Tag: 100-200

On July 2, 2020, Okuda, Yasuhiro; Imafuku, Kazuto; Tsuchida, Yoshiyuki; Seo, Tomoyo; Akashi, Haruo; Orita, Akihiro published an article.COA of Formula: C10H22S The title of the article was Process-Controlled Regiodivergent Copper-Catalyzed Azide-Alkyne Cycloadditions: Tailor-made Syntheses of 4- and 5-Bromotriazoles from Bromo(phosphoryl)ethyne. And the article contained the following:

We developed a regiodivergent syntheses of 4- and 5-bromo-substituted 1,2,3-triazoles in copper-catalyzed azide-alkyne cycloadditions (CuAACs) by taking advantage of bromo(phosphoryl)ethyne as a bromoethyne equivalent A one-shot dephosphorylative CuAAC afforded 4-bromotriazoles, which was transformed into a histone deacetylase 8 (HDAC8)-selective inhibitor, NCC-149. However, the direct CuAAC catalyzed by CuI/Cu(OAc)2 provided 5-bromo-4-phosphoryltriazoles. The consecutive nucleophilic substitution of the bromo group with thiols followed by MeOK-promoted dephosphorylation gave 5-thio-substituted triazoles. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).COA of Formula: C10H22S

The Article related to bromotriazole regiodivergent preparation copper catalyzed click cycloaddition bromophosphorylethyne, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.COA of Formula: C10H22S

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On January 11, 2017, Duan, Wenhu; Geng, Meiyu; Yan, Wei; Ding, Jian; Ai, Jing; Zhao, Bin; Fan, Jun; Peng, Xia; Chen, Yi published a patent.Electric Literature of 87674-15-5 The title of the patent was Preparation of 3-(heteroaryl)indazole derivatives useful as FGFR1 inhibitor for the treatment of cancer. And the patent contained the following:

The invention relates to 3-(heteroaryl)indazole derivatives of formula I, method for their preparation and their use as FGFR1 inhibitor for the treatment of cancer. Compounds of formula I, wherein R1, R2, R3 are independently H and halo; R9 is (un)substituted 5- to 7-membered heteroaryl; R8 and R10 are independently H, halo, C1-3alkyl and C1-3alkoxy; R4, R5, R6 and R7 are independently H, halo, (un)substituted C1-8alkyl, etc.; M is CH2, CH, N, O and S; W is O and NH; dotted bond is single or double bond and can not be same, are claimed. Example compound II was prepared via a multistep procedure (procedure given). All the invention compounds were evaluated for their FGFR1 inhibitory activity. From the assay, it was determined that example compound II exhibited IC50 value of < 10 nM towards FGFR1. The experimental process involved the reaction of 1-(3-Fluoropyridin-4-yl)ethanol(cas: 87674-15-5).Electric Literature of 87674-15-5

The Article related to heteroarylindazole preparation fgfr1 inhibitor treatment cancer, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Electric Literature of 87674-15-5

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Alcohol – Wikipedia,
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On January 19, 2017, Duan, Wenhu; Geng, Meiyu; Yan, Wei; Ding, Jian; Ai, Jing; Zhao, Bin; Fan, Jun; Peng, Xia; Chen, Yi published a patent.Formula: C7H8FNO The title of the patent was Preparation of 3-(heteroaryl)indazole derivatives useful as FGFR1 inhibitor for the treatment of cancer. And the patent contained the following:

The invention relates to 3-(heteroaryl)indazole derivatives of formula I, method for their preparation and their use as FGFR1 inhibitor for the treatment of cancer. Compounds of formula I, wherein R1, R2, R3 are independently H and halo; R9 is (un)substituted 5- to 7-membered heteroaryl; R8 and R10 are independently H, halo, C1-3alkyl and C1-3alkoxy; R4, R5, R6 and R7 are independently H, halo, (un)substituted C1-8alkyl, etc.; M is CH2, CH, N, O and S; W is O and NH; dotted bond is single or double bond and can not be same, are claimed. Example compound II was prepared via a multistep procedure (procedure given). All the invention compounds were evaluated for their FGFR1 inhibitory activity. From the assay, it was determined that example compound II exhibited IC50 value of < 10 nM towards FGFR1. The experimental process involved the reaction of 1-(3-Fluoropyridin-4-yl)ethanol(cas: 87674-15-5).Formula: C7H8FNO

The Article related to heteroarylindazole preparation fgfr1 inhibitor treatment cancer, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Formula: C7H8FNO

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On December 3, 2020, Castro, Alfredo C. published a patent.Application of 386704-04-7 The title of the patent was Sulfamides as TEAD inhibitors and their preparation, pharmaceutical compositions and use in the treatment of cancer. And the patent contained the following:

The invention provides sulfamide compounds I, compositions thereof, and methods of using the same. Compounds of formula I wherein L1 is (un)substituted (un)branched C1-6 alkylene, etc.; ring A is Ph, (un)substituted 5- to 6-membered heteroaryl, etc.; R2 is H, (un)substituted 4- to 6-membered heteroaryl, etc.; R4 is H, halo, -SO2NH2 and derivatives, -CONH2 and derivatives; R6 is H, (un)substituted C1-6 alkyl, etc.; and their pharmaceutically acceptable salts as TEAD inhibitors in the treatment of cancer thereof, are claimed. Example compound II was prepared by using etherification and cross-coupling as the key steps. All the invention compounds were evaluated for their TEAD inhibitory activity. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Application of 386704-04-7

The Article related to sulfamide preparation tead inhibitor treatment cancer, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Application of 386704-04-7

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On August 8, 2019, Bhujade, Paras Raybhan; Pawar, Rajesh; Naik, Maruti N.; Potlapally, Rajender Kumar; Tembhare, Nitin Ramesh; Autkar, Santosh Shridhar; Garg, Ruchi; Venkatesha, Hagalavadi M.; Klausener, Alexander G. M.; Ramakrishna, Visannagari; Adhav, Nilesh Bharat; Trivedi, Pooja published a patent.Category: alcohols-buliding-blocks The title of the patent was Novel oxadiazoles as pesticides and their preparation. And the patent contained the following:

The invention relates to oxadiazoles of formula I, as pesticides. Compounds of formula I wherein R1 is C1-2 haloalkyl; L1 is a bond, CO, O, S, SO, etc.; L2 is (CR7R8)0-4N:S(:O)R9, (CR7R8)0-4CON:S(:O)R9, CONR4SO2, etc.; A is (un)substituted (non)aromatic heterocyclyl; R4 is H, CN, OH, amino, etc.; R7 and R8 are independently H, halo, CN, C1-4 alkyl, etc.; R9 is H, amino, C1-6 alkyl, etc.; R10 is H, halo, OH, CN, NO2, etc.; and N-oxides, metal complexes, isomers, polymorphs and agriculturally acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their pesticidal activity (some data given). The experimental process involved the reaction of (2-Fluorophenyl)methanethiol(cas: 72364-46-6).Category: alcohols-buliding-blocks

The Article related to oxadiazole preparation pesticide, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Category: alcohols-buliding-blocks

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Alcohol – Wikipedia,
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Kaithal, Akash; Hoelscher, Markus; Leitner, Walter published an article in 2018, the title of the article was Catalytic Hydrogenation of Cyclic Carbonates using Manganese Complexes.SDS of cas: 78-26-2 And the article contains the following content:

Catalytic hydrogenation of cyclic carbonates to diols and methanol was achieved using a mol. catalyst based on earth-abundant manganese. The complex [Mn(CO)2(Br)][HN(C2H4PiPr2)2] 1 comprising com. available MACHO ligand is an effective pre-catalyst operating under relatively mild conditions (T=120 °C, p(H2)=30-60 bar). Upon activation with NaOtBu, the formation of coordinatively unsaturated complex [Mn(CO)2][N((C2H4PiPr2)2)] 5 was spectroscopically verified, which confirmed a kinetically competent intermediate. With the pre-activated complex, turnover numbers up to 620 and 400 were achieved for the formation of the diol and methanol, resp. Stoichiometric reactions under catalytically relevant conditions provide insight into the stepwise reduction form the CO2 level in carbonates to methanol as final product. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).SDS of cas: 78-26-2

The Article related to manganese complex cyclic carbonate hydrogenation diol methanol synthesis, carbon dioxide, carbonates, hydrogenation, manganese, methanol, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.SDS of cas: 78-26-2

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Matsagar, Babasaheb M.; Hsu, Chang-Yen; Chen, Season S.; Ahamad, Tansir; Alshehri, Saad M.; Tsang, Daniel C. W.; Wu, Kevin C.-W. published an article in 2020, the title of the article was Selective hydrogenation of furfural to tetrahydrofurfuryl alcohol over a Rh-loaded carbon catalyst in aqueous solution under mild conditions.Synthetic Route of 111-29-5 And the article contains the following content:

We describe the selective hydrogenation of furfural (FAL) into tetrahydrofurfuryl alc. (THFA) under mild conditions (30°C) in aqueous media using an Rh-loaded carbon (Rh/C) catalyst in a one-pot fashion. In FAL hydrogenation, the Rh/C catalyst showed a high THFA yield (92%) with 93% selectivity in aqueous media within 12 h, whereas the use of a dimethylacetamide (DMA) solvent system resulted in a 95% THFA yield within 32 h at 30°C. The study of the effect of the solvent on FAL hydrogenation reveals that polar solvents showed higher THFA yields than a toluene solvent. The Rh/C catalyst used in this study exhibited higher activity compared to Ru/C, Pd/C, Ni/C derived from Ni-based metal-organic framework (Ni-MOF), and Ni-loaded carbon black (Ni/CB) catalysts in FAL-to-THFA hydrogenation. The Rh/C catalyst is characterized in detail using various characterization techniques such as TEM, XRD, N2-adsorption-desorption, XPS, and ICP-OES to understand its physicochem. properties. The Rh/C catalyst shows similar high THFA yields in the recycling experiment of FAL hydrogenation under ambient conditions. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Synthetic Route of 111-29-5

The Article related to rhodium carbon catalyst furfural hydrogenation tetrahydrofurfuryl alc aqueous solution, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Synthetic Route of 111-29-5

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On July 21, 2021, Shao, Yuewen; Guo, Mingzhu; Wang, Junzhe; Sun, Kai; Zhang, Lijun; Zhang, Shu; Hu, Guangzhi; Xu, Leilei; Yuan, Xiangzhou; Hu, Xun published an article.Safety of Pentane-1,5-diol The title of the article was Selective Conversion of Furfural into Diols over Co-Based Catalysts: Importance of the Coordination of Hydrogenation Sites and Basic Sites. And the article contained the following:

1,5-Pentanediol (1,5-PDO) is a feedstock for synthesis of polyesters and polyurethanes, and its selective production from furfural is a desirable route but very challenging. In this study, the production of 1,5-PDO from furfural was investigated over the Co-Mg-Al catalyst, containing abundant hydrogenation sites and basic sites. Using layered double hydroxides as the catalyst precursor benefited dispersion of metallic Co particles via preventing migration of cobalt species and developing pore structures. Furthermore, the Co-Mg-Al catalyst possessed abundant basic sites, rendering its superior catalytic activity to Co-Al or Co-Mg catalysts. In situ diffuse reflectance IR spectroscopy (DRIFTS) characterization for FA conversion demonstrated that the cooperation of abundant hydrogenation sites and basic sites facilitated a strong adsorption of C-O-C and carbon-carbon double-bond groups, which benefited the conversion of FA into diols. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Safety of Pentane-1,5-diol

The Article related to selective hydrogenation furfural diol cobalt magnesium aluminum hydrogenation catalyst, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Safety of Pentane-1,5-diol

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Alcohol – Wikipedia,
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On October 31, 2021, Qiu, Qianqian; Wang, Yanjuan; Gu, Guolong; Yu, Fan; Zhang, Shichao; Zhao, Yining; Ling, Bai published an article.Related Products of 621-37-4 The title of the article was Design, synthesis, and biological evaluation of novel FXR agonists based on auraptene. And the article contained the following:

Farnesoid X receptor (FXR) has been considered as an attractive target for metabolic disorder and liver injury, while many current FXR agonists suffer from undesirable side effects, such as pruritus. Therefore, it is urgent to develop new structure types different from current FXR agonists. In this study, a series of structural optimizations were introduced to displace the unstable coumarin and geraniol scaffolds of auraptene (AUR), a novel and safe FXR agonist. All of these efforts led to the identification of compound 14 (I), a potent FXR agonist with nearly fourfold higher activity than AUR. Mol. modeling study suggested that compound 14 fitted well with binding pocket, and formed the key ionic bond with His291 and Arg328. In acetaminophen-induced acute liver injury model, compound 14 exerts better therapeutic effect than that of AUR, which highlighting its pharmacol. potential in the treatment of drug-induced liver injury. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Related Products of 621-37-4

The Article related to auraptene fxr agonist design synthesis, fxr, n-acetyl-p-aminophenol, Terpenes and Terpenoids: Monoterpenes (C10), Including Cannabinoids, Chrysanthemic Acids, and Iridoid Aglycons and other aspects.Related Products of 621-37-4

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Alcohol – Wikipedia,
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On May 5, 2020, Zhang, Wenguang; Xing, Lidan; Chen, Jiawei; Zhou, Hebin; Liang, Shimin; Huang, Weiyi; Li, Weishan published an article.COA of Formula: C10H22S The title of the article was Improving the cyclic stability of MoO2 anode for sodium ion batteries via film-forming electrolyte additive. And the article contained the following:

Application of film-forming electrolyte additive has been demonstrated to be an effective and economical approach to improve the performances of lithium ion batteries. However, investigations on the effect of electrolyte additives on the performances of sodium ion batteries is very limited. In this work, with vinylene carbonate (VC) as electrolyte additive, the cyclic stability of MoO2 anode for sodium ion batteries is greatly improved. After 1000 cycles at 300 mAg-1, the capacity retention of MoO2 electrode achieves 96.5% in comparison with that of 20.1% without additive. The poor long-term cyclic performance of MoO2 is mainly ascribed to the sever electrolyte reduction reaction during cycling, which results in significantly increase of electrode polarization. The VC-induced solid electrolyte interphase film effectively suppresses the decomposition of baseline electrolyte, and therefore, hinders the increase of interfacial reaction resistance and improves the interfacial stability of MoO2 electrode. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).COA of Formula: C10H22S

The Article related to molybdenum oxide anode sodium ion battery vinylene carbonate additive, vinylene carbonate additive electrolyte molybdenum oxide anode, Electrochemical, Radiational, and Thermal Energy Technology: Energy-Conversion Devices and Their Components and other aspects.COA of Formula: C10H22S

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Alcohol – Wikipedia,
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