Tag: 100-200

On December 3, 2021, Jo, Hwi Yul; Lee, Jeong Min; Pietrasiak, Ewa; Lee, Eunsung; Rhee, Young Ho; Park, Jaiwook published an article.Safety of H-Phg(4-OH)-OH The title of the article was Generation of N-H imines from α-Azidocarboxylic Acids through Ru-catalyzed Decarboxylation. And the article contained the following:

A new method for the synthesis of N-H imines from α-azidocarboxylic acids was developed, which proceeded through decarboxylative C-C bond cleavage catalyzed by a com. diruthenium complex ([CpRu(CO)2]2) under visible light irradiation at room temperature within several minutes. The reactive products undergo condensation forming cyclic trimers (2,4,6-trialkylhexahydro-1,3,5-triazines) or linear N,N’-bis(arylmethylidene)arylmethanediamines in quant. yields. Alternatively, the N-H imines was trapped with benzylamine and 2-(aminomethyl)aniline providing stable N-benzylimines and tetrahydroquinazolines, resp. Subsequent oxidation of tetrahydroquinazolines produced quinazolines. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Safety of H-Phg(4-OH)-OH

The Article related to azidoethanoic acid ruthenium catalyzed decarboxylation condensation, hexahydrotriazine bismethylidenemethanediamine preparation, benzylmethylidene amine preparation, quinazoline preparation and other aspects.Safety of H-Phg(4-OH)-OH

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On February 14, 2018, Peters, David S.; Romesberg, Floyd E.; Baran, Phil S. published an article.Synthetic Route of 32462-30-9 The title of the article was Scalable access to arylomycins via C-H functionalization logic. And the article contained the following:

Arylomycins are a promising class of “latent” antibacterial natural products currently in preclin. development. Access to analogs within this family has previously required a lengthy route involving multiple functional group manipulations that is costly and time-intensive on scale. This study presents a simplified route predicated on simple C-H functionalization logic that is enabled by a Cu-mediated oxidative phenol coupling that mimics the putative biosynthesis. This operationally simple macrocyclization is the largest of its kind and can be easily performed on gram scale. The application of this new route to a formal synthesis of the natural product and a collection of new analogs along with their biol. evaluation is also reported. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Synthetic Route of 32462-30-9

The Article related to natural product arylomycin analog synthesis antibacterial structure activity antibiotic, oxidative phenol coupling copper catalyst macrocyclization solvent effect, mol docking ligand protein interaction and other aspects.Synthetic Route of 32462-30-9

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On October 25, 2020, Zhang, Zhihao; Yang, Ming; Yin, Ailing; Chen, Minmin; Tan, Ninghua; Wang, Majie; Zhang, Yanke; Ye, Hesong; Zhang, Xuefeng; Zhou, Wei published an article.Electric Literature of 621-37-4 The title of the article was Serum metabolomics reveals the effect of electroacupuncture on urinary leakage in women with stress urinary incontinence. And the article contained the following:

Stress urinary incontinence (SUI), which is defined as an involuntary loss of urine upon phys. exertion coughing, sneezing or laughing, has a significant neg. impact on the quality of life of many women. Multi-center, large-scale and randomized clin. trials have illustrated that non-invasive electroacupuncture is an effective treatment for SUI, but its therapeutic mechanism in treating SUI remains unknown. Here, gas chromatog.-mass spectrometry based serum metabolomics was performed to reveal metabolic profiles and diagnostic biomarkers from recruitment of 25 patients and 25 healthy women before and after electroacupuncture. We identified 10 differentially abundant metabolites, including butantriol, 3,4-dihydroxybutanoic acid, succinic acid, 1-deoxypentitol, psicose, citric acid, 3-hydroxybutyric acid, hydracrylic acid, 3-hydroxyphenylacetic acid and D-mannitol, from patients between before and after electroacupuncture. The electroacupuncture therapy altered propanoate metabolism, butanoate metabolism and the tricarboxylic acid cycle. A panel of 8 biomarkers (butantriol, 3,4-dihydroxybutanoic acid, succinic acid, 1-deoxypentitol, psicose, citric acid, 3-hydroxybutyric acid and hydracrylic acid) was evaluated to determine the effect of electroacupuncture on SUI and differentiated well between before and after treatment. The area under the receiver operating characteristic curve was 0.962. The sensitivity, specificity and coincidence rate were 92%, 92% and 96%, resp., at a 95% confidence interval ranging from 0.9053 to 1. Furthermore, the levels of these diagnostic biomarkers were not significantly altered in healthy subjects after sham electroacupuncture. It was indicated that an 8-biomarker panel might be constructed for the therapeutic evaluation of electroacupuncture treatment for SUI. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Electric Literature of 621-37-4

The Article related to metabolomics electroacupuncture urine leakage stress incontinence human woman, electroacupuncture, gas chromatography-mass spectrometry, metabolomics, stress urinary incontinence, therapeutic evaluation and other aspects.Electric Literature of 621-37-4

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de Jesus Beleno-Saenz, Kelvin; Caceres-Tarazona, Juan Martin; Nol, Pauline; Jaimes-Mogollon, Aylen Lisset; Gualdron-Guerrero, Oscar Eduardo; Duran-Acevedo, Cristhian Manuel; Barasona, Jose Angel; Vicente, Joaquin; Torres, Maria Jose; Welearegay, Tesfalem Geremariam; Osterlund, Lars; Rhyan, Jack; Ionescu, Radu published an article in 2021, the title of the article was Non-invasive method to detect infection with Mycobacterium tuberculosis complex in wild boar by measurement of volatile organic compounds obtained from feces with an electronic nose system.Formula: C10H22S And the article contains the following content:

More effective methods to detect bovine tuberculosis, caused by Mycobacterium bovis, in wildlife, is of paramount importance for preventing disease spread to other wild animals, livestock, and human beings. In this study, we analyzed the volatile organic compounds emitted by fecal samples collected from free-ranging wild boar captured in Donana National Park, Spain, with an electronic nose system based on organically-functionalized gold nanoparticles. The animals were separated by the age group for performing the anal. Adult (>24 mo) and sub-adult (12-24 mo) animals were anesthetized before sample collection, whereas the juvenile (<12 mo) animals were manually restrained while collecting the sample. Good accuracy was obtained for the adult and sub-adult classification models: 100% during the training phase and 88.9% during the testing phase for the adult animals, and 100% during both the training and testing phase for the sub-adult animals, resp. The results obtained could be important for the further development of a non-invasive and less expensive detection method of bovine tuberculosis in wildlife populations. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Formula: C10H22S

The Article related to mycobacterium feces electronic nose system, mycobacterium bovis, sus scrofa, bovine tuberculosis, chemical gas sensors, diagnosis, feces, gold nanoparticles, organic ligands, volatile organic compounds and other aspects.Formula: C10H22S

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Newcombe, Sonya; Bobin, Mariusz; Shrikhande, Amruta; Gallop, Chris; Pace, Yannick; Yong, Helen; Gates, Rebecca; Chaudhuri, Shuvashri; Roe, Mark; Hoffmann, Eva; Viseux, Eddy M. E. published an article in 2013, the title of the article was Gold amides as anticancer drugs: synthesis and activity studies.HPLC of Formula: 32462-30-9 And the article contains the following content:

Access to modern chemotherapeutics with robust and flexible synthetic routes that are amenable to extensive customization is a key requirement in drug synthesis and discovery. A class of chiral gold amide complexes featuring amino acid derived ligands is reported herein. They all exhibit in vitro cytotoxicity against two slow growing breast cancer cell lines with limited toxicity towards normal epithelial cells. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).HPLC of Formula: 32462-30-9

The Article related to gold complex triflic amide amino acid derivative preparation, antitumor activity gold complex triflic amide amino acid derivative, thioredoxin reductase inhibition gold complex triflic amide amino acid and other aspects.HPLC of Formula: 32462-30-9

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Saleemi, Sidra; Aouraghe, Mohamed Amine; Wei, Xiaoxiao; Liu, Wei; Liu, Li; Siyal, M. Irfan; Bae, Jihyun; Xu, Fujun published an article in 2022, the title of the article was Bio-Inspired Hierarchical Carbon Nanotube Yarn with Ester Bond Cross-Linkages towards High Conductivity for Multifunctional Applications.Reference of Pentane-1,5-diol And the article contains the following content:

The cross-linked hierarchical structure in biol. systems provides insight into the development of innovative material structures. Specifically, the sarcoplasmic reticulum muscle is able to transmit elec. impulses in skeletal muscle due to its cross-linked hierarchical tubular cell structure. Inspired by the cross-linked tubular cell structure, we designed and built chem. cross-links between the carbon nanotubes within the carbon nanotube yarn (CNT yarn) structure by an esterification reaction. Consequently, compared with the pristine CNT yarn, its elec. conductivity dramatically enhanced 348%, from 557 S/cm to 1950 S/cm. Furthermore, when applied with three voltages, the electro-thermal temperature of esterified CNT yarn reached 261°C, much higher than that of pristine CNT yarn (175°C). In addition, the esterified CNT yarn exhibits a linear and stable piezo-resistive response, with a 158% enhanced gauge factor (the ratio of elec. resistance changing to strain change ∼1.9). The superconductivity, flexibility, and stable sensitivity of the esterified flexible CNT yarn demonstrate its great potential in the applications of intelligent devices, smart clothing, or other advanced composites. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Reference of Pentane-1,5-diol

The Article related to crosslinked carbon nanotube yarn preparation thermoelec conductivity sarcoplasmic reticulum, bio-inspired, carbon nanotube yarn, electrical properties, esterification, microstructures, smart materials and other aspects.Reference of Pentane-1,5-diol

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Alcohol – Wikipedia,
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On April 15, 1992, Belley, Michel L.; Leblanc, Yves; Labelle, Marc published a patent.Safety of Isochroman-3-ol The title of the patent was Preparation of 7-phenyl-5-[(quinolylmethoxy)phenyl]-4-thiaheptanoates and analogs as leukotriene antagonists. And the patent contained the following:

R1YZCR7[X2r(CR3R3)mZ1n(CR3R22)pQ1]X3r'(CR3R3)m’Z2n'(CR3R4)p’CR2R3Q2 [Q1 = CO2R3, tetrazolyl, cyano, CONH2, etc.; Q2 = OH, amino; R1 = (substituted)-2-quinolyl; R2 = alkyl, alkenyl, CF3, Ph, CH2Ph, etc.; R3 = H, groups cited for R2; CR3R22 = amino acid residue; R4 = halo, NO2, cyano, groups cited for R3, etc.; R7 = H, alkyl; X2, X3 = O, SO0-2, (substituted) CH2; Y = CR3R3X1, X1CR3R3, NR3CO, etc.; X1 = O, SO0-2, NR3; Z = (substituted) phenylenediyl; Z1, Z2 = (substituted) phenylenediyl, heteroarylenediyl; m, m’, p, p’ = 0-8; n, n’, r, r’ = 0, 1] were prepared as leukotriene antagonists (no data). Thus, 7-chloro-2-(bromomethyl)quinoline was condensed with 3-HOC6H4CHO and the product converted in 3 steps to RCH2PPh3Br (R = quinolylmethoxyphenyl group Q) which was condensed with 1H-3-hydroxy-3,4-dihydro-2-benzopyran to give, after oxidation, 2-(MeO2C)C6H4CH2CH:CHR (R = Q). The latter was condensed with HSCH2CHMeCO2H to give, after MeMgBr treatment, title compound I (R = Q). The experimental process involved the reaction of Isochroman-3-ol(cas: 42900-89-0).Safety of Isochroman-3-ol

The Article related to quinolylmethoxyphenylthiaheptanoate preparation leukotriene antagonist, antiasthmatic quinolylmethoxyphenylthiaheptanoate preparation, antiinflammatory quinolylmethoxyphenylthiaheptanoate preparation and other aspects.Safety of Isochroman-3-ol

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Alcohol – Wikipedia,
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On May 8, 2003, Minich, Martha Lou; Rast, Bryson; Sakya, Subas Man; Sahvnya, Andrei published a patent.Computed Properties of 72364-46-6 The title of the patent was An efficient synthesis of 1-[sulfonylphenyl(or pyridyl)] pyrazoles as COX-2 inhibitors. And the patent contained the following:

The title compounds [I; the ring of the formula (R5)-A-(SOmR4) = II-VIII; m = 0-2; X = CR5, N; R1 = H, NO2, CN, etc.; R2 = H, NO2, CN, etc.; R3 = NR6NR7R8, NR6OR7, OR7, SR7, NR7R8 (wherein R6 = H, alkyl, alkenyl, etc.; or R6 and R7 may optionally taken together with the N atom or O atom to which they are attached to form 3-8 membered heterocyclyl ring; R8 = H, alkyl, alkenyl, etc.; or NR7R8 = 3-8 membered heterocyclyl); R4 = NH2, mono- and dialkylamino, etc.; R5 = H, halo, OH, etc.], useful as antiinflammatory/analgesic agents, were prepared by reacting a compound IX [the ring of the formula (R5)-A-(SOmR4), m, R1-R8 are as defined above and R10 = halo, alkylSO3, arylSO3, alkylSO2, arylSO2; wherein each of said alkyl components may optionally be substituted on any carbon atom by 1-6 fluoro substituents per alkyl component] with a compound R3H [R3 is as defined above] in the presence of a fluoride containing salt and in the presence of a solvent. Thus, reacting 5-chloro-1-(5-methanesulfonylpyridin-2-yl)-3-trifluoromethyl-1H-pyrazole-4-carbonitrile with (4-methylenecyclohexyl)methanol in the presence of KF in DMSO afforded 68% the pyrazole X. Most compounds prepared in Examples showed IC50 values of 0.001 μM to 3 μM with respect to inhibition of COX-2 in either the canine or human assays. The experimental process involved the reaction of (2-Fluorophenyl)methanethiol(cas: 72364-46-6).Computed Properties of 72364-46-6

The Article related to sulfonylphenylpyrazole sulfonylpyridylpyrazole preparation cyclooxygenase cox2 inhibitor, pyrazole sulfonylphenyl sulfonylpyridyl preparation cyclooxygenase cox2 inhibitor antiinflammatory analgesic and other aspects.Computed Properties of 72364-46-6

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Alcohol – Wikipedia,
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On September 30, 2022, Chung, Hyuk-Jin; Lee, Hwanhui; Kim, Myeongsun; Lee, Ji Won; Saeed, Maham; Lee, Hayera; Jung, Seung-Hee; Shim, Jae-Jung; Lee, Jung-Lyoul; Heo, Keon; Choi, Hyung-Kyoon published an article.Recommanded Product: 2,3-Dihydroxypropanoic acid The title of the article was Development and metabolic profiling of a postbiotic complex exhibiting antibacterial activity against skin microorganisms and anti-inflammatory effect on human keratinocytes. And the article contained the following:

Beyond probiotics, the interest in the application of postbiotics to various fields has been growing. We aimed to develop a novel postbiotic complex (PC) with antibacterial and anti-inflammatory properties. Through antibacterial activity testing against Staphylococcus aureus or Cutibacterium acnes, a PC [a mixture of cell-free supernatants (postbiotics) from probiotic Lactobacillus helveticus (HY7801) and Lactococcus lactis (HY449)] was developed. Anti-inflammatory activity of the PC was investigated using HaCaT keratinocytes treated with S. aureus or C. acnes. PC significantly decreased IL-8 levels and increased hyaluronic acid levels in HaCaT cells cultured with S. aureus or C. acnes. GC-MS based metabolic profiling suggested 2-hydroxyisocaproic acid, hypoxanthine, succinic acid, ornithine, and γ-aminobutyric acid as potential contributing metabolites for the antibacterial and anti-inflammatory effects of PC. The PC developed in this study could be utilized in food, cosmetics, and pharmaceutical products as an alternative or complementary resources of probiotics. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Recommanded Product: 2,3-Dihydroxypropanoic acid

The Article related to skin microorganism postbiotic antibacterial antiinflammatory human keratinocyte metabolic profiling, anti-inflammatory activity, antibacterial activity, metabolic profiling, postbiotics, probiotics and other aspects.Recommanded Product: 2,3-Dihydroxypropanoic acid

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Lee, Ji-Youn; Seo, Sumin; Shin, Bohyun; Hong, Se Hee; Kwon, Eunjin; Park, Sunwha; Hur, Young Min; Lee, Dong-Kyu; Kim, Young Ju; Han, Sang Beom published an article in 2022, the title of the article was Development of a New Biomarker Model for Predicting Preterm Birth in Cervicovaginal Fluid.Name: 2,3-Dihydroxypropanoic acid And the article contains the following content:

Preterm birth (PTB) is a social problem that adversely affects not only the survival rate of the fetus, but also the premature babies and families, so there is an urgent need to find accurate biomarkers. We noted that among causes, eubiosis of the vaginal microbial community to dysbiosis leads to changes in metabolite composition In this study, short chain fatty acids (SCFAs) representing dysbiosis were derivatized using (N-tert-butyldimethylsilyl-N-methyltrifluoroacetamide, MTBSTFA) and targeted anal. was conducted in extracted organic phases of cervicovaginal fluid (CVF). In residual aqueous CVF, polar metabolites produced biochem. process were derivatized using methoxyamine and N,O-bis(trimethylsilyl)trifluoroacetamide (BSTFA), and non-targeted anal. were conducted. Nine SCFAs were quantified, and 58 polar metabolites were detected in 90 clin. samples using gas chromatog./mass spectrometry (GC/MS). The criteria of statistical anal. and detection rate of clin. sample for development of PTB biomarkers were presented, and 19 biomarkers were selected based on it, consisting of 1 SCFA, 2 organic acids, 4 amine compounds, and 12 amino acids. In addition, the model was evaluated as a suitable indicator for predicting PTB without distinction between sample collection time. We hope that the developed biomarkers based on microbiota-derived metabolites could provide useful diagnostic biomarkers for actual patients and pre-pregnancy. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Name: 2,3-Dihydroxypropanoic acid

The Article related to cervicovaginal fluid preterm birth biomarker model development, biomarker model, cervicovaginal fluid (cvf), polar metabolite, preterm birth (ptb), short chain fatty acid (scfa), vaginal microbiome and other aspects.Name: 2,3-Dihydroxypropanoic acid

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Alcohol – Wikipedia,
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