Tag: 100-200

On November 30, 2017, Foster, Alan C.; Rangel-Diaz, Natalie; Staubli, Ursula; Yang, Jia-Ying; Penjwini, Mahmud; Viswanath, Veena; Li, Yong-Xin published an article.Name: H-Phg(4-OH)-OH The title of the article was Phenylglycine analogs are inhibitors of the neutral amino acid transporters ASCT1 and ASCT2 and enhance NMDA receptor-mediated LTP in rat visual cortex slices. And the article contained the following:

The N-methyl-D-aspartate receptor (NMDA) co-agonist D-serine is a substrate for the neutral amino acid transporters ASCT1 (SLC1A4) and ASCT2 (SLC1A5). We identified L-phenylglycine (PG) and its analogs as inhibitors of ASCT1 and ASCT2. PG analogs were shown to be non-substrate inhibitors of ASCT1 and ASCT2 with a range of activities relative to other amino acid transport systems, including sodium-dependent glutamate transporters, the sodium-independent D-serine transporter asc-1 and system L. L-4-chloroPG was the most potent and selective ASCT1/2 inhibitor identified. The PG analogs facilitated theta-burst induced long-term potentiation in rat visual cortex slices in a manner that was dependent on extracellular D-serine. For structurally-related PG analogs, there was an excellent correlation between ASCT1/2 transport inhibition and enhancement of LTP which was not the case for inhibition of asc-1 or system L. The ability of PG analogs to enhance LTP is likely due to inhibition of D-serine transport by ASCT1/2, leading to elevated extracellular levels of D-serine and increased NMDA receptor activity. These results suggest that ASCT1/2 may play an important role in regulating extracellular D-serine and NMDA receptor-mediated physiol. effects and that ASCT1/2 inhibitors have the potential for therapeutic benefit. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Name: H-Phg(4-OH)-OH

The Article related to l phenylglycine asct1 asct2 inhibitor long term potentiation, asct1, asct2, d-serine, ltp, nmda, phenylglycine, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Name: H-Phg(4-OH)-OH

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On March 25, 2010, Gant, Thomas G.; Shahbaz, Manouchehr M. published a patent.Recommanded Product: 2-Methyl-2-propylpropane-1,3-diol The title of the patent was Preparation of deuterated carisoprodol as carbamate reducers of skeletal muscle tension with improved pharmacokinetics, pharmacodynamics, and toxicity properties. And the patent contained the following:

The present invention relates to novel carisoprodol of formula (I) (wherein R1-R24 are each independently selected from the group consisting of hydrogen and deuterium; and at least one of R1-R24 is deuterium) to be used as new carbamate skeletal muscle relaxants, pharmaceutical compositions thereof, and methods of use thereof. The carisoprodol compounds may be used for the treatment of a skeletal muscle tension-mediated disorder, such as musculoskeletal pain and hypertonia. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Recommanded Product: 2-Methyl-2-propylpropane-1,3-diol

The Article related to carisoprodol deuterium derivative preparation skeletal muscle relaxant stability toxicity, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Recommanded Product: 2-Methyl-2-propylpropane-1,3-diol

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On April 30, 2011, Dey, Raja; Chen, Lin published an article.Computed Properties of 32462-30-9 The title of the article was In search of allosteric modulators of α7-nAChR by solvent density guided virtual screening. And the article contained the following:

Nicotinic acetylcholine receptors (nAChR) are pentameric ligand gated ion channels whose activity can be modulated by endogenous neurotransmitters as well as by synthetic ligands that bind the same or distinct sites from the natural ligand. The subtype of α7 nAChR has been considered as a potential therapeutic target for Alzheimer’s disease, schizophrenia, and other neurol. and psychiatric disorders. A homol. model was developed for α7 nAChR based on 2 high resolution crystal structures with Brookhaven Protein Data Bank (PDB) codes 2QC1 and 2WN9 for threading on one monomer and then for building a pentamer, resp. A number of small mol. binding sites are identified using Pocket Finder of Internal Coordinate Mechanics (ICM). Remarkably, these computer-identified sites match perfectly with ordered solvent densities found in the high-resolution crystal structure of α1 nAChR, suggesting that the surface cavities in the α7 nAChR model are likely binding sites of small mols. A high throughput virtual screening by flexible ligand docking of 5008 small mol. compounds was performed at 3 potential allosteric modulator (AM) binding sites of α7 nAChR using Molsoft ICM software. Some exptl. verified allosteric modulators of α7 (CCMI comp-6, LY 7082101, 5-HI, TQS, PNU-120596, genistein, and NS-1738) ranked among top 100 compounds, while the rest of the compounds in the list could guide further search for new allosteric modulators. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Computed Properties of 32462-30-9

The Article related to nicotinic acetylcholine receptor allosteric modulator virtual screening homol modeling, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Computed Properties of 32462-30-9

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On May 12, 2011, Conn, P. Jeffrey; Lindsley, Craig W.; Hopkins, Corey R.; Weaver, Charles David; Niswender, Colleen M.; Cheung, Yiu-Yin published a patent.Formula: C7H7FS The title of the patent was Aryl and heteroaryl sulfones as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction. And the patent contained the following:

The present invention relates to (hetero)aryl sulfone compounds which are useful as allosteric potentiators/pos. allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4), synthetic methods for making the compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds, for example, in treating neurol. and psychiatric disorders or other diseases associated with glutamate dysfunction. Preparation of 5-(2-chlorobenzylsulfonyl)-2-(pyridin-2-yl)-1H-benzo[d]imidazole was exemplified (yield 59%). The experimental process involved the reaction of (2-Fluorophenyl)methanethiol(cas: 72364-46-6).Formula: C7H7FS

The Article related to aryl sulfone preparation mglur4 receptor potentiator neurol psychiatric disease, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Formula: C7H7FS

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On June 25, 2009, Raynolds, Peter Webb; Stykes, James A. published a patent.Application In Synthesis of 2-Methyl-2-propylpropane-1,3-diol The title of the patent was Aqueous dispersions of adhesion promoters for coating applications. And the patent contained the following:

An aqueous dispersion of a water-insoluble polyolefin-based adhesion promoter is produced by dissolving the adhesion promoter in at least one olefinically unsaturated monomer, forming a miniemulsion with high shear in the presence of water, a surfactant, and other additives, and polymerizing the monomer with a monomer-soluble, substantially water-insoluble radical initiator. The polymerized product, a stable dispersion (latex) of polyolefin adhesion promoter and the polymerized monomer in water, is useful as a primer or as an additive for improving the adhesion of coatings to polyolefin substrates. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Application In Synthesis of 2-Methyl-2-propylpropane-1,3-diol

The Article related to maleated polyolefin adhesion promoter aqueous dispersion coating ink adhesive, Coatings, Inks, and Related Products: Drying Oils, Solvents, Plasticizers, and Other Additives and other aspects.Application In Synthesis of 2-Methyl-2-propylpropane-1,3-diol

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On June 25, 2009, Raynolds, Peter Webb; Stykes, James A. published a patent.Recommanded Product: 78-26-2 The title of the patent was Aqueous dispersions of adhesion promoters for coating applications. And the patent contained the following:

An aqueous dispersion of a water-insoluble polyolefin-based adhesion promoter is produced by dissolving the adhesion promoter in at least one olefinically unsaturated monomer, forming a miniemulsion with high shear in the presence of water, a surfactant, and other additives, and polymerizing the monomer with a monomer-soluble, substantially water-insoluble radical initiator. The polymerized product, a stable dispersion (latex) of polyolefin adhesion promoter and the polymerized monomer in water, is useful as a primer or as an additive for improving the adhesion of coatings to polyolefin substrates. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Recommanded Product: 78-26-2

The Article related to maleated polyolefin adhesion promoter aqueous dispersion coating ink adhesive, Coatings, Inks, and Related Products: Drying Oils, Solvents, Plasticizers, and Other Additives and other aspects.Recommanded Product: 78-26-2

Referemce:
Alcohol – Wikipedia,
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On December 5, 2012, Wang, Guqi; Lu, Qi Long published a patent.Quality Control of 2-Methyl-2-propylpropane-1,3-diol The title of the patent was Nitrate esters and their use for the treatment of muscle and muscle related diseases. And the patent contained the following:

Alkyl nitrate ester compounds are provided for the delivery of nitric oxide to targeted muscle tissues, and in particular, to normal and dystrophic muscles. In one aspect, nitrate ester compounds are provided having the following formula I wherein, R1 is ONO2, CH2ONO2, CnH2n+1OH, CnH2n+1OH, CH3, CH2CH3, CH2CH2CH3, or H; R2 is ON02, CH2ONO2, Cn H2n +1OH, Cn H2n +1OH, CH3, CH2CH3, CH2CH2CH3, or H; R3 is ON02, CH2ONO2, Cn””H2n””+1OH, Cn””H2n””+1OH, CH3, CH2CH3, CH2CH2CH3, or H; and R4 is ON02, CH2ONO2, Cn””H2n””+1OH, Cn””H2n””+1OH, CH3, CH2CH3, CH2CH2CH3, or H; wherein n is an integer from 0 to 9, n’ is an integer from 0 to 9, and n”” is an integer from 0 to 9, and n+n’+n”” ≤ 9, and wherein at least one of R1, R2, and R3 is an ester nitrate selected from the group consisting of ON02, CH2ONO2, and combinations thereof. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Quality Control of 2-Methyl-2-propylpropane-1,3-diol

The Article related to alkyl nitrate ester nitric oxide prodrug muscular dystrophy treatment, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Quality Control of 2-Methyl-2-propylpropane-1,3-diol

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On January 22, 2021, Wallace, Jason U.; Marshall, Kenneth L.; Batesky, Donald J.; Kosc, Tanya Z.; Hoffman, Brittany N.; Papernov, Semyon; Garrett, Londrea; Shojaie, Jalil; Demos, Stavros G. published an article.Computed Properties of 111-29-5 The title of the article was Highly Saturated Glassy Liquid Crystal Films Having Nano- and Microscale Thicknesses for High-Power Laser Applications. And the article contained the following:

The optical properties of glassy liquid crystals (GLC’s) designed to provide high resistance to laser-induced damage are explored. GLC’s readily enable freezing of the anisotropic ordering of liquid crystals into the glassy state. This solidity avoids issues of fluid leakage while providing mech. robustness and the promise of single-substrate coatings or stand-alone films of nanometer to micrometer thicknesses. A series of three increasingly saturated GLC’s were synthesized and tested for their thin-film (hundreds of nanometers to tens of micrometers) high-peak-power laser-damage resistance with nanosecond pulses at 1053, 532, and 351 nm, as well as their durability under continuous-wave, broadband UV illumination. The GLC’s with higher degrees of saturation demonstrated high resistance to laser-induced damage, extending from the near-IR to the UV spectral region. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Computed Properties of 111-29-5

The Article related to saturated glassy liquid crystal film nano microscale thickness laser, Optical, Electron, and Mass Spectroscopy and Other Related Properties: Electronic Spectroscopy and other aspects.Computed Properties of 111-29-5

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On June 2, 2011, Wang, Guqi; Lu, Qi Long published a patent.Computed Properties of 78-26-2 The title of the patent was Nitrate esters and their use for the treatment of muscle and muscle related diseases. And the patent contained the following:

Alkyl nitrate ester compounds are provided for the delivery of nitric oxide to targeted muscle tissues, and in particular, to normal and dystrophic muscles. In one aspect, nitrate ester compounds are provided having the following formula: Et-C(R1)(R2)(R3), wherein,R1 is ONO2, CH2ONO2, CnH2n+1OH, CnH2n+1OH, or CH2CH2CH3, or H;R2 is ONO2, CH2ONO2, Cn””H2n””+1OH, Cn””H2n””+1OH, CH2CH2CH3 or H; andR3 is ONO2, CH2ONO2, Cn'””H2n””+1OH, Cn””H2n””+1OH, CH2CH2CH3 or H; wherein n is an integer from 0 to 9, n’ is an integer from 0 to 9, and n”” is an integer from 0 to 9, and n+n’+n””≤9, and wherein at least one of R1, R2, and R3 is an ester nitrate selected from the group consisting of ONO2, CH2ONO2, and combinations thereof. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Computed Properties of 78-26-2

The Article related to muscular dystrophy alkyl nitrate ester nitric oxide prodrug, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Computed Properties of 78-26-2

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On December 31, 2020, Wang, Jun; Zhao, Danyue; Tiano, Simoni; Esteban-Fernandez, Adelaida; Yuan, Bo; Smith, Chad; Brathwaite, Justin; Jlayer, Zahra; Wu, Qingli; Simon, James E.; Trageser, Kyle J.; Pasinetti, Giulio M. published an article.Category: alcohols-buliding-blocks The title of the article was Prophylactic effect of flavanol rich preparation metabolites in promoting resilience to a mouse model of social stress. And the article contained the following:

Major depressive disorder (MDD) is a leading cause of disability, and there is an urgent need for new therapeutics. Stress-mediated induction of pro-inflammation in the periphery contributes to depression-like behaviors both in humans and in exptl. models. Inflammatory cytokine interleukin-6 (IL-6) has emerged as a potential therapeutic target. Our studies demonstrated that metabolism of flavanol rich cocoa preparation (FRP) led to the accumulation of select phenolic acids that may contribute to its anti-inflammatory activity. Using a repeated social defeat stress (RSDS) model of depression, we showed that oral administration of FRP attenuates susceptibility to RSDS-mediated depression, supporting the further development of FRP as a novel therapeutic for the treatment of stress disorders and anxiety in humans. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Category: alcohols-buliding-blocks

The Article related to social stress flavanol metabolite resilience prophylaxis, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
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