Tag: 100-200

On August 31, 2022, Sakurai, Shuhei; Kawakami, Yuta; Kuroki, Manabu; Gotoh, Hiroaki published an article.Quality Control of 3-Hydroxyphenylacetic acid The title of the article was Structure-antioxidant activity (oxygen radical absorbance capacity) relationships of phenolic compounds. And the article contained the following:

Antioxidant capacity is the extent to which a compound can eliminate reactive oxygen species, and in vitro methods for its chem. evaluation have been proposed. Among these methods, the oxygen radical absorbance capacity (ORAC) assay comes close to the oxidation reaction in the living body because it generates radical species that mimic the lipid peroxyl radical involved in the peroxidation reaction of biol. components and react in a phosphate buffer. In this study, PM7, a semi-empirical MO method, was used to calculate the thermodn. properties (bond dissociation enthalpy, ionisation potential and proton affinity) associated with ORAC. We also applied the clusterwise linear regression anal. as a statistical method for grouping the antioxidants by structure. By analyzing the data for antioxidants, the trend in the hydrophilic ORAC values was determined using the calculated structures and bond dissociation enthalpies of the groups classified according to the presence or absence of oxygen functional groups in the ortho position of phenol. Further studies of indicators other than bond dissociation enthalpy are needed to predict the ORAC of other antioxidants such as flavonoids and indoles. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Quality Control of 3-Hydroxyphenylacetic acid

The Article related to phenolic compound oxygen radical absorbance capacity sar, Physical Organic Chemistry: Oxidation-Reduction, Including Dehydrogenation and Hydrogenolysis and other aspects.Quality Control of 3-Hydroxyphenylacetic acid

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On January 28, 2021, Kuttruff, Christian Andreas; Bretschneider, Tom; Godbout, Cedrickx; Koolman, Hannes Fiepko; Martyres, Domnic; Roth, Gerald Juergen published a patent.Computed Properties of 386704-04-7 The title of the patent was N-Methyl-N-(6-(methoxy)pyridazin-3-yl)amine derivatives as autotaxin (ATX) modulators for the treatment of inflammatory airway or fibrotic diseases and preparation thereof. And the patent contained the following:

The invention relates to N-methyl-N-(6-(methoxy)pyridazin-3-yl)amine derivatives of formula I as autotaxin (ATX) modulators for the treatment of inflammatory airway or fibrotic diseases such as e.g. idiopathic lung disease (IFF) or systemic sclerosis (SSc). Compounds of formula I wherein A is substituted pyridyl; E is (un)substituted Ph and (un)substituted pyridyl; K is substituted piperazinyl, substituted piperidinyl, substituted 2,6-diazabicyclo[3.3]heptanyl, etc.; are claimed. 1-(6-(4-(((6-((6-(Trifluoromethyl)pyridin-3-yl)methoxy)pyridazin-3-yl)amino)methyl)phenyl)-2,6-diazaspiro[3.3]heptan-2-yl)ethan-1-one (II) was prepared by N-arylation of 1-(6-(4-(aminomethyl)phenyl)-2,6-diazaspiro[3.3]heptan-2-yl)ethan-1-one with 3-Iodo-6-((6-(trifluoromethyl)pyridin-3-yl)methoxy)pyridazine. The invention compounds were evaluated for their ATX modulatory activity. From the assay, it was determined that compound II exhibited IC50 value of 3.4 nM. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Computed Properties of 386704-04-7

The Article related to pyridazinamine preparation autotaxin modulator, Heterocyclic Compounds (More Than One Hetero Atom): Pyridazines, Cinnolines, and Phthalazines and other aspects.Computed Properties of 386704-04-7

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On January 28, 2021, Kuttruff, Christian Andreas; Godbout, Cedrickx; Koolman, Hannes Fiepko; Roth, Gerald Juergen published a patent.Application In Synthesis of (6-(Trifluoromethyl)pyridin-3-yl)methanol The title of the patent was N-Methyl-N-(6-(methoxy)pyridazin-3-yl)amine derivatives as autotaxin (ATX) modulators for the treatment of inflammatory airway or fibrotic diseases and preparation thereof. And the patent contained the following:

The invention relates to N-methyl-N-(6-(methoxy)pyridazin-3-yl)amine derivatives of formula I as autotaxin (ATX) modulators for the treatment of inflammatory airway or fibrotic diseases such as e.g. idiopathic lung disease (IFF) or systemic sclerosis (SSc). Compounds of formula I wherein A is substituted pyridyl; E is (un)substituted Ph and (un)substituted pyridyl; K is substituted piperazinyl, substituted piperidinyl and substituted pyrrolidinyl; L and M are independently H, Me and CH2OH; LM can be taken together to form cyclopropyl; are claimed. 1-[4-(4-{1-[(6-{[6-(Trifluoromethyl)pyridin-3-yl]methoxy}pyridazin-3-yl)amino]cyclopropyl}-phenyl)piperazin-l-yl]ethan-1-one (II) was prepared by N-arylation of 1-{4-[4-(1-aminocyclopropyl)phenyl]-piperazin-1-yl}ethan-1-one with 3-iodo-6-((6-(trifluoromethyl)pyridin-3-yl)methoxy)pyridazine. The invention compounds were evaluated for their ATX modulatory activity. From the assay, it was determined that compound II exhibited IC50 value of 2.5 nM. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Application In Synthesis of (6-(Trifluoromethyl)pyridin-3-yl)methanol

The Article related to pyridazinamine preparation autotaxin modulator, Heterocyclic Compounds (More Than One Hetero Atom): Pyridazines, Cinnolines, and Phthalazines and other aspects.Application In Synthesis of (6-(Trifluoromethyl)pyridin-3-yl)methanol

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Alcohol – Wikipedia,
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On January 31, 2001, Zhu, Chun M.; Wang, Liang Y.; Kong, Lin R.; Yang, Xi; Wang, Lian S.; Zheng, Shao J.; Chen, Fei L.; Feng, Man Z.; Huang, Zong published an article.COA of Formula: C8H19NO2 The title of the article was QSPR study of quenching of singlet oxygen by aliphatic amines. And the article contained the following:

From the quenching rates of singlet O by aliphatic amines, a Quant. Structure-Property Relationship (QSPR) prediction equation was developed for 19 aliphatic amines:. Log(kq) = 71.639 + 7.148Ehomo – 0.0146α. N = 19, R = 0.911, SE = 0.892, F = 36.653, P < 0.00001. The quenching rate depends on two factors: the ionization potential and number of substituents and their size. The quenching rates of some substituted quinolines were determined according to B. Monroe's method. 8-Methylaminoquinoline shows greater quenching rate than the traditional quencher 1,4-diazobicyclo-[2.2.2]octane; it can be used as a good antioxidant. The experimental process involved the reaction of 2,2'-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).COA of Formula: C8H19NO2

The Article related to qspr quenching singlet oxygen aliphatic amine, Physical Organic Chemistry: Oxidation-Reduction, Including Dehydrogenation and Hydrogenolysis and other aspects.COA of Formula: C8H19NO2

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Alcohol – Wikipedia,
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On December 31, 2022, Sun, Litao; Wang, Yu; Ma, Dexin; Wang, Linlin; Zhang, Xiaomei; Ding, Yiqian; Fan, Kai; Xu, Ze; Yuan, Changbo; Jia, Houzhen; Ren, Yonglin; Ding, Zhaotang published an article.Safety of 2,3-Dihydroxypropanoic acid The title of the article was Differential responses of the rhizosphere microbiome structure and soil metabolites in tea (Camellia sinensis) upon application of cow manure. And the article contained the following:

The rhizosphere is the narrow zone of soil immediately surrounding the root, and it is a critical hotspot of microbial activity, strongly influencing the physiol. and development of plants. For analyzing the relationship between the microbiome and metabolome in the rhizosphere of tea (Camellia sinensis) plants, the bacterial composition and its correlation to soil metabolites were investigated under three different fertilization treatments (unfertilized, urea, cow manure) in different growing seasons (spring, early and late summer). The bacterial phyla Proteobacteria, Bacteroidetes, Acidobacteria and Actinobacteria dominated the rhizosphere of tea plants regardless of the sampling time. These indicated that the compositional shift was associated with different fertilizer/manure treatments as well as the sampling time. However, the relative abundance of these enriched bacteria varied under the three different fertilizer regimes. Most of the enriched metabolic pathways stimulated by different fertilizer application were all related to sugars, amino acids fatty acids and alkaloids metabolism Organic acids and fatty acids were potential metabolites mediating the plant-bacteria interaction in the rhizosphere. Bacteria in the genera Proteiniphilum, Fermentimonas and Pseudomonas in spring, Saccharimonadales and Gaiellales in early summer, Acidobacteriales and Gaiellales in late summer regulated relative contents of organic and fatty acids. This study documents the profound changes to the rhizosphere microbiome and bacterially derived metabolites under different fertilizer regimes and provides a conceptual framework towards improving the performance of tea plantations. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Safety of 2,3-Dihydroxypropanoic acid

The Article related to camellia rhizosphere microbiome soil metabolite cow manure, bacterial microbiome, fertilizer, metabolome, organic, rhizosphere, Fertilizers, Soils, and Plant Nutrition: Plant-Fertilizer-Soil Systems, Including Amendments and other aspects.Safety of 2,3-Dihydroxypropanoic acid

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Alcohol – Wikipedia,
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Patra, Alakananda; Swamynathan, K.; Kumar, Sandeep published an article in 2021, the title of the article was Synthesis of novel regioisomeric phenanthro[a]phenazine derivatives through the SNAr strategy and their self-assembly into columnar phases.Name: 1-Decanethiol And the article contains the following content:

The cyclocondensation reaction of triphenylene-1,2-diquinone with 1,2-diamino-4-nitrobenzene results in two regioisomers, and is succeeded by a nucleophilic substitution reaction with alkyl mercaptans. The synthesis of unsym. substituted phenazines, separation and characterization of their regioisomers are rare in discotic liquid crystal chem. Here, for the first time the synthesis of two regioisomers of phenanthro[a]phenazine via a simple SNAr substitution reaction was reported. Separation of these regioisomers was achieved successfully via column chromatog. and they were well characterized by spectroscopic anal. Both the regioisomers were found to be mesomorphic. This study throws a lot of light on the SNAr strategy for functionalizing diverse π-conjugated systems for various applications. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Name: 1-Decanethiol

The Article related to phenanthrophenazine preparation columnar phase self assembly, Heterocyclic Compounds (More Than One Hetero Atom): Other 6-Membered Rings, Two Hetero Atoms and other aspects.Name: 1-Decanethiol

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On December 21, 2006, Eliu, Victor Paul; Froehling, Beate; Kauffmann, Dominique published a patent.Computed Properties of 62640-03-3 The title of the patent was Styryl sulfide dyes, compositions thereof and processes for their preparation. And the patent contained the following:

Disclosed are styryl sulfide dyes of formula (I), wherein R1, R’1, R2, R’2, R3 and R’3 independently from each other are H; C1-C20 alkyl or C1-C20 alkoxy, which may be substituted by one or more C1-C5 alkoxy, halogen, -NH2, mono-C1-C5 alkylamino, di-C1-C5 alkylamino, -NO2 or hydroxy; C3-C6 cycloalkyl; -C(O)H; -C(O)-C1-C5 alkyl; halogen; NO2; OH; Ph, which may be substituted by one or more C1-C5 alkyl, C1-C5 alkoxy, halogen, -NH2, mono-C1-C5 alkylamino, di-C1-C5 alkylamino, -NO2 or hydroxy; or a radical of formula -NR4R5, wherein R4 and R5 independently from each other are H; C1-C12 alkyl, which may be substituted by one or more C1-C5 alkyl, C1-C5 alkoxy, hydroxy or -(CO)-H; -(CO)-C1-C5 alkyl; Ph or phenyl-C1-C4 alkyl, wherein the Ph moiety may be substituted by one or more C1-C5 alkyl, C1-C5 alkoxy, halogen, -NH2, mono-C1-C5 alkylamino, di-C1-C5 alkylamino, -NO2, carboxy or hydroxy; W1, W’1, W2, W’2, W3, W’3, W4 or W’4, independently from each other are -CH- or -N+-; wherein only one of W1/W’1, W2/W’2, W3/W’3, W4/W4′ is -N+; and the bivalent radical -Q-Z-Y-S-S-Y’-Z’-Q’- is bonded to W1 or W2 and W’1 or W’2 resp.; Y1 and Y2 independently from each other are C1-C10 alkylene; C5-C10 cycloalkylene; C5-C12 arylene; or C5-C12 arylene-(C1-C10 alkylene); Q and Q’ independently from each other are the direct bond; or -C(O)-; -C(O)O-; -OCO-; -N(R6)-; -N+(R6)(R7)-; -C(O)N(R6)-; -(R6)NC(O)-; -O-; -S-; -S(O)-; or -S(O)2-; and R6 and R7 independently from each other are H. Further, the present invention relates to novel styryl sulfide compounds, compositions thereof, especially comprising other dyes, and to processes for their preparation The novel styryl sulfide dyes are useful for the dyeing of organic materials, such as keratin fibers, wool, leather, silk, cellulose or polyamides, especially keratin-containing fibers, cotton or nylon, and human hair. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Computed Properties of 62640-03-3

The Article related to styryl sulfide dye composition process preparation, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Heterocyclics and other aspects.Computed Properties of 62640-03-3

Referemce:
Alcohol – Wikipedia,
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On May 10, 1999, Hii, King Kuok; Thornton-Pett, Mark; Jutand, Anny; Tooze, Robert P. published an article.Application In Synthesis of 2,2′-(tert-Butylazanediyl)diethanol The title of the article was Syntheses and Properties of Palladium Complexes Containing Phosphorus-Nitrogen-Phosphorus Ligands with a Tunable Hemilabile Site. And the article contained the following:

A series of phosphorus-nitrogen-phosphorus (PNP) ligands of the type R-N(CH2CH2PPh2)2 (R = C(:O)(C6H4OMe-p), tBu, Ph, C6H4OMe-p) have been prepared Their coordination chem. to palladium(II) and palladium(0) complexes was examined using a combination of x-ray crystallog., NMR, and electrochem. techniques. The palladium(0) complexes undergo reactions with aryl iodides to give the palladium(II) complexes [Pd(Ar){R-N(CH2CH2PPh2)2}]+I-, where the rate of oxidative addition was dependent on the nature of the aryl group, as well as the substitution on nitrogen. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).Application In Synthesis of 2,2′-(tert-Butylazanediyl)diethanol

The Article related to palladium phosphorus nitrogen ligand preparation oxidative addition aryl iodide, crystal mol structure phosphorus nitrogen ligand palladium complex, Organometallic and Organometalloidal Compounds: Group Viii – Co, Ni, Ru, Rh, Pd, Os, Ir, Pt and other aspects.Application In Synthesis of 2,2′-(tert-Butylazanediyl)diethanol

Referemce:
Alcohol – Wikipedia,
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On February 7, 2014, Raman, Jayaraman Venkat; Sahu, Rajesh; Parikh, Ankur; Patel, Naresh published a patent.Safety of 2-Methyl-2-propylpropane-1,3-diol The title of the patent was A process for preparing highly pure meprobamate. And the patent contained the following:

The invention relates to a process for preparing highly pure meprobamate (I). Compound I was prepared by O-acylation of 2-methyl-2-propyl-1,3-propanedione with phosgene; the resulting 2-methyl-2-propyl-1,3-propanediyl bis(chlorocarbonate) underwent amidation with ammonia to give compound I. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Safety of 2-Methyl-2-propylpropane-1,3-diol

The Article related to meprobamate preparation, propanediyl bischlorocarbonate preparation ammonia amidation, propanedione phosgene acylation, Aliphatic Compounds: Ureas, Carbamic Acids, Guanidines, and Their Sulfur-Containing Analogs and other aspects.Safety of 2-Methyl-2-propylpropane-1,3-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On February 27, 2020, Quattropani, Anna; Kulkarni, Santosh S.; Rakesh, Paul; Giri, Awadut Gajendra published a patent.Recommanded Product: (6-(Trifluoromethyl)pyridin-3-yl)methanol The title of the patent was Preparation of spiro compounds as glycosidase inhibitors. And the patent contained the following:

The invention relates to compounds of formula I, and pharmaceutically usable derivatives, solvates, salts, prodrugs, tautomers, enantiomers, racemates and stereoisomers thereof, including mixtures thereof in all ratios and compounds of formula I, wherein one or more H atoms may be replaced by D (deuterium) which are useful as glycosidase inhibitors, useful in the treatment of tauopathies and Alzheimer’s disease. Compounds of formula I wherein, R is (un)branched alkyl; L is CH2, NH2 and derivatives, N(CH2)0-2, etc.; Q1 is CH2, CO; Q2 is CH2 and CO; n = 0 – 2; A is benzothiazolyl, benzofuranyl, imidazolpyridyl, etc.; Z is H, halo, CN, OH, etc.; are claimed. The example compound II was prepared by condensation of 3-methyl-1,3,8-triazaspiro[4.5]decane-2,4-dione with 5-(1-chloroethyl)benzo[d]thiazole. Compounds I were evaluated for their glycosidase inhibtory activity (some data given). The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Recommanded Product: (6-(Trifluoromethyl)pyridin-3-yl)methanol

The Article related to piperazine preparation glycosidase inhibitor treatment tauopathy alzheimer, Heterocyclic Compounds (One Hetero Atom): Spiro Compounds With One Hetero Atom In Each Ring and other aspects.Recommanded Product: (6-(Trifluoromethyl)pyridin-3-yl)methanol

Referemce:
Alcohol – Wikipedia,
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