Tag: 100-200

On October 7, 2013, Wang, Guqi; Lu, Qilong published an article.Name: 2-Methyl-2-propylpropane-1,3-diol The title of the article was A Nitrate Ester of Sedative Alkyl Alcohol Improves Muscle Function and Structure in a Murine Model of Duchenne Muscular Dystrophy. And the article contained the following:

Nitric oxide (NO) has major physiol. and cellular effects on muscle growth, repair, and function. In most muscle biopsies from humans with myopathies, sarcolemma-localized neuronal nitric oxide synthase (nNOS) is either reduced or not detected, particularly in dystrophin-deficient Duchenne muscular dystrophy (DMD). Abnormal NO signaling at the sarcolemmal level is integrally involved in the pathogenesis and accounts, at least in part, for the muscle weakness of DMD. Dystrophic muscle fibers exhibit an increased susceptibility to contraction-induced membrane damage. Muscle relaxants function to prevent muscle wasting by decreasing nerve impulses and reducing calcium influx that regulates tensing or tightening of muscle fibers. We have recently developed a new class of nitric esters that combines the pharmacol. functions of NO and muscle relaxation. Here, we report the synthesis and properties of the nitric ester (MMPN) of 2-methyl-2-n-propyl-1,3-propanediol (MPP) and its effect in mdx dystrophic mice, a murine model of DMD. MMPN produced significant improvements in biochem., pathol., and functional phenotypes in the mouse model. The endurance of exercise was extended by 47% in time to exhaustion and 84% in running distance. Serum CK level was decreased by 30%. Addnl., MMPN decreased intracellular free calcium concentration without causing skeletal muscle weakness. No hepatic or renal toxicities were observed during the study. Our investigations unveil a potential new treatment for muscular diseases. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Name: 2-Methyl-2-propylpropane-1,3-diol

The Article related to nitrate ester sedative muscle duchenne dystrophy, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Name: 2-Methyl-2-propylpropane-1,3-diol

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Alcohol – Wikipedia,
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On June 30, 2021, Smith, Chad; Trageser, Kyle J.; Wu, Henry; Herman, Francis J.; Iqbal, Umar Haris; Sebastian-Valverde, Maria; Frolinger, Tal; Zeng, Emma; Pasinetti, Giulio Maria published an article.Recommanded Product: 621-37-4 The title of the article was Anxiolytic effects of NLRP3 inflammasome inhibition in a model of chronic sleep deprivation. And the article contained the following:

Sleep deprivation is a form of stress that provokes both inflammatory responses and neuropsychiatric disorders. Because persistent inflammation is implicated as a physiol. process in anxiety disorders, we investigated the contributions of NLRP3 inflammasome signaling to anxiety and anxiolytic properties of flavanol diets in a model of chronic sleep deprivation. The results show a flavanol-rich dietary preparation (FDP) exhibits anxiolytic properties by attenuating markers of neuroimmune activation, which included IL-1β upregulation, NLRP3 signaling, and microglia activation in the cortex and hippocampus of sleep-deprived mice. Production of IL-1β and NLRP3 were critical for both anxiety phenotypes and microglia activation. Individual FDP metabolites potently inhibited IL-1β production from microglia following stimulation with NLRP3-specific agonists, supporting anxiolytic properties of FDP observed in models of sleep deprivation involve inhibition of the NLRP3 inflammasome. The study further showed sleep deprivation alters the expression of the circadian gene Bmal1, which critically regulated NLRP3 expression and IL-1β production The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Recommanded Product: 621-37-4

The Article related to sleep deprivation nlrp3 inflammasome anxiolytic, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Recommanded Product: 621-37-4

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Alcohol – Wikipedia,
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On December 17, 2020, Hiscox, Afton; Stenne, Brice; Chrovian, Christa; Gelin, Christine; Samant, Andrew; Letavic, Michael A.; Dvorak, Curt published a patent.Related Products of 386704-04-7 The title of the patent was Substituted heteroaromatic pyrazolo-pyridines and their use as glun2b receptor modulators. And the patent contained the following:

Substituted Pyrazolo-pyridines as GluN2B receptor ligands. Such compounds may be used in GluN2B receptor modulation and in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by GluN2B receptor activity. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Related Products of 386704-04-7

The Article related to pyrazolopyridine glun2b receptor therapy, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Related Products of 386704-04-7

Referemce:
Alcohol – Wikipedia,
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On May 16, 2022, Yan, Hao; Zhao, Mingyue; Feng, Xiang; Zhao, Siming; Zhou, Xin; Li, Shangfeng; Zha, Minghao; Meng, Fanyu; Chen, Xiaobo; Liu, Yibin; Chen, De; Yan, Ning; Yang, Chaohe published an article.Computed Properties of 473-81-4 The title of the article was PO43- Coordinated Robust Single-Atom Platinum Catalyst for Selective Polyol Oxidation. And the article contained the following:

Achieving efficient catalytic conversion over a heterogeneous catalyst with excellent resistance against leaching is still a grand challenge for sustainable chem. synthesis in aqueous solution Herein, we devised a single-atom Pt1/hydroxyapatite (HAP) catalyst via a simple hydrothermal strategy. Gratifyingly, this robust Pt1/HAP catalyst exhibits remarkable catalytic selectivity and catalyst stability for the selective oxidation of C2-C4 polyols to corresponding primary hydroxy acids. It is found that the Pt-(O-P) linkages with strong electron-withdrawing function of PO43- (Pt1-OPO43- pair active site) not only realize the activation of the C-H bond, but also destabilize the transition state from adsorbed hydroxy acids toward the C-C cleavage, resulting in the sharply increased selectivity of hydroxy acids. Moreover, the strong PO43–coordination effect provides electrostatic stabilization for single-atom Pt, ensuring the highly efficient catalysis of Pt1/HAP for over 160 h with superior leaching resistance. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Computed Properties of 473-81-4

The Article related to polyol platinum oxidation mechanism kinetics free energy, coordination effects, hydroxyl acid, polyols, selective oxidation, single-atom catalysts, Physical Organic Chemistry: Oxidation-Reduction, Including Dehydrogenation and Hydrogenolysis and other aspects.Computed Properties of 473-81-4

Referemce:
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Alcohols – Chemistry LibreTexts

On October 19, 2010, Yu, Guixue; Ewing, William R.; Mikkilineni, Amarendra B.; Pendri, Annapurna; Ellsworth, Bruce A.; Sher, Philip M.; Gerritz, Samuel; Sun, Chongqing; Murugesan, Natesan; Wu, Ximao published a patent.Application of 386704-04-7 The title of the patent was Preparation of azabicyclic heterocycles as cannabinoid receptor modulators. And the patent contained the following:

The present application describes compounds I [R1, R2 = halo, CN, alkyl, etc.; R3 = H alkyl, alkenyl, cycloalkyl, etc.; R4 is absent when n is a double bond; R4 = H, alkyl, cycloalkyl, etc.; R5 = halo, (un)substituted OH, NH2, etc. when m is a single bond; R5 = O when m = a double bond; m, n = a single or double bond; when m is a single bond, n is a double bond; when m is a double bond, n is a single bond], pharmaceutical compositions comprising at least one compound I and optionally one or more addnl. therapeutic agents and methods of treatment using the compounds I both alone and in combination with one or more addnl. therapeutic agents. Over 40 compounds I were prepared E.g., a multi-step synthesis of II, starting from dichloromandelic anhydride and hydrazine dihydrochloride, was given. The exemplified compounds I showed the CB-1 receptor binding Ki values in the range of 0.01 nM to 10000 nM. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Application of 386704-04-7

The Article related to azabicyclic heterocycle triazolopyridazine preparation cannabinoid receptor cb1 modulator, Heterocyclic Compounds (More Than One Hetero Atom): Pyridazines, Cinnolines, and Phthalazines and other aspects.Application of 386704-04-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On July 16, 2009, Guzzo, Peter; Surman, Matthew David; Henderson, Alan John; Jiang, May Xiaowu; Hadden, Mark; Grabowski, James published a patent.Reference of (6-(Trifluoromethyl)pyridin-3-yl)methanol The title of the patent was Pyridoindole derivatives as MCH antagonists and their preparation, pharmaceutical compositions and use in the treatment of diseases. And the patent contained the following:

The invention relates to pyridoindole derivatives of formula I, which are MCH antagonists and useful in the treatment of various diseases. Compounds of formula I wherein R1 is H and (un)substituted alkyl; R2-R4 are independently H, alkoxy, alkylthio, alkyl, halo, CF3 and CN; G is (un)substituted -CH2NH- and derivatives and (un)substituted -NHCH2 and derivatives; R8-R11 are independently H and (un)substituted alkyl; R14 and R15 are independently H and halogen; L is -CH2O-, -CH2CH2-, -CH=CH- and a bond; B is (hetero)aryl and cycloalkyl; with the proviso that, when L is a direct bond, B cannot be unsubstituted heteroaryl or heteroaryl monosubstituted with fluorine; are claimed. Example compound II·HCl was prepared via cyclization of 3-bromophenylhydrazine with N-Boc-4-oxopiperidine; the resulting tert-Bu 7-bromo-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate underwent N-methylation to give tert-Bu 7-bromo-5-methyl-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate, which underwent condensation with 4-benzyloxypyridin-2(1H)-one to give tert-Bu 7-[4-benzyloxy-2-oxopyridin-1(2H)-yl]-5-methyl-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate, which underwent hydrolysis to give II·HCl. All the invention compounds were evaluated for their MCH1 antagonistic activity. From the assay, it was determined that the tested compounds exhibited the Ki values of ≤ 3.5 μM. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Reference of (6-(Trifluoromethyl)pyridin-3-yl)methanol

The Article related to pyridoindole derivative preparation mch antagonist treatment disease, Heterocyclic Compounds (More Than One Hetero Atom): Pyridazines, Cinnolines, and Phthalazines and other aspects.Reference of (6-(Trifluoromethyl)pyridin-3-yl)methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On January 28, 2021, Kuttruff, Christian Andreas; Bretschneider, Tom; Godbout, Cedrickx; Koolman, Hannes Fiepko; Martyres, Domnic; Roth, Gerald Juergen published a patent.HPLC of Formula: 386704-04-7 The title of the patent was 1-(6-(Methoxy)pyridazin-3-yl)cyclopropane-1-carboxamide derivatives as autotaxin (ATX) modulators for the treatment of inflammatory airway or fibrotic diseases and preparation thereof. And the patent contained the following:

The invention relates to 1-(6-(methoxy)pyridazin-3-yl)cyclopropan-1-carboxamide derivatives of formula I as autotaxin (ATX) modulators for the treatment of inflammatory airway or fibrotic diseases such as e.g. idiopathic lung disease (IFF) or systemic sclerosis (SSc). Compounds of formula I wherein A is substituted pyridyl; E is (un)substituted Ph and (un)substituted pyridyl; K is substituted piperazinyl, substituted piperidinyl, substituted 2,6-diazabicyclo[3.3]heptanyl, etc.; are claimed. N-(4-(7-Acetyl-2,7-diazaspiro[3.5]nonan-2-yl)benzyl)-1-(6-((6-(trifluoromethyl)pyridin-3-yl)methoxy)pyridazin-3-yl)cyclopropane-1-carboxamide (II) was prepared by amidation of 1-(6-((6-(trifluoromethyl)pyridin-3-yl)methoxy)pyridazin-3-yl)cyclopropane-1-carboxylic acid with 1-(2-(4-(aminomethyl)phenyl)-2,7-diazaspiro[3.5]nonan-7-yl)ethan-1-one. The invention compounds were evaluated for their ATX modulatory activity. From the assay, it was determined that compound II exhibited IC50 value of 4.0 nM. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).HPLC of Formula: 386704-04-7

The Article related to pyridazinylcyclopropanecarboxamide preparation autotaxin modulator, Heterocyclic Compounds (More Than One Hetero Atom): Pyridazines, Cinnolines, and Phthalazines and other aspects.HPLC of Formula: 386704-04-7

Referemce:
Alcohol – Wikipedia,
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On August 1, 2020, Aihara, Takeshi; Miura, Hiroki; Shishido, Tetsuya published an article.Formula: C5H12O2 The title of the article was Investigation of the mechanism of the selective hydrogenolysis of C-O bonds over a Pt/WO3/Al2O3 catalyst. And the article contained the following:

The hydrogenolysis of various polyols and ethers over a Pt/WO3/Al2O3 catalyst was investigated. The hydrogenolysis rate of a C-O bond at a secondary carbon was higher than that at a primary carbon, indicating that a hydroxyl (OH) group at a primary carbon played an important role in the dissociation of a C-O bond. Moreover, the dissociation position of the C-O bond in alcs. and ethers strongly depended on the stability of the carbocation intermediate, and hydrogenolysis via a secondary carbocation as an intermediate proceeded preferentially to that via a primary carbocation. The kinetics of the hydrogenolysis of C3 polyols were also investigated. The reaction orders with respect to the concentrations of glycerol, 1,2- and 1,3-propanediol were almost the same. In contrast, different reaction orders with respect to the H2 pressure were observed for the hydrogenolysis of C3 polyols with or without vicinal OH groups, indicating that the dissociation of a C-O bond at primary and secondary carbons proceeded via completely different mechanisms. These investigations suggested that both the structure and position of a substrate on the catalyst surface must be controlled for highly selective hydrogenolysis. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Formula: C5H12O2

The Article related to alc ether platinum catalyst hydrogenolysis kinetics mechanism, Physical Organic Chemistry: Oxidation-Reduction, Including Dehydrogenation and Hydrogenolysis and other aspects.Formula: C5H12O2

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Alcohol – Wikipedia,
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Al-Jawad, Selma M. H.; Taha, Ali A.; Muhsen, Mustafa M. published an article in 2021, the title of the article was Study the structural, morphological and optical properties of copper sulfide prepared by two-phase colloidal method.Electric Literature of 111-29-5 And the article contains the following content:

In this paper, copper sulfide nanoparticles were synthesized by two-phase colloidal method with different reaction temperatures (140, 160, 180 and 200°C). The structural, morphol. and optical properties of prepared CuS were analyzed by the X-Ray Diffractometer (XRD), Field Emission Scanning Electron Microscope (FESEM) and UV-VIS Spectrophotometer. The XRD peaks refer to the covellite copper sulfide with hexagonal structure. FESEM showed the rod formation at lower temperatures (140 and 160°C), whereas higher temperatures (180 and 200°C) form nanocrystals within spheres structures. UV-VIS showed that CuS nanoparticles have two absorption peaks, one at UV-VIS region and the second at NIR region and its energy gap decrease with increasing of reaction temperature The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Electric Literature of 111-29-5

The Article related to copper sulfide nanoparticle surface morphol colloidal method, Optical, Electron, and Mass Spectroscopy and Other Related Properties: Spectroscopic Theories and other aspects.Electric Literature of 111-29-5

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Alcohol – Wikipedia,
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On August 31, 2020, Wang, Chenguang; Liu, Yong; Cui, Zhibing; Yu, Xiaohu; Zhang, Xinghua; Li, Yuping; Zhang, Qi; Chen, Lungang; Ma, Longlong published an article.Recommanded Product: 111-29-5 The title of the article was In Situ Synthesis of Cu Nanoparticles on Carbon for Highly Selective Hydrogenation of Furfural to Furfuryl Alcohol by Using Pomelo Peel as the Carbon Source. And the article contained the following:

A facile approach was developed to directly synthesize carbon-supported metal nanoparticles with pomelo peel as the carbon source and metal nitrate solution as the metal source. Fe/C, Co/C, Ni/C, and Cu/C catalysts were prepared after calcination in N2 without further reduction The metal nanoparticles and formation mechanism were investigated by multiple techniques such as XRD, HRTEM, XPS, FTIR spectra, SEM, and TG-MS thermal anal. In the case of furfural hydrogenation, Cu/C catalyst exhibited the best activity and exclusive selectivity to produce furfuryl alc. with complete conversion, and excellent selectivity can be maintained at a higher temperature of 240°C. The particle size of Cu nanoparticles can be tuned by the calcination temperature and metal loading for improving catalytic activity. The excellent performance of Cu nanoparticles was also studied by d. functional theory calculation, agreeing well with the experiments A green and facile approach to in situ synthesis of metal nanoparticles on carbon for exclusively selective hydrogenation of furfural. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Recommanded Product: 111-29-5

The Article related to copper nanoparticle carbon hydrogenation furfural furfuryl alc, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Recommanded Product: 111-29-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts