Tag: 100-200

On June 30, 2022, Wu, Fan-lin; Hu, Yong-hao; Ji, Peng; Li, Chen-chen; He, Jian published an article.Recommanded Product: 2,3-Dihydroxypropanoic acid The title of the article was Metabonomics study on the hepatoprotective effect mechanism of polysaccharides from different processed products of Angelica sinensis on layer chickens based on UPLC-Q/TOF-MS/MS, multivariate statistical analysis and conjoint analysis. And the article contained the following:

Chicken colibacillosis is one of the most severe diseases in the poultry industry. Ceftiofur sodium (CS) is often used to treat it in clin. practice and lipopolysaccharide (LPS) accumulates in the chicken ′s body. Previous exptl. studies found that CS combined with LPS could induce liver injury in layer chickens, and polysaccharides from charred Angelica sinensis(CASP) had a better hepatoprotective effect than polysaccharides from unprocessed Angelica sinensis(UASP). However, the intervention mechanism was unclear. Thus, UPLC-Q/TOF-MS/MS-based metabonomics and transcriptomics were used in this study to clarify the hepatoprotective effect mechanism of CASP and UASP in layer chickens. Transcriptomics and ELISA were used for biol. verification of some critical mutual metabolic pathways screened with metabonomics. The comprehensive anal. results showed that in a layer chicken liver injury model built with LPS and CS, 12 critical metabolic pathways were disturbed, involving 10 important differential metabolites. The hepatoprotective effect mechanism of CASP is related to the arachidonic acid metabolism and mTOR signaling pathways, involving nine important differential metabolites. In contrast, the hepatoprotective effect mechanism of UASP is related to the arachidonic acid metabolism pathway, involving six important differential metabolites. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Recommanded Product: 2,3-Dihydroxypropanoic acid

The Article related to angelica sinensis polysaccharide hepatoprotective metabonomic multivariate statistical analysis, lps, layer chickens, liver injury, metabonomics, polysaccharides from charred angelica sinensis(casp), polysaccharides from unprocessed angelica sinensis(uasp) and other aspects.Recommanded Product: 2,3-Dihydroxypropanoic acid

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On October 3, 2013, Saito, Noriko; Egi, Jun; Nagai, Hiroshi; Ueno, Megumi; Shintani, Yusuke; Inaba, Yusuke; Adachi, Michiaki; Hirai, Yuichi; Kawazu, Takeshi; Yasutake, Koichi; Takahashi, Daiki published a patent.Synthetic Route of 386704-04-7 The title of the patent was Preparation of triazinone compounds as T-type calcium channel inhibitors. And the patent contained the following:

The title compounds [I; R1 = H, halo, each (un)substituted C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, mono- or di(C1-6 alkyl)amino, or C3-11 cycloalkyl; L1, L2 = a single bond, (un)substituted NH or C1-6 alkylene, O, S(O), SO2; B = each (un)substituted C3-11 cycloalkylene, C3-11 cycloalkenylene, 3-11 membered heterocyclylene, C6-14 arylene, 5-10 membered heteroarylene, C1-6 alkylene, C2-6 alkenylene, or C2-6 alkynylene; A = each (un)substituted C1-6 alkyl, C2-6 alkenyl, C3-11 cycloalkyl, C3-11 cycloalkenyl, 3-11 membered heterocyclyl, C6-14 aryl, or 5-10 membered heteroaryl; L3 = (un)substituted C1-6 alkylene optionally having one of the methylene groups replaced by C(O) or C(S); D = each (un)substituted C3-11 cycloalkyl, C3-11 cycloalkenyl, 3-11 membered heterocyclyl, C6-14 aryl, or 5-10 membered heteroaryl], tautomers or pharmaceutically acceptable salts of the compounds, or solvates of the compounds, the tautomers or the pharmaceutically acceptable salts are prepared These compounds have an inhibitory activity on a T-type voltage-dependent calcium channel and are useful for the prevention, treatment, and/or improvement of diseases for which the T-type calcium channel-inhibitory activity are effective, in particular pain, more specifically neuropathic pain. Thus, amination of 1,3,5-trichlorotriazine with 1-(4-fluorophenyl)piperazine dihydrochloride in the presence of Na2CO3 in THF at room temperature for 3 days quant. gave 2,4-dichloro-6-[4-(4-fluorophenyl)piperazin-1-yl]-1,3,5-triazine which underwent hydrolysis with aqueous NaOH solution at room temperature for 2 days and 2 h to give 79% 6-chloro-4-[4-(4-fluorophenyl)piperazin-1-yl]-1,3,5-triazin-2(1H)-one (II; X = Cl). Hydrogenation of II (X = Cl) in the presence of Pd(OH)2/activated charcoal in aqueous acetic acid solution under hydrogen atm. at room temperature for 3 days gave 99% 4-[4-(4-fluorophenyl)piperazin-1-yl]-1,3,5-triazin-2(1H)-one II (X = H) which underwent benzylation by 4-chlorobenzyl bromide in the presence of K2CO3 in N,N-dimethylformamide at 70° for 5 h to give 53% 1-(4-Chlorobenzyl)-4-[4-(4-fluorophenyl)piperazin-1-yl]-1,3,5-triazin-2(1H)-one (III). III and (R)-4-[4-(4-fluorophenyl)-5-hydroxy-5,6-dihydropyridin-1(2H)-yl]-1-[[5-(trifluoromethyl)thiophen-2-yl]methyl]-1,3,5-triazin-2(1H)-one (IV) showed IC50 of 0.17 and 0.00046 μM, resp., for inhibiting the cellular calcium influx in KSE293 cells expressing human type T calcium channel (Cav3.2). The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Synthetic Route of 386704-04-7

The Article related to triazinone preparation t type calcium channel inhibitor, benzylphenylpiperazinyltriazinone phenylpyridinylthiophenylmethyltriazinone preparation t type calcium channel inhibitor, pain neuropathic pain treatment prevention improvement triazinone preparation and other aspects.Synthetic Route of 386704-04-7

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On December 31, 2013, Bolden, Sidney Jr.; Zhu, Xue Y.; Etukala, Jagan R.; Boateng, Comfort; Mazu, Tryphon; Flores-Rozas, Hernan; Jacob, Melissa R.; Khan, Shabana I.; Walker, Larry A.; Ablordeppey, Seth Y. published an article.SDS of cas: 72364-46-6 The title of the article was Structure-activity relationship (SAR) and preliminary mode of action studies of 3-substituted benzylthioquinolinium iodide as anti-opportunistic infection agents. And the article contained the following:

Opportunistic infections are devastating to immunocompromised patients. And in especially sub-Saharan Africa where the AIDS epidemic is still raging, the mortality rate was recently as high as 70%. The paucity of anti-opportunistic drugs, the decreasing efficacy and the development of resistance against the azoles and even amphotericin B have stimulated the search for new drugs with new mechanisms of action. In a previous work, we showed that a new chemotype derived from the natural product cryptolepine displayed selective toxicity against opportunistic pathogens with minimal cytotoxicity to normal cells. In this manuscript, we report the design and synthesis of substituted benzylthioquinolinium iodides, evaluated their anti-infective properties and formulated some initial structure-activity relationships around Ph ring A from the original natural product. The sensitivity of the most potent analog 10l, to selected strains of C. cerevisiae was also evaluated leading to the observation that this scaffold may have a different mode of action from its predecessor, cryptolepine. The experimental process involved the reaction of (2-Fluorophenyl)methanethiol(cas: 72364-46-6).SDS of cas: 72364-46-6

The Article related to benzylthioquinolinium analog preparation sar antiinfective antifungal antibacterial, anti-opportunistic infections, antifungal agents, benzylthioquinolinium iodides, craig plot, cryptolepine, structure–activity relationships, substituted quinolinium salts and other aspects.SDS of cas: 72364-46-6

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Alcohol – Wikipedia,
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Kraiss, G.; Povarny, M.; Nador, K. published an article in 1976, the title of the article was Reduction of dicarboxylic acid esters with diisobutylaluminum hydride.HPLC of Formula: 42900-89-0 And the article contains the following content:

In reduction of di-Et homophthalate (I), phthalate (II), cis-1,2-cyclohexanedicarboxylate, or glutarate with 1-4 equivalent of (Me2CHCH2)2AlH, selective lactol formation occurred only in the case of I and II; with 3 equivalent (Me2CHCH2)2AlH I gave 100% III and II gave 82% IV. The experimental process involved the reaction of Isochroman-3-ol(cas: 42900-89-0).HPLC of Formula: 42900-89-0

The Article related to ester dicarboxylate reduction, carboxylate di ester reduction, aromatic dicarboxylate ester reduction, cyclohexanedicarboxylate ester reduction, glutarate ester reduction, lactol, isochromanol, isobenzofuranol, cyclization reduction dicarboxylate ester and other aspects.HPLC of Formula: 42900-89-0

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Alcohol – Wikipedia,
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On March 31, 2013, Krol, Piotr; Lechowicz, Jaromir B.; Krol, Bozena published an article.COA of Formula: C8H19NO2 The title of the article was Modelling the surface free energy parameters of polyurethane coats-part 1. Solvent-based coats obtained from linear polyurethane elastomers. And the article contained the following:

Polyurethane elastomers coating were synthesized by using typical diisocyanates, polyether and polyester polyols and HO-tertiary amines or diols as a chain extenders. Mole fractions of structural fragments (κexp) responsible for the polar interactions within polyurethane chains were calculated by 1H NMR method. Obtained results were confronted with the analogous parameter values (κtheor) calculated on the basis of process stoichiometry, considering the stage of the production of isocyanate prepolymers and reaction of their extension for polyurethanes. Trials of linear correlation between the κexp parameters and surface free energy (SFE) values of studied coatings were presented. SFE values were determined by Owens-Wendt method, using contact angles measured with the goniometric method. Based on achieved results, another empirical models, allowing for prediction the influence of the kind of polyurethane raw materials on SFE values of received coatings were determined It is possible to regulate the SFE in the range millijoules per cubic metre by the selection of appropriate substrates. Use of 2,2,3,3-tetrafluoro-1,4-butanediol as a fluorinated extender of prepolymer chains is essential to obtain coatings with increased hydrophobicity, applied among others as biomaterials-next to diphenylmethane diisocyanate and polyoxyethylene glycol. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).COA of Formula: C8H19NO2

The Article related to modeling surface free energy parameter linear polyurethane coating, additive model of the surface free energy, contact angles, nmr spectroscopy, owens–wendt method, prediction of the surface free energy parameter, synthesis of the polyurethane coatings and other aspects.COA of Formula: C8H19NO2

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On March 15, 2010, Reddy, M. V. Ramana; Pallela, Venkat R.; Cosenza, Stephen C.; Mallireddigari, Muralidhar R.; Patti, Revathi; Bonagura, Marie; Truongcao, May; Akula, Balaiah; Jatiani, Shashidhar S.; Reddy, E. Premkumar published an article.Category: alcohols-buliding-blocks The title of the article was Design, synthesis and evaluation of (E)-α-benzylthio chalcones as novel inhibitors of BCR-ABL kinase. And the article contained the following:

(E)-α-benzylthio and α-benzylsulfonyl chalcones such as I, an (E)-α-benzylsulfinyl chalcone, and an (E)-arylthiochalcone are prepared as inhibitors of the BCR-ABL kinase for potential use as antitumor agents; some of the chalcones act as inhibitors of BCR-ABL phosphorylation in leukemic K562 cells, known to express high levels of BCR-ABL, and in some cases show comparable cancer cell inhibition to the antitumor agent imatinib. The chalcones are prepared in two or three steps from α-bromoacetophenones, aryl or benzyl thiols, and aryl aldehydes by substitution of the α-bromoacetophenones with thiols followed by stereoselective aldol condensation of the benzylthioacetophenones with aryl aldehydes (with oxidation occurring, if necessary, before aldol condensation). Data for the inhibition of human leukemia and prostate cancer cells by approx. 500 related chalcones is provided. The experimental process involved the reaction of (2-Fluorophenyl)methanethiol(cas: 72364-46-6).Category: alcohols-buliding-blocks

The Article related to benzylthio benzylsulfinyl benzylsulfonyl chalcone stereoselective preparation kinase inhibitor, inhibition bcr abl kinase structure benzylthio benzylsulfinyl benzylsulfonyl chalcone, antitumor activity benzylthio benzylsulfinyl benzylsulfonyl chalcone and other aspects.Category: alcohols-buliding-blocks

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On January 11, 2021, Talukder, Muktadir Md; Miller, Justin T.; Cue, John Michael O.; Udamulle, Chinthaka M.; Bhadran, Abhi; Biewer, Michael C.; Stefan, Mihaela C. published an article.Application In Synthesis of 1-Decanethiol The title of the article was Mono- and Dinuclear α-Diimine Nickel(II) and Palladium(II) Complexes in C-S Cross-Coupling. And the article contained the following:

The usefulness of transition metal catalytic systems in C-S cross-coupling reactions is significantly reduced by air and moisture sensitivity, as well as harsh reaction conditions. Herein, the authors report four highly air- and moisture-stable well-defined mononuclear and bridged dinuclear α-diimine Ni(II) and Pd(II) complexes for C-S cross-coupling. Various ligand frameworks, including acenaphthene- and iminopyridine-based ligands, were employed, and the resulting steric properties of the catalysts were evaluated and correlated with reaction outcomes. Under aerobic conditions and low temperatures, both Ni and Pd systems exhibited broader substrate scope and functional group tolerance than previously reported catalysts. Over 40 compounds were synthesized from thiols containing alkyl, benzyl, and heteroaryl groups. Also, pharmaceutically active heteroaryl moieties are incorporated from thiol and halide sources. Notably, the bridged dinuclear five-coordinate Ni complex has outperformed the remaining three mono four- or six-coordinate complexes by giving almost quant. yields across a broad substrate scope. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Application In Synthesis of 1-Decanethiol

The Article related to mononuclear diimine palladium complex preparation catalyst thiol coupling reaction, crystal structure mononuclear dinuclear diimine nickel palladium complex, mol structure mononuclear dinuclear diimine nickel palladium complex, dinuclear diimine nickel complex preparation catalyst thiol coupling reaction and other aspects.Application In Synthesis of 1-Decanethiol

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Alcohol – Wikipedia,
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On April 16, 2021, Sunagawa, Denise E.; Ishida, Naoyoshi; Iwamoto, Hiroaki; Ohashi, Masato; Fruit, Corinne; Ogoshi, Sensuke published an article.HPLC of Formula: 143-10-2 The title of the article was Synthesis of Fluoroalkyl Sulfides via Additive-Free Hydrothiolation and Sequential Functionalization Reactions. And the article contained the following:

A modular synthetic method, involving a hydrothiolation, silylation, and fluoroalkylation, for the construction of highly functionalized fluoroalkyl sulfides has been developed. The use of the aprotic polar solvent N,N-dimethylacetamide enables the additive-free chemoselective hydrothiolation of tetrafluoroethylene, trifluorochloroethylene, and hexafluoropropene with various thiols. Stepwise functionalization of the tetrafluoroethyl ethers and a chlorotrifluoroethyl ether by silylation with TMSCl and LDA followed by reactions with aryl iodides, a chloroalkene, or acyl chlorides in the presence of CuOt-Bu and 1,10-phenanthroline convert the hydrothiolated intermediates into the tetrafluoroethyl sulfides in high efficiency. The method avoids the use of the environmental pollutant Halon-2402 (1,2-dibromo-1,1,2,2-tetrafluoroethane), which was employed as a building block in a reported synthetic route. Tetrafluoroethylene is a potential carcinogen and should be used in a well-ventilated fume hood. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).HPLC of Formula: 143-10-2

The Article related to tetrafluoroethyl silyltetrafluoroethyl thioether chemoselective preparation, dimethylacetamide solvent hydrothiolation tetrafluoroethylene chlorotrifluoroethylene hexafluoropropene thiol, fluoroalkyl thioether modular preparation, base mediated silylation hydrofluoroalkyl thioether chlorotrimethylsilane and other aspects.HPLC of Formula: 143-10-2

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Alcohol – Wikipedia,
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On November 30, 2012, Sinha, Debarshi; Mandal, Tanmay; Gogoi, Sanjib; Goldman, Joshua J.; Zhao, John Cong-gui published an article.Recommanded Product: H-Phg(4-OH)-OH The title of the article was Asymmetric Aldol Reaction Catalyzed by Modularly Designed Organocatalysts. And the article contained the following:

The self-assembly of pre-catalyst modules, which are amino acids and cinchona alkaloid derivatives, leads to a direct formation of the desired organocatalysts without any synthesis. These modularly designed organocatalysts (MDOs) may be used for catalyzed asym. aldol reaction. Depending on structure of the aldehyde substrates, the corresponding aldol products may be obtained in mediocre to excellent enantiomeric excess (ee) values (up to 92% ee) with moderate diastereoselectivities (up to 79:21 diastereomeric ratio, dr). The synthesis of the target compounds was achieved by a combination of amino acids and analogs, such as (αS)-α-amino-2-chlorobenzeneacetic acid, L-alanine, L-leucine, L-isoleucine. 3-methyl-L-valine, β-alanine. Cinchona alkaloids included N-[3,5-bis(trifluoromethyl)phenyl]-N’-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, (8α,9R)-cinchonan-6′,9-diol (cupreine), (9S)-cinchonan-6′,9-diol (cupreidine), O-benzoylquinine, (8α,9R)-6′-methoxy-9-(phenylmethoxy)cinchonan (O-benzylquinine), etc. The title compounds thus formed included (4S)-4-hydroxy-4-(4-nitrophenyl)-2-butanone (4R)-4-hydroxy-4-(4-nitrophenyl)-2-butanone and (2R)-2-[(R)-hydroxy(4-nitrophenyl)methyl]cyclohexanone (I) and related substances, such as (3R)-tetrahydro-3-[(R)-hydroxy(4-nitrophenyl)methyl]-4H-pyran-4-one, (3R)-tetrahydro-3-[(R)-hydroxy(4-nitrophenyl)methyl]-4H-thiopyran-4-one. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Recommanded Product: H-Phg(4-OH)-OH

The Article related to cinchona alkaloid amino acid chiral catalyst aldol reaction, cyclohexanone hydroxyalkyl preparation aldol addition cinchona alkaloid catalyst, pyranone hydroxyalkyl preparation aldol addition cinchona alkaloid catalyst, thiopyranone hydroxyalkyl preparation aldol addition cinchona alkaloid catalyst and other aspects.Recommanded Product: H-Phg(4-OH)-OH

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Alcohol – Wikipedia,
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On August 21, 2015, Dong, Yi; Du, Nana; Li, Xueyuan; Zheng, Litao; Liu, Gang published an article.Category: alcohols-buliding-blocks The title of the article was Tandem Chloropalladation/Cyclization and Dearomative Cyclization toward Functionalized Tricyclic Bridged [3.2.1] Skeleton Compounds. And the article contained the following:

In the presence of PdCl2(MeCN)2 and CuCl2, o-alkenylphenylalkynyl carbonyl compounds such as allyloxyphenylpropynamide I underwent aerobic chemoselective dearomative cyclization reactions to yield fused tricyclic dienones such as II (R = MeO, BuO, EtO, PhCH2O, Me). The structure of II (R = PhCH2O) was determined by X-ray crystallog. The experimental process involved the reaction of 2,4,6-Trihydroxy-3-methylbenzaldehyde(cas: 55743-13-0).Category: alcohols-buliding-blocks

The Article related to fused tricyclic dienone chemoselective preparation, palladium copper catalyst aerobic dearomative cyclization alkenylphenylalkynyl carbonyl compound, tandem aerobic chloropalladation dearomative cyclization alkenylphenylalkynyl carbonyl compound, oxatricyclododecanecarboxamide mol crystal structure and other aspects.Category: alcohols-buliding-blocks

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Alcohol – Wikipedia,
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