,2′-(tert-Butylazanediyl)diethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On March 15, 2020, Deng, Qian-ying; Liu, Man-yu; Shi, Ya-Jing; Wang, Lan-zhi; Feng, Qi; Song, Hui-Hua published an article.Application In Synthesis of H-Phg(4-OH)-OH The title of the article was A pair of stable Zn(II) enantiomeric coordination compounds: synthesis, crystal structures and luminescent recognition properties. And the article contained the following:

A pair of stable chiral coordination compounds {[Zn(D-hpg)(bpe)]·(NO3)·(C2H6O)}n 1-D, {[Zn(L-hpg)(bpe)]·(NO3)·(C2H6O)}n 1-L (D-Hhpg = D-(-)-4-Hydroxyphenylglycine, L-Hhpg = L-(+)-4-Hydroxyphenylglycine, bpe = 1,2-bis(4-pyridyl)ethane) were successfully synthesized. Their structures were determined by single-crystal x-ray diffraction anal. and characterized by elemental anal., IR spectroscopy, TGA and powder X-ray diffraction. They are 2D layer structures that consist of left- or right-handed helical chains, resp. CD and luminescent properties of compounds 1-D and 1-L were studied at room temperature Moreover, 1-D and 1-L show similar selectivity toward Cu2+ ions through luminescent quenching in aqueous solution In addition, 1-D also displays an excellent recognition ability on detecting CH3OH. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Application In Synthesis of H-Phg(4-OH)-OH

The Article related to chemical chains, helical, circular dichroism, crystal structure, luminescence, luminescence quenching, molecular structure, optical sensors, thermal stability and other aspects.Application In Synthesis of H-Phg(4-OH)-OH

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts