Tag: 100-200

On August 5, 2019, Brune, Veronika; Hegemann, Corinna; Mathur, Sanjay published an article.Safety of 2,2′-(tert-Butylazanediyl)diethanol The title of the article was Molecular Routes to Two-Dimensional Metal Dichalcogenides MX2 (M = Mo, W; X = S, Se). And the article contained the following:

New synthetic access to two-dimensional transition metal dichalcogenides (TMDCs) is highly desired to exploit their extraordinary semiconducting and optoelectronic properties for practical applications. We introduce here an entirely novel class of mol. precursors, [MIV(XEtN(Me)EtX)2] (MIV = MoIV, WIV, X = S, Se), enabling chem. vapor deposition of TMDC thin films. Molybdenum and tungsten complexes of dianionic tridentate pincer-type ligands (HXEt)2NR (R = Me, tert-Bu, phenyl) produced air-stable monomeric dichalcogenide complexes, [W(SEtN(Me)EtS)2] and [Mo(SEtN(Me)EtS)2], displaying W and Mo centers in an octahedral environment of 4 S and 2 N donor atoms. Owing to their remarkable volatility and clean thermal decomposition, both Mo and W complexes, when used in the chem. vapor deposition (CVD) process, produced crystalline MoS2 and WS2 thin films. X-ray diffraction anal. and at.-scale imaging confirmed the phase purity and 2D structural characteristics of MoS2 and WS2 films. The new set of ligands presented in this work open ups convenient access to a scalable and precursor-based synthesis of 2D transition metal dichalcogenides. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).Safety of 2,2′-(tert-Butylazanediyl)diethanol

The Article related to molybdenum tungsten methylazanediylethanethiolate complex preparation precursor metal dichalcogenide film, crystal structure molybdenum tungsten methylazanediylethanethiolate complex and other aspects.Safety of 2,2′-(tert-Butylazanediyl)diethanol

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On June 30, 2016, Sato, Takahiro; Nagayama, Sachiho; Yoshino, Yasuhiro; Inoue, Tsutomu; Kato, Hiroshige; Uda, Junichiro; Inaba, Masato; Yamoto, Noriko; Taniguchi, Tetsuya published a patent.HPLC of Formula: 386704-04-7 The title of the patent was Preparation of novel heterocyclic derivative as EPO production promoters for prevention or treatment of anemia. And the patent contained the following:

The present invention relates to a compound represented by the following general formula I [wherein X represents an oxygen atom, an imino group, a sulfur atom, sulfinyl, or sulfonyl, R1, R2, and R3 each independently represent a hydrogen atom or a C1-6 alkyl group, R4 represents a hydrogen atom, a C1-6 alkyl group, or an arylalkyl group, R5 represents an alkyl, alkenyl, alkynyl, aryl, or heteroaryl group]. This compound has excellent EPO-production acceleration activity and is useful as a pharmaceutical. Thus, addition of [5-(3,5-dichlorophenylsulfanyl)-7-hydroxy[1,2,4]triazolo[1,5-a]pyridine-8-carbonylamino]acetic acid, prepared from 3,5-dichlorobenzenethiol and 7-benzyloxy-5-iodo[1,2,4]triazolo[1,5-α]pyridine-8-carboxylic acid tert-Bu ester, to culture of Hep3B cells significantly increased erythropoietin production The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).HPLC of Formula: 386704-04-7

The Article related to heterocyclic amide compound preparation erythropoietin production promoter treatment anemia, triazolopyridinecarboxamidoacetic acid erythropoietin production promoter antianemic drug and other aspects.HPLC of Formula: 386704-04-7

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On March 1, 2012, Bartolozzi, Alessandra; Bosanac, Todd; Chen, Zhidong; De Lombaert, Stephane; Dines, Jonathon Alan; Huber, John D.; Liu, Weimin; Lo, Ho Yin; Loke, Pui Leng; Morwick, Tina Marie; Nemoto, Peter Allen; Olague, Alan; Riether, Doris; Tye, Heather; Wu, Lifen; Zindell, Renee M. published a patent.Related Products of 62640-03-3 The title of the patent was Preparation of oxadiazole inhibitors of leukotriene production. And the patent contained the following:

The present invention relates to compound I [R1 and R2 together with the carbon atom to which they are attached form (un)substituted carbocyclic ring or 5-11 membered heterocyclic ring; R3 = (un)substituted 5-11 membered heteroaryl containing 1-3 heteroatoms selected from N, O and S; R4 = H, halo, alkyl, nitrile; R5 = (un)substituted alkyl, cycloalkyl, 5-11 membered heterocyclyl, etc.] and pharmaceutically acceptable salt thereof. Over three-hundred compounds I were prepared E.g., a multi-step synthesis of II, starting from the nitrile III and 1,3-dibromopropane, was described. Representative compounds I showed activity in the FLAP binding assay and in the human whole blood LTB4 production inhibition assay (IC50 values were given). The invention also relates to pharmaceutical compositions comprising compounds I, methods of using I in the treatment of various diseases and disorders, processes for preparing I and intermediates useful in these processes. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Related Products of 62640-03-3

The Article related to oxadiazole preparation leukotriene ltb4 production flap inhibitor antitumor antiinflammatory, cardiovascular allergy pulmonary renal disease fibrosis treatment oxadiazole preparation and other aspects.Related Products of 62640-03-3

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On May 31, 2021, Sayago-Ayerdi, S. G.; Venema, K.; Tabernero, M.; Sarria, B.; Bravo, L.; Mateos, R. published an article.Recommanded Product: 3-Hydroxyphenylacetic acid The title of the article was Bioconversion of polyphenols and organic acids by gut microbiota of predigested Hibiscus sabdariffa L. calyces and Agave (A. tequilana Weber) fructans assessed in a dynamic in vitro model (TIM-2) of the human colon. And the article contained the following:

The present work aimed at understanding gut microbiota bioconversion of phenolic compounds (PC) and organic acids in predigested Hibiscus sabdariffa (Hb) calyces and the mixture of Hb and Agave (Agave tequilana Weber) fructans (AF). With this purpose, dried Hb and Hb/AF were predigested with enzymic treatment, and then fermented in a dynamic in vitro model of the human colon (TIM-2). After HPLC-ESI-QToF-MS anal. of samples taken at 0, 24, 48 and 72 h of fermentation, it was observed that hydroxycinnamic acids, flavanols, flavonols, and anthocyanins were mainly transformed into derivatives of hydroxyphenylpropionic, hydroxyphenylacetic and hydroxybenzoic acids. Moreover, organic acids, such as hydroxycitric and hibiscus acids, were formed along with unidentified lactones and reduced compounds Interestingly, no differences were observed between microbial-derived metabolites formed after the fermentation of Hb and Hb/AF. In conclusion, colonic fermentation of polyphenol-rich Hb yields a wide range of microbial phenolic metabolites with potential effects on health. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Recommanded Product: 3-Hydroxyphenylacetic acid

The Article related to hibiscus agave human colon metabolites fermentation fecal microbiota tim2, agave tequilana fructans, bioconversion, colonic fermentation, hplc-esi-qtof-ms, hibiscus sabdariffa, tim-2 and other aspects.Recommanded Product: 3-Hydroxyphenylacetic acid

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Alcohol – Wikipedia,
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Sillner, Nina; Walker, Alesia; Lucio, Marianna; Maier, Tanja V.; Bazanella, Monika; Rychlik, Michael; Haller, Dirk; Schmitt-Kopplin, Philippe published an article in 2021, the title of the article was Longitudinal profiles of dietary and microbial metabolites in formula- and breastfed infants.Quality Control of 3-Hydroxyphenylacetic acid And the article contains the following content:

The early-life metabolome of the intestinal tract is dynamically influenced by colonization of gut microbiota which in turn is affected by nutrition, i.e. breast milk or formula. A detailed examination of fecal metabolites was performed to investigate the effect of probiotics in formula compared to control formula and breast milk within the first months of life in healthy neonates. A broad metabolomics approach was conceptualized to describe fecal polar and semi-polar metabolites affected by feeding type within the first year of life. Fecal metabolomes were clearly distinct between formula- and breastfed infants, mainly originating from diet and microbial metabolism Unsaturated fatty acids and human milk oligosaccharides were increased in breastfed, whereas Maillard products were found in feces of formula-fed children. Altered microbial metabolism was represented by bile acids and aromatic amino acid metabolites. Elevated levels of sulfated bile acids were detected in stool samples of breastfed infants, whereas secondary bile acids were increased in formula-fed infants. Microbial co-metabolism was supported by significant correlation between chenodeoxycholic or lithocholic acid and members of Clostridia. Fecal metabolites showed strong inter- and intra-individual behavior with features uniquely present in certain infants and at specific time points. Nevertheless, metabolite profiles converged at the end of the first year, coinciding with solid food introduction. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Quality Control of 3-Hydroxyphenylacetic acid

The Article related to gene expression dietary oligosaccharide microbial metabolite formula breastfed infant, bifidobacteria, breastfed, feces, formula-fed, infant, infant formula, metabolomics, probiotics and other aspects.Quality Control of 3-Hydroxyphenylacetic acid

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On January 20, 2022, Lee, Hwanhui; To, Ngoc Bao; Kim, Myeongsun; Nguyen, Yen Thi-Kim; Cho, Somi Kim; Choi, Hyung-Kyoon published an article.Application In Synthesis of 2,3-Dihydroxypropanoic acid The title of the article was Metabolic and lipidomic characterization of radioresistant MDA-MB-231 human breast cancer cells to investigate potential therapeutic targets. And the article contained the following:

To provide preliminary insights into metabolic and lipidomic characteristics in radioresistant triple-neg. breast cancer (TNBC) cells and suggest potential therapeutic targets, we performed a comprehensive metabolic and lipidomic profiling of radioresistant MDA-MB-231 (MDA-MB-231/RR) TNBC cells and their parental cells using gas chromatog.-mass spectrometry and nano electrospray ionization-mass spectrometry, followed by multivariate statistical anal. Buthionine sulfoximine (BSO) and radiation were co-treated to radioresistant TNBC cells. The level of glutathione (GSH) was significantly increased, and the levels of GSH synthesis-related metabolites, such as cysteine, glycine, and glutamine were also increased in MDA-MB-231/RR cells. In contrast, the level of lactic acid was significantly reduced. In addition, reactive oxygen species (ROS) level was decreased in MDA-MB-231/RR cells. In the lipidomic profiles of MDA-MB-231/RR cells, the levels of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) were significantly increased, whereas those of most of the phosphatidylinositol species were significantly decreased. BSO sensitized MDA-MB-231/RR cells to radiotherapy, which resulted in decreased GSH level and increased ROS level and apoptosis. Radioresistant TNBC cells showed distinct metabolic and lipidomic characteristics compared to their parental cells. We suggested activated GSH, PC, and PE biosynthesis pathways as potential targets for treating radioresistant TNBC cells. Particularly, enhanced radiosensitivity was achieved by inhibition of GSH biosynthesis in MDA-MB-231/RR cells. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Application In Synthesis of 2,3-Dihydroxypropanoic acid

The Article related to radioresistant mda mb231 breast cancer cell metabolic lipidomic characterization, lipidomic profiling, mda-mb-231, metabolic profiling, radioresistance, triple-negative breast cancer and other aspects.Application In Synthesis of 2,3-Dihydroxypropanoic acid

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On June 5, 2020, Tran, Cong Chi; Kawaguchi, Shin-ichi; Sato, Fumiya; Nomoto, Akihiro; Ogawa, Akiya published an article.Application In Synthesis of 1-Decanethiol The title of the article was Photoinduced Cyclizations of o-Diisocyanoarenes with Organic Diselenides and Thiols that Afford Chalcogenated Quinoxalines. And the article contained the following:

This study describes the syntheses of 2,3-bis(selanyl)quinoxalines via the photoinduced cyclizations of o-diisocyanoarenes with diaryl or dialkyl diselenides, in addition to providing a detailed discussion of the corresponding mechanism and revealing that the developed procedure can also be applied to prepare 2-thiolated quinoxaline derivatives from o-diisocyanoarenes and thiols. The developed technique does not need the use of additives or metal catalysts and features the advantages of a high conversion, a broad substrate scope, and mild reaction conditions, thereby rendering it a valuable addition to the quinoxaline synthesis toolbox. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Application In Synthesis of 1-Decanethiol

The Article related to diselenide diisocyanoarene photoinduced cyclization light, bisselanyl quinoxaline preparation, thiol diisocyanoarene photoinduced cyclization light, thiolated quinoxaline preparation and other aspects.Application In Synthesis of 1-Decanethiol

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On February 3, 2021, Cao, Jian; Gao, Dejun; Li, Chun; Si, Xiaoqing; Jia, Jianshu; Qi, Junlei published an article.Product Details of 143-10-2 The title of the article was Bioinspired Metal-Intermetallic Laminated Composites for the Fabrication of Superhydrophobic Surfaces with Responsive Wettability. And the article contained the following:

Hundreds of copper and titanium foils were applied to prepare biomimetic metal-intermetallic laminated composites by diffusion bonding. The cross sections of the obtained diffusion bonded bulks were etched selectively with FeCl3 solution to get regular microarray structures. This kind of microstructure was controlled accurately and promptly by simple parameter adjustment. The etched surfaces were modified with 1-dodecanethiol, and the water contact angles (WCAs) were measured. The relationship between the microstructure and wettability of the achieved material was discussed, and the reason for the anisotropic wettability was also analyzed. Then etched surfaces were anodized in different electrolyte solutions to obtain different nanostructures. The morphol. and chem. compositions of the surfaces were analyzed. The surfaces with CuO nanostructures by modification show superhydrophobicity with self-cleaning, on which the WCA and water sliding angle are 160.9° and 0.8°, resp. The surfaces with TiO2 nanostructures without modification show UV light-responsive wettability. After modification with 11-mercaptoundecanoic acid and 1-decanethiol, the surfaces also exhibit pH-responsive wettability. The superhydrophobic surfaces with responsive wettability have potential applications in biotechnol. and microfluidics. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Product Details of 143-10-2

The Article related to laminated composite superhydrophobic surface wettability copper titanium, mil composites, biomimetic surfaces, controlled microstructures, responsive wettability, superhydrophobicity and other aspects.Product Details of 143-10-2

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Alcohol – Wikipedia,
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On July 15, 2020, Yuan, Bo; Zhao, Danyue; Kshatriya, Dushyant; Bello, Nicholas T.; Simon, James E.; Wu, Qingli published an article.Name: 3-Hydroxyphenylacetic acid The title of the article was UHPLC-QqQ-MS/MS method development and validation with statistical analysis: Determination of raspberry ketone metabolites in mice plasma and brain. And the article contained the following:

Raspberry ketone (RK) (4-(4-hydroxyphenyl)-2-butanone) is the major compound responsible for the characteristic aroma of red raspberries, and has long been used com. as a flavoring agent and recently as a weight loss supplement. A targeted UHPLC-QqQ-MS/MS method was developed and validated for anal. of RK and 25 associated metabolites in mouse plasma and brain. Dispersion and projection anal. and central composite design were used for method optimization. Random effect anal. of variance was applied for validation inference and variation partition. Within this framework, repeatability, a broader sense of precision, was calculated as fraction of accuracy variance, reflecting instrumental imprecision, compound degradation and carry-over effects. Multivariate correlation anal. and principle component anal. were conducted, revealing underlying association among the manifold of method traits. R programming was engaged in streamlined statistical anal. and data visualization. Two particular phenomena, the analytes’ background existence in the enzyme solution used for phase II metabolites deconjugation, and the noted lability of analytes in pure solvent at 4° vs. elevated stability in biomatrices, were found critical to method development and validation. The approach for the method development and validation provided a foundation for experiments that examine RK metabolism and bioavailability. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Name: 3-Hydroxyphenylacetic acid

The Article related to uhplc mass spectrometry statistical analysis raspberry ketone metabolite, design of experiment, metabolomics, multivariate analysis, random effects anova, surface response modelling and other aspects.Name: 3-Hydroxyphenylacetic acid

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Alcohol – Wikipedia,
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On January 25, 2022, Heremans, Isaac P.; Caligiore, Francesco; Gerin, Isabelle; Bury, Marina; Lutz, Marilena; Graff, Julie; Stroobant, Vincent; Vertommen, Didier; Teleman, Aurelio A.; Van Schaftingen, Emile; Bommera, Guido T. published an article.Related Products of 473-81-4 The title of the article was Parkinson′s disease protein PARK7 prevents metabolite and protein damage caused by a glycolytic metabolite. And the article contained the following:

Cells are continuously exposed to potentially dangerous compounds Progressive accumulation of damage is suspected to contribute to neurodegenerative diseases and aging, but the mol. identity of the damage remains largely unknown. Here we report that PARK7, an enzyme mutated in hereditary Parkinson′s disease, prevents damage of proteins and metabolites caused by a metabolite of glycolysis. We found that the glycolytic metabolite 1,3-bisphosphoglycerate (1,3-BPG) spontaneously forms a novel reactive intermediate that avidly reacts with amino groups. PARK7 acts by destroying this intermediate, thereby preventing the formation of proteins and metabolites with glycerate and phosphoglycerate modifications on amino groups. As a consequence, inactivation of PARK7 (or its orthologs) in human cell lines, mouse brain, and Drosophila melanogaster leads to the accumulation of these damaged compounds, most of which have not been described before. Our work demonstrates that PARK7 function represents a highly conserved strategy to prevent damage in cells that metabolize carbohydrates. This represents a fundamental link between metabolism and a type of cellular damage that might contribute to the development of Parkinson′s disease. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Related Products of 473-81-4

The Article related to park7 neuroprotectant metabolite protein cell damage glycolysis parkinson disease, parkinson’s disease, glycolysis, metabolite damage, posttranslational modification, protein damage and other aspects.Related Products of 473-81-4

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