Tag: 100-200

On October 4, 1996, Lukevics, Edmunds; Belyakov, Sergey; Pudova, Olga published an article.Reference of 2,2′-(tert-Butylazanediyl)diethanol The title of the article was A new pathway for the synthesis of 1,3-dioxa-6-aza-2-germacyclooctanes: molecular structure of 2,2-di(2-thienyl)-6-methyl-1,3-dioxa-6-aza-2-germacyclooctane. And the article contained the following:

A novel reaction pathway has been applied for the synthesis of 1,3-dioxa-6-aza-2-germacyclooctanes I (R = Me, CMe3). Compounds of this type were obtained by the dehydrocondensation of di(2-thienyl)germane and diethanolamines without a catalyst. The mol. structure of 2,2-di(2-thienyl)-6-methyl-1,3-dioxa-5-azacyclooctane I (R = Me) has been determined by x-ray diffraction study. The interat. N → Ge distance of 2.446 Å indicates the presence of a weak transannular bond. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).Reference of 2,2′-(tert-Butylazanediyl)diethanol

The Article related to azadioxagermacyclooctane thienyl methyl preparation, crystal mol structure dithienylmethyldioxaazacyclooctane, dehydrocondensation thienylgermane diethanolamine, germocane preparation crystal mol structure and other aspects.Reference of 2,2′-(tert-Butylazanediyl)diethanol

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On March 3, 2005, Orr, William C. published a patent.Category: alcohols-buliding-blocks The title of the patent was Fuel compositions employing catalyst combustion structure. And the patent contained the following:

Metallic vapor phase fuel compositions relating to a broad spectrum of pollution reducing, improved combustion performance, and enhanced stability fuel compositions for use in jet, aviation, turbine, diesel, gasoline, and other combustion applications include co-combustion agents preferably including trimethoxymethylsilane. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Category: alcohols-buliding-blocks

The Article related to fuel catalyst combustion jet diesel gasoline metal ester silane, oxygenated fuel oil additive combustion catalyst metal salt, gasoline fuel catalyst combustion glycol anhydride phosphite phosphonate ester and other aspects.Category: alcohols-buliding-blocks

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Alcohol – Wikipedia,
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On January 15, 2010, McConville, Matthew; Blacker, John; Xiao, Jianliang published an article.Application In Synthesis of 2-Methyl-2-propylpropane-1,3-diol The title of the article was Heck reaction in diols and cascade formation of cyclic ketals. And the article contained the following:

The regioselective Heck arylation of BuOCH:CH2 in alcs. was utilized for the formation of a variety of cyclic ketals. When carried out in ethylene glycol, propane-1,2-diol, or propane-1,3-diol, the Pd-catalyzed arylation afforded dioxolanes or dioxanes directly. With diols such as glycerol, 3-chloropropane-1,2-diol, and 2-methylpropane-1,3-diol, isolation of the Heck adducts and the use of an acid catalyst for the ketalization were necessary; an efficient phosphate was identified. The procedure provides a new pathway for the synthesis of cyclic ketals, particularly those that are functionalized. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Application In Synthesis of 2-Methyl-2-propylpropane-1,3-diol

The Article related to bu vinyl ether aryl bromide diol regioselective heck ketalization, enol ether diol ketalization phosphate catalyst, cyclic ketal green preparation, dioxolane green preparation, dioxane green preparation and other aspects.Application In Synthesis of 2-Methyl-2-propylpropane-1,3-diol

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On May 31, 2021, Ren, Ming Zhe; Yang, Ying Hui; Zhu, Zheng He; Zhang, Bo Sheng; Quan, Zheng Jun; Wang, Xi Cun published an article.Application In Synthesis of Pentane-1,5-diol The title of the article was Visible-light-Induced Sulfhydrylation and Oxylation of Olefins with Iodine as Catalyst. And the article contained the following:

Herein, the sulfhydrylation and oxylation of olefins RCH=CH2 (R = Ph, 4-methoxyphenyl, 3-methylphenyl, etc.) and 1H-indene were completed under visible light irradiation with iodine as catalyst, which realized more economical and green chem. conversion because of the absence of metal complexes or organic dyes. A series of bifunctional modifications of olefins were achieved with good yields RCH(O(CH2)nOH)CH2SR1 (R1 = 4-chlorophenyl, 2,4-dimethylphenyl, 3-methylphenyl, etc.; n = 2, 3, 4, 5) and RCH(OH)CH2SR1 by using diol derivatives OH(CH2)nOH, 2-(2-hydroxyethoxy)ethan-1-ol and water as nucleophiles. In addition, the control experiments show that the reaction is a free radical process. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Application In Synthesis of Pentane-1,5-diol

The Article related to alkoxysulfide preparation green chem, thiophenol olefin diol photochem sulfhydrylation oxylation iodine catalyst, hydroxysulfide preparation green chem, olefin thiophenol water photochem sulfhydrylation oxylation iodine catalyst and other aspects.Application In Synthesis of Pentane-1,5-diol

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Guidotti, Giulia; Soccio, Michelina; Gazzano, Massimo; Siracusa, Valentina; Lotti, Nadia published an article in 2021, the title of the article was Poly(Alkylene 2,5-Thiophenedicarboxylate) Polyesters: A New Class of Bio-Based High-Performance Polymers for Sustainable Packaging.Recommanded Product: 111-29-5 And the article contains the following content:

In the present study, 100% bio-based polyesters of 2,5-thiophenedicarboxylic acid were synthesized via two-stage melt polycondensation using glycols containing 3 to 6 methylene groups. The so-prepared samples were characterized from the mol. point of view and processed into free-standing thin films. Afterward, both the purified powders and the films were subjected to structural and thermal characterization. In the case of thin films, mech. response and barrier properties to O2 and CO2 were also evaluated. From the results obtained, it emerged that the length of glycolic sub-units is an effective tool to modulate the chain mobility and, in turn, the kind and amount of ordered phases developed in the samples. In addition to the usual amorphous and 3D crystalline phases, in all the samples investigated it was possible to evidence a further phase characterized by a lower degree of order (mesophase) than the crystalline one, whose amount is strictly related to the glycol sub-unit length. The relative fraction of all these phases is responsible for the different mech. and barrier performances. Last, but not least, a comparison between thiophene-based homopolymers and their furan-based homologues was carried out. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Recommanded Product: 111-29-5

The Article related to alkylene thiophenedicarboxylate polyester synthesis sustainable packaging, 2,5-thiophenedicarboxylic acid, 2d-ordered structure, barrier properties, mechanical properties, structure-property relationship, thermal properties and other aspects.Recommanded Product: 111-29-5

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On September 16, 2010, Ahmad, Saleem published a patent.Synthetic Route of 386704-04-7 The title of the patent was Preparation of aza-pyridone derivatives as antagonists of melanin concentrating hormone receptor-1 (MCHR1). And the patent contained the following:

Title compounds I [A1 and A2 independently = C or N; E = C or N; Q1, Q2 and Q3 independently = C or N provided that only one of them is N; D1 = bond, CC, 1,2-cyclopropyl, etc; R1, R2 and R3 independently = H, halogen, (un)substituted alkyl, etc; G = O, S or NR15; where R15 = H or (un)substituted alkyl; D2 = (un)substituted alkyl, cycloalkyl, cycloalkoxy, etc; Z1 and Z2 independently = H, (un)substituted alkyl, cycloalkyl, etc; R5, R6 and R7 independently = H, halogen, (un)substituted alkyl, etc], and their pharmaceutically acceptable salts or prodrugs, are prepared and disclosed. Thus, e.g., II was prepared by coupling reaction of (E)-4-chlorostyrylboronic acid with 6-chloro-3-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)pyrimidin-4(3H)-one (preparation given). Compounds of the invention were evaluated for their antagonistic activity of peptide agonist binding to human melanin concentrating hormone receptor-1 (MCHR1), e.g., II exhibited Ki value of 23 nM. The invention compounds are useful for the treatment of MCHR1 mediated diseases, such as obesity, diabetes, inflammatory bowel disease, depression, and anxiety. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Synthetic Route of 386704-04-7

The Article related to aza pyridone preparation melanin concentrating hormone receptor antagonist, obesity diabetes depression anxiety mchr1 antagonist pyrimidinone preparation, inflammatory bowel disease mchr1 antagonist pyridazinone preparation and other aspects.Synthetic Route of 386704-04-7

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Alcohol – Wikipedia,
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On October 2, 2014, Ebert, Sophia; Ludolph, Bjoern; Wigbers, Christof Wilhelm; Maas, Steffen; Huelskoetter, Frank; Scialla, Stefano; Boeckh, Dieter; Christmas, Kevin; Eichstadt Waun, Amy; Loughnane, Brian J.; Rees, Darren; Eidamshaus, Christian published a patent.COA of Formula: C7H16O2 The title of the patent was Aminated polyoxyalkylated 1,3-diols. And the patent contained the following:

Aminated C2-18-alkoxylated 1,3-diols compounds, such as aminated polypropoxylated 2-butyl-2-ethyl-1,3-propanediol (I), with d.p. 2-200 are manufactured for use as grease removers in laundry detergents and curing agents for epoxy resins. Thus, 322.6 g I was propoxylated with 467.8 g propylene oxide at 140° in the presence of KOH and aminated (600 g) 18 h with 1500 g NH3 in the presence of a metal catalyst at 205° and 270 bar pressure. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).COA of Formula: C7H16O2

The Article related to aminated alkoxylated diol grease removal additive laundry detergent, epoxy resin curing agent aminated alkoxylated diol, butylethylpropanediol polypropoxylated aminated manufacture grease removal additive laundry detergent and other aspects.COA of Formula: C7H16O2

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Alcohol – Wikipedia,
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On September 30, 2004, Goble, Stephen D.; Pasternak, Alexander; Mills, Sander G.; Zhou, Changyou; Yang, Lihu published a patent.Quality Control of (6-(Trifluoromethyl)pyridin-3-yl)methanol The title of the patent was Preparation of (tetrahydropyranylamino)cyclopentanecarbonyl-substituted fused azaheterocycles as modulators of cytokine receptors such as CCR2. And the patent contained the following:

Compounds I [A = R82C, C(:O), NR8, O; B = R22C, O, S(:O), SO2, NSO2R14, NC(:O)R13, NC(:O)NR122,C(:O); D, X = C, N; E = (CH2)n; G = CH:CH, CH2CH2; Y = O, R12N, S, S(:O), SO2, R112C, etc.; n = 0-2; R1 = H, NC, (un)substituted alkyl, heterocyclyl, Ph, R122N, R13C(:O)N(R12), R14SO2N(R12), R11C(:O), R122NC(:O); R2 = H, alkyl, F, HO, heterocyclyl, R13C(:O)NH, etc.; R3, R4 = absent, H, (un)substituted alkyl, HO, Cl, O, etc.; R5 = (un)substituted alkyl, alkoxy, alkylcarbonyl, alkylthio, pyridyl, etc.; R8 = H, alkyl, (un)substituted alkylcarbonylalkyl; R11 = HO, H, (un)substituted alkyl, alkoxy, cycloalkyl, benzyl, phenyl; R12 = H, (un)substituted alkyl, benzyl, Ph, cycloalkyl; R13 = H, (un)substituted alkyl, alkoxy, benzyl, Ph, cycloalkyl; R14 = H, HO, (un)substituted alkyl, benzyl, Ph, cycloalkyl; R15 = H, (un)substituted alkyl; R16 = H, (un)substituted alkyl, alkoxy, cycloalkyl, F, HO, etc.; R17 = H, HO, (un)substituted alkyl, alkoxy, R11C(:O); R18 = H, F, (un)substituted alkyl, cycloalkoxy, alkoxy; R16 and either R17 or R18 may be joined in a ring] such as II are prepared as modulators of cytokine receptors such as CCR2 for the treatment of inflammatory and immune system disorders such as rheumatoid arthritis. Coupling of (tert-butoxy)(trifluoromethyl)benzylamine III and nonracemic (tetrahydropyranylamino)cyclopentanecarboxylic acid IV followed by cleavage of the tert-Bu group, cyclocondensation with paraformaldehyde, and cleavage of the trifluoroacetamide yields II as its hydrochloride salt. III is prepared by nucleophilic substitution of 2-fluoro-5-(trifluoromethyl)benzonitrile with potassium tert-butoxide followed by hydrogenation of the nitrile moiety. IV is prepared by Boc protection of the amine moiety of V, benzylation of the carboxylic acid group, cleavage of the Boc group, reductive amination of the amine with tetrahydropyran-4-one, trifluoroacetylation of the secondary amine, stereoselective alkylation of the ester with potassium bis(trimethylsilyl)amide and iso-Pr iodide, and hydrogenolysis of the benzyl ester; a second route to IV is also described. Compounds of the invention inhibit CCR2 with IC50 values of < 1 μM (no data). The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Quality Control of (6-(Trifluoromethyl)pyridin-3-yl)methanol

The Article related to tetrahydropyranylamino cyclopentanecarbonyl substituted fused azaheterocycle preparation cytokine receptor modulator, ccr2 modulator tetrahydropyranylamino cyclopentanecarbonyl substituted fused azaheterocycle preparation and other aspects.Quality Control of (6-(Trifluoromethyl)pyridin-3-yl)methanol

Referemce:
Alcohol – Wikipedia,
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On July 31, 2022, Aydinli, Serdar Goksin; Bulut, Elif; Deniz, Nahide Gulsah; Sayil, Cigdem; Komarovska-Porokhnyavets, Olena; Lubenets, Vira; Zvarych, Viktor; Stasevych, Maryna; Nesterkina, Mariia; Kravchenko, Iryna published an article.Quality Control of 1-Decanethiol The title of the article was New Ketene Dithioacetals Generated from 2-Nitroperchlorobutadiene and Investigation of Their Antibacterial, Antifungal, Anticonvulsant and Antidepressant Activities. And the article contained the following:

The ketene dithioacetal 3 generated from 2-nitroperchlorobutadiene 1 reacted with various heterocyclic amines and aliphatic, aromatic and heterocyclic thiols to produce functionalized new ketene-N,S,S-acetals and S,S,S-acetals 4a-f, 5a-h as heterocyclic dithiolanes. They were separated/purified by chromatog. methods and their exact structure characterization were made clear by spectroscopic methods. These compounds synthesized could act as effective drugs for versatile activity. Evaluation of the antimicrobial effect of the obtained substances determined derivatives 4e and 5h, which have MIC=15.6 μg/mL for the test culture of Mycobacterium luteum bacteria closing to the control drug Vancomycin. The obtained compounds can be proposed as a promising synthetic objects for future mol. design to enhance the antimicrobial action. Ketene dithioacetals 3, 4a, 4b, 4e, 5g (50 mg/kg) exhibited antiseizure effect comparable with reference drug (valproic acid) on the model of pentylenetetrazole-induced convulsions after single oral administration both at 3 h and 24 h. Furthermore, tested dithioacetals possessed prolonged antidepressant activity in forced swim test (FST) considerable decreasing the duration of immobility time compared to reference drug amitriptyline. This is the first study of the investigation of anticonvulsant and antidepressant activities of ketene dithioacetals. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Quality Control of 1-Decanethiol

The Article related to ketene dithioacetals nitroperchlorobutadiene antibacterial antifungal anticonvulsant antidepressant activity, antibacterial activity, anticonvulsant action, antidepressant effect, antifungal activity, ketene dithioacetal and other aspects.Quality Control of 1-Decanethiol

Referemce:
Alcohol – Wikipedia,
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On July 18, 2014, Bentley, Keith W.; Wolf, Christian published an article.Recommanded Product: H-Phg(4-OH)-OH The title of the article was Comprehensive Chirality Sensing: Development of Stereodynamic Probes with a Dual (Chir)optical Response. And the article contained the following:

The attachment of a salicylaldehyde ring and a cofacial aryl or heteroaryl N-oxide chromophore onto a naphthalene scaffold affords stereodynamic probes designed to rapidly bind amines, amino alcs., or amino acids and to translate this binding event via substrate-to-receptor chirality amplification into a dual (chir)optical response. 1-(3′-Formyl-4′-hydroxyphenyl)-8-(9′-anthryl)naphthalene (1) was prepared via two consecutive Suzuki cross-coupling reactions, and the three-dimensional structure and racemization kinetics were studied by crystallog. and dynamic HPLC. This probe proved successful for chirality sensing of several compounds, but in situ IR monitoring of the condensation reaction between the salicylaldehyde moiety in 1 and phenylglycinol showed that the imine formation takes 2 h. Optimization of the substrate binding rate and the CD and fluorescence readouts led to the replacement of anthracene with smaller fluorophores capable of intramol. hydrogen bonding. 1-(3′-Formyl-4′-methoxyphenyl)-8-(4′-isoquinolyl)naphthalene N-oxide (2) and its pyridyl analog 3 combine fast substrate binding with distinctive chiral amplification. This asym. transformation of the 1st kind prompts CD and fluorescence responses that can be used for in situ determination of the absolute configuration, ee, and total concentration of many compounds The general utility of the three chemosensors was successfully tested on 18 substrates. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Recommanded Product: H-Phg(4-OH)-OH

The Article related to amine chirality sensing stereodynamic probe dual chiroptical response, amino alc chirality sensing stereodynamic probe dual chiroptical response, acid amino chirality sensing stereodynamic probe dual chiroptical response and other aspects.Recommanded Product: H-Phg(4-OH)-OH

Referemce:
Alcohol – Wikipedia,
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