Tag: 100-200

On August 30, 2020, Abid, Mehwish; Naveed, Muhammad; Azeem, Iqra; Faisal, Amir; Faizan Nazar, Muhammad; Yameen, Basit published an article.Computed Properties of 111-29-5 The title of the article was Colon specific enzyme responsive oligoester crosslinked dextran nanoparticles for controlled release of 5-fluorouracil. And the article contained the following:

Targeting bioactives selectively to diseased sites is one of the most challenging aspects of cancer therapy. Herein, fabrication of colonic enzyme-responsive dextran based oligoester crosslinked nanoparticles is reported for the controlled release of 5-fluorouracil (5-FU) – an anticancer drug. The 5-FU drug loaded nanoparticles (DNPs, size ∼237 ± 25 nm, ζ-potential -17.0 ± 3 mV) were developed by the in-situ crosslinking of dextran with a bifunctional telechelic oligoester followed by the phys. drug encapsulation via nanopptn. Drug encapsulation efficiency and drug loading capacity of DNPs were found to be ∼76% (±0.1) and ∼8% (±0.1), resp. The DNPs were demonstrated to release the encapsulated drug selectively in the presence of dextranase enzyme. The in vitro release kinetics assay revealed that the DNPs released about 75% (±4) of the entrapped drug within 12 h of incubation with dextranase enzyme. No drug was released in a control experiment where DNPs were exposed to pH conditions encountered in the stomach and small intestine. Moreover, the treatment of HCT116 colon cancer cell line with the developed DNPs highlighted its biocompatibility as well as dextranase triggered cytotoxicity. The developed system offers an avenue to reduce the non-specific cytotoxicity of the encapsulated 5-FU, and a colon specific delivery of the encapsulated drug in response to the dextranase enzyme. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Computed Properties of 111-29-5

The Article related to colon responsive oligoester crosslinked dextran nanoparticle fluorouracil, 5-fluorouracil, crosslinked dextran nanoparticles, dextranase responsive delivery system, telechelic oligoester and other aspects.Computed Properties of 111-29-5

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Masip, Jenifer; Rallon, Norma; Yeregui, Elena; Olona, Montserrat; Resino, Salvador; Benito, Jose M.; Vilades, Consuelo; Garcia-Pardo, Graciano; Alcami, Jose; Ruiz-Mateos, Ezequiel; Gomez-Bertomeu, Frederic; Vargas, Montserrat; Navarro, Marta; Oteo, Jose A.; Pineda, Juan A.; Marti, Anna; Alba, Veronica; Vidal, Francesc; Peraire, Joaquin; Rull, Anna; ECRIS Integrated In The Spanish AIDS Research Network published an article in 2022, the title of the article was Elevated α-ketoglutaric acid concentrations and a lipid-balanced signature are the key factors in long-term HIV control.Name: 2,3-Dihydroxypropanoic acid And the article contains the following content:

Long-term elite controllers (LTECs) are a fascinating small subset of HIV individuals with viral and immunol. HIV control in the long term that have been designated as models of an HIV functional cure. However, data on the LTEC phenotype are still scarce, and hence, the metabolomics and lipidomics signatures in the LTEC-extreme phenotype, LTECs with more than 10 years of viral and immunol. HIV control, could be pivotal to finding the keys for functional HIV remission. Metabolomics and lipidomics analyses were performed using high-resolution mass spectrometry (ultra-high-performance liquid chromatog.-electrospray ionization-quadrupole time of flight [UHPLC-(ESI) qTOF])in plasma samples of 13 patients defined as LTEC-extreme, a group of 20 LTECs that lost viral and/or immunol. control during the follow-up study (LTEC-losing) and 9 EC patients with short-term viral and immunol. control (less than 5 years; no-LTEC patients). Long-term viral and immunol. HIV-1 control was found to be strongly associated with elevated tricarboxylic acid (TCA) cycle function. Interestingly, of the nine metabolites identified in the TCA cycle, α-ketoglutaric acid (p = 0.004), a metabolite implicated in the activation of the mTOR complex, a modulator of HIV latency and regulator of several biol. processes, was found to be a key metabolite in the persistent control. On the other hand, a lipidomics panel combining 45 lipid species showed an optimal percentage of separation and an ability to differentiate LTEC-extreme from LTEC-losing, revealing that an elevated lipidomics plasma profile could be a predictive factor for the reignition of viral replication in LTEC individuals. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Name: 2,3-Dihydroxypropanoic acid

The Article related to long term hiv control alpha ketoglutaric acid lipidomics metabolomics, hiv infection, kreb’s cycle, elite controllers (ecs), lipidomics, long-term, mass spectrometry, metabolomics, viral and other aspects.Name: 2,3-Dihydroxypropanoic acid

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On July 19, 2020, Trinklein, Timothy J.; Prebihalo, Sarah E.; Warren, Cable G.; Ochoa, Grant S.; Synovec, Robert E. published an article.Application In Synthesis of 1-Decanethiol The title of the article was Discovery-based analysis and quantification for comprehensive three-dimensional gas chromatography flame ionization detection data. And the article contained the following:

Basic principles are introduced for implementing discovery-based anal. with automated quantification of data obtained using comprehensive three-dimensional gas chromatog. with flame ionization detection (GC3-FID). The GC3-FID instrument employs dynamic pressure gradient modulation, providing full modulation (100% duty cycle) with a fast modulation period (PM) of 100 ms. Specifically, tile-based Fisher-ratio anal., previously developed for comprehensive two-dimensional gas chromatog. with time-of-flight mass spectrometry (GCxGC-TOFMS), is adapted and applied for GC3-FID where the third chromatog. dimension (3D) is treated as the “spectral” dimension. To evaluate the instrumental platform and software implementation, ten “non-native” compounds were spiked into a ninety-component base mixture to create two classes with a concentration ratio of two for the spiked analyte compounds The Fisher ratio software identified 95 locations of potential interest (i.e., hits), with all ten spiked analytes discovered within the top fourteen hits. All 95 hits were quantified by a novel signal ratio (S-ratio) algorithm portion of the F-ratio software, which determines the time-dependent S-ratio of the 3D chromatograms from one class to another, thus providing relative quantification. The average S-ratio for spiked analytes was 1.94 ± 0.14 mean absolute error (close to the nominal concentration ratio of two), and 1.06 ± 0.16 mean absolute error for unspiked (i.e., matrix) components. The appearance of the S-ratio as a function of 3D retention time in the GC3 dataset, referred to as an S-ratiogram, provides indication of peak purity for each hit. The unique shape of the S-ratiogram for hit 1, α-pinene, suggested likely 3D overlap. Parallel factor anal. (PARAFAC) decomposition of the hit location confirmed that overlap was occurring and successfully decomposed α-pinene from a highly overlapped (3Rs = 0.1) matrix interferent. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Application In Synthesis of 1-Decanethiol

The Article related to discovery analysis 3d gas chromatog flame ionization detection data, chemometrics, dynamic pressure gradient modulation, comprehensive three-dimensional gas chromatography, fisher ratio and other aspects.Application In Synthesis of 1-Decanethiol

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Becker, Dominic; Kazmaier, Uli published an article in 2015, the title of the article was Synthesis of simplified halogenated chondramide derivatives with strong cytostatic properties.HPLC of Formula: 32462-30-9 And the article contains the following content:

Removing the Me groups and the stereogenic centers from the ω-hydroxy acid of the chondramides results in a significant drop in the cytotoxicity of these interesting depsipeptides. This effect can be almost compensated for by introduction of a second chlorine atom on the β-tyrosine moiety of the natural products. These simplified chondramides are much easier accessible than natural chondramides. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).HPLC of Formula: 32462-30-9

The Article related to cyclic peptide depsipeptide halogenated chondramide enantioselective synthesis antitumor agent, hydroxy acid esterification tryptophan protection amination peptide coupling cyclization and other aspects.HPLC of Formula: 32462-30-9

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On November 9, 2020, Lee, Yih Hong; Shi, Wenxiong; Yang, Yijie; Kao, Ya-Chuan; Lee, Hiang Kwee; Chu, Rongrong; Pang, Yee Ling; Lay, Chee Leng; Li, Shuzhou; Ling, Xing Yi published an article.Related Products of 111-29-5 The title of the article was Modulating Orientational Order to Organize Polyhedral Nanoparticles into Plastic Crystals and Uniform Metacrystals. And the article contained the following:

In nanoparticle self-assembly, the current lack of strategy to modulate orientational order creates challenges in isolating large-area plastic crystals. Here, we achieve two orientationally distinct supercrystals using one nanoparticle shape, including plastic crystals and uniform metacrystals. Our approach integrates multi-faceted Archimedean polyhedra with mol.-level surface polymeric interactions to tune nanoparticle orientational order during self-assembly. Experiments and simulations show that coiled surface polymer chains limit interparticle interactions, creating various geometrical configurations among Archimedean polyhedra to form plastic crystals. In contrast, brush-like polymer chains enable mol. interdigitation between neighboring particles, favoring consistent particle configurations and result in uniform metacrystals. Our strategy enhances supercrystal diversity for polyhedra comprising multiple nondegenerate facets. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Related Products of 111-29-5

The Article related to silver orientational order polyhedral nanoparticle plastic crystal, nanoparticle self-assembly, nanoscale surface chemistry, orientational order, plastic crystals, uniform metacrystals and other aspects.Related Products of 111-29-5

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On July 31, 2021, Karsai, Syrus; Weiss, Christel; Luetgerath, Constantin; Ott, Isabel; Faulhaber, Jorg published an article.Electric Literature of 111-29-5 The title of the article was Comparison of novel aluminium lactate versus aluminium chloride-based antiperspirant in excessive axillary perspiration: First prospective cohort study. And the article contained the following:

Aluminum chloride-based antiperspirants are an effective topical therapeutic option for mild to moderate states of excessive perspiration. Its use is primarily limited by the occurrence of skin irritation, especially in sensitive skin types. The objective of this study was to compare the antiperspirant efficacy and tolerability of a novel antiperspirant with 12.5% aluminum lactate, and a 12.5% aluminum chloride-based antiperspirant. This cohort study was conducted as a two-sided self-assessment comparison between both preparations in healthy volunteers to generate selfcare-related data. Almost half of the participants stated that aluminum chloride was more efficacious than aluminum lactate; 22% stated aluminum lactate was more efficacious than aluminum chloride; 28% observed no difference in the efficacy of both preparations (p = 0.04). However, 88% described greater tolerability with aluminum lactate (p < 0.0001). In this study, aluminum lactate showed significantly greater tolerability than aluminum chloride, although the latter tended to show slightly greater efficacy. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Electric Literature of 111-29-5

The Article related to aluminum lactate chloride antiperspirant axillary perspiration human, aluminium chloride, aluminium lactate, antiperspirant, clinical efficacy, cohort study, excessive perspiration, tolerability and other aspects.Electric Literature of 111-29-5

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On June 15, 2022, Li, Zhiheng; Chen, Jiazheng; Chen, Jie; Jin, Jiaojun; Chen, Hanmei; Liu, Huijun published an article.Product Details of 473-81-4 The title of the article was Metabolomic analysis of Scenedesmus obliquus reveals new insights into the phytotoxicity of imidazolium nitrate ionic liquids. And the article contained the following:

Due to the persistence of ionic liquids (ILs) in aquatic environments, it is necessary to reveal their ecol. risk to aquatic organisms. Herein, the biotoxicity of two alkyl-methylimidazolium nitrate ILs ([C10mim]NO3 and [C12mim]NO3) against Scenedesmus obliquus were studied. The results showed that the growth inhibition of S. obliquus increased with increasing concentrations of ILs, maximum values of 94.61% at 4 mg/L of [C10mim]NO3 and 97.34% at 0.8 mg/L of [C12min]NO3 were observed The fluorescence parameters of photosystem II, such as light quantum yield and electron transfer rate, showed a neg. relationship with the exposure dose. [C12mim]NO3 had a more significant effect than [C10mim]NO3. Moreover, the redox homeostasis of algae was disrupted; the accumulation of reactive oxygen species, leading to obvious inhibition of superoxide dismutase and catalase activities was observed A metabolomic anal. indicated that the contents of most metabolites were reduced significantly, and fructose and galactose decreased significantly by 42.3% and 88.6%, resp., in the [C10mim]NO3 treatment compared to those in the control. The inhibition of amino acid biosynthesis and glyoxylate and dicarboxylate metabolism explained the more serious biotoxicity of [C12mim]NO3 than that of [C10mim]NO3. This study facilitates a better understanding of the environmental safety and ecol. risks of ILs. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Product Details of 473-81-4

The Article related to scenedesmus phytotoxicity imidazolium nitrate ionic liquid, 1-alkyl-3-methylimidazolium nitrate ionic liquid, metabolomic analysis, oxidative stress, photosynthetic system, scenedesmus obliquus and other aspects.Product Details of 473-81-4

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On January 31, 2013, Li, Yalin; Yang, Hai-Jian; Zhou, Tao published an article.Reference of 2-Methyl-2-propylpropane-1,3-diol The title of the article was New CO2-philic propane derivatives: design, synthesis and phase behavior in supercritical carbon dioxide. And the article contained the following:

Three new potent CO2-philic propane derivatives, i.e. 1,3-bis(3-chloropropionyloxy)-2,2-diethylpropane, 1,3-bis(3-chloropropionyloxy)-2-butyl-2-ethylpropane, and 1,3-bis(3-chloropropionyloxy)-2-methyl-2-propylpropane, were designed and synthesized. Their structures were characterized by NMR, FTIR, and elemental anal. Phase behavior of the three compounds was investigated at temperatures ranging from 313 K to 333 K and pressures from 9.1 MPa to 16.1 MPa in supercritical carbon dioxide, the solubility differences were discussed. The exptl. solubility data were calculated and correlated by the two d.-based models: Bartle and Chrastil, and satisfied agreements were obtained. Addnl., the partial molar volumes V2 for each compound were also estimated in the supercritical phase using the theory developed by Kumar and Johnston. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Reference of 2-Methyl-2-propylpropane-1,3-diol

The Article related to propanediol chloropropionic acid diester preparation carbon dioxide philic, solubility supercritical carbon dioxide, kumar johnston theory partial molar volume, bartle chrastil model solubility and other aspects.Reference of 2-Methyl-2-propylpropane-1,3-diol

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On January 23, 2020, De Francesco, Raffaele; Donnici, Lorena; Guidotti, Luca; Iannacone, Matteo; Di Fabio, Romano; Summa, Vincenzo; Bencheva, Leda Ivanova; De Matteo, Marilenia; Ferrante, Luca; Prandi, Adolfo; Randazzo, Pietro published a patent.Electric Literature of 62640-03-3 The title of the patent was Preparation of arylaminocarbonyl bicyclic sulfonamides as inhibitors of hepatitis B virus. And the patent contained the following:

The invention relates to preparation of arylaminocarbonyl bicyclic sulfonamides (I) that are inhibitors of hepatitis B virus (HBV). Compounds I wherein B is a 6-membered aryl optionally containing one or more N atoms; X is N (un)substituted with R4, or is O; Y is a single bond, a double bond, C1-4 alkanediyl, etc.; Z is C(O) or CR2R3; R1 is H, OH, etc.; R2 is H, DNH2, etc.; R3 is absent, H, D, etc.; R4 is H, OH, C1-4 alkyl; R5 is C1-3 alkyl (un)substituted with OH; R6 is C1-4 alkyl; etc., are claimed. The example compound II was prepared from an intermediate (also prepared) and formaldehyde (procedure given). The compounds of the invention were evaluated for their biol. activity (data given). Compounds I are useful alone or in combination with other agents for treating, ameliorating, preventing or curing HBV infection and related conditions. The invention also relates to pharmaceutical compositions containing I. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Electric Literature of 62640-03-3

The Article related to arylaminocarbonyl bicyclic sulfonamide preparation antiviral hepatitis b combination therapy, hbv infection prophylaxis combination treatment arylaminocarbonyl bicyclic sulfonamide preparation and other aspects.Electric Literature of 62640-03-3

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On January 22, 2020, De Francesco, Raffaele; Donnici, Lorena; Guidotti, Luca; Iannacone, Matteo; Di Fabio, Romano; Summa, Vincenzo; Bencheva, Leda Ivanova; De Matteo, Marilenia; Ferrante, Luca; Prandi, Adolfo; Randazzo, Pietro published a patent.Related Products of 62640-03-3 The title of the patent was Preparation of arylaminocarbonyl bicyclic sulfonamides as inhibitors of hepatitis B virus. And the patent contained the following:

The invention relates to preparation of arylaminocarbonyl bicyclic sulfonamides (I) that are inhibitors of hepatitis B virus (HBV). Compounds I wherein B is a 6-membered aryl optionally containing one or more N atoms; X is N (un)substituted with R4, or is O; Y is a single bond, a double bond, C1-4 alkanediyl, etc.; Z is C(O) or CR2R3; R1 is H, OH, etc.; R2 is H, DNH2, etc.; R3 is absent, H, D, etc.; R4 is H, OH, C1-4 alkyl; R5 is C1-3 alkyl (un)substituted with OH; R6 is C1-4 alkyl; etc., are claimed. The example compound II was prepared from an intermediate(also prepared) and formaldehyde (procedure given). The compounds of the invention were evaluated for their biol. activity (data given). Compounds I are useful alone or in combination with other agents for treating, ameliorating, preventing or curing HBV infection and related conditions. The invention also relates to pharmaceutical compositions containing I. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Related Products of 62640-03-3

The Article related to arylaminocarbonyl bicyclic sulfonamide preparation antiviral hepatitis b combination therapy, hbv infection prophylaxis combination treatment arylaminocarbonyl bicyclic sulfonamide preparation and other aspects.Related Products of 62640-03-3

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