Tag: 100-200

On May 1, 2020, Behera, Rakesh R.; Ghosh, Rahul; Panda, Surajit; Khamari, Subrat; Bagh, Bidraha published an article.Name: Pentane-1,5-diol The title of the article was Hydrosilylation of Esters Catalyzed by Bisphosphine Manganese(I) Complex: Selective Transformation of Esters to Alcohols. And the article contained the following:

A tricarbonylruthenium Xantphos complex I was prepared and characterized by X-ray crystallog.; in the presence of I, esters underwent chemoselective hydrosilylation with phenylsilane under neat conditions (followed by workup with base) to yield esters. Aryl, alkyl, and alkenyl mono- and dicarboxylates and lactones underwent chemoselective reduction to alcs. and diols; ketoesters underwent reduction to diols. Poly(1,6-hexanediol adipate) underwent hydrosilylation to 1,6-hexanediol. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Name: Pentane-1,5-diol

The Article related to alc diol preparation, xantphos manganese complex preparation chemoselective hydrosilylation catalyst crystal structure, manganese catalyst chemoselective hydrosilylation ester and other aspects.Name: Pentane-1,5-diol

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On June 30, 2020, Chen, Haitao; Xu, Chao; Zhang, Fan; Liu, Yu; Guo, Yong; Yao, Qinghua published an article.Computed Properties of 621-37-4 The title of the article was The gut microbiota attenuates muscle wasting by regulating energy metabolism in chemotherapy-induced malnutrition rats. And the article contained the following:

Malnutrition is a common clin. symptom in cancer patients after chemotherapy, which is characterized by muscle wasting and metabolic dysregulation. The regulation of muscle metabolism by gut microbiota has been studied recently. However, there is no direct convincing evidence proving that manipulating gut microbiota homeostasis could regulate muscle metabolic disorder caused by chemotherapy. Here, we investigate the potential role of gut microbiota in the regulation of the muscle metabolism in 5-fluorouracil (5-Fu)-induced malnutrition rat model. Male Sprague-Dawley rats were randomly divided into two groups (n = 8/group): control group and 5-Fu group. In the 5-Fu group, rats received 5-Fu (40 mg/kg/day) by i.p. injection for 4 days, and all rats were raised for 8 days. Nutritional status, muscle function, muscle metabolites, and gut microbiota were assessed. Fecal microbiota transplantation (FMT) was applied to explore the potential regulation of gut microbiota on muscle metabolism 5-Fu-treated rats exhibited loss of body weight and food intake compared to control group. 5-Fu decreased the levels of total protein and albumin in serum, and significantly increased the levels of IL-6 and TNF-α in muscle tissue. Rats that received 5-Fu displayed concurrent reduction of muscle function and fiber size. Moreover, 5-Fu group showed a distinct profile of gut microbiota compared to control group, including the relative lower abundance of Firmicutes and a higher abundance of Proteobacteria and Verrucomicrobia. Fourteen differential muscle metabolites were identified between two groups, which were mainly related to glycolysis, amino acid metabolism, and TCA cycle pathway. Furthermore, fecal transplantation from healthy rats improved nutritional status and muscle function in 5-Fu-treated rats. Notably, FMT inhibited the inflammatory response in muscle, and reversed the changes of several differential muscle metabolites and energy metabolism in 5-Fu-treated rats. Study demonstrated that gut microbiota played an important role in the regulation of muscle metabolism and promoting muscle energy production in 5-Fu-induced malnutrition rats, suggesting the potential attenuation of chemotherapy-induced muscle wasting by manipulating gut microbiota homeostasis. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Computed Properties of 621-37-4

The Article related to muscle wasting gut microbiota energy metabolism malnutrition proteins albumins, chemotherapy, fecal microbiota transplantation, gut microbiota, malnutrition, muscle metabolism and other aspects.Computed Properties of 621-37-4

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Pena-Lopez, Miguel; Neumann, Helfried; Beller, Matthias published an article in 2016, the title of the article was Iron-Catalyzed Reaction of Urea with Alcohols and Amines: A Safe Alternative for the Synthesis of Primary Carbamates.Application In Synthesis of 2-Methyl-2-propylpropane-1,3-diol And the article contains the following content:

A general study of the iron-catalyzed reaction of urea with nucleophiles is here presented. The carbamoylation of alcs. allows for the synthesis of N-unsubstituted (primary) carbamates, including present drugs (Felbamate and Meprobamate), without the necessity to apply phosgene and related derivatives Using amines as nucleophiles gave rise to the resp. mono- and disubstituted ureas via selective transamidation reaction. These atom-economical transformations provide a direct and selective access to valuable compounds from cheap and readily available urea using a simple Lewis-acidic iron(II) catalyst. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Application In Synthesis of 2-Methyl-2-propylpropane-1,3-diol

The Article related to primary carbamate urea preparation green chem, urea alc amine carbamoylation transamidation iron catalyst, catalysis, iron, nucleophilic substitution, primary carbamates, urea and other aspects.Application In Synthesis of 2-Methyl-2-propylpropane-1,3-diol

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Alcohol – Wikipedia,
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On March 10, 2021, Lesch, Bernhard; Jakob, Florian; Pletinckx, Katrien; Arndt, Verena; Wagener, Markus; Dunkern, Torsten published a patent.Electric Literature of 386704-04-7 The title of the patent was Preparation of piperidines or piperidones substituted with urea and heteroaryl as FPR2 modulators. And the patent contained the following:

The invention relates to compounds of formula I which acts as a modulator of FPR2 and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by FPR2 which include but are not limited to inflammatory and autoimmune diseases, diabetes, obstructive airway disorders, sepsis, etc. Compounds of formula I [wherein X1 = CH2, or C(O) and X2 = CH2; or X2 = CH2 or C(O) and X1 = CH2; R1 = Ph or 5 or 6-membered heteroaryl; Z = 5 or 6-membered heteroaryl which mono-, di, or trisubstituted with R2; each R2 independently = H, F, Cl, CF3, etc.; L = bond, C1-6alkylene, C(O), S(O)2, etc.; R3 = H, C1-6alkyl, C3-6cycloalkyl, 3-to 6-membered heterocycloalkyl, etc.; wherein C1-6alkyl in each case independently from one another is linear or branched, saturated or unsaturated; wherein C1-6alkylene is linear and saturated or unsaturated; wherein C1-6alkyl, C1-6alkylene, C3-6cycloalkyl, and 3 to 6-membered heterocycloalkyl in each case independently from one another are unsubstituted or mono- or polysubstituted; with proviso] in form of free compounds or physiol. acceptable salts thereof, are claimed and exemplified. Example compound II was synthesized from the reaction of prepared intermediate trans-1-(4-chloro-phenyl)-3-(6′-methoxy-1,2,3,4,5,6-hexahydro-3,3′-bipyridinyl-4-yl)-urea hydrochloride with 4-iodo-pyrimidine in the presence of L-proline and CuI in 14% yield. Candidate compounds of formula I were evaluated for agonistic activity using hFPR2-Aq-CHO cells from which II demonstrated an EC50 = 0.00600μM. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Electric Literature of 386704-04-7

The Article related to piperidine urea heteroaryl derivative preparation fpr2 inflammatory autoimmune disease, piperidone urea heteroaryl derivative preparation diabetes obstructive airway disorder and other aspects.Electric Literature of 386704-04-7

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Pavelyev, Roman S.; Zaripova, Yulia F.; Yarkovoi, Vladimir V.; Vinogradova, Svetlana S.; Razhabov, Sherzod; Khayarov, Khasan R.; Nazarychev, Sergei A.; Stoporev, Andrey S.; Mendgaziev, Rais I.; Semenov, Anton P.; Valiullin, Lenar R.; Varfolomeev, Mikhail A.; Kelland, Malcolm A. published an article in 2020, the title of the article was Performance of waterborne polyurethanes in inhibition of gas hydrate formation and corrosion: influence of hydrophobic fragments.Safety of 2,2′-(tert-Butylazanediyl)diethanol And the article contains the following content:

The design of new dual-function inhibitors simultaneously preventing hydrate formation and corrosion is a relevant issue for the oil and gas industry. The structure-property relationship for a promising class of hybrid inhibitors based on waterborne polyurethanes (WPU) was studied in this work. Variation of diethanolamines differing in the size and branching of N-substituents (Me, Bu, and tert-butyl), as well as the amount of these groups, allowed the structure of polymer mols. to be preset during their synthesis. To assess the hydrate and corrosion inhibition efficiency of developed reagents pressurized rocking cells, electrochem. and weight-loss techniques were used. A distinct effect of these variables altering the hydrophobicity of obtained compounds on their target properties was revealed. Polymers with increased content of diethanolamine fragments with n- or tert-Bu as N-substituent (WPU-6 and WPU-7, resp.) worked as dual-function inhibitors, showing nearly the same efficiency as com. ones at low concentration (0.25 wt%), with the branched one (tert-butyl; WPU-7) turning out to be more effective as a corrosion inhibitor. Com. kinetic hydrate inhibitor Luvicap 55 W and corrosion inhibitor Armohib CI-28 were taken as reference samples. Preliminary study reveals that WPU-6 and WPU-7 polyurethanes as well as Luvicap 55 W are all poorly biodegradable compounds; BODt/CODcr (ratio of BOD and COD) value is 0.234 and 0.294 for WPU-6 and WPU-7, resp., compared to 0.251 for com. kinetic hydrate inhibitor Luvicap 55 W. Since the obtained polyurethanes have a bifunctional effect and operate at low enough concentrations, their employment is expected to reduce both operating costs and environmental impact. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).Safety of 2,2′-(tert-Butylazanediyl)diethanol

The Article related to polyurethane gas hydrate corrosion, corrosion inhibitor, dual function inhibitor, flow assurance, kinetic hydrate inhibitor, methane-propane hydrate, waterborne polyurethane and other aspects.Safety of 2,2′-(tert-Butylazanediyl)diethanol

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Alcohol – Wikipedia,
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Zhang, Ziyan; Wu, Xiaojin; Zhou, Meng; Qi, Jiaqian; Zhang, Rui; Li, Xueqian; Wang, Chang; Ruan, Changgeng; Han, Yue published an article in 2022, the title of the article was Plasma metabolomics identifies the dysregulated metabolic profile of primary immune thrombocytopenia (ITP) based on GC-MS.Computed Properties of 473-81-4 And the article contains the following content:

ITP is a common autoimmune bleeding disorder with elusive pathogenesis. Author study was implemented to profile the plasma metabolic alterations of patients diagnosed with ITP, aiming at exploring the potential novel biomarkers and partial mechanism of ITP. The metabolomic anal. of plasma samples was conducted using GC-MS on 98 ITP patients and 30 healthy controls (HCs). Age and gender matched samples were selected to enter the training set or test set resp. OPLS-DA, t-test with FDR correction and ROC analyses were employed to screen out and evaluate the differential metabolites. Possible pathways were enriched based on metabolomics pathway anal. (MetPA). A total of 85 metabolites were investigated in author’s study and 17 differential metabolites with diagnostic potential were identified between ITP patients and HCs. MetPA showed that the metabolic disorders of ITP patients were mainly related to phenylalanine, tyrosine and tryptophan biosynthesis, phenylalanine metabolism and glyoxylate and dicarboxylate metabolism Addnl., author discriminated 6 differential metabolites and 5 enriched pathways in predicting the resistance to glucocorticoids in chronic ITP patients. The distinct metabolites discovered in author’s study could become novel biomarkers for the auxiliary diagnosis and prognosis prediction of ITP. Besides, the dysregulated pathways might contribute to the development of ITP. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Computed Properties of 473-81-4

The Article related to metabolome immune thrombocytopenia gcms, opls -da, gas chromatography tandem mass spectrometry, metabolomics, metabolomics pathway analysis, primary immune thrombocytopenia and other aspects.Computed Properties of 473-81-4

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Alcohol – Wikipedia,
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On March 31, 2021, Bresciani, Letizia; Di Pede, Giuseppe; Favari, Claudia; Calani, Luca; Francinelli, Veronica; Riva, Antonella; Petrangolini, Giovanna; Allegrini, Pietro; Mena, Pedro; Del Rio, Daniele published an article.SDS of cas: 621-37-4 The title of the article was In vitro (poly)phenol catabolism of unformulated- and phytosome-formulated cranberry (Vaccinium macrocarpon) extracts. And the article contained the following:

Cranberries (Vaccinium macrocarpon) represent an important source of anthocyanins, flavan-3-ols and flavonols. This study aimed at investigating in vitro the human microbial metabolism of (poly)phenols, principally flavan-3-ols, of unformulated- and phytosome-formulated cranberry extracts After powder characterization, a 24-h fermentation with human faecal slurries was performed, standardizing the concentration of incubated proanthocyanidins. Cranberry (poly)phenol metabolites were quantified by uHPLC-MS2 analyses. The native compounds of both unformulated- and phytosome-formulated cranberry extracts were metabolized under faecal microbiota activity, resulting in twenty-four microbial metabolites. Although some differences appeared when considering different classes of colonic metabolites, no significant differences in the total amount of metabolites were established after 24 h of incubation period. These results suggested that a different formulation had no effect on flavan-3-ol colonic metabolism of cranberry and both unformulated- and phytosome-formulated extract Both formulations displayed the capability to be a potential source of compounds which could lead to a wide array of gut microbiota metabolites in vitro. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).SDS of cas: 621-37-4

The Article related to vaccinium extract microbial polyphenol metabolism phytosome, cranberry, flavan-3-ols, in vitro fermentation, microbial metabolism, phytosome formulation, proanthocyanidins and other aspects.SDS of cas: 621-37-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nannini, Giulia; Meoni, Gaia; Tenori, Leonardo; Ringressi, Maria Novella; Taddei, Antonio; Niccolai, Elena; Baldi, Simone; Russo, Edda; Luchinat, Claudio; Amedei, Amedeo published an article in 2021, the title of the article was Fecal metabolomic profiles: a comparative study of patients with colorectal cancer vs adenomatous polyps.Application In Synthesis of 3-Hydroxyphenylacetic acid And the article contains the following content:

BACKGROUND Colorectal cancer (CRC), the third most common cause of death in both males and females worldwide, shows a pos. response to therapy and usually a better prognosis when detected at an early stage. However, the survival rate declines when the diagnosis is late and the tumor spreads to other organs. Currently, the measures widely used in the clinic are fecal occult blood test and evaluation of serum tumor markers, but the lack of sensitivity and specificity of these markers restricts their use for CRC diagnosis. Due to its high sensitivity and precision, colonoscopy is currently the gold-standard screening technique for CRC, but it is a costly and invasive procedure. Therefore, the implementation of custom-made methodologies including those with minimal invasiveness, protection, and reproducibility is highly desirable. With regard to other screening methods, the screening of fecal samples has several benefits, and metabolomics is a successful method to classify the metabolite shift in living systems as a reaction to pathophysiol. influences, genetic modifications, and environmental factors. AIM To characterize the variation groups and potentially recognize some diagnostic markers, we compared with healthy controls (HCs) the fecal NMR (NMR) metabolomic profiles of patients with CRC or adenomatous polyposis (AP). METHODS Proton NMR spectroscopy was used in combination with multivariate and univariate statistical approaches, to define the fecal metabolic profiles of 32 CRC patients, 16 AP patients, and 38 HCs well matched in age, sex, and body mass index. RESULTS NMR metabolomic analyses revealed that fecal sample profiles differed among CRC patients, AP patients, and HCs, and some discriminatory metabolites including acetate, butyrate, propionate, 3-hydroxyphenylacetic acid, valine, tyrosine and leucine were identified. CONCLUSION In conclusion, we are confident that our data can be a forerunner for future studies on CRC management, especially the diagnosis and evaluation of the effectiveness of treatments. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Application In Synthesis of 3-Hydroxyphenylacetic acid

The Article related to metabolomics feces adenomatous polyps colorectal cancer, adenomatous polyps, colorectal cancer, fecal metabolomics, fecal samples, nuclear magnetic resonance metabolomics and other aspects.Application In Synthesis of 3-Hydroxyphenylacetic acid

Referemce:
Alcohol – Wikipedia,
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On March 22, 2022, Elimelech, Orian; Aviv, Omer; Oded, Meirav; Peng, Xiaogang; Harries, Daniel; Banin, Uri published an article.Name: 1-Decanethiol The title of the article was Entropy of Branching Out: Linear versus Branched Alkylthiols Ligands on CdSe Nanocrystals. And the article contained the following:

Surface ligands of semiconductor nanocrystals (NCs) play key roles in determining their colloidal stability and physicochem. properties and are thus enablers also for the NCs flexible manipulation toward numerous applications. Attention is usually paid to the ligand binding group, while the impact of the ligand chain backbone structure is less discussed. Using isothermal titration calorimetry (ITC), we studied the effect of structural changes in the ligand chain on the thermodn. of the exchange reaction for oleate coated CdSe NCs, comparing linear and branched alkylthiols. The investigated alkylthiol ligands differed in their backbone length, branching position, and branching group length. Compared to linear ligands, lower exothermicity and entropy loss were observed for an exchange with branched ligands, due to steric hindrance in ligand packing, thereby justifying their previous classification as “entropic ligands”. Mean-field calculations for ligand binding demonstrate the contribution to the overall entropy originating from ligand conformational entropy, which is diminished upon binding mainly by packing of NC-bound ligands. Model calculations and the exptl. ITC data both point to an interplay between the branching position and the backbone length in determining the entropic nature of the branched ligand. Our findings suggest that the most entropic ligand should be a short, branched ligand with short branching group located toward the middle of the ligand chain. The insights provided by this work also contribute to a future smarter NC surface design, which is an essential tool for their implementation in diverse applications. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Name: 1-Decanethiol

The Article related to entropy linear branched alkylthiol ligand cdse nanocrystal, cdse nanocrystals, branched ligands, conformational entropy, isothermal titration calorimetry, ligand exchange and other aspects.Name: 1-Decanethiol

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Alcohol – Wikipedia,
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On October 31, 2021, Van de Voorde, Babs; Benmeridja, Lara; Giol, Elena Diana; Van der Meeren, Louis; Van Damme, Lana; Liu, Zhen; Toncheva, Antoniya; Raquez, Jean-Marie; Van den Brande, Niko; Skirtach, Andre; Declercq, Heidi; Dubruel, Peter; Van Vlierberghe, Sandra published an article.Recommanded Product: Pentane-1,5-diol The title of the article was Potential of poly(alkylene terephthalate)s to control endothelial cell adhesion and viability. And the article contained the following:

Poly(ethylene terephthalate) (PET) is known for its various useful characteristics, including its applicability in cardiovascular applications, more precisely as synthetic bypass grafts for large diameter (≥ 6 mm) blood vessels. Although it is widely used, PET is not an optimal material as it is not interactive with endothelial cells, which is required for bypasses to form a complete endothelium. Therefore, in this study, poly(alkylene terephthalate)s (PATs) have been studied. They were synthesized via a single-step solution polycondensation reaction, which requires mild reaction conditions and avoids the use of a catalyst or additives like heat stabilizers. A homologous series was realized in which the alkyl chain length varied from 5 to 12 methylene groups (n = 5-12). Molar masses up to 28,000 g/mol were obtained, while various odd-even trends were observed with modulated differential scanning calorimetry (mDSC) and rapid heat-cool calorimetry (RHC) to access the thermal properties within the homologous series. The synthesized PATs have been subjected to in vitro cell viability assays using Human Umbilical Vein Endothelial Cells (HUVECs) and Human Dermal Microvascular Endothelial Cells (HDMECs). The results showed that HUVECs adhere and proliferate most pronounced onto PAT(n = 9) surfaces, which could be attributed to the surface roughness and morphol. as determined by at. force microscopy (AFM) (i.e. Rq = 204.7 nm). HDMECs were investigated in the context of small diameter vessels and showed superior adhesion and proliferation after seeding onto PAT(n = 6) substrates. These preliminary results already pave the way towards the use of PAT materials as substrates to support endothelial cell adhesion and growth. Indeed, as superior endothelial cell interactivity compared to PET was observed, time-consuming and costly surface modifications of PET grafts could be avoided by exploiting this novel material class. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Recommanded Product: Pentane-1,5-diol

The Article related to polyalkylene terephthalate endothelial cell adhesion viability, endothelial cell adhesion, poly(alkylene terephthalate), solution polycondensation, synthetic bypass graft and other aspects.Recommanded Product: Pentane-1,5-diol

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts